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Jul 2025
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Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps

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  DOI: 10.1016/j.ccell.2025.06.007
  
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sciencedirect.com/science/article/pii/S1535610825002570
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The immune response against cancer is modulated by stromal cell fibronectin

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  DOI: 10.1016/j.neo.2025.101196
  
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sciencedirect.com/science/article/pii/S1476558625000764
Jun 2025
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PTEN protein phosphatase activity regulates metastasis by targeting PKCδ

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  DOI: 10.1016/j.isci.2025.112741
  
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sciencedirect.com/science/article/pii/S2589004225010028
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes

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1. scibot 24 May 2025
  
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  DOI: 10.1096/fj.202402764RR
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12093284/
Feb 2025
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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  DOI: 10.1016/j.xcrm.2025.101943
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
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Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization

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  DOI: 10.1007/s10456-024-09965-1
  
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link.springer.com/article/10.1007/s10456-024-09965-1
Jan 2025
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Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation

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1. scibot 27 Jan 2025
  
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  DOI: 10.1021/acsami.4c15459
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11758775/
Dec 2024
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Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

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1. scibot 19 Dec 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0164
  
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aacrjournals.org/cancerrescommun/article/4/12/3124/750544/Clotting-Promotes-Glioma-Growth-and-Infiltration
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1-s2.0-S2589004224027913-main-html.html

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111564
  
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52.53.155.43/bb9e8a3f1ed0d9e1121d67e11af5663597f8cb3d/1-s2.0-S2589004224027913-main-html.html
Nov 2024
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A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.chembiol.2024.10.008
  
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sciencedirect.com/science/article/pii/S2451945624004434
Sep 2024
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Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene

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1. scibot 25 Sep 2024
  
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  DOI: 10.1038/s41417-024-00809-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11405271/
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Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation

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1. scibot 18 Sep 2024
  
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  DOI: 10.1038/s41523-024-00687-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11401886/
Jul 2024
www.cell.com www.cell.com

A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.chembiol.2024.06.012
  
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cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00273-3
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Paradoxical activation of c-Src as a drug-resistant mechanism

2
1. scibot 03 Jul 2024
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.celrep.2021.108876
  
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  DOI: 10.1016/j.celrep.2021.108876
  
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sciencedirect.com/science/article/pii/S221112472100190X
Jun 2024
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Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization

1
1. scibot 13 Jun 2024
  
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  DOI: 10.1007/s00403-024-03032-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11161541/
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A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo

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1. scibot 06 Jun 2024
  
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  DOI: 10.1002/dneu.22950
  
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onlinelibrary.wiley.com/doi/10.1002/dneu.22950
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FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

1
1. scibot 04 Jun 2024
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.celrep.2024.114297
  
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sciencedirect.com/science/article/pii/S2211124724006259
May 2024
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A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells

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1. scibot 30 May 2024
  
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  DOI: 10.1038/s42003-024-06320-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11126613/
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Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.isci.2024.109829
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
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ATG9B regulates bacterial internalization via actin rearrangement

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1. scibot 05 May 2024
  
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  DOI: 10.1016/j.isci.2024.109623
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11066431/
Apr 2024
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Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

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1. scibot 28 Apr 2024
  
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  DOI: 10.7554/eLife.94265
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11045221/
Mar 2024
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IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF

2
1. scibot 28 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113989
  
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2. scibot 28 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113989
  
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sciencedirect.com/science/article/pii/S2211124724003176
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Astrocyte focal adhesion kinase reduces passive stress coping by inhibiting ciliary neurotrophic factor only in female mice

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1. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.ynstr.2024.100621
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10955429/
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Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells

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1. scibot 03 Mar 2024
  
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  DOI: 10.3389/fncel.2024.1357499
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10902920/
Feb 2024
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Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation

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1. scibot 10 Feb 2024
  
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  DOI: 10.1096/fj.202201088R
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10586062/
Jan 2024
52.53.155.43 52.53.155.43

Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer

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1. scibot 12 Jan 2024
  
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  DOI: 10.1210/jendso/bvae001
  
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52.53.155.43/1275268acb8a22f11b9f453254726460ddb0b773/bvae001-html.html
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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner

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1. scibot 10 Jan 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-0964
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
Dec 2023
www.biorxiv.org www.biorxiv.org

Together, Neuropilin 1 and Neuropilin 2 direct α5 integrin trafficking through GTPase-activating-protein p120RasGAP in endothelial cells to promote fibronectin fibrillogenesis

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1. scibot 02 Dec 2023
  
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  DOI: 10.1101/2023.11.28.568967
  
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biorxiv.org/content/10.1101/2023.11.28.568967v1
Nov 2023
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PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113414
  
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sciencedirect.com/science/article/pii/S2211124723014262
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The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

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1. scibot 02 Nov 2023
  
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  DOI: 10.7554/eLife.89141
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10615368/
Oct 2023
aiche.onlinelibrary.wiley.com aiche.onlinelibrary.wiley.com

Mechanochemical coupling of MGF mediates periodontal regeneration

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1. scibot 09 Oct 2023
  
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  DOI: 10.1002/btm2.10603
  
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aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10603
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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

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1. scibot 06 Oct 2023
  
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  DOI: 10.1016/j.neuron.2023.08.012
  
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sciencedirect.com/science/article/pii/S0896627323006232
Sep 2023
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bvad117-html.html

