1,002 Matching Annotations
  1. Jul 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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    1. scibot 14 Jul 2021
      AB_2315049

      DOI: 10.1210/jendso/bvab102

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    ncbi.nlm.nih.gov/pmc/articles/PMC8271203/
  3. www.sciencedirect.com www.sciencedirect.com
    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
    1
    1. scibot 14 Jul 2021
      RRID:AB_2315049

      DOI: 10.1016/j.isci.2021.102724

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    sciencedirect.com/science/article/pii/S2589004221006921
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
    1
    1. scibot 10 Jul 2021
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      DOI: 10.1016/j.molcel.2021.06.017

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    sciencedirect.com/science/article/pii/S1097276521004974
  5. www.sciencedirect.com www.sciencedirect.com
    Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability
    1
    1. scibot 09 Jul 2021
      RRID:AB_10234665

      DOI: 10.1016/j.celrep.2021.109327

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      Curator comments: Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb antibody Cell Signaling Technology Cat# 4060

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    sciencedirect.com/science/article/pii/S2211124721007038
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3
    1
    1. scibot 08 Jul 2021
      RRID:AB_2315049

      DOI: 10.3389/fncel.2021.679413

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    ncbi.nlm.nih.gov/pmc/articles/PMC8258110/
  7. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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      DOI: 10.1016/j.biocel.2021.106028

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    sciencedirect.com/science/article/pii/S1357272521001060
  8. Jun 2021
  9. www.cell.com www.cell.com
    Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
    1
    1. scibot 25 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.isci.2021.102653

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    cell.com/iscience/abstract/S2589-0042(21)00621-0
  10. www.sciencedirect.com www.sciencedirect.com
    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    1. scibot 22 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.molcel.2021.05.031

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    sciencedirect.com/science/article/pii/S1097276521004445
  11. www.sciencedirect.com www.sciencedirect.com
    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
    1
    1. scibot 18 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.ccell.2021.05.015

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    sciencedirect.com/science/article/pii/S1535610821002816
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
    1
    1. scibot 17 Jun 2021
      RRID:AB_2315049

      DOI: 10.7554/eLife.67315

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    ncbi.nlm.nih.gov/pmc/articles/PMC8192125/
  13. www.embopress.org www.embopress.org
    Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy
    1
    1. scibot 17 Jun 2021
      RRID:AB_2315049

      DOI: 10.15252/emmm.202114059

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    embopress.org/doi/abs/10.15252/emmm.202114059
  14. cmbl.biomedcentral.com cmbl.biomedcentral.com
    β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275
    1
    1. scibot 17 Jun 2021
      RRID:AB_2315049

      DOI: 10.1186/s11658-021-00261-0

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    cmbl.biomedcentral.com/articles/10.1186/s11658-021-00261-0
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
    1
    1. scibot 16 Jun 2021
      RRID:AB_2315049

      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
  16. www.sciencedirect.com www.sciencedirect.com
    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
    1
    1. scibot 16 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2021.109264

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    sciencedirect.com/science/article/pii/S2211124721006318
  17. www.sciencedirect.com www.sciencedirect.com
    NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma
    1
    1. scibot 16 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2021.109238

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    sciencedirect.com/science/article/pii/S2211124721005970
  18. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    1. scibot 15 Jun 2021
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      DOI: 10.1002/2211-5463.13165

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    febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13165
  19. www.sciencedirect.com www.sciencedirect.com
    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
    1
    1. scibot 15 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.crmeth.2021.100015

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    sciencedirect.com/science/article/pii/S2667237521000151
  20. www.sciencedirect.com www.sciencedirect.com
    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
    1
    1. scibot 10 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.chembiol.2021.05.009

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    sciencedirect.com/science/article/pii/S2451945621002543
  21. www.sciencedirect.com www.sciencedirect.com
    TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
    1
    1. scibot 09 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.cmet.2021.05.014

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    sciencedirect.com/science/article/pii/S155041312100231X
  22. www.sciencedirect.com www.sciencedirect.com
    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
    1
    1. scibot 04 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.ccell.2021.05.002

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    sciencedirect.com/science/article/pii/S1535610821002683
  23. www.sciencedirect.com www.sciencedirect.com
    Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia
    1
    1. scibot 04 Jun 2021
      RRID:AB_2315049

      DOI: 10.1016/j.cub.2021.04.079

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    sciencedirect.com/science/article/pii/S0960982221006266
  24. May 2021
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
    1
    1. scibot 27 May 2021
      cat#4060S

      DOI: 10.1038/s41467-021-23271-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC8134423/
  26. www.sciencedirect.com www.sciencedirect.com
    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
    1
    1. scibot 26 May 2021
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2021.109184

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    sciencedirect.com/science/article/pii/S2211124721005295
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limited inhibition of multiple nodes in a driver network blocks metastasis
    1
    1. scibot 21 May 2021
      RRID:AB_2315049

      DOI: 10.7554/eLife.59696

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    ncbi.nlm.nih.gov/pmc/articles/PMC8128439/
  28. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
    1
    1. scibot 20 May 2021
      RRID:AB_2315049

