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Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma

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1. scibot 15 Oct 2026
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.celrep.2026.117997
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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sciencedirect.com/science/article/pii/S2211124726010752
Jun 2026
aacrjournals.org aacrjournals.org

Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

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1. scibot 30 Jun 2026
  
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  RRID:AB_2228244
  
  DOI: 10.1158/0008-5472.CAN-24-3974
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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aacrjournals.org/cancerres/article/86/1/236/771157/Targeting-SUV4-20H-Epigenetic-Enzymes-Enhances
Mar 2026
54.241.53.176 54.241.53.176

1-s2.0-S2589004226006425-main-html.html

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1. scibot 10 Mar 2026
  
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  AB_2228244
  
  DOI: 10.1016/j.isci.2026.115267
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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54.241.53.176/a98184ef834a3544c2ffe9ee345455810bca4f71/1-s2.0-S2589004226006425-main-html.html
Feb 2026
www.sciencedirect.com www.sciencedirect.com

Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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1. scibot 05 Feb 2026
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.celrep.2026.116941
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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sciencedirect.com/science/article/pii/S2211124726000197
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SM08502-Mediated β-Catenin Repression Synergizes with Olaparib to Inhibit Tumor Progression

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1. scibot 06 Dec 2025
  
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  RRID:AB_2228244
  
  DOI: 10.1158/2767-9764.CRC-25-0267
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12676110/
Nov 2025
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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

1
1. scibot 06 Nov 2025
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.celrep.2025.116495
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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sciencedirect.com/science/article/pii/S2211124725012665
May 2025
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Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

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1. scibot 16 May 2025
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.cell.2025.04.012
  
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sciencedirect.com/science/article/pii/S0092867425004143
Sep 2024
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Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

1
1. scibot 17 Sep 2024
  
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  AB_2228244
  
  DOI: 10.1016/j.celrep.2024.114751
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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sciencedirect.com/science/article/pii/S2211124724011021
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

1
1. scibot 21 Aug 2024
  
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  RRID:AB_2228244
  
  DOI: 10.1038/s41388-024-03094-1
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

1
1. scibot 08 Feb 2024
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.isci.2024.108925
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
Oct 2023
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Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells

1
1. scibot 27 Oct 2023
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.celrep.2023.113308
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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sciencedirect.com/science/article/pii/S2211124723013207
Apr 2023
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The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining

1
1. scibot 12 Apr 2023
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.molcel.2023.03.017
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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sciencedirect.com/science/article/abs/pii/S1097276523002071
Jul 2021
www.cell.com www.cell.com

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

1
1. scibot 03 Jul 2021
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.molcel.2021.06.011
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00458-5
Sep 2020
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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

1
1. scibot 03 Sep 2020
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.celrep.2020.01.052
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2228244
  
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  RRID:AB_2228244 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720300772
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic interactions of G-quadruplexes in humans

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2228244
  
  DOI: 10.7554/eLife.46793
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
  Curator: @Naa003
  
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  RRID:AB_2228244 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6615864/
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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2228244
  
  DOI: 10.1016/j.ccell.2019.09.004
  
  Resource: (Cell Signaling Technology Cat# 9010, RRID:AB_2228244)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2228244
  
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  RRID:AB_2228244 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819304246