133 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    eEF2K regulates pain through translational control of BDNF
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    1. scibot 18 Dec 2024
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    sciencedirect.com/science/article/pii/S1097276524009481
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFRD1 is required for maintenance of bladder epithelial homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11613175/
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    DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways
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    sciencedirect.com/science/article/pii/S2211124724013354
  6. Sep 2024
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    C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology
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    sciencedirect.com/science/article/pii/S258900422402162X
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    Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1535610819301606
  9. Aug 2024
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    An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation
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    sciencedirect.com/science/article/pii/S2211124724009689
  11. Jun 2024
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    Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes
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    sciencedirect.com/science/article/pii/S2589004224011519
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    The ribotoxic stress response drives UV-mediated cell death
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    sciencedirect.com/science/article/pii/S0092867424005270
  14. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 06 Jun 2024
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      DOI: 10.1111/bph.16436

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16436
  15. May 2024
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    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    1. scibot 25 May 2024
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      DOI: 10.1113/JP285339

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    ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling
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    1. scibot 09 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11070602/
  18. Apr 2024
  19. aacrjournals.org aacrjournals.org
    miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress
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    1. scibot 19 Apr 2024
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      DOI: 10.1158/1541-7786.MCR-23-0676

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    aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
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    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
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    Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
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    Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
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  23. Mar 2024
  24. www.embopress.org www.embopress.org
    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
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    embopress.org/doi/full/10.1038/s44318-023-00008-x
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    Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis
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    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
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      DOI: 10.1038/s44319-023-00026-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10897205/
  27. Feb 2024
  28. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
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    sciencedirect.com/science/article/pii/S1097276524000510
  30. Jan 2024
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    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
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    sciencedirect.com/science/article/pii/S2211124723016698
  32. Dec 2023
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    Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
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    sciencedirect.com/science/article/pii/S2212877823001850
  34. Nov 2023
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    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
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    sciencedirect.com/science/article/pii/S0092867423011777
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
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    1. scibot 15 Nov 2023
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      DOI: 10.1101/2023.03.19.533325

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    ncbi.nlm.nih.gov/pmc/articles/PMC10055232/
  37. Oct 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
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      DOI: 10.1016/j.isci.2023.107956

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    ncbi.nlm.nih.gov/pmc/articles/PMC10562789/
  39. www.cell.com www.cell.com
    Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice
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    cell.com/iscience/abstract/S2589-0042(23)02159-4
  40. Sep 2023
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
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      DOI: 10.1016/j.xcrm.2023.101206

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    sciencedirect.com/science/article/pii/S2666379123003737
  42. Jul 2023
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    Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape
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      DOI: 10.1016/j.cels.2023.06.001

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    sciencedirect.com/science/article/abs/pii/S2405471223001540
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    Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
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      DOI: 10.1016/j.neuron.2023.06.017

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    sciencedirect.com/science/article/abs/pii/S0896627323004762
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    Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2
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      DOI: 10.1016/j.molcel.2023.06.020

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    sciencedirect.com/science/article/pii/S1097276523004677
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    Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
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      DOI: 10.1016/j.chom.2023.05.030

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    sciencedirect.com/science/article/pii/S1931312823002238
  47. Jun 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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      DOI: 10.1016/j.celrep.2023.112632

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    sciencedirect.com/science/article/pii/S2211124723006435
  49. May 2023
  50. academic.oup.com academic.oup.com
    Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes
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      DOI: 10.1210/endocr/bqad035

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    academic.oup.com/endo/article/164/4/bqad035/7056674
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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      DOI: 10.1016/j.celrep.2022.111077

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    sciencedirect.com/science/article/pii/S2211124722008750
  52. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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    1. scibot 05 May 2023
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      DOI: 10.1038/s41467-022-31905-0

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    nature.com/articles/s41467-022-31905-0
  53. Mar 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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      DOI: 10.1016/j.cell.2023.02.037

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    sciencedirect.com/science/article/pii/S0092867423002155
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  56. Feb 2023
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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      DOI: 10.1158/2159-8290.CD-21-1672

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  58. Jan 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging
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  60. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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      DOI: 10.1158/2159-8290.CD-21-0680

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  62. Dec 2022
  63. www.sciencedirect.com www.sciencedirect.com
    The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
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      DOI: 10.1016/j.celrep.2022.111803

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  64. Nov 2022
  65. www.mdpi.com www.mdpi.com
    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
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  66. www.sciencedirect.com www.sciencedirect.com
    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
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  67. www.cell.com www.cell.com
    Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
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  68. www.cell.com www.cell.com
    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
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  69. Sep 2022
  70. www.sciencedirect.com www.sciencedirect.com
    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    Sublethal cytochrome c release generates drug-tolerant persister cells
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  73. Jul 2022
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    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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  75. Jun 2022
  76. 52.53.155.43 52.53.155.43
    cd-21-0680-html.html
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  77. www.sciencedirect.com www.sciencedirect.com
    Triangulating variation in the population to define mechanisms for precision management of genetic disease
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  78. www.nature.com www.nature.com
    A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
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  79. Mar 2022
  80. www.sciencedirect.com www.sciencedirect.com
    Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy
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    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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  83. Feb 2022
  84. www.sciencedirect.com www.sciencedirect.com
    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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  86. Jan 2022
  87. journals.plos.org journals.plos.org
    Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
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    Cytosolic adaptation to mitochondria-induced proteostatic stress causes progressive muscle wasting
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    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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  90. Dec 2021
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
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  92. Oct 2021
  93. www.sciencedirect.com www.sciencedirect.com
    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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  94. Aug 2021
  95. www.sciencedirect.com www.sciencedirect.com
    GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
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    ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
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    sciencedirect.com/science/article/pii/S2211124721009281
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  98. www.sciencedirect.com www.sciencedirect.com
    Acetylation of Cytidine in mRNA Promotes Translation Efficiency
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  100. Jul 2021
  101. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
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      eIF2α

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14678
  102. www.sciencedirect.com www.sciencedirect.com
    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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  103. www.sciencedirect.com www.sciencedirect.com
    Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
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      AB_2230924

      DOI: 10.1016/j.cell.2016.11.013

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  104. www.sciencedirect.com www.sciencedirect.com
    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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  105. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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      RRID:AB_10695409

      DOI: 10.1111/jnc.14306

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14306
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuronal activity‐dependent local activation of dendritic unfolded protein response promotes expression of brain‐derived neurotrophic factor in cell soma
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      DOI: 10.1111/jnc.14221

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14221/full
  107. www.cell.com www.cell.com
    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
  108. May 2021
  109. www.sciencedirect.com www.sciencedirect.com
    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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      DOI: 10.1016/j.neuron.2020.07.023

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  157. www.sciencedirect.com www.sciencedirect.com
    The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
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  158. www.nature.com www.nature.com
    Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice
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  159. www.sciencedirect.com www.sciencedirect.com
    Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
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  160. www.sciencedirect.com www.sciencedirect.com
    Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
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    Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
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  162. www.sciencedirect.com www.sciencedirect.com
    The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis
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  163. www.jneurosci.org www.jneurosci.org
    Endoplasmic reticulum stress contributes to the loss of newborn hippocampal neurons after traumatic brain injury
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  164. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)
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  165. europepmc.org europepmc.org
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  166. nutritionandmetabolism.biomedcentral.com nutritionandmetabolism.biomedcentral.com
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  167. Nov 2017
  168. www.sciencedirect.com www.sciencedirect.com
    The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
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  169. elifesciences.org elifesciences.org
    Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational control of auditory imprinting and structural plasticity by eIF2α
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