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  1. Last 7 days
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    1. scibot 02 Oct 2024
      AB_2291505

      DOI: 10.1016/j.xcrm.2024.101752

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    sciencedirect.com/science/article/pii/S2666379124004828
  3. Aug 2024
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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      RRID:AB_2291505

      DOI: 10.1016/j.chembiol.2024.07.005

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    sciencedirect.com/science/article/pii/S2451945624003076
  5. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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      AB_2291505

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    sciencedirect.com/science/article/pii/S1097276524001758
  7. Jan 2024
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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    1. scibot 25 Jan 2024
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      DOI: 10.1038/s41388-024-02947-z

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    nature.com/articles/s41388-024-02947-z
  9. Nov 2023
  10. www.nature.com www.nature.com
    Selective inhibition of CDK9 in triple negative breast cancer
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    1. scibot 25 Nov 2023
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      DOI: 10.1038/s41388-023-02892-3

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    nature.com/articles/s41388-023-02892-3
  11. Jul 2023
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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      RRID:AB_2291505

      DOI: 10.1101/2023.06.27.546707

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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
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    Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation
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    sciencedirect.com/science/article/abs/pii/S1097276523005087
  14. Jul 2022
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
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    1. scibot 27 Jul 2022
      RRID:AB_2291505

      DOI: 10.1111/febs.16375

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    ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
  16. May 2022
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    Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells
    1
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      RRID:AB_2291505

      DOI: 10.1016/j.cels.2022.04.005

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    sciencedirect.com/science/article/pii/S2405471222001703
  18. Mar 2022
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    Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP
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    1. scibot 26 Mar 2022
      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2022.03.001

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    sciencedirect.com/science/article/pii/S1097276522002106
  20. Aug 2021
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2019.01.033

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    ncbi.nlm.nih.gov/pmc/articles/PMC6482433/
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    1. scibot 11 Aug 2021
      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2017.04.027

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    ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
  23. Jul 2021
  24. www.sciencedirect.com www.sciencedirect.com
    RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control
    1
    1. scibot 28 Jul 2021
      CDK9

      DOI: 10.1016/j.molcel.2019.05.007

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    sciencedirect.com/science/article/pii/S1097276519303600
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    Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
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    1. scibot 22 Jul 2021
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2021.109394

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    sciencedirect.com/science/article/pii/S2211124721007920
  26. Jun 2021
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    1. scibot 23 Jun 2021
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2021.109281

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    sciencedirect.com/science/article/pii/S2211124721006483
  28. May 2021
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    1. scibot 18 May 2021
      RRID:AB_2291505

      DOI: 10.1016/j.cell.2021.04.022

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    sciencedirect.com/science/article/pii/S009286742100502X
  30. Apr 2021
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    1. scibot 28 Apr 2021
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2021.109013

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    sciencedirect.com/science/article/pii/S2211124721003272
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    The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming
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    1. scibot 15 Apr 2021
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2021.108965

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    sciencedirect.com/science/article/pii/S2211124721002795
  33. Feb 2021
  34. www.sciencedirect.com www.sciencedirect.com
    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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    1. scibot 24 Feb 2021
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2021.108749

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    sciencedirect.com/science/article/pii/S2211124721000620
  35. Jan 2021
  36. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
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    1. scibot 07 Jan 2021
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2020.108532

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    sciencedirect.com/science/article/pii/S2211124720315217
  37. Dec 2020
  38. www.sciencedirect.com www.sciencedirect.com
    CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
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    1. scibot 24 Dec 2020
      RRID:AB_2291505

      DOI: 10.1016/j.celrep.2020.108545

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    sciencedirect.com/science/article/pii/S2211124720315345
  39. Oct 2020
  40. www.sciencedirect.com www.sciencedirect.com
    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    1. scibot 27 Oct 2020
      RRID:AB_2291505

      DOI: 10.1016/j.chembiol.2020.10.001

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    sciencedirect.com/science/article/pii/S2451945620303809
  41. Sep 2020
  42. www.cell.com www.cell.com
    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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    1. scibot 17 Sep 2020
      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2018.11.006

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    cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
  43. Jan 2020
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma
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    1. scibot 13 Jan 2020
      RRID:AB_2291505

      DOI: 10.1002/jcb.29420

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    onlinelibrary.wiley.com/doi/10.1002/jcb.29420
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    Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
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      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2019.07.013

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    sciencedirect.com/science/article/pii/S109727651930543X
  46. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2019.01.033

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    sciencedirect.com/science/article/pii/S109727651930053X
  47. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 13 Jan 2020
      RRID:AB_2291505

      DOI: 10.1016/j.chembiol.2019.02.015

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    sciencedirect.com/science/article/pii/S2451945619300704
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 13 Jan 2020
      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2018.11.006

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    ncbi.nlm.nih.gov/pmc/articles/PMC6375729/
  49. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 12 Jan 2020
      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2018.11.006

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    sciencedirect.com/science/article/pii/S1097276518309481
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    MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis
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    1. scibot 12 Jan 2020
      RRID:AB_2291505

      DOI: 10.1016/j.molcel.2018.09.031

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    sciencedirect.com/science/article/pii/S1097276518308025
  51. Nov 2018
  52. www.sciencedirect.com www.sciencedirect.com
    The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
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    1. scibot 05 Nov 2018
      RRID:AB_2291505

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276517310080
  53. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
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    sciencedirect.com/science/article/pii/S1097276517308419
  54. www.sciencedirect.com www.sciencedirect.com
    Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells
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      RRID:AB_2291505

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    sciencedirect.com/science/article/pii/S1097276517307001
  55. Nov 2017
  56. www.sciencedirect.com www.sciencedirect.com
    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    1. scibot 08 Nov 2017
      AB_2291505

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S109727651730312X