129 Matching Annotations
  1. Jun 2024
  2. www.cell.com www.cell.com
    Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies
    1
    1. scibot 29 Jun 2024
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      DOI: 10.1016/j.isci.2024.110068

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    cell.com/iscience/abstract/S2589-0042(24)01293-8
  3. May 2024
  4. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224013270-main-html.html
    1
    1. scibot 30 May 2024
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      DOI: 10.1016/j.isci.2024.110102

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    52.53.155.43/1301be9e3dafcfe2a26d7e31d500f0e5fec0604e/1-s2.0-S2589004224013270-main-html.html
  5. www.sciencedirect.com www.sciencedirect.com
    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
    1
    1. scibot 07 May 2024
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      DOI: 10.1016/j.ejps.2024.106789

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    sciencedirect.com/science/article/pii/S0928098724001003
  6. Apr 2024
  7. aacrjournals.org aacrjournals.org
    EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
    1
    1. scibot 19 Apr 2024
      RRID:AB_2246311

      DOI: 10.1158/2159-8290.CD-23-0434

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    aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
  8. Mar 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
    1
    1. scibot 22 Mar 2024
      RRID:AB_2246311

      DOI: 10.1038/s41467-024-46284-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
  10. Feb 2024
  11. 52.53.155.43 52.53.155.43
    can-22-3965-html.html
    1
    1. scibot 23 Feb 2024
      RRID:AB_2246311

      DOI: 10.1158/0008-5472.can-22-3965

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    52.53.155.43/b267fbdd19a530509c54979d05951e91bb2c0d21/3693-html.html
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer
    1
    1. scibot 09 Feb 2024
      RRID:AB_2246311

      DOI: 10.1016/j.isci.2024.108984

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    ncbi.nlm.nih.gov/pmc/articles/PMC10847745/
  13. www.sciencedirect.com www.sciencedirect.com
    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
    1
    1. scibot 06 Feb 2024
      RRID:AB_2246311

      DOI: 10.1016/j.devcel.2024.01.010

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    sciencedirect.com/science/article/pii/S1534580724000303
  14. Jan 2024
  15. dx.doi.org dx.doi.org
    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells
    1
    1. scibot 25 Jan 2024
      RRID:AB_2246311

      DOI: 10.1158/0008-5472.CAN-22-3965

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    dx.doi.org/10.1158/0008-5472.CAN-22-3965
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TNIK drives Castration-Resistant Prostate Cancer via phosphorylating EGFR
    1
    1. scibot 18 Jan 2024
      RRID:AB_2246311

      DOI: 10.1016/j.isci.2023.108713

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    ncbi.nlm.nih.gov/pmc/articles/PMC10788198/
  17. Dec 2023
  18. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
    1
    1. scibot 29 Dec 2023
      RRID:AB_2246311

      DOI: 10.1016/j.ccell.2023.12.002

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    sciencedirect.com/science/article/pii/S1535610823004300
  19. www.sciencedirect.com www.sciencedirect.com
    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
    1
    1. scibot 22 Dec 2023
      RRID:AB_2246311

      DOI: 10.1016/j.celrep.2023.113603

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    sciencedirect.com/science/article/pii/S2211124723016157
  20. www.sciencedirect.com www.sciencedirect.com
    Heterogeneity and transcriptional drivers of triple-negative breast cancer
    1
    1. scibot 16 Dec 2023
      RRID:AB_2246311

      DOI: 10.1016/j.celrep.2023.113564

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    sciencedirect.com/science/article/pii/S2211124723015760
  21. Nov 2023
  22. www.sciencedirect.com www.sciencedirect.com
    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma
    1
    1. scibot 28 Nov 2023
      RRID:AB_2246311

      DOI: 10.1016/j.molcel.2023.10.025

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    sciencedirect.com/science/article/abs/pii/S1097276523008626
  23. 52.53.155.43 52.53.155.43
    can-22-3965-html.html
    1
    1. scibot 10 Nov 2023
      RRID:AB_2246311

      DOI: 10.1158/0008-5472.can-22-3965

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    52.53.155.43/b267fbdd19a530509c54979d05951e91bb2c0d21/3693-html.html
  24. Oct 2023
  25. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
    1
    1. scibot 14 Oct 2023
      AB_2246311