      DOI: 10.1111/bph.15384

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15384
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
    1
    1. scibot 19 May 2021
      RRID:AB_2315049

      DOI: 10.7554/eLife.68348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8118655/
  30. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    1. scibot 19 May 2021
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2021.109128

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    sciencedirect.com/science/article/pii/S2211124721004678
  31. www.sciencedirect.com www.sciencedirect.com
    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
    1
    1. scibot 18 May 2021
      anti-Phospho-Akt (Ser473)

      DOI: 10.1016/j.jbc.2021.100739

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    sciencedirect.com/science/article/pii/S0021925821005287
  32. academic.oup.com academic.oup.com
    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
    1
    1. scibot 10 May 2021
      RRID:AB_2315049

      DOI: 10.1210/endocr/bqaa133

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    academic.oup.com/endo/article/161/10/bqaa133/5881724
  33. academic.oup.com academic.oup.com
    SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem
    1
    1. scibot 10 May 2021
      RRID:AB_2315049

      DOI: 10.1210/endocr/bqaa132

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    academic.oup.com/endo/article/161/10/bqaa132/5889974
  34. mcr.aacrjournals.org mcr.aacrjournals.org
    Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM
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    1. scibot 10 May 2021
      RRID:AB_2315049

      DOI: 10.1158/1541-7786.MCR-20-0420

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    mcr.aacrjournals.org/content/19/1/150
  35. academic.oup.com academic.oup.com
    Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice
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    1. scibot 10 May 2021
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      DOI: 10.1210/jendso/bvab024

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    academic.oup.com/jes/article/5/5/bvab024/6145120
  36. www.sciencedirect.com www.sciencedirect.com
    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    1. scibot 10 May 2021
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      DOI: 10.1016/j.chembiol.2021.04.013

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    sciencedirect.com/science/article/pii/S2451945621002063
  37. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.15423

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15423
  38. www.sciencedirect.com www.sciencedirect.com
    Hdac9 inhibits medial artery calcification through down-regulation of Osterix
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      DOI: 10.1016/j.vph.2020.106775

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    sciencedirect.com/science/article/pii/S1537189120300392
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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      DOI: 10.1016/j.stem.2020.06.005

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    sciencedirect.com/science/article/pii/S1934590920302721
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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      DOI: 10.1016/j.stem.2020.04.005

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    sciencedirect.com/science/article/pii/S1934590920301442
  41. www.sciencedirect.com www.sciencedirect.com
    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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      AB_2315049

      DOI: 10.1016/j.phymed.2020.153324

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    sciencedirect.com/science/article/pii/S0944711320301562
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2021.03.008

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    sciencedirect.com/science/article/pii/S0896627321001562
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    Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
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      DOI: 10.1016/j.neuron.2020.09.034

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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice
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    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway
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      Rabbit anti-AKT S473

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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
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    miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  124. Oct 2020
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    TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity
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    PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle
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    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
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    Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression
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    Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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  181. elifesciences.org elifesciences.org
    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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      Phospho-AKT ser473

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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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      Anti-phospho-Akt (Ser473)

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    Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
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      Rabbit anti-Phospho Akt: Ser473

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  185. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      anti-pAKT

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    Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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      pAkt

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    Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
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  191. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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      pS473-AKT

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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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      rabbit anti-phospho-AKT

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  193. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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      phosphorylated‐AKT (S473)

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    High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer
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      anti-phospho-Akt (Ser473) (D9E) XP® rabbit mAb

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  195. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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      p-Akt

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  196. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal rabbit phospho-Akt S473

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    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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  198. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK‐3β in 3xTg‐AD mice
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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      DOI: 10.1523/JNEUROSCI.0642-19.2019

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  200. Mar 2020
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  202. Jan 2020
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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  204. academic.oup.com academic.oup.com
    Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons
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    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis
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  208. dev.biologists.org dev.biologists.org
    Nutrient restriction causes reversible G2 arrest in Xenopus neural progenitors
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  209. www.sciencedirect.com www.sciencedirect.com
    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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      RRID:AB_2315049

      DOI: 10.1016/j.chembiol.2019.05.009

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    sciencedirect.com/science/article/pii/S2451945619301783
  210. www.sciencedirect.com www.sciencedirect.com
    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    1. scibot 13 Jan 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2019.12.017

      Resource: (Cell Signaling Technology Cat# 4060, RRID:AB_2315049)

      Curator: @ethanbadger

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      RRID:AB_2315049 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719316675
  211. www.frontiersin.org www.frontiersin.org
    Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine
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    1. scibot 13 Jan 2020
      RRID:AB_2315049

      DOI: 10.3389/fneur.2019.01041

      Resource: (Cell Signaling Technology Cat# 4060, RRID:AB_2315049)

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      RRID:AB_2315049 RRIDCUR:Validated
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    frontiersin.org/articles/10.3389/fneur.2019.01041/full
  212. www.sciencedirect.com www.sciencedirect.com
    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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    1. scibot 13 Jan 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2019.08.092

      Resource: (Cell Signaling Technology Cat# 4060, RRID:AB_2315049)

      Curator: @ethanbadger

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      RRID:AB_2315049 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719311544