1,002 Matching Annotations
  1. Jun 2022
  2. www.nature.com www.nature.com
    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
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    1. scibot 07 Jun 2022
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      DOI: 10.1038/s41419-022-04988-2

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    nature.com/articles/s41419-022-04988-2
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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    1. scibot 07 Jun 2022
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      DOI: 10.1158/2159-8290.CD-21-0209

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  4. academic.oup.com academic.oup.com
    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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    1. scibot 02 Jun 2022
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      DOI: 10.1210/endocr/bqac048

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    academic.oup.com/endo/article/163/6/bqac048/6569208
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    1. scibot 01 Jun 2022
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  6. May 2022
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
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    1. scibot 27 May 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9130554/
  8. www.sciencedirect.com www.sciencedirect.com
    Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells
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    1. scibot 26 May 2022
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      DOI: 10.1016/j.celrep.2022.110848

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    sciencedirect.com/science/article/pii/S2211124722006210
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    1. scibot 26 May 2022
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    sciencedirect.com/science/article/pii/S1097276522004348
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    1. scibot 20 May 2022
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    sciencedirect.com/science/article/pii/S1097276522003938
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    1. scibot 19 May 2022
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    sciencedirect.com/science/article/pii/S2211124722005952
  12. aacrjournals.org aacrjournals.org
    Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms
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    1. scibot 14 May 2022
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      DOI: 10.1158/1535-7163.MCT-21-0317

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    aacrjournals.org/mct/article/21/5/844/694774/The-Irreversible-FLT3-Inhibitor-FF-10101-Is-Active
  13. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    1. scibot 13 May 2022
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      DOI: 10.1158/2159-8290.CD-21-1168

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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  14. aacrjournals.org aacrjournals.org
    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
    1
    1. scibot 13 May 2022
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      DOI: 10.1158/1541-7786.MCR-21-0699

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    aacrjournals.org/mcr/article/20/5/810/694642/Tumor-Microenvironment-Acidity-Triggers-Lipid
  15. www.sciencedirect.com www.sciencedirect.com
    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
    1
    1. scibot 11 May 2022
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      DOI: 10.1016/j.celrep.2022.110796

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    sciencedirect.com/science/article/pii/S2211124722005630
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
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    1. scibot 05 May 2022
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      DOI: 10.1158/1535-7163.MCT-21-0126

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    ncbi.nlm.nih.gov/pmc/articles/PMC8571000/
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    Patient-derived models of brain metastases recapitulate human disseminated disease
    1
    1. scibot 05 May 2022
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      DOI: 10.1016/j.xcrm.2022.100623

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    sciencedirect.com/science/article/pii/S2666379122001409
  18. Apr 2022
  19. academic.oup.com academic.oup.com
    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
    1
    1. scibot 29 Apr 2022
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      DOI: 10.1210/endocr/bqac035

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    academic.oup.com/endo/article/163/5/bqac035/6550639
  20. www.sciencedirect.com www.sciencedirect.com
    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110721

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    sciencedirect.com/science/article/pii/S221112472200482X
  21. www.sciencedirect.com www.sciencedirect.com
    In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography
    1
    1. scibot 27 Apr 2022
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      DOI: 10.1016/j.apsb.2022.04.010

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    sciencedirect.com/science/article/pii/S2211383522001812
  22. www.sciencedirect.com www.sciencedirect.com
    L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy
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    1. scibot 26 Apr 2022
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      DOI: 10.1016/j.isci.2022.104249

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    sciencedirect.com/science/article/pii/S2589004222005193
  23. www.sciencedirect.com www.sciencedirect.com
    IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming
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    1. scibot 26 Apr 2022
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      DOI: 10.1016/j.isci.2022.104209

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    sciencedirect.com/science/article/pii/S2589004222004795
  24. www.sciencedirect.com www.sciencedirect.com
    The role of PTEN in primary sensory neurons in processing itch and thermal information in mice
    1
    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110724

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    sciencedirect.com/science/article/pii/S2211124722004855
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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    1. scibot 15 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110670

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    sciencedirect.com/science/article/pii/S2211124722004223
  26. www.sciencedirect.com www.sciencedirect.com
    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
    1
    1. scibot 13 Apr 2022
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      DOI: 10.1016/j.molcel.2022.03.026