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  DOI: 10.1210/jendso/bvad117
  
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  DOI: 10.1210/jendso/bvad117
  
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Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

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Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis

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Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex

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Identification of a comprehensive alternative splicing function during epithelial-mesenchymal transition

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Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo

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FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

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Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis

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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

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Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

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Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

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A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration

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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

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Sep 2022
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Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis

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Exploring the target scope of KEAP1 E3 ligase-based PROTACs

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Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions

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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice

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Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice

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Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

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LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

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Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression

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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

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βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer

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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

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PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

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Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1

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Biosensors based on peptide exposure show single molecule conformations in live cells

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Senescent immune cells release grancalcin to promote skeletal aging

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Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways

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Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF

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  DOI: 10.1016/j.expneurol.2018.11.002
  
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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

1
1. scibot 27 Jul 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.cell.2018.10.025
  
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Modulation of Akt vs Stat3 activity by the focal adhesion kinase in non-neoplastic mouse fibroblasts

1
1. scibot 15 Jul 2021
  
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  Cell-signalling technology Cat. #3285
  
  DOI: 10.1016/j.yexcr.2021.112731
  
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sciencedirect.com/science/article/pii/S0014482721002639
Jun 2021
cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org

TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.

1
1. scibot 29 Jun 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1158/2159-8290.CD-20-0797
  
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cancerdiscovery.aacrjournals.org/content/11/6/1411
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Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis

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1. scibot 02 Jun 2021
  
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  3285s
  
  DOI: 10.1016/j.canlet.2021.05.033
  
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sciencedirect.com/science/article/pii/S0304383521002573
May 2021
mcr.aacrjournals.org mcr.aacrjournals.org

Adaptor protein ShcD/SHC4 interacts with Tie2 receptor to synergistically promote glioma cell invasion

1
1. scibot 10 May 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1158/1541-7786.MCR-20-0188
  
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mcr.aacrjournals.org/content/19/5/757
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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

1
1. scibot 07 May 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.molcel.2020.06.021
  
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sciencedirect.com/science/article/pii/S1097276520304238
Apr 2021
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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

1
1. scibot 24 Apr 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.cell.2020.06.021
  
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sciencedirect.com/science/article/pii/S0092867420307534
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK

1
1. scibot 31 Mar 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.devcel.2020.11.017
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8005871/
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Paradoxical activation of c-Src as a drug-resistant mechanism

1
1. scibot 24 Mar 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.celrep.2021.108876
  
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A modular, injectable, non-covalently assembled hydrogel system features widescale tunable degradability for controlled release and tissue integration

1
1. scibot 08 Mar 2021
  
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  AB_2269034
  
  DOI: 10.1016/j.biomaterials.2020.120637
  
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sciencedirect.com/science/article/pii/S014296122030884X
Feb 2021
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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

1
1. scibot 24 Feb 2021
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.celrep.2021.108750
  
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cell.com/cell-reports/fulltext/S2211-1247(21)00063-2
Dec 2020
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Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma

1
1. scibot 15 Dec 2020
  
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  total-FAK
  
  DOI: 10.1016/j.tranon.2020.100982
  
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sciencedirect.com/science/article/pii/S1936523320304745
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Adaptation of endothelial cells to shear stress under atheroprone conditions by modulating internalization of vascular endothelial cadherin and vinculin

1
1. scibot 12 Dec 2020
  
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  RRID:AB_2269034
  
  DOI: 10.21037/atm-20-3426
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7723531/
Sep 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF

1
1. scibot 23 Sep 2020
  
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  RRID:AB_10829239
  
  DOI: 10.1002/glia.23498
  
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onlinelibrary.wiley.com/doi/full/10.1002/glia.23498
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Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2269034
  
  DOI: 10.7554/eLife.57617
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7494359/
link.springer.com link.springer.com

Targeting the Tie2–α v β 3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

1
1. scibot 16 Sep 2020
  
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  RRID:AB_10694068
  
  DOI: 10.1186/s12915-018-0557-9
  
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link.springer.com/article/10.1186/s12915-018-0557-9
Jan 2020
jcs.biologists.org jcs.biologists.org

Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling

1
1. scibot 13 Jan 2020
  
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  AB_2269034
  
  DOI: 10.1242/jcs.202580
  
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jcs.biologists.org/content/131/3/jcs202580
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2269034
  
  DOI: 10.1111/bph.14813
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14813
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Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.expneurol.2019.113088
  
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sciencedirect.com/science/article/pii/S0014488619302353
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A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.celrep.2019.06.036
  
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sciencedirect.com/science/article/pii/S2211124719308022
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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10694068
  
  DOI: 10.1016/j.molcel.2019.09.007
  
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sciencedirect.com/science/article/pii/S1097276519306926
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Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

1
1. scibot 13 Jan 2020
  
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  AB_2269034
  
  DOI: 10.1016/j.ccell.2019.05.003
  
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sciencedirect.com/science/article/pii/S1535610819302417
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2269034
  
  DOI: 10.1016/j.ccell.2019.01.009
  
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sciencedirect.com/science/article/pii/S1535610819300431
Nov 2018
academic.oup.com academic.oup.com

Insulinlike Growth Factor–Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance

1
1. scibot 05 Nov 2018
  
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  AB_2269034
  
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academic.oup.com/endo/article/159/2/696/4657266
Nov 2017
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Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma

1
1. scibot 08 Nov 2017
  
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  AB_2269034
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1934590917301376

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