80 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Ethanol modulates astrocyte activation and neuroinflammation via miR-339/NLRP6 inflammasome signaling
    1
    1. scibot 24 Nov 2024
      RRID:AB_2490202

      DOI: 10.1016/j.freeradbiomed.2024.11.014

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    sciencedirect.com/science/article/pii/S089158492401044X
  3. Oct 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
    1
    1. scibot 09 Oct 2024
      AB_2885199

      DOI: 10.1016/j.immuni.2024.09.004

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    sciencedirect.com/science/article/pii/S1074761324004485
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The emerging role of mesenchymal stem cell–derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence
    1
    1. scibot 02 Oct 2024
      RRID:AB_2490202

      DOI: 10.4103/NRR.NRR-D-23-01397

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    ncbi.nlm.nih.gov/pmc/articles/PMC11438346/
  6. Sep 2024
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 27 Sep 2024
      AB_2490202

      DOI: 10.1111/bph.17320

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17320
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
    1
    1. scibot 26 Sep 2024
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2024.114609

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    ncbi.nlm.nih.gov/pmc/articles/PMC11398858/
  9. elifesciences.org elifesciences.org
    S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi
    1
    1. scibot 18 Sep 2024
      RRID:AB_2490202

      DOI: 10.7554/eLife.94302

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    elifesciences.org/articles/94302
  10. Jul 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation
    1
    1. scibot 18 Jul 2024
      AB_2490202

      DOI: 10.1016/j.isci.2024.110459

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    sciencedirect.com/science/article/pii/S2589004224016845
  12. Jun 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
    1
    1. scibot 21 Jun 2024
      RRID:AB_2490202

      DOI: 10.1016/j.cell.2024.05.034

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    ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
  14. www.sciencedirect.com www.sciencedirect.com
    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
    1
    1. scibot 08 Jun 2024
      RRID:AB_2490202

      DOI: 10.1016/j.isci.2024.109940

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    sciencedirect.com/science/article/pii/S2589004224011623
  15. May 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists
    1
    1. scibot 01 May 2024
      AB_2885199

      DOI: 10.1101/2024.04.19.590338

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    ncbi.nlm.nih.gov/pmc/articles/PMC11042255/
  17. Apr 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3′-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome
    1
    1. scibot 24 Apr 2024
      RRID:AB_2490202

      DOI: 10.4103/1673-5374.392887

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034599/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects
    1
    1. scibot 10 Apr 2024
      RRID:AB_2490202

      DOI: 10.1016/j.isci.2024.109544

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    ncbi.nlm.nih.gov/pmc/articles/PMC10995871/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
    2
    1. scibot 09 Apr 2024
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2024.114070

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    2. scibot 09 Apr 2024
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2024.114070

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    pmc.ncbi.nlm.nih.gov/articles/PMC11130711/
  21. www.sciencedirect.com www.sciencedirect.com
    Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis
    2
    1. scibot 09 Apr 2024
      RRID:AB_2490202

      DOI: 10.1016/j.xcrm.2024.101503

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    2. scibot 09 Apr 2024
      RRID:AB_2490202

      DOI: 10.1016/j.xcrm.2024.101503

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    sciencedirect.com/science/article/pii/S2666379124001721
  22. Mar 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
    2
    1. scibot 12 Mar 2024
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2024.113935

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    2. scibot 12 Mar 2024
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2024.113935

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    sciencedirect.com/science/article/pii/S2211124724002638
  24. Feb 2024
  25. dx.doi.org dx.doi.org
    HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs
    1
    1. scibot 28 Feb 2024
      RRID:AB_2490202

      DOI: 10.1210/endocr/bqae011

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    dx.doi.org/10.1210/endocr/bqae011
  26. www.sciencedirect.com www.sciencedirect.com
    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
    1
    1. scibot 13 Feb 2024
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2024.113752

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    sciencedirect.com/science/article/pii/S2211124724000809
  27. Dec 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
    1
    1. scibot 13 Dec 2023
      RRID:AB_2490202

      DOI: 10.1186/s43556-023-00158-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10703753/
  29. Sep 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
    1
    1. scibot 08 Sep 2023
      RRID:AB_2490202

      DOI: 10.1016/j.isci.2023.107698

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    ncbi.nlm.nih.gov/pmc/articles/PMC10480325/
  31. Jun 2023
  32. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 30 Jun 2023
      RRID:AB_2490202

      DOI: 10.1111/bph.16074

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16074
  33. May 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
    1
    1. scibot 12 May 2023
      RRID:AB_2490202

      DOI: 10.1016/j.cell.2023.03.036

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    sciencedirect.com/science/article/pii/S0092867423003331
  35. Mar 2023
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro
    1
    1. scibot 30 Mar 2023
      RRID:AB_2490202

