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www.biorxiv.org www.biorxiv.org

Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response

1
1. scibot 23 Oct 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1101/2025.10.16.682859
  
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biorxiv.org/content/10.1101/2025.10.16.682859v2
Oct 2025
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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

1
1. scibot 08 Oct 2025
  
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  AB_2277617
  
  DOI: 10.1016/j.cmet.2025.09.004
  
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sciencedirect.com/science/article/pii/S1550413125003894
Sep 2025
52.53.155.43 52.53.155.43

2025.09.04.674332v2.full-html.html

1
1. scibot 18 Sep 2025
  
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  AB_2277617
  
  DOI: 10.1101/2025.09.04.674332
  
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52.53.155.43/304402c0b5b5e8844bb324b2732dfcb1e481f20c/2025.09.04.674332v2.full-html.html
Jul 2025
www.science.org www.science.org

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

1
1. scibot 25 Jul 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1126/sciadv.adt3142
  
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science.org/doi/10.1126/sciadv.adt3142
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma

1
1. scibot 20 May 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1158/0008-5472.CAN-24-1393
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12079101/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

1
1. scibot 28 Mar 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1126/sciadv.adt3142
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11939056/
Feb 2025
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The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

1
1. scibot 13 Feb 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.molcel.2025.01.017
  
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sciencedirect.com/science/article/pii/S1097276525000474
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A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation

1
1. scibot 04 Feb 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.molcel.2025.01.003
  
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sciencedirect.com/science/article/pii/S1097276525000036
Jan 2025
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Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation

1
1. scibot 07 Jan 2025
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.immuni.2024.12.004
  
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sciencedirect.com/science/article/pii/S1074761324005685
Dec 2024
www.science.org www.science.org

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

1
1. scibot 03 Dec 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1126/scisignal.adp1375
  
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science.org/doi/10.1126/scisignal.adp1375
Jun 2024
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The ribotoxic stress response drives UV-mediated cell death

1
1. scibot 06 Jun 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.cell.2024.05.018
  
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sciencedirect.com/science/article/pii/S0092867424005270
Apr 2024
www.embopress.org www.embopress.org

Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis

1
1. scibot 18 Apr 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1038/s44318-023-00008-x
  
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embopress.org/doi/full/10.1038/s44318-023-00008-x
Mar 2024
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Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis

3
1. scibot 15 Mar 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1038/s44318-023-00008-x
  
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2. scibot 15 Mar 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1038/s44318-023-00008-x
  
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3. scibot 03 Mar 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1038/s44318-023-00008-x
  
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embopress.org/doi/full/10.1038/s44318-023-00008-x
www.embopress.org www.embopress.org

Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis

1
1. scibot 15 Mar 2024
  
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  RRID:AB_2277617
  
  DOI: 10.1038/s44318-023-00008-x
  
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embopress.org/doi/10.1038/s44318-023-00008-x
Jan 2024
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Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes

1
1. scibot 11 Jan 2024
  
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  RRID:AB_10694800
  
  DOI: 10.1016/j.celrep.2023.113658
  
  Resource: (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
  Curator: @evieth
  
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  RRIDCUR:Unresolved RRID:AB_2277617
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sciencedirect.com/science/article/pii/S2211124723016698
Jul 2023
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Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome

1
1. scibot 21 Jul 2023
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.neuron.2023.06.017
  
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sciencedirect.com/science/article/abs/pii/S0896627323004762
Jan 2023
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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

1
1. scibot 19 Jan 2023
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.cell.2022.12.025
  
  Resource: (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
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sciencedirect.com/science/article/pii/S0092867422015380
Oct 2022
elifesciences.org elifesciences.org

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

1
1. scibot 19 Oct 2022
  
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  RRID:AB_2277617
  
  DOI: 10.7554/eLife.81083
  
  Resource: (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
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elifesciences.org/articles/81083
Jul 2022
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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

1
1. scibot 08 Jul 2022
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.stem.2022.06.004
  
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sciencedirect.com/science/article/pii/S1934590922002533
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling

1
1. scibot 08 Apr 2022
  
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  RRID:AB_2277617
  
  DOI: 10.1158/1541-7786.MCR-21-0374
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8983529/
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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

1
1. scibot 07 Apr 2022
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.molcel.2022.03.016
  
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sciencedirect.com/science/article/pii/S1097276522002544
Mar 2022
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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

1
1. scibot 26 Mar 2022
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.molcel.2022.02.031
  
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sciencedirect.com/science/article/pii/S1097276522002052
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

1
1. scibot 04 Mar 2022
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.molcel.2022.02.007
  
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sciencedirect.com/science/article/pii/S1097276522001125
Oct 2021
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GCN2 adapts protein synthesis to scavenging-dependent growth

1
1. scibot 27 Oct 2021
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.cels.2021.09.014
  
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sciencedirect.com/science/article/pii/S2405471221003823
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Translation in amino-acid-poor environments is limited by tRNAGln charging

1
1. scibot 27 Feb 2021
  
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  RRID:AB_2277617
  
  DOI: 10.7554/eLife.62307
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
Sep 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

1
1. scibot 15 Sep 2020
  
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  RRID:AB_2277617
  
  DOI: 10.1111/jnc.14979
  
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  Curator: @Naa003
  
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  RRID:AB_2277617 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/10.1111/jnc.14979
www.nature.com www.nature.com

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy

1
1. scibot 03 Sep 2020
  
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  rabbit polyclonal antibody against GCN2
  
  DOI: 10.1038/s41419-020-2642-6
  
  Resource: (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2277617
  
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  RRID:AB_2277617 RRIDCUR:Missing
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nature.com/articles/s41419-020-2642-6
Jan 2020
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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2277617
  
  DOI: 10.1016/j.neuron.2019.08.007
  
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  Curator: @ethanbadger
  
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  RRID:AB_2277617 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627319306919
Nov 2018
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Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2277617
  
  Curator: @evieth
  
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  RRID:AB_2277617 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124718312610
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Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2277617
  
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sciencedirect.com/science/article/pii/S1931312818302038
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2277617
  
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  (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
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sciencedirect.com/science/article/pii/S1550413118301207
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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2277617
  
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  (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
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sciencedirect.com/science/article/pii/S153561081730555X
Nov 2017
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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

1
1. scibot 08 Nov 2017
  
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  RRID:AB_2277617
  
  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 3302, RRID:AB_2277617)
  
  SciCrunch record: RRID:AB_2277617
  
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  RRID:AB_2277617 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276517306081