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Growth factor VEGF-B sustains intestinal Tfh cell stemness to restrict Taurinivorans outgrowth and microbiota-driven obesity

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  DOI: 10.1016/j.immuni.2026.10.004
  
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sciencedirect.com/science/article/pii/S1074761326004309
Oct 2026
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Microbial aldehyde-alcohol dehydrogenase degrades metformin to limit therapeutic response in type 2 diabetes

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sciencedirect.com/science/article/pii/S1550413126003785
Sep 2026
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A commensal-derived sugar protects against obesity by regulating immunometabolism

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1. scibot 27 Sep 2026
  
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  DOI: 10.1016/j.chom.2026.08.018
  
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sciencedirect.com/science/article/pii/S1931312826003604
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POMC AMPKα1 deletion drives male-specific BAT thermogenesis and obesity resistance

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1. scibot 16 Sep 2026
  
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  DOI: 10.1038/s44319-026-00915-0
  
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link.springer.com/article/10.1038/s44319-026-00915-0
Aug 2026
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Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism

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1. scibot 27 Aug 2026
  
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  DOI: 10.1126/sciadv.aec7066
  
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  DOI: 10.1126/sciadv.aec7066
  
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science.org/doi/10.1126/sciadv.aec7066
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Lineage tracing reveals a shared cellular origin for supraclavicular brown and inguinal beige adipocytes

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  DOI: 10.1016/j.celrep.2026.117836
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13641681/
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Intermittent fasting promotes remodeling of neural and vascular networks in visceral white adipose tissue

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  DOI: 10.1016/j.isci.2026.117028
  
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sciencedirect.com/science/article/pii/S2589004226024065
Jul 2026
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EID1 overexpression in brown adipose tissue enhances cold-induced thermogenesis in male mice

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  DOI: 10.1016/j.isci.2026.116703
  
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sciencedirect.com/science/article/pii/S2589004226020791
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Otopetrin 1 protects against adipose tissue wasting during cancer cachexia progression

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HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in murine brown adipocytes

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1. scibot 03 Jul 2026
  
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  DOI: 10.1038/s41598-026-54659-x
  
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54.241.53.176/2633d736d0dd3651ebd26d23eaeb4323299a55cd/s41598-026-54659-x_reference-html.html
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11-Oxygenated Androgens Inhibit Brown Adipose Tissue Differentiation

1
1. scibot 01 Jul 2026
  
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  DOI: 10.1210/endocr/bqaf172
  
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dx.doi.org/10.1210/endocr/bqaf172
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A mouse model of lipoatrophy reveals relationships between beige fat appearance and female fertility

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  DOI: 10.1210/endocr/bqaf164
  
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dx.doi.org/10.1210/endocr/bqaf164
Jun 2026
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Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria

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1. scibot 17 Jun 2026
  
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  DOI: 10.1002/mco2.70820
  
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onlinelibrary.wiley.com/doi/10.1002/mco2.70820
May 2026
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Bmal1 regulates thermogenic function by modulation of lipolytic and OXPHOS gene expression in male mice brown adipocytes

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1. scibot 29 May 2026
  
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  DOI: 10.1210/endocr/bqag023
  
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dx.doi.org/10.1210/endocr/bqag023
Apr 2026
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A skin-hypothalamus axis couples heat stress and metabolic dysfunction

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  DOI: 10.1016/j.cell.2026.03.045
  
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sciencedirect.com/science/article/pii/S0092867426003466
Mar 2026
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Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β

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1. scibot 21 Mar 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12999355/
Feb 2026
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MEDAG functions as an A-kinase-anchoring protein in adipocytes

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.02.001
  
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sciencedirect.com/science/article/pii/S1097276526000961
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Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

1
1. scibot 19 Feb 2026
  
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  DOI: 10.1016/j.cmet.2026.01.012
  
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sciencedirect.com/science/article/pii/S1550413126000124
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Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.ccell.2026.01.014
  
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sciencedirect.com/science/article/pii/S153561082600053X
Jan 2026
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NCOA1 is a gatekeeper of the sexually dimorphic thermogenic activity of white adipose tissue

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1. scibot 23 Jan 2026
  
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  DOI: 10.1038/s41467-025-65229-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12820275/
Nov 2025
54.241.53.176 54.241.53.176

jaeckstein-et-al-2025-purinergic-adipocyte-macrophage-crosstalk-promotes-degeneration-of-thermogenic-brown-adipose-html.html

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54.241.53.176/f747cb2da22a4018614419251bb372fb2280d9d1/jaeckstein-et-al-2025-purinergic-adipocyte-macrophage-crosstalk-promotes-degeneration-of-thermogenic-brown-adipose-html.html
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Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG

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sciencedirect.com/science/article/pii/S221112472501349X
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Chrna2-driven CRE Is Expressed in Beige Adipocytes

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  DOI: 10.1210/endocr/bqae153
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11630559/
Oct 2025
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Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism

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sciencedirect.com/science/article/pii/S1550413125004334
Sep 2025
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Development of a Functional Beige Fat Cell Line Uncovers Independent Subclasses of Cells Expressing UCP1 and the Futile Creatine Cycle

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pmc.ncbi.nlm.nih.gov/articles/PMC12005060/
Jul 2025
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An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia

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  DOI: 10.1101/2025.07.16.664180
  
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Pantothenate protects against obesity via brown adipose tissue activation

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  DOI: 10.1152/ajpendo.00293.2021
  
