106 Matching Annotations
  1. Last 7 days
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    Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease
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    link.springer.com/article/10.1038/s44318-026-00899-6
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30
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    pmc.ncbi.nlm.nih.gov/articles/PMC13560928/
  4. Aug 2026
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    Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction
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    sciencedirect.com/science/article/pii/S0896627326005775
  6. Jun 2026
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    Postnatal deletion of ZIP9 leads to premature mortality and hippocampal-dependent cognitive decline with disrupted brain–gut–lipid homeostasis
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    sciencedirect.com/science/article/pii/S3117817026000068
  8. May 2026
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    Human cerebral organoids with microglia and vasculature model glioma stem cell interactions and radiotherapy response
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    sciencedirect.com/science/article/pii/S2667237526001256
  10. Apr 2026
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    Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin
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    sciencedirect.com/science/article/pii/S1931312826001319
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    Tau seeds induce neurofibrillary tangle formation across brain regions via individual-specific connectivity
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    sciencedirect.com/science/article/pii/S0896627326001649
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    Evaluating Chronic Sex-Specific Changes in Glutamatergic Signaling Markers Following Traumatic Brain Injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC13026189/
  14. Mar 2026
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    Human-specific features of the cerebellum and ZP2-regulated synapse development
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    sciencedirect.com/science/article/pii/S0092867426002217
  16. Feb 2026
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD
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    pmc.ncbi.nlm.nih.gov/articles/PMC12856326/
  18. Jan 2026
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    Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome
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    sciencedirect.com/science/article/pii/S2211124725016298
  20. Dec 2025
  21. 54.241.53.176 54.241.53.176
    s12974-025-03648-4_reference-html.html
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    Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670740/
  23. Oct 2025
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    TREK-1 Channel Blockade Mediates the Antidepressant-like Effects of Hydroxynorketamine
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    sciencedirect.com/science/article/pii/S0028390825004599
  25. Sep 2025
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    Deletion of the SHORT Syndrome Gene Prkce Results in Brain Atrophy and Cognitive and Motor Behavior Deficits in Mice
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    link.springer.com/article/10.1007/s12264-025-01497-y
  27. Jul 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12296469/
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    Subchronic amphetamine decreases hyperactivity, anti-social behaviour and anhedonia in dopamine transporter knockout rats: role of prefrontal glutamate
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    sciencedirect.com/science/article/pii/S0028390825003053
  30. May 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12120816/
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    Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70087
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    RNF13 variants L311S and L312P associated with developmental epileptic encephalopathy alter dendritic organization in hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12018061/
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    A novel carbamate-based hybrid derivative with anti-neuroinflammatory properties as a selective butyrylcholinesterase inhibitor for Alzheimer's disease therapy
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    sciencedirect.com/science/article/pii/S0045206825004316
  35. Apr 2025
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Donepezil Improves PSD95 Expression, Mitigates Neuroinflammation via PI3K/Akt/NF-κB and Mitochondrial Dysfunction in a Rodent Model of Subarachnoid Haemorrhage
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70063
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    Repeated cocaine exposure and prolonged withdrawal induce spatial memory impairment and dysregulate the glutamatergic synapse composition in the dorsal hippocampus of male rats
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    sciencedirect.com/science/article/pii/S0028390825001595
  38. Mar 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sub-Immunosuppressive Tacrolimus Ameliorates Amyloid-Beta and Tau Pathology in 3xTg-AD Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898583/
  40. Dec 2024
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17403
  42. Nov 2024
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of synapse density by Pumilio RNA-binding proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC11544588/
  44. Oct 2024
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    Compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5 × FAD mice
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    sciencedirect.com/science/article/pii/S0024320524006751
  46. Sep 2024
  47. analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com
    Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro
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    analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.4690
  48. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
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    currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.948
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    Sodium butyrate improves cognitive dysfunction in high-fat diet/ streptozotocin-induced type 2 diabetic mice by ameliorating hippocampal mitochondrial damage through regulating AMPK/PGC-1α pathway
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    sciencedirect.com/science/article/pii/S0028390824003083
  50. Aug 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chronic Lithium Treatment Alters NMDA and AMPA Receptor Synaptic Availability and Dendritic Spine Organization in the Rat Hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11333793/
  52. Jul 2024
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    A hominoid-specific signaling axis regulating the tempo of synaptic maturation
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    sciencedirect.com/science/article/pii/S2211124724008775
  54. Jun 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148342/
  56. May 2024
  57. www.mdpi.com www.mdpi.com
    Transcranial Magneto-Acoustic Stimulation Protects Synaptic Rehabilitation from Amyloid-Beta Plaques via Regulation of Microglial Functions
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    mdpi.com/1422-0067/25/9/4651
  58. Apr 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer’s disease by inhibiting neuroinflammation and neuronal necroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11056062/
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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    sciencedirect.com/science/article/pii/S2211124724004455
  61. Mar 2024
  62. 52.53.155.43 52.53.155.43
    Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome
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  63. Feb 2024
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint
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    onlinelibrary.wiley.com/doi/10.1111/ejn.16279
  65. content.iospress.com content.iospress.com
    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
  66. Jan 2024
  67. www.jneurosci.org www.jneurosci.org
    Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
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    jneurosci.org/content/43/50/8812
  68. Dec 2023
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10748464/
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    Pre- and postsynaptic nanostructures increase in size and complexity after induction of long-term potentiation
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    sciencedirect.com/science/article/pii/S2589004223027566