      DOI: 10.1111/jnc.15778

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15778
  37. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 03 Mar 2023
      RRID:AB_2490202

      DOI: 10.1111/bph.16036

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16036
  38. Feb 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome
    1
    1. scibot 23 Feb 2023
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2023.112133

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    sciencedirect.com/science/article/pii/S2211124723001444
  40. Jan 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
    1
    1. scibot 11 Jan 2023
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2022.111941

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    sciencedirect.com/science/article/pii/S2211124722018423
  42. Nov 2022
  43. www.science.org www.science.org
    Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
    1
    1. scibot 15 Nov 2022
      RRID:AB_2490202

      DOI: 10.1126/sciadv.abn9912

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    science.org/doi/10.1126/sciadv.abn9912
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35
    1
    1. scibot 02 Nov 2022
      RRID:AB_2490202

      DOI: 10.3389/fimmu.2022.1019365

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    ncbi.nlm.nih.gov/pmc/articles/PMC9606686/
  45. Jul 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome
    1
    1. scibot 31 Jul 2022
      RRID:AB_2490202

      DOI: 10.3389/fphar.2022.938391

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    ncbi.nlm.nih.gov/pmc/articles/PMC9332914/
  47. www.sciencedirect.com www.sciencedirect.com
    Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model
    1
    1. scibot 27 Jul 2022
      RRID:AB_2490202

      DOI: 10.1016/j.ebiom.2022.104184

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    sciencedirect.com/science/article/pii/S2352396422003656
  48. www.sciencedirect.com www.sciencedirect.com
    Impaired interferon-γ signaling promotes the development of silicosis
    1
    1. scibot 08 Jul 2022
      RRID:AB_2490202

      DOI: 10.1016/j.isci.2022.104647

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    sciencedirect.com/science/article/pii/S2589004222009191
  49. Jun 2022
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination
    1
    1. scibot 17 Jun 2022
      RRID:AB_2490202

      DOI: 10.1111/jnc.15650

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15650
  51. Apr 2022
  52. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 28 Apr 2022
      RRID:AB_2490202

      DOI: 10.1111/bph.15838

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15838
  53. academic.oup.com academic.oup.com
    Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans
    1
    1. scibot 05 Apr 2022
      RRID:AB_2490202

      DOI: 10.1210/endocr/bqac014

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    academic.oup.com/endo/article/163/4/bqac014/6523230
  54. Mar 2022
  55. link.springer.com link.springer.com
    Reconstitution System of NLRP3 Inflammasome in HEK293T Cells
    1
    1. scibot 23 Mar 2022
      RRID:AB_2490202

      DOI: 10.1007/978-1-0716-2144-8_8

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    link.springer.com/protocol/10.1007/978-1-0716-2144-8_8
  56. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
    1
    1. scibot 04 Mar 2022
      AdipoGen cat# AG-20B-0014

      DOI: 10.1016/j.celrep.2022.110354

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      Curator: @sophiastull

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    sciencedirect.com/science/article/pii/S2211124722000705
  57. Feb 2022
  58. www.sciencedirect.com www.sciencedirect.com
    Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion
    1
    1. scibot 23 Feb 2022
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2022.110414

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    sciencedirect.com/science/article/pii/S2211124722001383
  59. Nov 2021
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leptin Signaling in the Ovary of Diet-Induced Obese Mice Regulates Activation of NOD-Like Receptor Protein 3 Inflammasome
    1
    1. scibot 19 Nov 2021
      RRID:AB_2490202

      DOI: 10.3389/fcell.2021.738731

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    ncbi.nlm.nih.gov/pmc/articles/PMC8595835/
  61. Oct 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
    1
    1. scibot 30 Oct 2021
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2021.109904

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sacubitril/Valsartan Alleviates Experimental Autoimmune Myocarditis by Inhibiting Th17 Cell Differentiation Independently of the NLRP3 Inflammasome Pathway
    1
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      RRID:AB_2490202

      DOI: 10.3389/fphar.2021.727838

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    ncbi.nlm.nih.gov/pmc/articles/PMC8479108/
  64. Aug 2021
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2490202

      DOI: 10.1016/j.immuni.2019.02.006

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1523/JNEUROSCI.3045-16.2017

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  67. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2018.09.071

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  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1002/glia.23568

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  69. Jul 2021
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
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      DOI: 10.1002/glia.23568

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  71. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2018.10.103

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  72. www.sciencedirect.com www.sciencedirect.com
    The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
    2
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      AB_2490202

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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2490202

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  74. www.sciencedirect.com www.sciencedirect.com
    The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
    1
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      RRID: A27391510