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    sciencedirect.com/science/article/pii/S1097276522002647
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide
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    1. scibot 13 Apr 2022
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      DOI: 10.14814/phy2.15241

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    ncbi.nlm.nih.gov/pmc/articles/PMC8988121/
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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    1. scibot 12 Apr 2022
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      DOI: 10.1111/cns.13839

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    onlinelibrary.wiley.com/doi/10.1111/cns.13839
  29. www.jneurosci.org www.jneurosci.org
    ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination
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    1. scibot 06 Apr 2022
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      DOI: 10.1523/JNEUROSCI.1341-21.2022

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    jneurosci.org/content/42/12/2433
  30. Mar 2022
  31. www.sciencedirect.com www.sciencedirect.com
    PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation
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    1. scibot 31 Mar 2022
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    sciencedirect.com/science/article/pii/S2211124722003515
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    1. scibot 26 Mar 2022
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      DOI: 10.1002/glia.23583

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    onlinelibrary.wiley.com/doi/10.1002/glia.23583
  33. www.sciencedirect.com www.sciencedirect.com
    Coordinated changes in glycosylation regulate the germinal center through CD22
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    sciencedirect.com/science/article/pii/S2211124722002480
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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      DOI: 10.1038/s41598-022-07600-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
  35. journals.lww.com journals.lww.com
    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.335163

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    journals.lww.com/nrronline/Fulltext/2022/17090/Urolithin_A_alleviates_blood_brain_barrier.32.aspx
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8820717/
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    Regulation of GTPase function by autophosphorylation
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    sciencedirect.com/science/article/pii/S1097276522001162
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    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276522001058
  40. elifesciences.org elifesciences.org
    Pathway-specific effects of ADSL deficiency on neurodevelopment
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      DOI: 10.7554/eLife.70518

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    elifesciences.org/articles/70518
  41. link.springer.com link.springer.com
    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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      DOI: 10.1007/s00418-022-02091-3

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    link.springer.com/article/10.1007/s00418-022-02091-3
  42. www.sciencedirect.com www.sciencedirect.com
    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    sciencedirect.com/science/article/pii/S1534580722000703
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    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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    sciencedirect.com/science/article/pii/S2589004222001511
  44. Feb 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
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    T-cell–derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2
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    Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling
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    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
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    The early reduction of left ventricular mass after sleeve gastrectomy depends on the fall of branched-chain amino acid circulating levels
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
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    Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors
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    MiR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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      RRID:AB_2315049

      DOI: 10.1523/ENEURO.0086-19.2019

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  174. www.embopress.org www.embopress.org
    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
    1
    1. scibot 30 Jul 2021
      p‐AKT

      DOI: 10.15252/embr.201948058

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    embopress.org/doi/10.15252/embr.201948058
  175. www.cell.com www.cell.com
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      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2017.01.027

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    cell.com/molecular-cell/abstract/S1097-2765(17)30053-9
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2315049

      DOI: 10.7554/eLife.40396

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  177. www.sciencedirect.com www.sciencedirect.com
    Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
    1
    1. scibot 30 Jul 2021
      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2018.09.007

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    sciencedirect.com/science/article/pii/S1097276518307548
  178. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_2315049

      DOI: 10.1002/brb3.1123

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    onlinelibrary.wiley.com/doi/full/10.1002/brb3.1123
  179. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
    1
    1. scibot 29 Jul 2021
      RRID: AB_2315049

      DOI: 10.1111/jnc.14874

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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer
    1
    1. scibot 29 Jul 2021
      p-AKT-S473

      DOI: 10.1084/jem.20181936

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    ncbi.nlm.nih.gov/pmc/articles/PMC6363423/
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TrkB‐mediated activation of the phosphatidylinositol‐3‐kinase/Akt cascade reduces the damage inflicted by oxygen‐glucose deprivation in area CA3 of the rat hippocampus
    1
    1. scibot 29 Jul 2021
      RRID:AB_2315049

      DOI: 10.1111/ejn.13880

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    ncbi.nlm.nih.gov/pmc/articles/PMC5938095/
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2315049

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  183. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Akt3-mTOR regulates hippocampal neurogenesis in adult mouse
    1
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      RRID:AB_2315049

      DOI: 10.1111/jnc.15441

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15441
  184. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas
    2
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      RRID:AB_2315049

