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  1. Last 7 days
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    Uncoupling the CRMP2-CaV2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model
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    1. scibot 03 Jul 2024
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      DOI: 10.1101/2024.06.05.596514

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    ncbi.nlm.nih.gov/pmc/articles/PMC11185632/
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA
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    1. scibot 09 Jun 2024
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      DOI: 10.7554/eLife.74940

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    ncbi.nlm.nih.gov/pmc/articles/PMC11149935/
  5. May 2024
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    N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
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    1. scibot 02 May 2024
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      DOI: 10.1016/j.immuni.2024.04.004

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    sciencedirect.com/science/article/pii/S1074761324002097
  7. Apr 2024
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    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis
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    1. scibot 11 Apr 2024
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      DOI: 10.7554/eLife.89776

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    ncbi.nlm.nih.gov/pmc/articles/PMC11003743/
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    Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment
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    1. scibot 03 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-0046

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592379/
  10. Mar 2024
  11. www.sciencedirect.com www.sciencedirect.com
    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
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    1. scibot 28 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724003383
  12. Feb 2024
  13. www.sciencedirect.com www.sciencedirect.com
    ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
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    sciencedirect.com/science/article/pii/S2211124724000482
  14. Jan 2024
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    1. scibot 24 Jan 2024
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      DOI: 10.1126/science.adi3448

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801813/
  16. Dec 2023
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    SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells
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    sciencedirect.com/science/article/pii/S2211124723015188
  18. Sep 2023
  19. 52.53.155.43 52.53.155.43
    Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
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    1. scibot 30 Sep 2023
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      DOI: 10.1210/endocr/bqad143

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    Estradiol and 3β-diol protect female cortical astrocytes by regulating connexin 43 Gap Junctions
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    1. scibot 29 Sep 2023
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  21. Aug 2023
  22. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    1. scibot 29 Aug 2023
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      DOI: 10.1126/science.adi3448

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  23. Jun 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo
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    1. scibot 27 Jun 2023
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      DOI: 10.3389/fnmol.2023.1142361

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    Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers
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  26. dx.doi.org dx.doi.org
    Novel MKRN3 Missense Mutations Associated with Central Precocious Puberty Reveal Distinct Effects on Ubiquitination
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    1. scibot 10 Jun 2023
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      DOI: 10.1210/clinem/dgad151

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  27. dx.doi.org dx.doi.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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      DOI: 10.1158/2159-8290.CD-22-0825

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    dx.doi.org/10.1158/2159-8290.CD-22-0825
  28. May 2023
  29. www.sciencedirect.com www.sciencedirect.com
    ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines
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    sciencedirect.com/science/article/pii/S0092867423004208
  30. Apr 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation
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      DOI: 10.1016/j.neuron.2023.01.013

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    sciencedirect.com/science/article/pii/S0896627323000375
  32. Mar 2023
  33. www.embopress.org www.embopress.org
    Two Hippo signaling modules orchestrate liver size and tumorigenesis
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      DOI: 10.15252/embj.2022112126

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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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      DOI: 10.1158/0008-5472.CAN-22-0631

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  35. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.16035

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16035
  36. Feb 2023
  37. www.sciencedirect.com www.sciencedirect.com
    TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
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      DOI: 10.1016/j.celrep.2023.112125

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    sciencedirect.com/science/article/pii/S2211124723001365
  38. Jan 2023
  39. 52.53.155.43 52.53.155.43
    SSRN-id4254517-html.html
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  40. Nov 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
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    1. scibot 24 Nov 2022
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    sciencedirect.com/science/article/pii/S2211124722015492
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    Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis
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    1. scibot 18 Nov 2022
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      DOI: 10.1016/j.molcel.2022.10.027

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    sciencedirect.com/science/article/pii/S1097276522010553
  43. Aug 2022
  44. www.sciencedirect.com www.sciencedirect.com
    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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      DOI: 10.1016/j.celrep.2022.111296

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    sciencedirect.com/science/article/pii/S2211124722011160
  45. 52.53.155.43 52.53.155.43
    can-22-0631-html.html
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    Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development
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      DOI: 10.1016/j.isci.2022.104905

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    sciencedirect.com/science/article/pii/S2589004222011774
  47. May 2022
  48. www.sciencedirect.com www.sciencedirect.com
    NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
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    sciencedirect.com/science/article/pii/S1097276522003264
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    The Mettl3 epitranscriptomic writer amplifies p53 stress responses
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    sciencedirect.com/science/article/pii/S1097276522003215
  50. Apr 2022
  51. www.sciencedirect.com www.sciencedirect.com
    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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      DOI: 10.1016/j.molcel.2022.03.027

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    sciencedirect.com/science/article/pii/S1097276522002659
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve.
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      DOI: 10.1016/j.isci.2022.104132

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    ncbi.nlm.nih.gov/pmc/articles/PMC9010646/
  53. www.sciencedirect.com www.sciencedirect.com
    Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
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      DOI: 10.1016/j.cmet.2022.03.005

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    sciencedirect.com/science/article/pii/S1550413122000936
  54. Mar 2022
  55. link.springer.com link.springer.com
    Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function
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      DOI: 10.1007/s11064-022-03573-5

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    link.springer.com/article/10.1007/s11064-022-03573-5
  56. www.sciencedirect.com www.sciencedirect.com
    Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
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      DOI: 10.1016/j.isci.2022.103869

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    sciencedirect.com/science/article/pii/S2589004222001390
  57. Dec 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis
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      DOI: 10.1016/j.cub.2021.11.040

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    sciencedirect.com/science/article/pii/S0960982221015992
  59. Nov 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
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      DOI: 10.1016/j.molcel.2021.10.015

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    sciencedirect.com/science/article/pii/S1097276521009072
  61. Oct 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation
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  63. www.embopress.org www.embopress.org
    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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  64. Sep 2021
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    Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors
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  66. Aug 2021
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    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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  69. Jul 2021
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    Thyroid Hormone Receptor β Suppression of RUNX2 is Mediated by Brahma Related Gene 1 Dependent Chromatin Remodeling
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    ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer
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    Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis
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  74. Jun 2021
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    STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer
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  76. May 2021
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    Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
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    A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation
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    Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling
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    TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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  84. Mar 2021
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    PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
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    Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease
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      mouse‐anti‐rabbit HRP

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    The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner
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  88. Feb 2021
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    Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit
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  91. Jan 2021
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    Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma
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    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
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  94. Dec 2020
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    Slc26a6 is an apical membrane anion exchanger that drives HCO3−-dependent fluid secretion in murine pancreatic acinar cells
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  96. Oct 2020
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    MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression
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  98. Sep 2020
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    An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
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    Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies
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    p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells
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    FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
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    Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex
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    Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase
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      Peroxidase IgG fraction monoclonal mouse anti-rabbit IgG, light chain specific

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    Slc26a6 is an apical membrane anion exchanger that drives HCO3−-dependent fluid secretion in murine pancreatic acinar cells | American Journal of Physiology-Cell Physiology
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  108. Jan 2020
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    Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains
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    CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
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    KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae
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    TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
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    FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer
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  119. Nov 2018
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    WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation
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    Hsp90 Mediates Membrane Deformation and Exosome Release
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    The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival
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    Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
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    DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4
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    TALE factors use two distinct functional modes to control an essential zebrafish gene expression program
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    ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease
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    Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
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    RAPGEF5 Regulates Nuclear Translocation of β-Catenin
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    MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
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  132. Nov 2017
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    p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
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    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
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