117 Matching Annotations
  1. Last 7 days
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    Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094420/
  3. May 2024
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    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
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      DOI: 10.7554/eLife.89100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  5. Mar 2024
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    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
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    Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate
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      DOI: 10.7554/eLife.89015

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    ncbi.nlm.nih.gov/pmc/articles/PMC10957176/
  8. Feb 2024
  9. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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      DOI: 10.1101/2023.08.23.554263

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    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
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    Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830855/
  12. Jan 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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      DOI: 10.1016/j.jbc.2023.105619

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    ncbi.nlm.nih.gov/pmc/articles/PMC10839450/
  14. Dec 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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    1. scibot 06 Dec 2023
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      DOI: 10.7554/eLife.80944

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    ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
  16. Nov 2023
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    1. scibot 29 Nov 2023
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    sciencedirect.com/science/article/pii/S2589004223023556
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    PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/abs/pii/S1550413123004114
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    CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
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      DOI: 10.1016/j.celrep.2023.113306

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    sciencedirect.com/science/article/pii/S2211124723013189
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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      DOI: 10.1016/j.celrep.2023.113269

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  21. Oct 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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    1. scibot 05 Oct 2023
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      DOI: 10.7554/eLife.85898

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  23. Aug 2023
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    Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
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    sciencedirect.com/science/article/pii/S2211124723010434
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    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
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      DOI: 10.1016/j.molcel.2023.07.017

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    sciencedirect.com/science/article/abs/pii/S1097276523005609
  26. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
  28. Jun 2023
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    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
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      DOI: 10.1016/j.neuron.2023.05.033

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    sciencedirect.com/science/article/pii/S0896627323004348
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    Regulation of RNG105/caprin1 dynamics by pathogenic cytoplasmic FUS and TDP-43 in neuronal RNA granules modulates synaptic loss
    1
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      DOI: 10.1016/j.heliyon.2023.e17065

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    sciencedirect.com/science/article/pii/S2405844023042731
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    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
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      DOI: 10.1016/j.xcrm.2023.101073

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    sciencedirect.com/science/article/pii/S2666379123001921
  32. May 2023
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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      DOI: 10.1002/mc.23284

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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
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    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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      DOI: 10.1016/j.celrep.2022.111085

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    sciencedirect.com/science/article/pii/S2211124722008877
  35. Apr 2023
  36. www.sciencedirect.com www.sciencedirect.com
    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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      DOI: 10.1016/j.isci.2023.106578

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    sciencedirect.com/science/article/pii/S2589004223006557
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    sciencedirect.com/science/article/pii/S1550413123001262
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S266637912300112X
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    Translational and post-translational dynamics in a model peptidergic system
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      DOI: 10.1016/j.mcpro.2023.100544

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    sciencedirect.com/science/article/pii/S1535947623000543
  40. Feb 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Injury primes mutation-bearing astrocytes for dedifferentiation in later life
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      DOI: 10.1016/j.cub.2023.02.013

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    sciencedirect.com/science/article/pii/S0960982223001525
  42. www.frontiersin.org www.frontiersin.org
    Prostaglandins limit nuclear actin to control nucleolar function during oogenesis
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      DOI: 10.3389/fcell.2023.1072456

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    frontiersin.org/articles/10.3389/fcell.2023.1072456/full
  43. Jan 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma
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      DOI: 10.1158/0008-5472.CAN-21-1222

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  45. 52.53.155.43 52.53.155.43
    SSRN-id4201001-html.html
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      DOI: 10.2139/ssrn.4201001

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    52.53.155.43/36d292ba6a35036ba493fd13dd1895996b7f9f6e/SSRN-id4201001-html.html
  46. Dec 2022
  47. www.sciencedirect.com www.sciencedirect.com
    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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      DOI: 10.1016/j.celrep.2022.111821

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    sciencedirect.com/science/article/pii/S2211124722017132
  48. Nov 2022
  49. www.nature.com www.nature.com
    mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
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      DOI: 10.1038/s41467-022-34763-y

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    nature.com/articles/s41467-022-34763-y
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells
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      DOI: 10.1158/2767-9764.crc-22-0270

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    ncbi.nlm.nih.gov/pmc/articles/PMC9648415/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shared and unique phosphoproteomics responses in skeletal muscle from exercise models and in hyperammonemic myotubes
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      DOI: 10.1016/j.isci.2022.105325

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    ncbi.nlm.nih.gov/pmc/articles/PMC9636548/
  52. Sep 2022
  53. www.sciencedirect.com www.sciencedirect.com
    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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      DOI: 10.1016/j.xcrm.2022.100741

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    sciencedirect.com/science/article/pii/S2666379122002907
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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      DOI: 10.1158/2159-8290.CD-21-0551

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  55. aacrjournals.org aacrjournals.org
    Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
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      DOI: 10.1158/2767-9764.CRC-22-0270

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    aacrjournals.org/cancerrescommun/article/2/8/842/708157/Na-H-exchanger-1-Enhances-Antitumor-Activity-of
  56. Aug 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
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      DOI: 10.1016/j.celrep.2022.111198

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    sciencedirect.com/science/article/pii/S2211124722010154
  58. Jun 2022
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parsing the role of NSP1 in SARS-CoV-2 infection
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      DOI: 10.1016/j.celrep.2022.110954

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  62. May 2022
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    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
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    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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  70. Feb 2022
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  72. Jan 2022
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  74. Dec 2021
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    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
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    Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy
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  77. Nov 2021
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    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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  79. Sep 2021
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  82. Aug 2021
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  85. Jul 2021
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    Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
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  92. May 2021
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways
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  97. Apr 2021
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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  101. Mar 2021
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  103. Feb 2021
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  105. Jan 2021
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  107. Dec 2020
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  109. Nov 2020
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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    Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis
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  112. Oct 2020
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  115. Sep 2020
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    Mitochondrial Regulation of the 26S Proteasome
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    PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
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    Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy
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    mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
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    Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  153. Nov 2017
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    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
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    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
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    Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
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      Mouse anti-S6Cell Signaling2317

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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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    Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
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