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    FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
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    sciencedirect.com/science/article/pii/S1550413124004479
  3. Dec 2024
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    DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways
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    Proteolethargy is a pathogenic mechanism in chronic disease
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    sciencedirect.com/science/article/pii/S0092867424012741
  6. Sep 2024
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    Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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  9. Jul 2024
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    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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      DOI: 10.1210/endocr/bqae069

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    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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  12. Jun 2024
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    Insulin and leptin oscillations license food-entrained browning and metabolic flexibility
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    sciencedirect.com/science/article/pii/S2211124724007186
  14. May 2024
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    Contrasting consequences of podocyte IGF1R inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
  16. Apr 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993184/
  18. Nov 2023
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    sciencedirect.com/science/article/pii/S2666379123004792
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance
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  21. Sep 2023
  22. dx.doi.org dx.doi.org
    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
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  23. Aug 2023
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  25. Jul 2023
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    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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      DOI: 10.1210/clinem/dgad413

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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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  28. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  29. May 2023
  30. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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  31. Apr 2023
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    CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice
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    sciencedirect.com/science/article/pii/S2589004223006016
  33. Mar 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma
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      DOI: 10.1158/1541-7786.MCR-22-0090

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  35. Jan 2023
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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    sciencedirect.com/science/article/pii/S2211124722018885
  37. Dec 2022
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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  41. Nov 2022
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    Simultaneous SGLT2 inhibition and caloric restriction improves insulin resistance and kidney function in OLETF rats
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    sciencedirect.com/science/article/pii/S0303720722002593
  43. Aug 2022
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    Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers
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  45. Jun 2022
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    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
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  47. Dec 2021
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    Hypothalamic miR-1983 targets insulin receptor beta and the insulin-mediated miR-1983 increase is blocked by metformin
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      DOI: 10.1210/endocr/bqab241

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    academic.oup.com/endo/article/163/1/bqab241/6433013
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    TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver
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  50. Oct 2021
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling
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      DOI: 10.7554/eLife.70885

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    ncbi.nlm.nih.gov/pmc/articles/PMC8516413/
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    Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
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    sciencedirect.com/science/article/pii/S2589004221011196
  53. Sep 2021
  54. academic.oup.com academic.oup.com
    Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling
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      DOI: 10.1210/endocr/bqab182

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    academic.oup.com/endo/article/162/11/bqab182/6359854
  55. Aug 2021
  56. www.sciencedirect.com www.sciencedirect.com
    GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
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    sciencedirect.com/science/article/pii/S2211124721009293
  57. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  58. academic.oup.com academic.oup.com
    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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      DOI: 10.1210/en.2017-00489

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    academic.oup.com/endo/article/158/10/3399/4037402/Renal-Metabolic-Programming-Is-Linked-to-the
  59. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14553
  60. Jul 2021
  61. www.sciencedirect.com www.sciencedirect.com
    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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      DOI: 10.1016/j.cell.2018.09.055

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    sciencedirect.com/science/article/pii/S0092867418313060
  62. academic.oup.com academic.oup.com
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    academic.oup.com/endo/article/160/2/377/5235619
  63. academic.oup.com academic.oup.com
    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
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  64. academic.oup.com academic.oup.com
    Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
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      DOI: 10.1210/en.2016-1583

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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  66. Jun 2021
  67. academic.oup.com academic.oup.com
    Endothelial insulin receptors promote VEGF-A signaling via ERK1/2 and sprouting angiogenesis
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      DOI: 10.1210/endocr/bqab104

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    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
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      DOI: 10.1210/endocr/bqab064

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  69. Apr 2021
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    Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference
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    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
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    The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells
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  73. Feb 2021
  74. www.cell.com www.cell.com
    Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
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  75. Jan 2021
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    Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3
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  77. Oct 2020
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    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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  79. Sep 2020
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    Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats
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  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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  82. www.jbc.org www.jbc.org
    Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels
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  83. academic.oup.com academic.oup.com
    DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice
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      DOI: 10.1210/endocr/bqaa139

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  84. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal rabbit insulin receptor-β

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  85. Jan 2020
  86. elifesciences.org elifesciences.org
    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
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  87. www.sciencedirect.com www.sciencedirect.com
    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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      DOI: 10.1016/j.ebiom.2019.08.033

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  89. academic.oup.com academic.oup.com
    Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
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      RRID:AB_2280448

      DOI: 10.1210/en.2019-00236

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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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  91. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice
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      RRID:AB_2280448

      DOI: 10.1111/bph.14570

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  92. www.sciencedirect.com www.sciencedirect.com
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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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  94. Nov 2018
  95. www.sciencedirect.com www.sciencedirect.com
    Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
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    Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells
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    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    COMMD5/HCaRG Hooks Endosomes on Cytoskeleton and Coordinates EGFR Trafficking
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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  101. academic.oup.com academic.oup.com
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  102. Nov 2017
  103. www.sciencedirect.com www.sciencedirect.com
    Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation
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    Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
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