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139 Matching Annotations

Aug 2025
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Principles of cotranslational mitochondrial protein import

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  DOI: 10.1016/j.cell.2025.07.021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12396113/
Jul 2025
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2025.07.14.664742v1.full-html.html

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1. scibot 25 Jul 2025
  
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  DOI: 10.1101/2025.07.14.664742
  
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52.53.155.43/0ddeb0d5c1e9d78409db30015477d90afb34bbce/2025.07.14.664742v1.full-html.html
Jun 2025
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A first-in-class EGFR-directed KRAS G12V selective inhibitor

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.016
  
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sciencedirect.com/science/article/pii/S1535610825002259
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Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.chembiol.2025.05.005
  
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sciencedirect.com/science/article/pii/S2451945625001667
May 2025
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mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

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1. scibot 22 May 2025
  
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  DOI: 10.7554/eLife.104979
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092004/
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The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110487
  
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sciencedirect.com/science/article/pii/S0028390825001935
Apr 2025
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Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.02.009
  
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sciencedirect.com/science/article/pii/S1550413125000671
Mar 2025
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In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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1. scibot 26 Mar 2025
  
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  DOI: 10.1101/2025.03.20.644389
  
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biorxiv.org/content/10.1101/2025.03.20.644389v1
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

1
1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115403
  
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Feb 2025
52.53.155.43 52.53.155.43

SSRN-id4201001-html.html

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1. scibot 27 Feb 2025
  
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  DOI: 10.1038/s41563-021-01125-w
  
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52.53.155.43/9f725bf3f599e42d5dbb6f9ce5bf62e7266e766b/bd26a435-800e-42f7-b486-b37feef9c55a-meca-html.html
52.53.155.43 52.53.155.43

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

1
1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.22.614256
  
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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Jan 2025
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Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.neuron.2024.12.026
  
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sciencedirect.com/science/article/pii/S0896627324009267
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Repeated sevoflurane exposure causes hypomyelination in the prefrontal cortex of adult male mice

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1. scibot 15 Jan 2025
  
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  DOI: 10.1038/s41598-025-85834-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718107/
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Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115128
  
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Dec 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224027913-main-html.html

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1. scibot 12 Dec 2024
  
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  RRID:AB_2238583
  
  DOI: 10.1016/j.isci.2024.111564
  
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52.53.155.43/bb9e8a3f1ed0d9e1121d67e11af5663597f8cb3d/1-s2.0-S2589004224027913-main-html.html
Nov 2024
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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111133
  
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sciencedirect.com/science/article/pii/S2589004224023587
Sep 2024
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Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels

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1. scibot 27 Sep 2024
  
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  RRID:AB_2238583
  
  DOI: 10.1093/hmg/ddae135
  
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dx.doi.org/10.1093/hmg/ddae135
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RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages

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1. scibot 14 Sep 2024
  
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  RRID: AB_2238583
  
  DOI: 10.1016/j.molcel.2024.08.023
  
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sciencedirect.com/science/article/pii/S1097276524007007
52.53.155.43 52.53.155.43

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

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1. scibot 05 Sep 2024
  
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  DOI: 10.1101/2024.07.26.605278
  
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52.53.155.43/76e736f0a40c1a2ebb10a21ddca6aa06b484cb52/2024.07.26.605278v1.full-html.html
Aug 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 13 Aug 2024
  
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  DOI: 10.1126/science.adk0775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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1. scibot 02 Aug 2024
  
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  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
May 2024
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Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.xpro.2024.103082
  
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sciencedirect.com/science/article/pii/S2666166724002478
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Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types

1
1. scibot 17 May 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-1763
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11094420/
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Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

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1. scibot 03 May 2024
  
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  RRID:AB_2238583
  
  DOI: 10.7554/eLife.89100
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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1. scibot 27 Mar 2024
  
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  RRID:AB_2238583
  
  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
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Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate

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1. scibot 23 Mar 2024
  
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  RRID:AB_2238583
  
  DOI: 10.7554/eLife.89015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10957176/
Feb 2024
52.53.155.43 52.53.155.43

An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

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1. scibot 22 Feb 2024
  
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  RRID:AB_2238583
  
  DOI: 10.1101/2023.08.23.554263
  
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52.53.155.43/d64025fcba7405c73976a9e0dc65e9989e0d835f/2023.08.23.554263v1.full-html.html
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CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway

