91 Matching Annotations
  1. Dec 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
  3. Nov 2025
  4. www.biorxiv.org www.biorxiv.org
    Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs
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    biorxiv.org/content/10.1101/2025.11.14.688272v1
  5. Oct 2025
  6. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  7. Sep 2025
  8. www.biorxiv.org www.biorxiv.org
    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    biorxiv.org/content/10.1101/2025.09.05.674562v1
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct co-targeting of Bcl-xL and Mcl-1 exhibits synergistic effects in AR-V7-expressing CRPC models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12368576/
  10. Aug 2025
  11. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225016840-main-html.html
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    52.53.155.43/23fa3039143e04e3669aa6d24e522324d4b71ce2/1-s2.0-S2589004225016840-main-html.html
  12. Jul 2025
  13. www.biorxiv.org www.biorxiv.org
    Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance
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    biorxiv.org/content/10.1101/2025.06.24.661170v1
  14. Jun 2025
  15. www.cell.com www.cell.com
    BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways
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    cell.com/cell-reports/fulltext/S2211-1247(25)00550-9
  16. May 2025
  17. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225008454-main-html.html
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  18. Apr 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11964295/
  20. Feb 2025
  21. www.preprints.org www.preprints.org
    The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation
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    preprints.org/manuscript/202405.1740/v1
  22. www.sciencedirect.com www.sciencedirect.com
    Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML
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    sciencedirect.com/science/article/pii/S0006497124110634
  23. 52.53.155.43 52.53.155.43
    PDF-html.html
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  24. Dec 2024
  25. www.nature.com www.nature.com
    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
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    Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit
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    sciencedirect.com/science/article/pii/S2666379124006396
  27. Oct 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    ncbi.nlm.nih.gov/pmc/articles/PMC11456883/
  29. Sep 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation
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    sciencedirect.com/science/article/pii/S2211124719306230
  31. Aug 2024
  32. breast-cancer-research.biomedcentral.com breast-cancer-research.biomedcentral.com
    Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer
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    breast-cancer-research.biomedcentral.com/article/10.1186/s13058-020-01374-8
  33. Jul 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11274534/
  35. May 2024
  36. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
  37. Apr 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden
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    ncbi.nlm.nih.gov/pmc/articles/PMC11003453/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972828/
  40. Mar 2024
  41. www.sciencedirect.com www.sciencedirect.com
    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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    sciencedirect.com/science/article/pii/S0092867424002253
  42. www.sciencedirect.com www.sciencedirect.com
    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
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    sciencedirect.com/science/article/pii/S109727652400176X
  43. Feb 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527398/
  45. Dec 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
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    sciencedirect.com/science/article/pii/S2211124723015255
  47. Nov 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
  49. Sep 2023
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects
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    onlinelibrary.wiley.com/doi/10.1111/acel.13954
  51. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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    sciencedirect.com/science/article/pii/S2211124723010951
  52. Aug 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10393801/
  54. Jul 2023
  55. 52.53.155.43 52.53.155.43
    HIV-1 Tat Upregulates TREM1 Expression in Human Microglia
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  56. Jun 2023
  57. www.sciencedirect.com www.sciencedirect.com
    SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury
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    sciencedirect.com/science/article/pii/S2589004223010301
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
  59. May 2023
  60. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation
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    sciencedirect.com/science/article/pii/S2589004223007514
  61. Apr 2023
  62. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  63. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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    sciencedirect.com/science/article/pii/S2211124723003352
  64. Feb 2023
  65. www.sciencedirect.com www.sciencedirect.com
    IFNγ signaling sensitizes melanoma cells to BH3 Mimetics
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    sciencedirect.com/science/article/pii/S0022202X23000726
  66. Nov 2022
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  68. Sep 2022
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC9440292/
  70. Jul 2022
  71. academic.oup.com academic.oup.com
    Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function
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    academic.oup.com/endo/article/163/7/bqac081/6596276
  72. Jun 2022
  73. www.sciencedirect.com www.sciencedirect.com
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    sciencedirect.com/science/article/pii/S2211124722008087
  74. May 2022
  75. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  76. journals.sagepub.com journals.sagepub.com
    Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats - Martina L. Hernandez, Michael Marone, Karen M. Gorse, Audrey D. Lafrenaye, 2022
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    journals.sagepub.com/doi/full/10.1177/17590914221099112
  77. Apr 2022
  78. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
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    sciencedirect.com/science/article/pii/S1534580722002295
  79. www.sciencedirect.com www.sciencedirect.com
    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
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    sciencedirect.com/science/article/pii/S0092867422003403
  80. Mar 2022
  81. elifesciences.org elifesciences.org
