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Viral infection activates the IRF1-BAK axis to drive mitochondria-derived inflammation

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  DOI: 10.1016/j.celrep.2026.117968
  
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sciencedirect.com/science/article/pii/S2211124726010466
Aug 2026
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Claudin-12 sustains urothelial barrier defense against uropathogenic E. coli via calcium-dependent immunomodulation

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  DOI: 10.1016/j.isci.2026.117190
  
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sciencedirect.com/science/article/pii/S258900422602568X
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Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation

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1. scibot 01 Aug 2026
  
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  DOI: 10.1016/j.cell.2026.07.011
  
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sciencedirect.com/science/article/pii/S0092867426008093
May 2026
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Triptolide enhances anti-cancer activities of irinotecan in human colon cancer HT-29 cells in vitro and HT-29 cell xenograft tumor model in nude mice

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1. scibot 29 May 2026
  
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  DOI: 10.1177/15347354261448871
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13201951/
Jan 2026
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CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

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  DOI: 10.1016/j.xcrm.2025.102565
  
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sciencedirect.com/science/article/pii/S266637912500638X
Dec 2025
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A 20-amino-acid Cardiovirus protein exhibits cytokine-mimicry activity to regulate viral replication

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1. scibot 17 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116740
  
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sciencedirect.com:5037/science/article/pii/S2211124725015128
Nov 2025
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LUBAC modulates CBM complex functions downstream of TRAF6 in T cells

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1. scibot 24 Nov 2025
  
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  DOI: 10.1038/s41467-025-65879-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12602705/
Jul 2025
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The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone

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1. scibot 22 Jul 2025
  
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  DOI: 10.3390/ijms26146893
  
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mdpi.com/1422-0067/26/14/6893
Jun 2025
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BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

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1. scibot 28 Jun 2025
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
Apr 2025
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Red blood cells undergo lytic programmed cell death involving NLRP3

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.039
  
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sciencedirect.com/science/article/pii/S0092867425003897
Mar 2025
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7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

2
1. scibot 06 Mar 2025
  
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  DOI: 10.1111/bph.17464
  
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  DOI: 10.1111/bph.17464
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
Feb 2025
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Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP

1
1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115297
  
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sciencedirect.com/science/article/pii/S2211124725000683
Oct 2024
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Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

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1. scibot 02 Oct 2024
  
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  DOI: 10.1038/s41467-024-52110-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11427689/
Aug 2024
www.cell.com www.cell.com

RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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1. scibot 02 Aug 2024
  
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  hCASP8
  
  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
Jun 2024
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Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1

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1. scibot 08 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109828
  
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sciencedirect.com/science/article/pii/S2589004224010502
May 2024
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Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia

1
1. scibot 16 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114237
  
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sciencedirect.com/science/article/pii/S2211124724005655
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

1
1. scibot 29 Dec 2023
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.isci.2023.108659
  
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sciencedirect.com/science/article/pii/S2589004223027360
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The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113581
  
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sciencedirect.com/science/article/pii/S2211124723015930
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores

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1. scibot 08 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107698
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10480325/
Mar 2023
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FAM193A is a positive regulator of p53 activity

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1. scibot 10 Mar 2023
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2023.112230
  
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sciencedirect.com/science/article/pii/S2211124723002413
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decitabine enhances the tumoricidal potential of TRAIL via the epigenetic regulation of death receptor 4 in gastric cancer

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1. scibot 15 Jan 2023
  
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  DOI: 10.21037/jgo-22-928
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9830339/
www.nature.com www.nature.com

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer

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1. scibot 04 Jan 2023
  
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  RRID:AB_2275120
  
  DOI: 10.1038/s41419-022-05535-9
  
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nature.com/articles/s41419-022-05535-9
Dec 2022
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Tumor necrosis factor is a necroptosis-associated alarmin

1
1. scibot 30 Dec 2022
  
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  AB_2275120
  
  DOI: 10.3389/fimmu.2022.1074440
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9791252/
Oct 2022
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Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

