123 Matching Annotations
  1. May 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling
    1
    1. scibot 09 May 2024
      RRID:AB_2230924

      DOI: 10.1016/j.isci.2024.109787

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    ncbi.nlm.nih.gov/pmc/articles/PMC11070602/
  3. Apr 2024
  4. aacrjournals.org aacrjournals.org
    miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress
    1
    1. scibot 19 Apr 2024
      RRID:AB_2230924

      DOI: 10.1158/1541-7786.MCR-23-0676

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    aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
  5. www.embopress.org www.embopress.org
    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
    2
    1. scibot 18 Apr 2024
      Cell Signaling TechnologyCat# 9722, RRID:AB_2230924

      DOI: 10.1038/s44318-023-00008-x

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    2. scibot 18 Apr 2024
      RRID:AB_2230924

      DOI: 10.1038/s44318-023-00008-x

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    embopress.org/doi/full/10.1038/s44318-023-00008-x
  6. www.sciencedirect.com www.sciencedirect.com
    Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
    1
    1. scibot 12 Apr 2024
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2024.114069

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    sciencedirect.com/science/article/pii/S2211124724003978
  7. www.nature.com www.nature.com
    Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1038/s41593-024-01615-5

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    nature.com/articles/s41593-024-01615-5
  8. Mar 2024
  9. www.embopress.org www.embopress.org
    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
    3
    1. scibot 15 Mar 2024
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      DOI: 10.1038/s44318-023-00008-x

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    2. scibot 15 Mar 2024
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      DOI: 10.1038/s44318-023-00008-x

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    3. scibot 03 Mar 2024
      RRID:AB_2230924

      DOI: 10.1038/s44318-023-00008-x

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    embopress.org/doi/full/10.1038/s44318-023-00008-x
  10. www.embopress.org www.embopress.org
    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
    1
    1. scibot 15 Mar 2024
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      DOI: 10.1038/s44318-023-00008-x

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    embopress.org/doi/10.1038/s44318-023-00008-x
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
    1
    1. scibot 03 Mar 2024
      RRID:AB_2230924

      DOI: 10.1038/s44319-023-00026-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10897205/
  12. Feb 2024
  13. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
    1
    1. scibot 22 Feb 2024
      RRID:AB_22

      DOI: 10.1101/2023.10.02.560521

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    52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
  14. www.sciencedirect.com www.sciencedirect.com
    Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
    1
    1. scibot 13 Feb 2024
      RRID:AB_2230924

      DOI: 10.1016/j.molcel.2024.01.015

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    sciencedirect.com/science/article/pii/S1097276524000510
  15. Jan 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
    1
    1. scibot 11 Jan 2024
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2023.113658

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    sciencedirect.com/science/article/pii/S2211124723016698
  17. Dec 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
    1
    1. scibot 14 Dec 2023
      RRID:AB_2230924

      DOI: 10.1016/j.molmet.2023.101851

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    sciencedirect.com/science/article/pii/S2212877823001850
  19. Nov 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
    1
    1. scibot 22 Nov 2023
      RRID:AB_2230924

      DOI: 10.1016/j.cell.2023.10.026

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    sciencedirect.com/science/article/pii/S0092867423011777
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
    1
    1. scibot 15 Nov 2023
      RRID:AB_2230924

      DOI: 10.1101/2023.03.19.533325

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    ncbi.nlm.nih.gov/pmc/articles/PMC10055232/
  22. Oct 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
    1
    1. scibot 14 Oct 2023
      RRID:AB_2230924

      DOI: 10.1016/j.isci.2023.107956

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    ncbi.nlm.nih.gov/pmc/articles/PMC10562789/
  24. www.cell.com www.cell.com
    Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice
    1
    1. scibot 13 Oct 2023
      RRID:AB_2230924

      DOI: 10.1016/j.isci.2023.108082

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    cell.com/iscience/abstract/S2589-0042(23)02159-4
  25. Sep 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
    1
    1. scibot 30 Sep 2023
      RRID:AB_2230924

      DOI: 10.1016/j.xcrm.2023.101206

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    sciencedirect.com/science/article/pii/S2666379123003737
  27. Jul 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape
    1
    1. scibot 21 Jul 2023
      RRID:AB_2230924

      DOI: 10.1016/j.cels.2023.06.001

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    sciencedirect.com/science/article/abs/pii/S2405471223001540
  29. www.sciencedirect.com www.sciencedirect.com
    Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
    1
    1. scibot 21 Jul 2023
      RRID:AB_2230924

      DOI: 10.1016/j.neuron.2023.06.017

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    sciencedirect.com/science/article/abs/pii/S0896627323004762
  30. www.sciencedirect.com www.sciencedirect.com
    Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2
    1
    1. scibot 08 Jul 2023
      RRID:AB_2230924

      DOI: 10.1016/j.molcel.2023.06.020

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    sciencedirect.com/science/article/pii/S1097276523004677
  31. www.sciencedirect.com www.sciencedirect.com
    Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
    1
    1. scibot 01 Jul 2023
      RRID:AB_2230924

      DOI: 10.1016/j.chom.2023.05.030

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    sciencedirect.com/science/article/pii/S1931312823002238
  32. Jun 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
    1
    1. scibot 22 Jun 2023
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2023.112632

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    sciencedirect.com/science/article/pii/S2211124723006435
  34. May 2023
  35. academic.oup.com academic.oup.com
    Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes
    1
    1. scibot 12 May 2023
      RRID:AB_2230924

