92 Matching Annotations
  1. Jul 2025
  2. www.cell.com www.cell.com
    A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
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    cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00200-4
  3. Jun 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neonatal NLRP3 Inflammasome Activation Leads to Perineuronal Net Deficits in Early Adulthood
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    pmc.ncbi.nlm.nih.gov/articles/PMC12179493/
  5. May 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071306/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
  8. Apr 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005378/
  10. www.sciencedirect.com www.sciencedirect.com
    Red blood cells undergo lytic programmed cell death involving NLRP3
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    sciencedirect.com/science/article/pii/S0092867425003897
  11. link.springer.com link.springer.com
    Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides
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    link.springer.com/article/10.1186/s12865-025-00685-9
  12. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70040
  13. 52.53.155.43 52.53.155.43
    Lysosome positioning affects NLRP3 inflammasome activation
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    52.53.155.43/5e725b42faf6f4894ebfb1897ac6165b04d7cac3/PDF-html.html
  14. Mar 2025
  15. www.sciencedirect.com www.sciencedirect.com
    The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene
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    sciencedirect.com/science/article/pii/S2211124725002335
  16. Jan 2025
  17. www.sciencedirect.com www.sciencedirect.com
    A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis
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    sciencedirect.com/science/article/pii/S1074761325000263
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11691456/
  19. Nov 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Ethanol modulates astrocyte activation and neuroinflammation via miR-339/NLRP6 inflammasome signaling
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    sciencedirect.com/science/article/pii/S089158492401044X
  21. Oct 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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    sciencedirect.com/science/article/pii/S1074761324004485
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The emerging role of mesenchymal stem cell–derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11438346/
  24. Sep 2024
  25. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17320
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11398858/
  27. elifesciences.org elifesciences.org
    S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi
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    elifesciences.org/articles/94302
  28. Jul 2024
  29. www.sciencedirect.com www.sciencedirect.com
    Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation
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    sciencedirect.com/science/article/pii/S2589004224016845
  30. Jun 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
  32. www.sciencedirect.com www.sciencedirect.com
    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
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    sciencedirect.com/science/article/pii/S2589004224011623
  33. May 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042255/
  35. Apr 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3′-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034599/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects
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    ncbi.nlm.nih.gov/pmc/articles/PMC10995871/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11130711/
  39. www.sciencedirect.com www.sciencedirect.com
    Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis
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    sciencedirect.com/science/article/pii/S2666379124001721
  40. Mar 2024
  41. www.sciencedirect.com www.sciencedirect.com
    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S2211124724002638
  42. Feb 2024
  43. dx.doi.org dx.doi.org
    HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs
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    dx.doi.org/10.1210/endocr/bqae011
  44. www.sciencedirect.com www.sciencedirect.com
    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
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    sciencedirect.com/science/article/pii/S2211124724000809
  45. Dec 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10703753/
  47. Sep 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
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    ncbi.nlm.nih.gov/pmc/articles/PMC10480325/
  49. Jun 2023
  50. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16074
  51. May 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
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    sciencedirect.com/science/article/pii/S0092867423003331
  53. Mar 2023
  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15778
  55. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16036
  56. Feb 2023
  57. www.sciencedirect.com www.sciencedirect.com
    Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S2211124723001444
  58. Jan 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
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    sciencedirect.com/science/article/pii/S2211124722018423
  60. Nov 2022
  61. www.science.org www.science.org
    Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
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    science.org/doi/10.1126/sciadv.abn9912
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35
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    ncbi.nlm.nih.gov/pmc/articles/PMC9606686/
  63. Jul 2022
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome
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    ncbi.nlm.nih.gov/pmc/articles/PMC9332914/
  65. www.sciencedirect.com www.sciencedirect.com
    Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model
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    sciencedirect.com/science/article/pii/S2352396422003656
  66. www.sciencedirect.com www.sciencedirect.com
    Impaired interferon-γ signaling promotes the development of silicosis
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    sciencedirect.com/science/article/pii/S2589004222009191
  67. Jun 2022
  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15650
  69. Apr 2022
  70. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15838
  71. academic.oup.com academic.oup.com
    Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans
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    academic.oup.com/endo/article/163/4/bqac014/6523230
  72. Mar 2022
  73. link.springer.com link.springer.com
