77 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit
    1
    1. scibot 10 Dec 2024
      RRID:AB_2228008

      DOI: 10.1016/j.xcrm.2024.101868

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    sciencedirect.com/science/article/pii/S2666379124006396
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
    1
    1. scibot 09 Oct 2024
      AB_2228008

      DOI: 10.1210/endocr/bqae129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11456883/
  5. Sep 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation
    1
    1. scibot 25 Sep 2024
      RRID:AB_2228008

      DOI: 10.1016/j.celrep.2019.05.012

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    sciencedirect.com/science/article/pii/S2211124719306230
  7. Aug 2024
  8. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer
    1
    1. scibot 02 Aug 2024
      BCL-XL

      DOI: 10.1186/s13058-020-01374-8

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    breast-cancer-research.biomedcentral.com/article/10.1186/s13058-020-01374-8
  9. Jul 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation
    1
    1. scibot 31 Jul 2024
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      DOI: 10.3390/biomedicines12071612

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    ncbi.nlm.nih.gov/pmc/articles/PMC11274534/
  11. May 2024
  12. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 03 May 2024
      RRID:AB_2228008

      DOI: 10.1111/bph.16391

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
  13. Apr 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden
    1
    1. scibot 11 Apr 2024
      RRID:AB_2228008

      DOI: 10.1158/2767-9764.CRC-23-0430

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    ncbi.nlm.nih.gov/pmc/articles/PMC11003453/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death
    1
    1. scibot 03 Apr 2024
      RRID:AB_2228008

      DOI: 10.1016/j.isci.2024.109384

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    ncbi.nlm.nih.gov/pmc/articles/PMC10972828/
  16. Mar 2024
  17. www.sciencedirect.com www.sciencedirect.com
    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
    1
    1. scibot 19 Mar 2024
      RRID:AB_2228008

      DOI: 10.1016/j.cell.2024.02.023

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    sciencedirect.com/science/article/pii/S0092867424002253
  18. www.sciencedirect.com www.sciencedirect.com
    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
    2
    1. scibot 19 Mar 2024
      RRID:AB_2228008

      DOI: 10.1016/j.molcel.2024.02.035

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    2. scibot 19 Mar 2024
      RRID:AB_2228008

      DOI: 10.1016/j.molcel.2024.02.035

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    sciencedirect.com/science/article/pii/S109727652400176X
  19. Feb 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer
    1
    1. scibot 16 Feb 2024
      RRID:AB_2228008

      DOI: 10.1158/1078-0432.CCR-23-0375

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527398/
  21. Dec 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113513

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    sciencedirect.com/science/article/pii/S2211124723015255
  23. Nov 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
    2
    1. scibot 11 Nov 2023
      RRID:AB_2228008

      DOI: 10.1097/BS9.0000000000000168

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    2. scibot 11 Nov 2023
      RRID:AB_2228008

      DOI: 10.1097/BS9.0000000000000168

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
  25. Sep 2023
  26. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects
    1
    1. scibot 22 Sep 2023
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      DOI: 10.1111/acel.13954

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    onlinelibrary.wiley.com/doi/10.1111/acel.13954
  27. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
    1
    1. scibot 19 Sep 2023
      RRID:AB_2228008

      DOI: 10.1016/j.celrep.2023.113084

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    sciencedirect.com/science/article/pii/S2211124723010951
  28. Aug 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
    1
    1. scibot 04 Aug 2023
      RRID:AB_2228008

      DOI: 10.1016/j.isci.2023.107369

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    ncbi.nlm.nih.gov/pmc/articles/PMC10393801/
  30. Jul 2023
  31. 52.53.155.43 52.53.155.43
    HIV-1 Tat Upregulates TREM1 Expression in Human Microglia
    1
    1. scibot 13 Jul 2023
      RRID:AB_2228008

      DOI: 10.4049/jimmunol.2300152

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    52.53.155.43/628fffd9a87f1df77eec88cccea8cf0c58502533/ji2300152-html.html
  32. Jun 2023
  33. www.sciencedirect.com www.sciencedirect.com
    SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury
    1
    1. scibot 08 Jun 2023
      RRID:AB_2228008

      DOI: 10.1016/j.isci.2023.106953

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    sciencedirect.com/science/article/pii/S2589004223010301
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
    1
    1. scibot 07 Jun 2023
      RRID:AB_2228008

      DOI: 10.1158/0008-5472.CAN-22-0370

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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  35. May 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation
    1
    1. scibot 13 May 2023
      RRID:AB_2228008

      DOI: 10.1016/j.isci.2023.106674

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    sciencedirect.com/science/article/pii/S2589004223007514
  37. Apr 2023
  38. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    1
    1. scibot 08 Apr 2023
      RRID:AB_2228008