      DOI: 10.1101/2023.06.16.545259

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    52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
  26. www.sciencedirect.com www.sciencedirect.com
    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
    1
    1. scibot 13 Oct 2023
      RRID:AB_2246311

      DOI: 10.1016/j.chembiol.2023.09.013

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    sciencedirect.com/science/article/abs/pii/S245194562300332X
  27. 52.53.155.43 52.53.155.43
    can-22-3965-html.html
    1
    1. scibot 07 Oct 2023
      RRID:AB_2246311

      DOI: 10.1158/0008-5472.can-22-3965

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    52.53.155.43/b267fbdd19a530509c54979d05951e91bb2c0d21/3693-html.html
  28. Sep 2023
  29. www.sciencedirect.com www.sciencedirect.com
    CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance
    1
    1. scibot 16 Sep 2023
      RRID:AB_2246311

      DOI: 10.1016/j.celrep.2023.113130

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    sciencedirect.com/science/article/pii/S2211124723011427
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
    1
    1. scibot 02 Sep 2023
      RRID:AB_2246311

      DOI: 10.1002/pro.4742

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    ncbi.nlm.nih.gov/pmc/articles/PMC10461461/
  31. Aug 2023
  32. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
    2
    1. scibot 18 Aug 2023
      RRID:AB_2246311

      DOI: 10.1016/j.xcrm.2023.101142

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    2. scibot 10 Aug 2023
      RRID:AB_2246311

      DOI: 10.1016/j.xcrm.2023.101142

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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  33. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
    1
    1. scibot 04 Aug 2023
      RRID:AB_2246311

      DOI: 10.1016/j.ccell.2023.07.005

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    sciencedirect.com/science/article/pii/S1535610823002453
  34. Jul 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Protocol for evaluation of tumor-derived exosome-induced cancer cell metastasis in a mouse model
    1
    1. scibot 22 Jul 2023
      RRID:AB_2246311

      DOI: 10.1016/j.xpro.2023.102444

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    sciencedirect.com/science/article/pii/S2666166723004112
  36. Jun 2023
  37. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
    1
    1. scibot 21 Jun 2023
      RRID:AB_2246311

      DOI: 10.1016/j.canlet.2023.216264

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    sciencedirect.com/science/article/pii/S030438352300215X
  38. www.sciencedirect.com www.sciencedirect.com
    How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view
    1
    1. scibot 21 Jun 2023
      RRID:AB_2246311

      DOI: 10.1016/j.str.2023.05.017

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    sciencedirect.com/science/article/pii/S0969212623001934
  39. aacrjournals.org aacrjournals.org
    Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities
    1
    1. scibot 03 Jun 2023
      RRID:AB_2246311

      DOI: 10.1158/0008-5472.CAN-22-1577

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    aacrjournals.org/cancerres/article/83/6/890/718574/Olig1-2-Expressing-Intermediate-Lineage
  40. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
    1
    1. scibot 03 Jun 2023
      RRID:AB_2246311

      DOI: 10.1158/0008-5472.CAN-22-1549

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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
  41. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
    1
    1. scibot 03 Jun 2023
      RRID:AB_2246311

      DOI: 10.1016/j.celrep.2023.112581

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    sciencedirect.com/science/article/pii/S2211124723005922
  42. May 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
    1
    1. scibot 31 May 2023
      RRID:AB_2246311

      DOI: 10.1016/j.celrep.2023.112570

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    sciencedirect.com/science/article/pii/S2211124723005818
  44. Apr 2023
  45. www.biorxiv.org www.biorxiv.org
    EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
    1
    1. scibot 21 Apr 2023
      RRID:AB_2246311

      DOI: 10.1101/2023.04.15.536974

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    biorxiv.org/content/10.1101/2023.04.15.536974v1
  46. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
    1
    1. scibot 18 Apr 2023
      RRID:AB_2246311

      DOI: 10.1038/s41416-023-02264-4

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    nature.com/articles/s41416-023-02264-4
  47. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
    1
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      DOI: 10.1016/j.celrep.2023.112324

