159 Matching Annotations
  1. Last 7 days
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    Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014669
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    sciencedirect.com/science/article/pii/S2211124724014554
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    The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
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    1. scibot 17 Dec 2024
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      DOI: 10.1016/j.immuni.2024.11.017

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    sciencedirect.com/science/article/pii/S1074761324005326
  5. Dec 2024
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    Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress
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    1. scibot 10 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724013998
  7. Nov 2024
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
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    1. scibot 08 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
  9. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
  11. Aug 2024
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    1. scibot 20 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009586
  13. Jul 2024
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    A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1
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    sciencedirect.com/science/article/pii/S1931312824002622
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    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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    Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11261061/
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    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    sciencedirect.com/science/article/pii/S1097276524004799
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    pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism
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    sciencedirect.com/science/article/pii/S1097276524004775
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    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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      DOI: 10.1111/acel.14258

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    onlinelibrary.wiley.com/doi/10.1111/acel.14258
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
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    Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00362-8
  22. Jun 2024
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    The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11175508/
  24. May 2024
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    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
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    sciencedirect.com/science/article/pii/S2211124724006223
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    N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
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    sciencedirect.com/science/article/pii/S1074761324002097
  27. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2666379124001976
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    sciencedirect.com/science/article/pii/S1535610824001284
  30. Mar 2024
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    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    sciencedirect.com/science/article/pii/S2211124724002730
  32. Feb 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  34. Jan 2024
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    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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    sciencedirect.com/science/article/pii/S2589004224000294
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276523010298
  37. Nov 2023
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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      DOI: 10.1158/1078-0432.CCR-23-0103

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
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    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
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    sciencedirect.com/science/article/pii/S2211124723013700
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    Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products
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    sciencedirect.com/science/article/abs/pii/S0003986123003077
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    Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape
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    sciencedirect.com/science/article/pii/S2211124723012743
  43. Oct 2023
  44. www.sciencedirect.com www.sciencedirect.com
    SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing
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      DOI: 10.1016/j.immuni.2023.10.001

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    sciencedirect.com/science/article/pii/S1074761323004417
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    Regulation of STING activity in DNA sensing by ISG15 modification
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    sciencedirect.com/science/article/pii/S2211124723012895
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    TAK1 is an essential kinase for STING trafficking
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    sciencedirect.com/science/article/abs/pii/S1097276523007049
  47. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
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  48. Sep 2023
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    sciencedirect.com/science/article/pii/S1534580723004094
  50. Aug 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
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      DOI: 10.1126/sciadv.adg5211

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    ncbi.nlm.nih.gov/pmc/articles/PMC10438455/
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    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
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    sciencedirect.com/science/article/pii/S2211124723010513
  53. www.science.org www.science.org
    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
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      DOI: 10.1126/sciadv.adg5211

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    science.org/doi/10.1126/sciadv.adg5211
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    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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  56. Jul 2023
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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    Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production
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  60. Jun 2023
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    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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  66. May 2023
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    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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  72. Mar 2023
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    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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  75. europepmc.org europepmc.org
    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
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  76. Dec 2022
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    Mitochondrial cristae architecture protects against mtDNA release and inflammation
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  80. Nov 2022
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    LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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  85. Oct 2022
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    Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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  88. Sep 2022
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    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
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    DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
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  92. Jul 2022
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    Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity
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    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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  98. May 2022
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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  104. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  109. Feb 2022
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    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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  111. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TBK1-METTL3 axis facilitates antiviral immunity
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    The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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  113. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  116. Dec 2021
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    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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  118. Nov 2021
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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    IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation
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  121. Aug 2021
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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  132. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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  133. Jul 2021
  134. www.nature.com www.nature.com
    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
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    sciencedirect.com/science/article/pii/S1097276519301005
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  138. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
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      RRID:AB_225566

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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
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  140. www.nature.com www.nature.com
    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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      3504

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  141. Jun 2021
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    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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    Translation stress and collided ribosomes are co-activators of cGAS
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      RRID:AB_2255663

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  144. May 2021
  145. www.sciencedirect.com www.sciencedirect.com
    Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
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      RRID:AB_2255663

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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    sciencedirect.com/science/article/pii/S1934590920302897
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    sciencedirect.com/science/article/pii/S1097276521001684
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    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
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    TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
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    Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation
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    sciencedirect.com/science/article/pii/S1074761320304970
  152. Apr 2021
  153. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    sciencedirect.com/science/article/pii/S1535610821000416
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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      rabbit anti‐TBK1

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    sciencedirect.com/science/article/pii/S2352396421001079
  156. www.sciencedirect.com www.sciencedirect.com
    Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation
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    Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback
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    Evasion of type-I interferon by SARS-CoV-2
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  162. Jan 2021
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    The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling
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  165. Oct 2020
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    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    Evasion of type-I interferon by SARS-CoV-2
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  168. Sep 2020
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    Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
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    ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway
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    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages
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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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  178. Jan 2020
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    Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
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    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
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    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
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  188. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TNF‐α Upregulates IKKε Expression via the Lin28B/let‐7a Pathway to Induce Catecholamine Resistance in Adipocytes
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      DOI: 10.1002/oby.22434

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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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    NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
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    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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  194. Nov 2018
  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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    Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
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  200. Nov 2017
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    Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses
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    Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression
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    sciencedirect.com/science/article/pii/S193459091630457X
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    Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
    1
    1. scibot 08 Nov 2017
      AB_2255663

      Curator: @Zeljana_Babic

      Resource used:

      (Cell Signaling Technology Cat# 3504S, RRID:AB_2255663)

      SciCrunch record: RRID:AB_2255663

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2255663 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276516308644