75 Matching Annotations
  1. Last 7 days
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    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/
  3. Jun 2025
  4. www.nature.com www.nature.com
    PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
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    nature.com/articles/s41388-025-03468-z
  5. 52.53.155.43 52.53.155.43
    PDF-html.html
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  6. May 2025
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    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  8. Apr 2025
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    Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
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    sciencedirect.com/science/article/pii/S1074761325001244
  10. Feb 2025
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    PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
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    nature.com/articles/s41593-024-01865-3
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases
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    pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
  13. Nov 2024
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    PTEN deletion in the adult dentate gyrus induces epilepsy
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    sciencedirect.com/science/article/pii/S0969996124003383
  15. Sep 2024
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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    sciencedirect.com/science/article/pii/S1550413124003334
  17. Aug 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY
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    ncbi.nlm.nih.gov/pmc/articles/PMC11326251/
  19. Jul 2024
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    Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration
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    sciencedirect.com/science/article/pii/S221112472400843X
  21. May 2024
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    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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    nature.com/articles/s41416-024-02697-5
  23. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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    science.org/doi/10.1126/scisignal.adh4475
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    Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity
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    sciencedirect.com/science/article/pii/S2211124724005898
  25. Mar 2024
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    Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer
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    sciencedirect.com/science/article/pii/S2451945624000370
  27. Feb 2024
  28. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  29. Jan 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0021925824000176
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  32. Dec 2023
  33. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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  35. Nov 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  37. Oct 2023
  38. 52.53.155.43 52.53.155.43
    PTEN deletion in spinal pathways via retrograde transduction with AAV-RG enhances forelimb motor recovery after cervical spinal cord injury; Sex differences and late-onset pathophysiologies
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    52.53.155.43/f13c34c9fadfb88429a8376892a5323067fb5f83/1-s2.0-S0014488623002364-main-html.html
  39. Sep 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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    ncbi.nlm.nih.gov/pmc/articles/PMC9975769/
  41. Aug 2023
  42. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    sciencedirect.com/science/article/pii/S1097276523005580
  43. Jul 2023
  44. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328280/
  46. Jun 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
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    sciencedirect.com/science/article/pii/S096999612300205X
  48. Apr 2023
  49. www.biorxiv.org www.biorxiv.org
    PTEN deletion in spinal pathways via retrograde transduction with AAV-retro enhances forelimb motor recovery after cervical spinal cord injury; sex differences and late-onset pathophysiologies
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    biorxiv.org/content/10.1101/2023.03.20.533502v1
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    sciencedirect.com/science/article/pii/S2211124723003881
  51. Mar 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444962/
  53. Feb 2023
  54. 52.53.155.43 52.53.155.43
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  55. Jan 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
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    sciencedirect.com/science/article/pii/S2666979X22002130
  57. journals.lww.com journals.lww.com
    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/PTEN_inhibitor_bisperoxovanadium_protects_against.36.aspx
  58. Dec 2022
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage
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    ncbi.nlm.nih.gov/pmc/articles/PMC9727431/
  60. Sep 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC9499684/
  62. Aug 2022
  63. 52.53.155.43 52.53.155.43
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    MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
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    sciencedirect.com/science/article/pii/S0361923022002076
  65. Jun 2022
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    sciencedirect.com/science/article/pii/S2211124722008087
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  68. May 2022
  69. www.tandfonline.com www.tandfonline.com
    Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
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    tandfonline.com/doi/full/10.1080/09537104.2022.2026908
  70. Mar 2022
  71. www.sciencedirect.com www.sciencedirect.com
    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276522001058
  72. Feb 2022
  73. www.tandfonline.com www.tandfonline.com
    Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
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  74. Jan 2022
  75. www.sciencedirect.com www.sciencedirect.com
    Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury
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    sciencedirect.com/science/article/pii/S0014488621003733
  76. Nov 2021
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure
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    ncbi.nlm.nih.gov/pmc/articles/PMC8599682/
  78. Sep 2021
  79. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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    sciencedirect.com/science/article/pii/S1097276521007140
  80. Aug 2021
  81. academic.oup.com academic.oup.com
    Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects
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    academic.oup.com/endo/article/162/10/bqab142/6321973
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    Untitled document
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    academic.oup.com/endo/article/157/12/4641/2758409
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    ncbi.nlm.nih.gov/pmc/articles/PMC5133353/
  84. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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    sciencedirect.com/science/article/pii/S1097276517307025
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    ncbi.nlm.nih.gov/pmc/articles/PMC5678281/
  86. Jul 2021
  87. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PTEN knockdown alters dendritic spine/protrusion morphology, not density
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    onlinelibrary.wiley.com/doi/10.1002/cne.23488/full
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
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    ncbi.nlm.nih.gov/pmc/articles/PMC5824782/
  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock‐down
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    onlinelibrary.wiley.com/doi/10.1002/cne.23987/full
  90. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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    sciencedirect.com/science/article/pii/S1357272521001060
  91. May 2021
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt
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    Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation
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  95. Apr 2021
  96. www.sciencedirect.com www.sciencedirect.com
    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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  97. Mar 2021
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC7480098/
  99. Feb 2021
  100. academic.oup.com academic.oup.com
    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    academic.oup.com/endo/article/161/4/bqaa037/5788411
  101. Sep 2020
  102. www.sciencedirect.com www.sciencedirect.com
    Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
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    sciencedirect.com/science/article/pii/S2211124720300772
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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    sciencedirect.com/science/article/pii/S1074761318302425
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7391766/
  105. Jan 2020
  106. www.sciencedirect.com www.sciencedirect.com
    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    sciencedirect.com/science/article/pii/S2211124719309672
  107. www.sciencedirect.com www.sciencedirect.com
    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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    sciencedirect.com/science/article/pii/S1535610819302417
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS
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    ncbi.nlm.nih.gov/pmc/articles/PMC6776443/
  109. www.sciencedirect.com www.sciencedirect.com
    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    sciencedirect.com/science/article/pii/S2405471219303874
  110. Nov 2018
  111. www.sciencedirect.com www.sciencedirect.com
    Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S1535610818302617
  112. www.sciencedirect.com www.sciencedirect.com
    Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice
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    sciencedirect.com/science/article/pii/S0014488618300529
  113. www.sciencedirect.com www.sciencedirect.com
    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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    sciencedirect.com/science/article/pii/S1074761317304855
  114. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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    sciencedirect.com/science/article/pii/S1097276517307025
  115. Nov 2017
  116. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
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    academic.oup.com/endo/article/157/12/4641/2758409/Developmental-Programming-Insulin-Sensitizer
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    Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype
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    sciencedirect.com/science/article/pii/S001448861500148X