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  DOI: 10.1016/j.isci.2022.105118
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9519628/
Mar 2022
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Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases

1
1. scibot 27 Mar 2022
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.molcel.2022.03.010
  
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sciencedirect.com/science/article/pii/S1097276522002192
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BPS Publications

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  DOI: 10.1111/bph.15758
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15758
Nov 2021
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A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

1
1. scibot 09 Nov 2021
  
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  9746
  
  DOI: 10.1016/j.celrep.2021.109953
  
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sciencedirect.com/science/article/pii/S2211124721014303
Oct 2021
www.embopress.org www.embopress.org

Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

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1. scibot 12 Oct 2021
  
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  RRID:AB_2275120
  
  DOI: 10.15252/embr.202052254
  
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embopress.org/doi/full/10.15252/embr.202052254
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

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1. scibot 22 Sep 2021
  
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  RRID:AB_2068482
  
  DOI: 10.21769/BioProtoc.2222
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8410427/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells

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1. scibot 18 Sep 2021
  
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  RRID:AB_2275120
  
  DOI: 10.7150/thno.59728
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8419049/
Aug 2021
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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.026
  
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sciencedirect.com/science/article/pii/S0092867421008850
elifesciences.org elifesciences.org

Untitled document

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1. scibot 13 Aug 2021
  
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  DOI: 10.7554/eLife.30224
  
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elifesciences.org/articles/30224
Jul 2021
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Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

1
1. scibot 31 Jul 2021
  
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  Mouse monoclonal anti-Caspase-8
  
  DOI: 10.1016/j.celrep.2019.11.014
  
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sciencedirect.com/science/article/pii/S2211124719314858
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Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8

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1. scibot 29 Jul 2021
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2019.10.090
  
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sciencedirect.com/science/article/pii/S2211124719314123
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

2
1. scibot 29 Jul 2021
  
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  RRID:AB_2275120
  
  DOI: 10.7554/eLife.30224
  
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2. scibot 29 Jul 2021
  
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  RRID:AB_2275120
  
  DOI: 10.7554/eLife.30224
  
  Resource: (Cell Signaling Technology Cat# 9746, RRID:AB_2275120)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5773178/
May 2021
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A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

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1. scibot 28 May 2021
  
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  RRID:AB_2275120
  
  DOI: 10.7554/eLife.67409
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8143796/
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RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

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1. scibot 12 May 2021
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2021.109112
  
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sciencedirect.com/science/article/pii/S2211124721004460
Jan 2021
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 08 Jan 2021
  
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  RRID:AB_2275120
  
  DOI: 10.1111/bph.15306
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15306
Sep 2020
link.springer.com link.springer.com

Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

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1. scibot 17 Sep 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1186/s13148-020-00839-z
  
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link.springer.com/article/10.1186/s13148-020-00839-z
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TMEM173 Drives Lethal Coagulation in Sepsis

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1. scibot 14 Sep 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.chom.2020.02.004
  
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sciencedirect.com/science/article/pii/S1931312820301128
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Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

1
1. scibot 06 Sep 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2020.108008
  
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sciencedirect.com/science/article/pii/S2211124720309931
Jan 2020
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Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2019.07.066
  
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sciencedirect.com/science/article/pii/S2211124719309702
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21-benzylidene digoxin decreases proliferation by inhibiting the egfr/erk signaling pathway and induces apoptosis in hela cells

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.steroids.2019.108551
  
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sciencedirect.com/science/article/pii/S0039128X19302417
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2019.01.081
  
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sciencedirect.com/science/article/pii/S221112471930110X
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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

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1. scibot 13 Jan 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.molcel.2019.01.036
  
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Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

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1. scibot 12 Jan 2020
  
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  RRID:AB_2275120
  
  DOI: 10.1016/j.celrep.2019.02.096
  
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sciencedirect.com/science/article/pii/S2211124719302827
Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1931312818304918