273 Matching Annotations
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    Lithocholic acid phenocopies anti-ageing effects of calorie restriction
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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  4. Dec 2024
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    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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    CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
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  9. Nov 2024
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    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
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    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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  12. Oct 2024
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    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
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    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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  15. Sep 2024
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    Activating mTOR mutations are detrimental in nutrient-poor conditions
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    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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  20. Aug 2024
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    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
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    Sestrin2 drives ER-phagy in response to protein misfolding
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  23. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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  24. Jul 2024
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    Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells
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    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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  28. Jun 2024
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    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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  30. May 2024
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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  35. Apr 2024
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    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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  39. Mar 2024
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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  42. Feb 2024
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    Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
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  46. Jan 2024
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    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  49. Dec 2023
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    sciencedirect.com/science/article/pii/S0092867423010814
  51. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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    Protein signaling in response to ex vivo dynamic contractions is independent of training status in rat skeletal muscle
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    Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway.
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    Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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  156. 52.53.155.43 52.53.155.43
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  157. 52.53.155.43 52.53.155.43
    ajpcell.00385.2020-html.html
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  158. www.sciencedirect.com www.sciencedirect.com
    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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  160. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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  165. Sep 2021
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  167. Aug 2021
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  178. Jul 2021
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    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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      rabbit anti‐P‐S6K (P‐p70S6K)

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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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      Phospho-p70 S6 Kinase T389

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    Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
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    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
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    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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    Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs
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    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
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  195. May 2021
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
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    A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies
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    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
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    Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation
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      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2269803

      What is this?
      RRIDCUR:Validated RRID:AB_2269803
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    sciencedirect.com/science/article/pii/S1097276520300034