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52.53.155.43/f18296890df03cc01daf6d6fc459bb8037271e03/zhou-et-al-2022-pantothenate-protects-against-obesity-via-brown-adipose-tissue-activation-html.html
52.53.155.43 52.53.155.43

matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html

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  DOI: 10.6084/m9.figshare.29333861
  
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52.53.155.43/0eec343059498565fba813ed54e166140d5ee93f/matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
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The impact of neuregulin 4 on metabolic dysregulation in lipodystrophy

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pmc.ncbi.nlm.nih.gov/articles/PMC12236340/
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AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice

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  DOI: 10.1152/ajpendo.00012.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11390115/
Apr 2025
elifesciences.org elifesciences.org

Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

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1. scibot 19 Apr 2025
  
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  DOI: 10.7554/eLife.100581
  
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elifesciences.org/articles/100581
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Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.007
  
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sciencedirect.com/science/article/pii/S2451945625000972
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Ceramide-induced FGF13 impairs systemic metabolic health

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  DOI: 10.1016/j.cmet.2025.03.002
  
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Mar 2025
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Effects of systemic oxytocin and beta‐3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet‐induced obese rats

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RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

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Adenylate cyclase 10 promotes brown adipose tissue thermogenesis

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Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

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1-s2.0-S2212877824002229-main-html.html

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Dec 2024
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Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

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Lithocholic acid phenocopies anti-ageing effects of calorie restriction

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Thyroid hormones are required for thermogenesis of beige adipocytes induced by Zfp423 inactivation

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Mammary alveolar epithelial cells convert to brown adipocytes in post‐lactating mice

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Exosomal miRNA 16-5p/29a-3p from pancreatic cancer induce adipose atrophy by inhibiting adipogenesis and promoting lipolysis

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Adipose Kiss1 controls aerobic exercise-related adaptive responses in adipose tissue energy homeostasis

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Short-term cold exposure induces persistent epigenomic memory in brown fat

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Smooth muscle cell-derived Cxcl12 directs macrophage accrual and sympathetic innervation to control thermogenic adipose tissue

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Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease

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Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass and adipose metabolism for the promotion of thermogenesis

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Mar 2024
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MAFB in macrophages regulates cold-induced neuronal density in brown adipose tissue

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Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning

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Jan 2024
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Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB

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Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk

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Cold-inducible lncRNA266 promotes browning and the thermogenic program in white adipose tissue

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Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes

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Sep 2023
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Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes

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Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain

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Aug 2023
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Hypothalamic astrocytic-BMAL1 regulates energy homeostasis in a sex-dependent manner

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PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ

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White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice

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HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway

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Selective activation of PPARα maintains thermogenic capacity of beige adipocytes

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xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity

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Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression

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Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure

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Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation

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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

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Apr 2023
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Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue

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Neuronal blockade of thyroid hormone signaling increases sensitivity to diet-induced obesity in adult male mice

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SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

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Smad4-mediated angiogenesis facilitates the beiging of white adipose tissue in mice

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Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice

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Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues

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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation

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Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation

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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

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Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue

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Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies

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Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis

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Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade

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NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes

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Jun 2022
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ajpendo.00293.2021-html.html

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Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity

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ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

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Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

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Local hyperthermia therapy induces browning of white fat and treats obesity

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Eosinophils regulate intra-adipose axonal plasticity

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Jan 2022
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ACE2 pathway regulates thermogenesis and energy metabolism

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Dec 2021
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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

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Hindbrain Administration of Oxytocin Reduces Food Intake, Weight Gain and Activates Catecholamine Neurons in the Hindbrain Nucleus of the Solitary Tract in Rats

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Oct 2021
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Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

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Sep 2021
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Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats

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A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

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The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy

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Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation

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Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis

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Loss of CREB coactivator CRTC1 in SF1 cells leads to hyperphagia and obesity by high-fat diet but not normal chow diet

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Untitled document

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Untitled document

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Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

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  DOI: 10.1016/j.molcel.2019.03.021
  
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Untitled document

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FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue

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Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice

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In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

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Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

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Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice

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The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity

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FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

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Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells

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OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

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Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human

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Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21

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Glibenclamide restores dopaminergic reward circuitry in obese mice through interscauplar brown adipose tissue

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Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation

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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

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Identification of ALK in Thinness

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Hypothalamic bile acid-TGR5 signaling protects from obesity

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Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

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A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

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The involvement of neuroimmune cells in adipose innervation

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Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

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A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism

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Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT

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Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

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Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue

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Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis

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Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

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Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

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Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration

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Transcriptional regulation of ZNF638 in thermogenic cells by the cAMP response element binding protein CREB in male mice

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Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

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Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

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Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

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Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

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SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis

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Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α

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Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

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Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism

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Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16

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Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice

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Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

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Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

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Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

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Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine

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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

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CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

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HDAC3-selective inhibition activates brown and beige fat through PRDM16

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Impact of pregnancy and lactation on the long-term regulation of energy balance in female mice

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A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

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Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

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Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

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Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis

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Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

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An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents

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IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

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Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

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Male Brown Fat–Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity

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Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue

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Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice

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Glucocorticoids Suppress the Browning of Adipose Tissue via miR-19b in Male Mice

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Lack of Ovarian Secretions Reverts the Anabolic Action of Olanzapine in Female Rats

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Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

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Untitled document

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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

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The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity

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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

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Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

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A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

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A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes

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Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice

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Mammary alveolar epithelial cells convert to brown adipocytes in post‐lactating mice

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PKA-RIIB Deficiency Induces Brown Fatlike Adipocytes in Inguinal WAT and Promotes Energy Expenditure in Male FVB/NJ Mice

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Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling

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