139 Matching Annotations
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    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875962/
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    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/
  4. Aug 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12341233/
  6. Jul 2025
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    High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
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    cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
  8. Jun 2025
  9. 52.53.155.43 52.53.155.43
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    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
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    Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells
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  12. May 2025
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    A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction
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    De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
  15. Apr 2025
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    Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
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    RAF1 kinase contributes to autophagic lysosome reformation
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  18. Jan 2025
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    Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies
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    Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome
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    sciencedirect.com/science/article/pii/S1934590924004478
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    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668527/
  22. Nov 2024
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
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  24. Sep 2024
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    Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function
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    GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
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    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
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    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
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    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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  33. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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  36. Jul 2024
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    Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes
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  38. May 2024
  39. journals.asm.org journals.asm.org
    Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum
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  40. Apr 2024
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    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
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    Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum
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  43. Mar 2024
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    Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis
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    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells
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  48. Feb 2024
  49. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
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    Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function
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  51. Jan 2024
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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  55. Dec 2023
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring
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  57. Sep 2023
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    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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  59. Aug 2023
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    Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  65. Jul 2023
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    Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
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    Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice
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    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
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  69. Jun 2023
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    Nutrient-dependent regulation of β-cell proinsulin content
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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  72. May 2023
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    onlinelibrary.wiley.com/doi/10.1002/cac2.12332
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    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
  75. Apr 2023
  76. www.sciencedirect.com www.sciencedirect.com
    Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue
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    sciencedirect.com/science/article/pii/S2589004223006296
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    VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms
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    Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction
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  79. Mar 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
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    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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  82. Feb 2023
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
  84. Jan 2023
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    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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  86. Dec 2022
  87. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    embopress.org/doi/10.15252/embj.2022111961
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    N-acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9794981/
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  90. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    sciencedirect.com/science/article/pii/S2211124722012694
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    Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9271144/
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    Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma
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    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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    link.springer.com/article/10.1007/s00401-022-02491-8
  95. Aug 2022
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    sciencedirect.com/science/article/pii/S2211124722010774
  97. Jun 2022
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    Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
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    ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
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  100. May 2022
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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  102. Apr 2022
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    Functional elements of the cis-regulatory lincRNA-p21
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    In vitro and in vivo evaluation of antioxidant and neuroprotective properties of antipsychotic D2AAK1
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    link.springer.com/article/10.1007/s11064-022-03570-8
  105. Mar 2022
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    Mucus sialylation determines intestinal host-commensal homeostasis
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    sciencedirect.com/science/article/pii/S0092867422001933
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    Gold(I)-Catalyzed Intramolecular Hydrothiophenylation of N-Thiophen-3-yl Alkynylamides for Accessing Thieno[3,2-b]pyridine-5(4H)-ones: Development of F-Actin Specific Fluorescent Probes
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  108. Jan 2022
  109. elifesciences.org elifesciences.org
    Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA
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    elifesciences.org/articles/70472
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  111. Dec 2021
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    sciencedirect.com/science/article/pii/S1534580721009941
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of extracellular vesicle-associated MMP2 abrogates intercellular hepatic miR-122 transfer to liver macrophages and curtails inflammation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8633982/
  114. Oct 2021
  115. www.sciencedirect.com www.sciencedirect.com
    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    sciencedirect.com/science/article/pii/S2211124721012444
  116. Sep 2021
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    Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome
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  118. Aug 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC6277851/
  122. Jul 2021
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
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