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Senescent T cells within the tumor microenvironment are a potent driver for tumor growth, stemness, and chemotherapy resistance

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  DOI: 10.1016/j.xcrm.2026.103141
  
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Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy

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  DOI: 10.1016/j.xcrm.2026.103127
  
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Nemo-like kinase limits T cell activation while preserving anti-tumor responses

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TRIM2 facilitates macrophage mediated anti-tumor immunity in renal cell carcinoma through enhancing SIRPA ubiquitination and degradation

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  DOI: 10.1016/j.intimp.2026.117628
  
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Oct 2026
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mTORC1 suppression by Trp53 mutation drives resistance to immune checkpoint blockade

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1. scibot 02 Oct 2026
  
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  DOI: 10.1038/s41419-026-09067-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13620114/
Sep 2026
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Myeloid reprogramming generates myeloid-derived activating cells to potentiate radiotherapy and suppress metastasis

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Dopamine polymerization-mediated surface functionalization of living cells for advanced therapeutic applications

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  DOI: 10.1038/s41596-026-01422-1
  
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Evolution of SPP1+ cavity macrophage-mediated immunotherapy resistance in peritoneal metastasis of colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13522804/
Aug 2026
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Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis

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1. scibot 20 Aug 2026
  
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  DOI: 10.1038/s41418-026-01846-y
  
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nature.com/articles/s41418-026-01846-y
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Cblb Gene Editing in T Cells Sustains Expansion and Immunogenic CAR T Tumor Killing Under Chronic Antigenic Stimulation

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1. scibot 14 Aug 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13464884/
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Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy

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  DOI: 10.1016/j.ccell.2026.06.022
  
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sciencedirect.com/science/article/pii/S1535610826003090
Jul 2026
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Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells

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Investigating the role of baseline gut Akkermansia muciniphila and its co-metabolite palmitoleic acid in BCG vaccine efficacy: a preclinical study

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1. scibot 25 Jul 2026
  
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  DOI: 10.1016/j.ebiom.2026.106404
  
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sciencedirect.com/science/article/pii/S2352396426002884
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T Cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite Stable Colorectal Cancer

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0079
  
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aacrjournals.org/cancerres/article/86/3/785/771916/Tumor-Associated-Macrophages-Produce-PGE2-to
Jun 2026
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Type I IFN-controlled Qa-2 expression identifies and maps the generation of Eomes+ thymic innate CD8 T cells

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1. scibot 29 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116530
  
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Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid

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1. scibot 03 Jun 2026
  
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  DOI: 10.1016/j.chom.2026.05.002
  
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sciencedirect.com/science/article/pii/S1931312826001782
May 2026
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Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.immuni.2026.05.001
  
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Apr 2026
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FcRγ-dependent NK cell licensing through CD244 promotes antitumour immunity

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1. scibot 23 Apr 2026
  
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aacrjournals.org/cancerimmunolres/article/13/12/2075/768337/FcR-Dependent-NK-Cell-Licensing-through-CD244
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Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

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Mar 2026
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1-s2.0-S2589004226008679-main-html.html

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1. scibot 31 Mar 2026
  
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Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration

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Chemically Engineered L. reuteri Delivering αPD-L1 and Gallium Ions via Metal-Phenolic Networks Potentiate Anti-Tumor Immunity and Ferroptosis

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1. scibot 31 Mar 2026
  
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  DOI: 10.1002/advs.202521638
  
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Feb 2026
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Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer

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Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation

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Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis

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Jan 2026
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Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

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  DOI: 10.1016/j.ccell.2025.12.021
  
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Depletion of myeloid cells in AG129 mice reduces the infection-mediated oxidative stress and restrains dengue virus-induced thymic atrophy

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  DOI: 10.1186/s12964-025-02572-7
  
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Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation

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Dec 2025
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Microbial-derived immunostimulatory small molecule augments anti-PD-1 therapy in lung cancer

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Targeting CTGF overcomes resistance to CSF1R inhibitors by preventing CAF activation in colorectal cancer

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  DOI: 10.1016/j.xcrm.2025.102480
  
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2025.12.04.692214v1.full-html.html

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1. scibot 16 Dec 2025
  
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  DOI: 10.64898/2025.12.04.692214
  
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54.241.53.176/5fc200e8d22c6941d9a65233a02e8f8a1a806803/2025.12.04.692214v1.full-html.html
54.241.53.176 54.241.53.176

1-s2.0-S258900422502646X-main-html.html

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114385
  
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54.241.53.176/93de8e6290387b0a29b7a2c9729bf4f9de57ced1/1-s2.0-S258900422502646X-main-html.html
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Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2159-8290.CD-25-0587
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670078/
Nov 2025
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Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges

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Oct 2025
54.241.53.176 54.241.53.176

2025.10.24.684274v1.full-html.html

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Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance

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In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence

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Aug 2025
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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Jul 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225014956-main-html.html

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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

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Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

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KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression

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MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors

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52.53.155.43 52.53.155.43

1-s2.0-S2589004225007692-main-html.html

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Apr 2025
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Tailoring an intravenously injectable oncolytic virus for augmenting radiotherapy

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Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection

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SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance

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Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME

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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33

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AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity

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Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor

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Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity

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52.53.155.43 52.53.155.43

can-24-1611-html.html

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Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior

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Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

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Sep 2024
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PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2

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Aug 2024
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Epithelial organoid supports resident memory CD8 T cell differentiation

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Nuclear HMGB1 is critical for CD8 T cell IFN-γ production and anti-tumor immunity

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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

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Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation

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Jul 2024
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Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

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PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies

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Jun 2024
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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer

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T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells

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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

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Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

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NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

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Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity

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Detection of the CD8+ T cell immune response in mice infected with OVA-Listeriamonocytogenes

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IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells

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PIIS2211124723009622-html.html

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SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification

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CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection

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Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation

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METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells

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Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

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Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system

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Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

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Mar 2023
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Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance

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BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection

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The altering cellular components and function in tumor microenvironment during remissive and relapsed stages of anti-CD19 CAR T-cell treated lymphoma mice

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Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses

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NKG2D signaling shifts the balance of CD8 T cells from single cytokine- to polycytokine-producing effector cells

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P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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Ischemic stroke impacts the gut microbiome, ileal epithelial and immune homeostasis

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Isolating and targeting a highly active, stochastic dendritic cell subpopulation for improved immune responses

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Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection

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Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis

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Jul 2022
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Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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cell.com/cell-metabolism/fulltext/S1550-4131(22)00228-5
May 2022
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Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

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Mar 2022
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Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection

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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

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Insular cortex neurons encode and retrieve specific immune responses

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Mice with diverse microbial exposure histories as a model for preclinical vaccine testing

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Cognate recognition of microbial antigens defines constricted CD4+ T cell receptor repertoires in the inflamed colon

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CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

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The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

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Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

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Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection

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TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

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In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

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Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

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Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

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Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

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  DOI: 10.1016/j.celrep.2020.01.099
  
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T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

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Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

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The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

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CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

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Untitled document

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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Untitled document

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Nov 2018
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Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity

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TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.

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europepmc.org/articles/PMC5629024/

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