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Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction

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  DOI: 10.1158/2767-9764.CRC-25-0281
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12541299/
Oct 2025
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Adipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing β-adrenergic signaling and lipolysis

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sciencedirect.com/science/article/pii/S2211124725012161
Sep 2025
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Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice

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1. scibot 10 Sep 2025
  
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  DOI: 10.1007/s12264-025-01497-y
  
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link.springer.com/article/10.1007/s12264-025-01497-y
Aug 2025
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1-s2.0-S2589004225010338-main-html.html

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Jul 2025
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The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function

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dx.doi.org/10.1210/endocr/bqae041
Jun 2025
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SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes

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PI3K in the VMH attenuates diet-induced obesity and participates in the effects of E2 on energy expenditure in mice

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pmc.ncbi.nlm.nih.gov/articles/PMC12104622/
Apr 2025
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BPS Publications

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  DOI: 10.1111/bph.70039
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70039
Mar 2025
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Safety and Efficacy of Copanlisib in Combination with Nivolumab: A Phase Ib Study in Patients with Advanced Solid Tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC11907410/
Feb 2025
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PDF-html.html

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52.53.155.43/14aa111ce8a1e5484e892552f2e3d7e5be8c5aa9/PDF-html.html
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Akt is a mediator of artery specification during zebrafish development

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1. scibot 20 Feb 2025
  
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  DOI: 10.1242/dev.202727
  
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journals.biologists.com/dev/article/151/17/dev202727/361847/Akt-is-a-mediator-of-artery-specification-during
Dec 2024
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CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells

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  DOI: 10.1016/j.xcrm.2024.101844
  
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sciencedirect.com/science/article/pii/S2666379124006153
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Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.stem.2024.10.015
  
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sciencedirect.com/science/article/pii/S1934590924003771
Sep 2024
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mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes

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sciencedirect.com/science/article/pii/S2589004224021059
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Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming

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  DOI: 10.1016/j.immuni.2024.08.008
  
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sciencedirect.com/science/article/pii/S1074761324004072
Aug 2024
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Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

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sciencedirect.com/science/article/pii/S2211124724010143
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M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival

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tandfonline.com/doi/full/10.1080/15548627.2021.1938912
May 2024
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Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion

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1. scibot 30 May 2024
  
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cell.com/cell-reports/abstract/S2211-1247(24)00611-9
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Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation

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sciencedirect.com/science/article/pii/S1074761324002280
Apr 2024
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A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism

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12958_2024_1204_MOESM1_ESM-html.html

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52.53.155.43/d3bb518aa444c98d6cfb77a0666830bf57a4ed47/12958_2024_1204_MOESM1_ESM-html.html
Mar 2024
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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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sciencedirect.com/science/article/pii/S1550413124000500
Jan 2024
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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

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  DOI: 10.1126/sciadv.adk6524
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
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O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK

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ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
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SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells

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ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
Dec 2023
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De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

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  DOI: 10.1016/j.celrep.2023.113518
  
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sciencedirect.com/science/article/pii/S2211124723015309
Sep 2023
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Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos

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  DOI: 10.1016/j.xpro.2023.102569
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10509694/
Aug 2023
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Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

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  DOI: 10.1016/j.isci.2023.107465
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10433125/
Jun 2023
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Identification of XAF1 as an endogenous AKT inhibitor

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  DOI: 10.1016/j.celrep.2023.112690
  
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sciencedirect.com/science/article/pii/S2211124723007015
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Pregnancy-associated steroid effects on insulin sensitivity, adipogenesis and lipogenesis: Role of Wnt/β-catenin pathway

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  DOI: 10.1210/jendso/bvad076
  
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52.53.155.43/0e2f928f1674babd136ee902d8de869217b4f809/bvad076 (1)-html.html
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KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway

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  DOI: 10.1083/jcb.202208108
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9735414/
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Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing

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  DOI: 10.1210/endocr/bqad045
  
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academic.oup.com/endo/article/164/6/bqad045/7079002
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BPS Publications

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  DOI: 10.1111/bph.16080
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
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Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome

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1. scibot 01 Jun 2023
  
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  DOI: 10.1111/bph.16073
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16073
Apr 2023
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Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

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A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH

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KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

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Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes

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Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer

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A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells

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Acetylation-dependent regulation of BRAF oncogenic function

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Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance

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Translational and post-translational control of human naïve versus primed pluripotency

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver

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Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study

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Untitled document

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Untitled document

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Selective androgen receptor modulator S42 suppresses prostate cancer cell proliferation

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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease

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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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Upregulation of C Terminus of Hsc70-Interacting Protein Attenuates Apoptosis and Procoagulant Activity and Facilitates Brain Repair After Traumatic Brain Injury

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PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury

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HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State

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PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

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  Phospho-AKT Thr308
  
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Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1

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Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

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Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

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New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

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Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development

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Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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  2965
  
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The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

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Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

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Systematic Functional Annotation of Somatic Mutations in Cancer

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mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy

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  rabbit anti-p-AKT (T308) (1:2000, Cell Signaling #2965)
  
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Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells

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Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation

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Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity

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Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice

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Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

1
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  CSTCat#2965
  
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PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes

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TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1

1
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  rabbit anti-phospho-Akt (Thr308) monoclonal antibody (1:1500 dilution; Cell Signaling Technology #2965
  
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