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1. scibot 03 Feb 2024
  
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  RRID:AB_2238583
  
  DOI: 10.1016/j.isci.2024.108843
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
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Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9

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1. scibot 03 Feb 2024
  
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  RRID:AB_13
  
  DOI: 10.1016/j.isci.2024.108857
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830855/
Jan 2024
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Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model

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1. scibot 06 Jan 2024
  
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  RRID:AB_2238583
  
  DOI: 10.1016/j.jbc.2023.105619
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
Dec 2023
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Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

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1. scibot 06 Dec 2023
  
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  RRID:AB_2238583
  
  DOI: 10.7554/eLife.80944
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
Nov 2023
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Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

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1. scibot 29 Nov 2023
  
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  RRID:AB_2238583
  
  DOI: 10.1016/j.isci.2023.108278
  
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sciencedirect.com/science/article/pii/S2589004223023556
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PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2

1
1. scibot 28 Nov 2023
  
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  RRID:AB_2238583
  
  DOI: 10.1016/j.cmet.2023.11.001
  
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sciencedirect.com/science/article/abs/pii/S1550413123004114
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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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1. scibot 02 Nov 2023
  
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  RRID:AB_2238583
  
  DOI: 10.1016/j.celrep.2023.113306
  
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sciencedirect.com/science/article/pii/S2211124723013189
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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

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1. scibot 02 Nov 2023
  
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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

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Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

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FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1

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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

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Regulation of RNG105/caprin1 dynamics by pathogenic cytoplasmic FUS and TDP-43 in neuronal RNA granules modulates synaptic loss

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Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model

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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

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N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.

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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer

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Translational and post-translational dynamics in a model peptidergic system

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Injury primes mutation-bearing astrocytes for dedifferentiation in later life

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Prostaglandins limit nuclear actin to control nucleolar function during oogenesis

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Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma

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AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

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mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

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Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells

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Shared and unique phosphoproteomics responses in skeletal muscle from exercise models and in hyperammonemic myotubes

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PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

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Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia

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Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells

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Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids

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Parsing the role of NSP1 in SARS-CoV-2 infection

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Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

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Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle

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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

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Regulation of GTPase function by autophosphorylation

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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia

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A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice

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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

1
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  DOI: 10.7554/eLife.69729
  
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Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy

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  DOI: 10.3389/fnmol.2021.772847
  
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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia

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Oncogene-dependent sloppiness in mRNA translation

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Untitled document

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Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis

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Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

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Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers

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Protein synthetic machinery and mRNA in regenerating tips of spinal cord axons in lamprey

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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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Pumilio2 and Staufen2 selectively balance the synaptic proteome

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Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

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Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes

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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

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mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

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Coordinate regulation of the senescent state by selective autophagy

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Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

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  DOI: 10.1016/j.cmet.2021.01.017
  
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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Mar 2021
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Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

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Feb 2021
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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

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  anti-S6
  
  DOI: 10.1038/s42255-020-0256-z
  
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Jan 2021
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth

1
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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

1
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Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

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  DOI: 10.7554/eLife.60445
  
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Oct 2020
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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

1
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  DOI: 10.7554/eLife.58941
  
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The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

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Mitochondrial Regulation of the 26S Proteasome

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PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes

1
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Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

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Tau Reduction Prevents Key Features of Autism in Mouse Models

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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  monoclonal mouse S6 ribosomal protein
  
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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Untitled document

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  DOI: 10.1016/j.cmet.2018.12.020
  
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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

1
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  RRID:AB_2238583
  
  DOI: 10.1016/j.ccell.2019.01.006
  
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Untitled document

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Untitled document

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Untitled document

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Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool

1
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Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome

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Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis

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Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

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mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

1
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Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy

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mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

1
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

1
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mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10694551
  
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Systematic Functional Annotation of Somatic Mutations in Cancer

1
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Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

1
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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

1
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Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye

1
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Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism

1
1. scibot 08 Nov 2017
  
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  Mouse anti-S6Cell Signaling2317
  
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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

1
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  AB_2238583
  
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

1
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  AB_2238583
  
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Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

1
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  AB_2238583
  
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  RRID:AB_2238583 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2238583

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scibot

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sciencedirect.com/science/article/pii/S009286741631460X

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