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    Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10327040/
  72. Oct 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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    ncbi.nlm.nih.gov/pmc/articles/PMC10576558/
  74. Sep 2023
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    Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons
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    sciencedirect.com/science/article/abs/pii/S0896627323006293
  76. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Plk2 promotes synaptic destabilization through disruption of N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15948
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    Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8
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    sciencedirect.com/science/article/pii/S2666379123003282
  78. Jul 2023
  79. www.sciencedirect.com www.sciencedirect.com
    TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration
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    sciencedirect.com/science/article/abs/pii/S107476132300273X
  80. Jun 2023
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC10275401/
  82. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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    jneurosci.org/content/43/15/2631
  83. May 2023
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
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    ncbi.nlm.nih.gov/pmc/articles/PMC10198456/
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    Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain
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    sciencedirect.com/science/article/pii/S0896627323003057
  86. link.springer.com link.springer.com
    Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures
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    link.springer.com/article/10.1186/s40478-023-01553-6
  87. Apr 2023
  88. www.sciencedirect.com www.sciencedirect.com
    A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging
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    sciencedirect.com/science/article/pii/S2211124723004412
  89. Mar 2023
  90. www.mdpi.com www.mdpi.com
    Dysregulation of AMPA Receptor Trafficking and Intracellular Vesicular Sorting in the Prefrontal Cortex of Dopamine Transporter Knock-Out Rats
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    mdpi.com/2218-273X/13/3/516
  91. Dec 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9684630/
  93. Nov 2022
  94. journals.lww.com journals.lww.com
    Blunt dopamine transmission due to decreased GDNF in the... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/05000/Blunt_dopamine_transmission_due_to_decreased_GDNF.30.aspx
  95. Sep 2022
  96. www.sciencedirect.com www.sciencedirect.com
    Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors
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    sciencedirect.com/science/article/pii/S0960982222014609
  97. www.sciencedirect.com www.sciencedirect.com
    Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy
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    sciencedirect.com/science/article/pii/S2667237522001837
  98. Aug 2022
  99. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice
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    onlinelibrary.wiley.com/doi/10.1002/brb3.2736
  100. Feb 2022
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    Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system
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    sciencedirect.com/science/article/pii/S0896627322000071
  102. Dec 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
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    sciencedirect.com/science/article/pii/S0896627321009867
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust Expression of Functional NMDA Receptors in Human Induced Pluripotent Stem Cell-Derived Neuronal Cultures Using an Accelerated Protocol
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    ncbi.nlm.nih.gov/pmc/articles/PMC8661903/
  105. Nov 2021
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Zinc induces reactive astrogliosis through ERK dependent activation of Stat3 and promotes synaptic degeneration
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15531
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    Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
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    sciencedirect.com/science/article/pii/S2589004221012311
  108. www.sciencedirect.com www.sciencedirect.com
    Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
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    sciencedirect.com/science/article/pii/S2589004221012967
  109. Aug 2021
  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24616
  111. Jul 2021
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24616
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    jneurosci.org/content/38/49/10411
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Synaptic protein changes after a chronic period of sensorimotor perturbation in adult rats: a potential role of phosphorylation/O‐GlcNAcylation interplay
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14474
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Probabilistic fluorescence-based synapse detection
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    ncbi.nlm.nih.gov/pmc/articles/PMC5411093/table/pcbi.1005493.t001/
  116. www.sciencedirect.com www.sciencedirect.com
    Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD
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    sciencedirect.com/science/article/pii/S2211124721007968
  117. www.sciencedirect.com www.sciencedirect.com
    Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines
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    sciencedirect.com/science/article/pii/S089662732100427X
  118. Jun 2021
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8185223/
  120. May 2021
  121. www.sciencedirect.com www.sciencedirect.com
    VEGF counteracts amyloid-β-induced synaptic dysfunction
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    sciencedirect.com/science/article/pii/S2211124721004605
  122. Apr 2021
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs
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    ncbi.nlm.nih.gov/pmc/articles/PMC8058733/
  124. Mar 2021
  125. www.sciencedirect.com www.sciencedirect.com
    Presynaptic activity and protein turnover are correlated at the single-synapse level
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    sciencedirect.com/science/article/pii/S2211124721001558
  126. Feb 2021
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels
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    ncbi.nlm.nih.gov/pmc/articles/PMC7892898/
  128. Dec 2020
  129. www.mdpi.com www.mdpi.com
    Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats
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    mdpi.com/2072-6643/12/12/3661
  130. Oct 2020
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  133. Sep 2020
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    SynGAP Splice Variants Display Heterogeneous Spatio‐Temporal Expression And Subcellular Distribution In The Developing Mammalian Brain
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  138. www.jneurosci.org www.jneurosci.org
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    Quantitative immunoblotting analyses reveal that the abundance of actin, tubulin, synaptophysin and EEA1 proteins is altered in the brains of aged mice
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  140. Jan 2020
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    The Ubiquitin-Editing Enzyme A20 Regulates Synapse Remodeling and Efficacy
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    Early growth response‐1‐mediated down‐regulation of drebrin correlates with loss of dendritic spines
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    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
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  146. Nov 2018
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    A Computational Synaptic Antibody Characterization Tool for Array Tomography
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    Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement
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    Modulation of Autophagy by BDNF Underlies Synaptic Plasticity
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    The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors
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    GluA1 Phosphorylation Contributes to Postsynaptic Amplification of Neuropathic Pain in the Insular Cortex
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