      DOI: 10.1002/jcp.26830

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      RRID:AB_2315049

      DOI: 10.1002/jcp.26830

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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling
    2
    1. scibot 29 Jul 2021
      RRID:AB_2315049

      DOI: 10.7554/eLife.32021

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      RRID:AB_2315049

      DOI: 10.7554/eLife.32021

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    ncbi.nlm.nih.gov/pmc/articles/PMC5839742/
  186. www.sciencedirect.com www.sciencedirect.com
    Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
    1
    1. scibot 28 Jul 2021
      AB_2315049

      DOI: 10.1016/j.ajpath.2018.12.008

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    sciencedirect.com/science/article/pii/S0002944018306746
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
    1
    1. scibot 28 Jul 2021
      RRID:AB_2315049

      DOI: 10.1038/s41540-018-0075-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC6218484/
  188. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
    1
    1. scibot 28 Jul 2021
      Phospho-Akt (Ser473) (D9E) XPu00a0Rabbit mAb

      DOI: 10.1016/j.immuni.2019.03.005

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    sciencedirect.com/science/article/pii/S1074761319300950
  189. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2315049

      DOI: 10.1016/j.immuni.2018.09.018

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    sciencedirect.com/science/article/pii/S1074761318304333
  190. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
    1. scibot 28 Jul 2021
      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2017.09.024

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    sciencedirect.com/science/article/pii/S1097276517307025
  191. www.sciencedirect.com www.sciencedirect.com
    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
    1
    1. scibot 28 Jul 2021
      RRID:AB_2315049

      DOI: 10.1016/j.ccell.2018.11.016

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    sciencedirect.com/science/article/pii/S1535610818305373
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2017.09.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC5678281/
  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2315049

      DOI: 10.1016/j.cmet.2018.08.013

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    ncbi.nlm.nih.gov/pmc/articles/PMC6331339/
  194. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PTEN knockdown alters dendritic spine/protrusion morphology, not density
    1
    1. scibot 27 Jul 2021
      Anti-pAKTMonoclonalRabbitEpitope surrounds serine 473 of AKT sequence1:200Cell Signaling4060AB_916027

      DOI: 10.1002/cne.23488

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    onlinelibrary.wiley.com/doi/10.1002/cne.23488/full
  195. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_2315049

      DOI: 10.1002/glia.23472

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23472
  196. www.cell.com www.cell.com
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      RRID:AB_2315049

      DOI: 10.1016/j.devcel.2017.10.027

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    cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
  197. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_2315049

      DOI: 10.1111/jnc.14311

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14311
  198. www.heliyon.com www.heliyon.com
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      AB_2315049

      DOI: 10.1016/j.heliyon.2018.e00772

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    heliyon.com/article/e00772
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      AB_2315049

      DOI: 10.1210/en.2017-00693

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761602/
  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      AB_2315049

      DOI: 10.1210/en.2017-00585

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  201. www.sciencedirect.com www.sciencedirect.com
    Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
    1
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      RRID:AB_10234665

      DOI: 10.1016/j.stem.2019.09.009

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    sciencedirect.com/science/article/pii/S1934590919304205
  202. www.sciencedirect.com www.sciencedirect.com
    OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling
    1
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      RRID:AB_2341228

      DOI: 10.1016/j.ebiom.2019.02.051

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    sciencedirect.com/science/article/pii/S2352396419301306
  203. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_10234665

      DOI: 10.1016/j.neuron.2018.10.051

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    sciencedirect.com/science/article/pii/S0896627318309590
  204. www.sciencedirect.com www.sciencedirect.com
    Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance
    1
    1. scibot 27 Jul 2021
      RRID:AB_2750995

      DOI: 10.1016/j.celrep.2018.11.015

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      Curator comments: Cell Signaling Technology Cat# 4060 Phospho-Akt (Ser473) antibody

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    sciencedirect.com/science/article/pii/S2211124718317613
  205. www.sciencedirect.com www.sciencedirect.com
    Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway
    1
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      AB_916024

      DOI: 10.1016/j.ebiom.2017.01.040

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  206. www.sciencedirect.com www.sciencedirect.com
    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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      AB_2315049

      DOI: 10.1016/j.schres.2021.07.014

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    sciencedirect.com/science/article/pii/S092099642100267X
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells
    1
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      RRID:AB_2315049

      DOI: 10.1111/jnc.15268

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    ncbi.nlm.nih.gov/pmc/articles/PMC8284875/