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  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
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  3. Dec 2024
  4. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224027809-main-html.html
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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  6. Nov 2024
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    Reprogramming of fibroblasts into cancer-associated fibroblasts via IGF2-mediated autophagy promotes metastasis of lung cancer cells
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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  9. Sep 2024
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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  11. Aug 2024
  12. josr-online.biomedcentral.com josr-online.biomedcentral.com
    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
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  14. Jul 2024
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    A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
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    1. scibot 19 Jul 2024
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    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits
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  18. Jun 2024
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    Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice
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    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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  21. May 2024
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    Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis
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  23. Apr 2024
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
  25. Mar 2024
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    sciencedirect.com/science/article/pii/S2211124724002286
  27. Feb 2024
  28. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  30. Jan 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bruton’s Tyrosine Kinase Inhibitors With Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
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  33. Dec 2023
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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  35. 52.53.155.43 52.53.155.43
    mct-22-0642 (1)-html.html
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  36. Nov 2023
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
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  39. Oct 2023
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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  41. Jul 2023
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    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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      DOI: 10.1158/0008-5472.CAN-22-0945

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  43. Jun 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression
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    sciencedirect.com/science/article/pii/S2589004223010763
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  47. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.16069

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16069
  48. May 2023
  49. www.sciencedirect.com www.sciencedirect.com
    A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation
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      DOI: 10.1016/j.ebiom.2023.104594

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    sciencedirect.com/science/article/pii/S2352396423001597
  50. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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      DOI: 10.1038/s41467-023-38165-6

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    nature.com/articles/s41467-023-38165-6
  51. Apr 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP
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    sciencedirect.com/science/article/pii/S2589004223006156
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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      DOI: 10.1016/j.isci.2023.106639

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    Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
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    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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    Identification of a comprehensive alternative splicing function during epithelial-mesenchymal transition
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    sciencedirect.com/science/article/pii/S2589004223005941
  57. Mar 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
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    β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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  70. Aug 2022
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    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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  118. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
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  122. Mar 2021
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells
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  125. Feb 2021
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    Intravenous Administration of Triptonide Attenuates CFA-Induced Pain Hypersensitivity by Inhibiting DRG AKT Signaling Pathway in Mice
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  127. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    (+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma
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  129. atm.amegroups.com atm.amegroups.com
    MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro
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  130. Jan 2021
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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  132. Dec 2020
  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Functional inhibition of heat shock protein 70 by VER‐155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism
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      AKT (pan) (11E7) rabbit mAb

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    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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  135. Oct 2020
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    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance
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  137. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
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  139. Sep 2020
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    Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla
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  141. www.sciencedirect.com www.sciencedirect.com
    GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
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  142. elifesciences.org elifesciences.org
    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
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    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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  144. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats
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    H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells
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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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  148. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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    OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling
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    Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1
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      Rabbit anti-AKT pan (11EZ)

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    Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes
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    Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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  153. Jan 2020
  154. elifesciences.org elifesciences.org
    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
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    Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet
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    GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
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    Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation
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      AB_2225340

      DOI: 10.1152/ajpendo.00050.2018

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    Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide
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    Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
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    12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
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    Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice
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      DOI: 10.1210/en.2018-00989

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      DOI: 10.1016/j.celrep.2019.02.081

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  163. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition
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      RRID:AB_2225340

      DOI: 10.1111/bph.14652

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  164. www.sciencedirect.com www.sciencedirect.com
    Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
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      DOI: 10.1016/j.ajpath.2018.12.008

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      DOI: 10.1016/j.scr.2019.101390

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  166. Nov 2018
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    Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor
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    Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
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    Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells
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    Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs
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  171. academic.oup.com academic.oup.com
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress
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  174. europepmc.org europepmc.org
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  176. Nov 2017
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    Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
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  178. academic.oup.com academic.oup.com
    Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice
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      AB_2225340

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    EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis
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    1. scibot 08 Nov 2017
      AB_2225340

      Curator: @chewbeccax

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  180. link.springer.com link.springer.com
    Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats
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      AB_2225340

      Curator: @chewbeccax

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    link.springer.com/article/10.1007/s12035-017-0538-y
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    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
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      AB_2225340

      Curator: @kaitlinsung

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