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    sciencedirect.com/science/article/pii/S2211124723003352
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone H3 phospho-regulation by KimH3 in both interphase and mitosis
    1
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      DOI: 10.1016/j.isci.2023.106372

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    ncbi.nlm.nih.gov/pmc/articles/PMC10066537/
  49. Mar 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions
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      DOI: 10.1016/j.jbc.2023.104650

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    sciencedirect.com/science/article/pii/S0021925823002922
  51. www.sciencedirect.com www.sciencedirect.com
    Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers
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      DOI: 10.1016/j.xcrm.2023.100977

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    sciencedirect.com/science/article/pii/S2666379123000836
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
    1
    1. scibot 05 Mar 2023
      RRID:AB_2246311

      DOI: 10.1158/1541-7786.MCR-22-0090

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    ncbi.nlm.nih.gov/pmc/articles/PMC9444924/
  53. Feb 2023
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
    1
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      RRID:AB_2246311

      DOI: 10.1126/scisignal.abj5879

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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  55. www.sciencedirect.com www.sciencedirect.com
    GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1016/j.devcel.2023.01.006

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    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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  57. Dec 2022
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer
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    Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes
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  62. Nov 2022
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    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
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  64. Oct 2022
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    Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas
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  66. Sep 2022
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    A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration
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    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
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  69. Aug 2022
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    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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    Multi-facet roles of RNA editing in promoting loss-of-function of PODXL in cancer
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    Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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  78. Apr 2022
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    Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
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    Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells
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    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  85. Feb 2022
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    Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  89. Dec 2021
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    MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells
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    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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  94. Nov 2021
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  96. Oct 2021
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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  105. Jul 2021
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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  109. Jun 2021
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    Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling
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    Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling
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    Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
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    Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment
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    YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
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    A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration
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    Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles
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  130. Oct 2020
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    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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    BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS
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    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
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    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
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    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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  142. Jan 2020
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    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  155. Nov 2018
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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    Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer
    1
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      RRID:AB_2246311

      Curator: @anp055

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    sciencedirect.com/science/article/pii/S1535610818302617
  159. www.sciencedirect.com www.sciencedirect.com
    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
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    1. scibot 05 Nov 2018
      RRID:AB_2246311

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    sciencedirect.com/science/article/pii/S0092867417310668
  160. www.sciencedirect.com www.sciencedirect.com
    Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling
    1
    1. scibot 05 Nov 2018
      RRID:AB_2246311

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    sciencedirect.com/science/article/pii/S1535610818302174
  161. www.sciencedirect.com www.sciencedirect.com
    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
    1
    1. scibot 05 Nov 2018
      RRID:AB_2246311

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      (Cell Signaling Technology Cat# 4267, RRID:AB_2246311)

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    sciencedirect.com/science/article/pii/S1535610818300655
  162. europepmc.org europepmc.org
    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
    1
    1. scibot 05 Nov 2018
      AB_2246311

      Curator: @evieth

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      (Cell Signaling Technology Cat# 4267, RRID:AB_2246311)

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    europepmc.org/articles/PMC5663478/
  163. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
    1. scibot 05 Nov 2018
      RRID:AB_2246311

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    sciencedirect.com/science/article/pii/S1097276517307025
  164. Nov 2017
  165. www.sciencedirect.com www.sciencedirect.com
    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
    1
    1. scibot 08 Nov 2017
      4267

      Curator: @Jmenke

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      RRID:AB_2246311 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867417310474
  166. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Leptin suppresses adenosine triphosphate‐induced impairment of spinal cord astrocytes
    1
    1. scibot 08 Nov 2017
      Cell Signaling Technology, rabbit monoclonal, 4267S, AB_2246311

      Curator: @bandrow

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23795/full
  167. academic.oup.com academic.oup.com
    EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis
    1
    1. scibot 08 Nov 2017
      AB_2246311

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 4267, RRID:AB_2246311)

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      RRID:AB_2246311 RRIDCUR:Validated
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    academic.oup.com/jes/article/1/2/127/2930778/EGFR-Induces-E2F1-Mediated-Corticotroph
  168. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis
    1
    1. scibot 08 Nov 2017
      AB_2246311

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 4267, RRID:AB_2246311)

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      RRID:AB_2246311 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580717300072