    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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    elifesciences.org/articles/73150
  82. Feb 2022
  83. www.sciencedirect.com www.sciencedirect.com
    BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer
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    sciencedirect.com/science/article/pii/S221112472200095X
  84. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
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    pubmed.ncbi.nlm.nih.gov/35139355/
  85. Jan 2022
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  87. Nov 2021
  88. www.sciencedirect.com www.sciencedirect.com
    TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
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    sciencedirect.com/science/article/pii/S2211124721014583
  89. www.sciencedirect.com www.sciencedirect.com
    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
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    sciencedirect.com/science/article/pii/S2211124721014674
  90. Oct 2021
  91. www.sciencedirect.com www.sciencedirect.com
    Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
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    sciencedirect.com/science/article/pii/S1934590921003854
  92. Aug 2021
  93. www.sciencedirect.com www.sciencedirect.com
    Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition
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    sciencedirect.com/science/article/pii/S153458072100602X
  94. elifesciences.org elifesciences.org
    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways
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    elifesciences.org/articles/64148
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5659703/
  96. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
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    sciencedirect.com/science/article/pii/S1550413119300117
  97. academic.oup.com academic.oup.com
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    academic.oup.com/endo/article/158/10/3647/4080743
  98. Jul 2021
  99. www.sciencedirect.com www.sciencedirect.com
    lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis
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    sciencedirect.com/science/article/pii/S0890850819304153
  100. link.springer.com link.springer.com
    GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma
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    link.springer.com/article/10.1186/s12885-019-6195-y
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    sciencedirect.com/science/article/pii/S221112471831725X
  102. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
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    sciencedirect.com/science/article/pii/S1550413119300117
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    Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord
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    sciencedirect.com/science/article/pii/S1044743116301579
  104. May 2021
  105. www.sciencedirect.com www.sciencedirect.com
    Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells
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    sciencedirect.com/science/article/pii/S1074761321001746
  106. www.sciencedirect.com www.sciencedirect.com
    Invariant natural killer T cells coordinate removal of senescent cells
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    sciencedirect.com/science/article/pii/S266663402100163X
  107. www.sciencedirect.com www.sciencedirect.com
    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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    sciencedirect.com/science/article/pii/S0168365921001267
  108. www.sciencedirect.com www.sciencedirect.com
    Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
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    sciencedirect.com/science/article/pii/S1550413121000115
  109. Apr 2021
  110. www.sciencedirect.com www.sciencedirect.com
    ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
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    sciencedirect.com/science/article/pii/S0092867420308734
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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    sciencedirect.com/science/article/pii/S1535610820305419
  112. Feb 2021
  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA RP6‐65G23.1 accelerates proliferation and inhibits apoptosis via p‐ERK1/2/p‐AKT signaling pathway on keratinocytes
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29685
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength
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    ncbi.nlm.nih.gov/pmc/articles/PMC7870138/
  115. Oct 2020
  116. www.cell.com www.cell.com
    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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    cell.com/cell-reports/abstract/S2211-1247(20)31275-4
  117. Sep 2020
  118. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    sciencedirect.com/science/article/pii/S1535610819305768
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    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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    BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells
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    sciencedirect.com/science/article/pii/S2211124720303521
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    Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
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    sciencedirect.com/science/article/pii/S2211124720307117
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    sciencedirect.com/science/article/pii/S2211124720305209
  123. Jan 2020
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    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
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    sciencedirect.com/science/article/pii/S009286741930563X
  125. mbio.asm.org mbio.asm.org
    TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
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    mbio.asm.org/content/10/6/e02638-19
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    Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover
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    sciencedirect.com/science/article/pii/S1097276519304976
  127. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14773
  128. www.sciencedirect.com www.sciencedirect.com
    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
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  130. Nov 2018
  131. www.nature.com www.nature.com
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    NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
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  134. Nov 2017
  135. academic.oup.com academic.oup.com
    Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival
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    Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
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