      DOI: 10.1016/j.xcrm.2023.101007

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    sciencedirect.com/science/article/pii/S2666379123001179
  39. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
    1
    1. scibot 06 Apr 2023
      RRID:AB_2228008

      DOI: 10.1016/j.celrep.2023.112324

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    sciencedirect.com/science/article/pii/S2211124723003352
  40. Feb 2023
  41. www.sciencedirect.com www.sciencedirect.com
    IFNγ signaling sensitizes melanoma cells to BH3 Mimetics
    1
    1. scibot 04 Feb 2023
      AB_2228008

      DOI: 10.1016/j.jid.2023.01.017

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    sciencedirect.com/science/article/pii/S0022202X23000726
  42. Nov 2022
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
    1
    1. scibot 18 Nov 2022
      RRID:AB_2228008

      DOI: 10.1016/j.isci.2022.105458

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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  44. Sep 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A
    1
    1. scibot 08 Sep 2022
      RRID:AB_2228008

      DOI: 10.1016/j.isci.2022.104952

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    ncbi.nlm.nih.gov/pmc/articles/PMC9440292/
  46. Jul 2022
  47. academic.oup.com academic.oup.com
    Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function
    1
    1. scibot 02 Jul 2022
      AB_2228008

      DOI: 10.1210/endocr/bqac081

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    academic.oup.com/endo/article/163/7/bqac081/6596276
  48. Jun 2022
  49. www.sciencedirect.com www.sciencedirect.com
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
    1
    1. scibot 29 Jun 2022
      RRID:AB_2228008

      DOI: 10.1016/j.celrep.2022.111019

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    sciencedirect.com/science/article/pii/S2211124722008087
  50. May 2022
  51. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
    1
    1. scibot 13 May 2022
      RRID:AB_2228008

      DOI: 10.1158/2159-8290.CD-21-1168

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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  52. journals.sagepub.com journals.sagepub.com
    Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats - Martina L. Hernandez, Michael Marone, Karen M. Gorse, Audrey D. Lafrenaye, 2022
    1
    1. scibot 10 May 2022
      RRID:AB_2228008

      DOI: 10.1177/17590914221099112

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    journals.sagepub.com/doi/full/10.1177/17590914221099112
  53. Apr 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
    1
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      RRID:AB_2228008

      DOI: 10.1016/j.devcel.2022.03.019

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    sciencedirect.com/science/article/pii/S1534580722002295
  55. www.sciencedirect.com www.sciencedirect.com
    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
    1
    1. scibot 21 Apr 2022
      RRID:AB_2228008

      DOI: 10.1016/j.cell.2022.03.030

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    sciencedirect.com/science/article/pii/S0092867422003403
  56. Mar 2022
  57. elifesciences.org elifesciences.org
    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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      RRID:AB_2228008

      DOI: 10.7554/eLife.73150

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    elifesciences.org/articles/73150
  58. Feb 2022
  59. www.sciencedirect.com www.sciencedirect.com
    BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer
    1
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      RRID:AB_2228008

      DOI: 10.1016/j.celrep.2022.110374

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    sciencedirect.com/science/article/pii/S221112472200095X
  60. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
    2
    1. scibot 11 Feb 2022
      RRID:AB_2228008

      DOI: 10.1016/j.immuni.2022.01.003

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    2. scibot 09 Feb 2022
      RRID:AB_2228008

      DOI: 10.1016/j.immuni.2022.01.003

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    pubmed.ncbi.nlm.nih.gov/35139355/
  61. Jan 2022
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
    1
    1. scibot 15 Jan 2022
      RRID:AB_10695729

      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  63. Nov 2021
  64. www.sciencedirect.com www.sciencedirect.com
    TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
    1
    1. scibot 10 Nov 2021
      RRID:AB_2228008

      DOI: 10.1016/j.celrep.2021.109979

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    sciencedirect.com/science/article/pii/S2211124721014583
  65. www.sciencedirect.com www.sciencedirect.com
    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
    1
    1. scibot 10 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109988

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  66. Oct 2021
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    Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
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  68. Aug 2021
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    Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition
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  70. elifesciences.org elifesciences.org
    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  72. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
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  74. Jul 2021
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    lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis
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  76. link.springer.com link.springer.com
    GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma
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      Bcl-XL

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    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
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    Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord
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  80. May 2021
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    Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells
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    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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    Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
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  85. Apr 2021
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    ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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  88. Feb 2021
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    LncRNA RP6‐65G23.1 accelerates proliferation and inhibits apoptosis via p‐ERK1/2/p‐AKT signaling pathway on keratinocytes
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    Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength
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  91. Oct 2020
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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  93. Sep 2020
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells
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    Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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  99. Jan 2020
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    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
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  101. mbio.asm.org mbio.asm.org
    TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
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    Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover
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  103. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
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  106. Nov 2018
  107. www.nature.com www.nature.com
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    NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma
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    MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
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  110. Nov 2017
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    Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival
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    Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
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