    Reconstitution System of NLRP3 Inflammasome in HEK293T Cells
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    link.springer.com/protocol/10.1007/978-1-0716-2144-8_8
  74. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    sciencedirect.com/science/article/pii/S2211124722000705
  75. Feb 2022
  76. www.sciencedirect.com www.sciencedirect.com
    Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion
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    sciencedirect.com/science/article/pii/S2211124722001383
  77. Nov 2021
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leptin Signaling in the Ovary of Diet-Induced Obese Mice Regulates Activation of NOD-Like Receptor Protein 3 Inflammasome
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    ncbi.nlm.nih.gov/pmc/articles/PMC8595835/
  79. Oct 2021
  80. www.sciencedirect.com www.sciencedirect.com
    Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
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    sciencedirect.com/science/article/pii/S2211124721013747
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sacubitril/Valsartan Alleviates Experimental Autoimmune Myocarditis by Inhibiting Th17 Cell Differentiation Independently of the NLRP3 Inflammasome Pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC8479108/
  82. Aug 2021
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6477154/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5373137/
  85. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S2211124718315316
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23568
  87. Jul 2021
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Immunodeficiency Virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia
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    ncbi.nlm.nih.gov/pmc/articles/PMC6493331/
  89. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S221112471831725X
  90. www.sciencedirect.com www.sciencedirect.com
    The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
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    sciencedirect.com/science/article/pii/S107476131730568X
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5772169/
  92. www.sciencedirect.com www.sciencedirect.com
    The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
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    sciencedirect.com/science/article/pii/S1074761318302036
  93. May 2021
  94. www.sciencedirect.com www.sciencedirect.com
    Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation
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    sciencedirect.com/science/article/pii/S1097276520305785
  95. www.sciencedirect.com www.sciencedirect.com
    Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis
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    sciencedirect.com/science/article/pii/S1074761320301680
  96. Mar 2021
  97. www.sciencedirect.com www.sciencedirect.com
    Itaconate confers tolerance to late NLRP3 inflammasome activation
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    sciencedirect.com/science/article/pii/S2211124721000693
  98. Feb 2021
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC7410064/
  100. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia
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    onlinelibrary.wiley.com/doi/10.1002/glia.23970
  101. Dec 2020
  102. www.mdpi.com www.mdpi.com
    Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux
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    mdpi.com/2076-3921/9/12/1299/htm
  103. Nov 2020
  104. www.sciencedirect.com www.sciencedirect.com
    RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly
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    sciencedirect.com/science/article/pii/S2211124720313942
  105. Sep 2020
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14962
  107. www.sciencedirect.com www.sciencedirect.com
    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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    sciencedirect.com/science/article/pii/S0092867420303330
  108. www.sciencedirect.com www.sciencedirect.com
    Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming
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    sciencedirect.com/science/article/pii/S2211124720305532
  109. www.sciencedirect.com www.sciencedirect.com
    Platelets Fuel the Inflammasome Activation of Innate Immune Cells
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    sciencedirect.com/science/article/pii/S2211124720305647
  110. www.sciencedirect.com www.sciencedirect.com
    β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
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    sciencedirect.com/science/article/pii/S2211124720301868
  111. Jan 2020
  112. iovs.arvojournals.org iovs.arvojournals.org
    Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal
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    iovs.arvojournals.org/article.aspx
  113. www.sciencedirect.com www.sciencedirect.com
    HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
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    sciencedirect.com/science/article/pii/S2211124719302815
  114. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S107476131930072X
  115. www.sciencedirect.com www.sciencedirect.com
    Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
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    sciencedirect.com/science/article/pii/S1074761319301852
  116. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S2211124718319776
  117. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia‐induced brain injury
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14673
  118. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging
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    sciencedirect.com/science/article/pii/S221112471832076X
  119. Nov 2018
  120. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages
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    sciencedirect.com/science/article/pii/S1074761318303844
  121. www.sciencedirect.com www.sciencedirect.com
    Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis
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    sciencedirect.com/science/article/pii/S1550413118300561
  122. www.sciencedirect.com www.sciencedirect.com
    Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication
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    sciencedirect.com/science/article/pii/S1931312817305504
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
  124. Nov 2017
  125. www.sciencedirect.com www.sciencedirect.com
    NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
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    sciencedirect.com/science/article/pii/S1097276517306147
  126. www.jneurosci.org www.jneurosci.org
    HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation
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    jneurosci.org/content/37/13/3599