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Organotypic vascularization improves maturation of human stem cell-derived islets and restores normoglycemia in diabetic mice

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  DOI: 10.1016/j.stem.2026.09.011
  
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sciencedirect.com/science/article/pii/S193459092600353X
Sep 2026
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Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background

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1. scibot 19 Sep 2026
  
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  DOI: 10.1016/j.isci.2026.117560
  
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sciencedirect.com/science/article/pii/S2589004226029391
May 2026
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Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

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1. scibot 20 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.012
  
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sciencedirect.com/science/article/pii/S1534580726001590
Apr 2026
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Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.stem.2026.03.004
  
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sciencedirect.com/science/article/pii/S1934590926001141
Feb 2026
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Implanted flexible electronics reveal principles of human islet cell electrical maturation

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1. scibot 24 Feb 2026
  
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  DOI: 10.1126/science.aeb3295
  
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science.org/doi/10.1126/science.aeb3295
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Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116990
  
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sciencedirect.com/science/article/pii/S2211124726000689
Dec 2025
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DEC1 regulates human β cell functional maturation and circadian rhythm

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116666
  
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sciencedirect.com:5037/science/article/pii/S221112472501438X
Oct 2025
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Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction

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1. scibot 22 Oct 2025
  
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sciencedirect.com/science/article/pii/S1534580725006033
Aug 2025
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Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo

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1. scibot 09 Aug 2025
  
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sciencedirect.com/science/article/pii/S1934590925002632
May 2025
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Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

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1. scibot 29 May 2025
  
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sciencedirect.com/science/article/pii/S153458072500262X
Mar 2025
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Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.02.018
  
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sciencedirect.com/science/article/pii/S0092867425002065
Feb 2025
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Expression of genes involved in thyroid hormone action in human induced pluripotent stem cells during differentiation to insulin-producing cells: Effects of iopanoic acid on differentiation

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.mce.2025.112490
  
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sciencedirect.com/science/article/pii/S0303720725000413
Dec 2024
www.cell.com www.cell.com

Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors

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1. scibot 05 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101832
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(24)00603-7
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Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

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1. scibot 03 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.10.044
  
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sciencedirect.com/science/article/pii/S0092867424012546
Sep 2024
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Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient

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1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.09.004
  
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sciencedirect.com/science/article/pii/S0092867424010225
May 2024
www.biorxiv.org www.biorxiv.org

Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation

1
1. scibot 29 May 2024
  
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  DOI: 10.1101/2024.03.18.585551
  
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  RRID:AB_2255626 DOI:10.1101/2024.03.18.585551
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biorxiv.org/content/10.1101/2024.03.18.585551v1
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Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.010
  
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sciencedirect.com/science/article/pii/S1934590924001371
Apr 2024
dx.doi.org dx.doi.org

Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal

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1. scibot 04 Apr 2024
  
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  RRID:AB_2255626
  
  DOI: 10.1210/endocr/bqad197
  
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dx.doi.org/10.1210/endocr/bqad197
Oct 2023
elifesciences.org elifesciences.org

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

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1. scibot 14 Oct 2023
  
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  DOI: 10.7554/eLife.85056
  
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elifesciences.org/articles/85056
May 2023
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Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

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1. scibot 18 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112529
  
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sciencedirect.com/science/article/pii/S2211124723005405
Jan 2023
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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

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1. scibot 04 Jan 2023
  
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  DOI: 10.1016/j.xcrm.2022.100879
  
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sciencedirect.com/science/article/pii/S2666379122004438
Dec 2022
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An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.stem.2022.12.001
  
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sciencedirect.com/science/article/pii/S1934590922004854
Jun 2022
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SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis

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1. scibot 30 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104594
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9212970/
Dec 2021
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Integrated analysis of the pancreas and islets reveals unexpected findings in human male with type 1 diabetes

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1. scibot 04 Dec 2021
  
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  DOI: 10.1210/jendso/bvab162
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8633619/
Nov 2021
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A human ESC line for efficient CRISPR editing of pluripotent stem cells

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1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.scr.2021.102591
  
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sciencedirect.com/science/article/pii/S1873506121004384
Sep 2021
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Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models

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1. scibot 04 Sep 2021
  
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  DOI: 10.1016/j.stem.2021.08.001
  
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sciencedirect.com/science/article/pii/S1934590921003386
Aug 2021
www.nature.com www.nature.com

Generation of insulin-producing pancreatic β cells from multiple human stem cell lines

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1. scibot 16 Aug 2021
  
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  DOI: 10.1038/s41596-021-00560-y
  
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nature.com/articles/s41596-021-00560-y
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Untitled document

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  DOI: 10.1016/j.cels.2016.08.011
  
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sciencedirect.com/science/article/pii/S2405471216302666
Jul 2021
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Untitled document

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  DOI: 10.1016/j.cell.2017.11.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5786493/
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Retrieval and purification of human β cells from stem cell-derived islet engrafted mice

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1. scibot 17 Jul 2021
  
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  DOI: 10.1016/j.xpro.2021.100675
  
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sciencedirect.com/science/article/pii/S2666166721003828
Apr 2021
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Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.scr.2021.102371
  
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sciencedirect.com/science/article/pii/S1873506121002178
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Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.018
  
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sciencedirect.com/science/article/pii/S2451945620303408
Nov 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

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1. scibot 24 Nov 2020
  
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  DOI: 10.1016/j.cmet.2020.11.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
Sep 2020
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SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

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1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107687
  
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sciencedirect.com/science/article/pii/S2211124720306409
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

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1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.xcrm.2020.100097
  
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Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

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1. scibot 14 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107623
  
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sciencedirect.com/science/article/pii/S2211124720305763
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Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

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1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108067
  
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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107894
  
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sciencedirect.com/science/article/pii/S2211124720308755
Jan 2020
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Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

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1. scibot 13 Jan 2020
  
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  DOI: 10.1007/s00125-019-05030-5
  
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Circadian Entrainment Triggers Maturation of Human In Vitro Islets

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.stem.2019.11.011
  
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Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.12.009
  
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Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.04.083
  
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sciencedirect.com/science/article/pii/S2211124719305637
Nov 2018
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Intrinsic Immunity Shapes Viral Resistance of Stem Cells

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1. scibot 05 Nov 2018
  
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Nov 2017
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Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development

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1. scibot 08 Nov 2017
  
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