      DOI: 10.1016/j.immuni.2018.04.032

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  75. May 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation
    1
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      DOI: 10.1016/j.molcel.2020.08.015

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  77. www.sciencedirect.com www.sciencedirect.com
    Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis
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    sciencedirect.com/science/article/pii/S1074761320301680
  78. Mar 2021
  79. www.sciencedirect.com www.sciencedirect.com
    Itaconate confers tolerance to late NLRP3 inflammasome activation
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      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2021.108756

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    sciencedirect.com/science/article/pii/S2211124721000693
  80. Feb 2021
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
    1
    1. scibot 25 Feb 2021
      RRID:AB_2490202

      DOI: 10.1172/JCI136174

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    ncbi.nlm.nih.gov/pmc/articles/PMC7410064/
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia
    2
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      RRID:AB_2490202

      DOI: 10.1002/glia.23970

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      DOI: 10.1002/glia.23970

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    onlinelibrary.wiley.com/doi/10.1002/glia.23970
  83. Dec 2020
  84. www.mdpi.com www.mdpi.com
    Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux
    1
    1. scibot 22 Dec 2020
      anti-NLRP3

      DOI: 10.3390/antiox9121299

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    mdpi.com/2076-3921/9/12/1299/htm
  85. Nov 2020
  86. www.sciencedirect.com www.sciencedirect.com
    RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly
    1
    1. scibot 24 Nov 2020
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2020.108405

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    sciencedirect.com/science/article/pii/S2211124720313942
  87. Sep 2020
  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria
    1
    1. scibot 26 Sep 2020
      RRID:AB_2490202

      DOI: 10.1111/jnc.14962

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14962
  89. www.sciencedirect.com www.sciencedirect.com
    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
    1
    1. scibot 25 Sep 2020
      RRID:AB_2490202

      DOI: 10.1016/j.cell.2020.03.040

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    sciencedirect.com/science/article/pii/S0092867420303330
  90. www.sciencedirect.com www.sciencedirect.com
    Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming
    1
    1. scibot 23 Sep 2020
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2020.107604

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    sciencedirect.com/science/article/pii/S2211124720305532
  91. www.sciencedirect.com www.sciencedirect.com
    Platelets Fuel the Inflammasome Activation of Innate Immune Cells
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      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2020.107615

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    sciencedirect.com/science/article/pii/S2211124720305647
  92. www.sciencedirect.com www.sciencedirect.com
    β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
    1
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      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2020.02.025

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    sciencedirect.com/science/article/pii/S2211124720301868
  93. Jan 2020
  94. iovs.arvojournals.org iovs.arvojournals.org
    Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal
    1
    1. scibot 13 Jan 2020
      RRID:AB_2490202

      DOI: 10.1167/iovs.18-26360

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    iovs.arvojournals.org/article.aspx
  95. www.sciencedirect.com www.sciencedirect.com
    HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
    1
    1. scibot 13 Jan 2020
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2019.02.095

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    sciencedirect.com/science/article/pii/S2211124719302815
  96. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2490202

      DOI: 10.1016/j.immuni.2019.02.006

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    sciencedirect.com/science/article/pii/S107476131930072X
  97. www.sciencedirect.com www.sciencedirect.com
    Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
    1
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      AB_2490202

      DOI: 10.1016/j.immuni.2019.04.005

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    sciencedirect.com/science/article/pii/S1074761319301852
  98. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2018.12.047

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    sciencedirect.com/science/article/pii/S2211124718319776
  99. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia‐induced brain injury
    1
    1. scibot 13 Jan 2020
      RRID:AB_2490202

      DOI: 10.1111/bph.14673

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14673
  100. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging
    1
    1. scibot 13 Jan 2020
      RRID:AB_2490202

      DOI: 10.1016/j.celrep.2018.12.101

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  101. Nov 2018
  102. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages
    1
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      RRID:AB_2490202

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  103. www.sciencedirect.com www.sciencedirect.com
    Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis
    1
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      RRID:AB_2490202

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    sciencedirect.com/science/article/pii/S1550413118300561
  104. www.sciencedirect.com www.sciencedirect.com
    Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication
    1
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      RRID:AB_2490202

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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
    2
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      RRID:AB_2490202

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      RRID:AB_2490202

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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
  106. Nov 2017
  107. www.sciencedirect.com www.sciencedirect.com
    NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
    1
    1. scibot 08 Nov 2017
      RRID:AB_2490202

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  108. www.jneurosci.org www.jneurosci.org
    HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation
    1
    1. scibot 08 Nov 2017
      AB_2490202

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    jneurosci.org/content/37/13/3599