      DOI: 10.1210/endocr/bqad035

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    academic.oup.com/endo/article/164/4/bqad035/7056674
  36. www.sciencedirect.com www.sciencedirect.com
    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
    1
    1. scibot 05 May 2023
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2022.111077

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    sciencedirect.com/science/article/pii/S2211124722008750
  37. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
    1
    1. scibot 05 May 2023
      RRID:AB_2230924

      DOI: 10.1038/s41467-022-31905-0

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    nature.com/articles/s41467-022-31905-0
  38. Mar 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Large neutral amino acid levels tune perinatal neuronal excitability and survival
    1
    1. scibot 30 Mar 2023
      RRID:AB_2230924

      DOI: 10.1016/j.cell.2023.02.037

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    sciencedirect.com/science/article/pii/S0092867423002155
  40. www.sciencedirect.com www.sciencedirect.com
    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
    1
    1. scibot 28 Mar 2023
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  41. Feb 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
    1
    1. scibot 09 Feb 2023
      RRID:AB_2230924

      DOI: 10.1158/2159-8290.CD-21-1672

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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  43. Jan 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging
    1
    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.celrep.2023.112042

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    sciencedirect.com/science/article/pii/S2211124723000530
  45. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
    1
    1. scibot 25 Jan 2023
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2022.111965

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    sciencedirect.com/science/article/pii/S2211124722018691
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
    1
    1. scibot 07 Jan 2023
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      DOI: 10.1158/2159-8290.CD-21-0680

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    ncbi.nlm.nih.gov/pmc/articles/PMC9262860/
  47. Dec 2022
  48. www.sciencedirect.com www.sciencedirect.com
    The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
    1
    1. scibot 18 Dec 2022
      AB_2230924

      DOI: 10.1016/j.celrep.2022.111803

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    sciencedirect.com/science/article/pii/S2211124722016916
  49. Nov 2022
  50. www.mdpi.com www.mdpi.com
    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
    1
    1. scibot 22 Nov 2022
      RRID:AB_2230924

      DOI: 10.3390/cells11223665

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    mdpi.com/2073-4409/11/22/3665
  51. www.sciencedirect.com www.sciencedirect.com
    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
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    1. scibot 17 Nov 2022
      RRID:AB_2230924

      DOI: 10.1016/j.cmet.2022.10.011

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    sciencedirect.com/science/article/pii/S1550413122004892
  52. www.cell.com www.cell.com
    Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
    1
    1. scibot 10 Nov 2022
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2022.111498

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    cell.com/cell-reports/abstract/S2211-1247(22)01348-1
  53. www.cell.com www.cell.com
    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
    1
    1. scibot 10 Nov 2022
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2022.111497

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    cell.com/cell-reports/abstract/S2211-1247(22)01347-X
  54. Sep 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
    1
    1. scibot 28 Sep 2022
      RRID:AB_2230924

      DOI: 10.1016/j.celrep.2022.111433

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    sciencedirect.com/science/article/pii/S2211124722012748
  56. www.sciencedirect.com www.sciencedirect.com
    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
    1
    1. scibot 24 Sep 2022
      RRID:AB_2230924

      DOI: 10.1016/j.ccell.2022.08.016

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    Sublethal cytochrome c release generates drug-tolerant persister cells
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  58. Jul 2022
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    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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  60. Jun 2022
  61. 52.53.155.43 52.53.155.43
    cd-21-0680-html.html
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  63. www.nature.com www.nature.com
    A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
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  64. Mar 2022
  65. www.sciencedirect.com www.sciencedirect.com
    Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy
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    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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  68. Feb 2022
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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  71. Jan 2022
  72. journals.plos.org journals.plos.org
    Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
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    Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting
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    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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  75. Dec 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
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  77. Oct 2021
  78. www.sciencedirect.com www.sciencedirect.com
    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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  79. Aug 2021
  80. www.sciencedirect.com www.sciencedirect.com
    GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
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    ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  83. www.sciencedirect.com www.sciencedirect.com
    Acetylation of Cytidine in mRNA Promotes Translation Efficiency
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  85. Jul 2021
  86. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
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  87. www.sciencedirect.com www.sciencedirect.com
    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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    Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
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  89. www.sciencedirect.com www.sciencedirect.com
    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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      RRID:AB_10695409

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  91. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuronal activity‐dependent local activation of dendritic unfolded protein response promotes expression of brain‐derived neurotrophic factor in cell soma
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  92. www.cell.com www.cell.com
    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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  93. May 2021
  94. www.sciencedirect.com www.sciencedirect.com
    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
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  97. www.sciencedirect.com www.sciencedirect.com
    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation
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  99. Apr 2021
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism
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    Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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  105. Feb 2021
  106. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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      DOI: 10.1016/j.molcel.2020.11.036

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    High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers
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    Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
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    The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis
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    Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)
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  152. Nov 2017
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    The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
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      (Cell Signaling Technology Cat# 9722, RRID:AB_2230924)

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      RRID:AB_2230924 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517305798
  154. elifesciences.org elifesciences.org
    Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
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    1. scibot 08 Nov 2017
      AB_2230924

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 9722, RRID:AB_2230924)

      SciCrunch record: RRID:AB_2230924

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      RRID:AB_2230924 RRIDCUR:Validated
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    elifesciences.org/content/6/e20725
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational control of auditory imprinting and structural plasticity by eIF2α
    1
    1. scibot 08 Nov 2017
      AB_2230924

      Curator: @gabimpine

      Resource used:

      (Cell Signaling Technology Cat# 9722, RRID:AB_2230924)

      SciCrunch record: RRID:AB_2230924

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_2230924 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5245967/