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163 Matching Annotations

Oct 2025
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Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke

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1. scibot 08 Oct 2025
  
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  DOI: 10.1186/s40478-025-02125-6
  
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2. scibot 02 Oct 2025
  
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  DOI: 10.1186/s40478-025-02125-6
  
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link.springer.com/article/10.1186/s40478-025-02125-6
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Efficient Gene Knockdown in Adult Zebrafish Retina by Intravitreal Injection

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1. scibot 20 Sep 2025
  
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  DOI: 10.21769/BioProtoc.5436
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12423274/
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Tumor suppressor protein p53 governs human trophoblast lineage development

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116310
  
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sciencedirect.com/science/article/pii/S2211124725010812
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Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling

1
1. scibot 18 Sep 2025
  
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  DOI: 10.1016/j.stem.2025.08.013
  
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sciencedirect.com/science/article/pii/S1934590925003285
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High-throughput bioprinting to produce micropatterened neuroepithelial tissues and model TSC2-deficient brain malformations

1
1. scibot 18 Sep 2025
  
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  DOI: 10.1016/j.crmeth.2025.101177
  
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sciencedirect.com/science/article/pii/S2667237525002139
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis

1
1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.cub.2024.07.074
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11387132/
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Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development

1
1. scibot 06 Sep 2025
  
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  DOI: 10.1093/biolre/ioae128
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11565232/
Jul 2025
dx.doi.org dx.doi.org

The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function

1
1. scibot 02 Jul 2025
  
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  DOI: 10.1210/endocr/bqae041
  
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dx.doi.org/10.1210/endocr/bqae041
Jun 2025
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A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration

1
1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115812
  
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sciencedirect.com/science/article/pii/S2211124725005832
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In Vitro Comparison of Two Python‐Based Programs for the Automated Analysis of Tight‐Junction Phenotype in Brain Endothelium During Bacterial Infection

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1. scibot 18 Jun 2025
  
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  DOI: 10.1002/cbf.70093
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12169080/
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Lysophosphatidic acid and sphingosine-1-phosphate are apical polarity cues in multiple organoid systems

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115842
  
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sciencedirect.com/science/article/pii/S2211124725006138
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Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115831
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00602-3
May 2025
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Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud

1
1. scibot 18 May 2025
  
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  DOI: 10.1016/j.stem.2025.04.008
  
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sciencedirect.com/science/article/pii/S1934590925001432
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Harmonizing TUNEL with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death

1
1. scibot 17 May 2025
  
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  AB_2533147
  
  DOI: 10.1016/j.crmeth.2025.101047
  
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sciencedirect.com/science/article/pii/S2667237525000839
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225006595-main-html.html

1
1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.isci.2025.112398
  
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52.53.155.43/90c9af30b85d34e98a6e786ac3b79b6637c58e1c/1-s2.0-S2589004225006595-main-html.html
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ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability

1
1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115511
  
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sciencedirect.com/science/article/pii/S2211124725002827
Nov 2024
elifesciences.org elifesciences.org

Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

1
1. scibot 07 Nov 2024
  
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  RRID:AB_2533147
  
  DOI: 10.7554/eLife.96831
  
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elifesciences.org/articles/96831
Oct 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 03 Oct 2024
  
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  RRID:AB_2533147
  
  DOI: 10.1111/bph.16477
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16477
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Protocol for generating a 3D culture of epiblast stem cells

1
1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.xpro.2024.103347
  
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sciencedirect.com/science/article/pii/S2666166724005124
Sep 2024
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Katanin regulatory subunit B1 (KATNB1) regulates BTB dynamics through changes in cytoskeletal organization

1
1. scibot 27 Sep 2024
  
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  AB_2533147
  
  DOI: 10.1096/fj.202400966R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202400966R
www.jneurosci.org www.jneurosci.org

Zebrafish Crb1, localizing uniquely to the cell membranes around cone photoreceptor axonemes, alleviates light damage to photoreceptors and modulates cones’ light responsiveness

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1. scibot 25 Sep 2024
  
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  RRID:AB_87181
  
  DOI: 10.1523/JNEUROSCI.0497-20.2020
  
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jneurosci.org/content/40/37/7065
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Tau reduction in aged mice does not impact Microangiopathy

1
1. scibot 25 Sep 2024
  
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  RRID:AB_87181
  
  DOI: 10.1186/s40478-020-01014-4
  
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link.springer.com/article/10.1186/s40478-020-01014-4
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Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

1
1. scibot 25 Sep 2024
  
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  RRID:AB_87181
  
  DOI: 10.1016/j.celrep.2020.107924
  
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sciencedirect.com/science/article/pii/S2211124720309050
Jul 2024
52.53.155.43 52.53.155.43

1-s2.0-S258900422401825X-main-html.html

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1. scibot 30 Jul 2024
  
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  RRID:AB_2533147
  
  DOI: 10.1016/j.isci.2024.110600
  
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52.53.155.43/7b2053fa2b6f1dae1cb07986f7ba7cee9e5d1284/1-s2.0-S258900422401825X-main-html.html
52.53.155.43 52.53.155.43

Substrate Stiffness Alters Layer Architecture and Biophysics of Human Induced Pluripotent Stem Cells to Modulate their Differentiation Potential

1
1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110557
  
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52.53.155.43/019bcc93a6d44d3591c94ce256a2c9ee30ed8e90/1-s2.0-S2589004224017826-main (1)-html.html
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An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114247
  
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sciencedirect.com/science/article/pii/S2211124724005758
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A human pluripotent stem cell-based somitogenesis model using microfluidics

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.stem.2024.06.004
  
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sciencedirect.com/science/article/pii/S1934590924002121
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DCX knockout ferret reveals a neurogenic mechanism in cortical development

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114508
  
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sciencedirect.com/science/article/pii/S2211124724008374
May 2024
52.53.155.43 52.53.155.43

Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells

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1. scibot 29 May 2024
  
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  RRID:AB_2533147
  
  DOI: 10.1101/2024.03.09.584233
  
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2. scibot 29 May 2024
  
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  RRID:AB_2533147
  
  DOI: 10.1101/2024.03.09.584233
  
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52.53.155.43/2b92d11b8fe97a4914ca774f880354d9ae603ad1/2024.03.09.584233v1.full-html.html
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Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.019
  
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sciencedirect.com/science/article/pii/S1934590924001462
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Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model

1
1. scibot 03 May 2024
  
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  DOI: 10.1016/j.stem.2024.03.016
  
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sciencedirect.com/science/article/pii/S1934590924000973
Apr 2024
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Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling

1
1. scibot 10 Apr 2024
  
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  DOI: 10.1016/j.neuron.2024.03.011
  
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sciencedirect.com/science/article/pii/S089662732400165X
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Basal delamination during mouse gastrulation primes pluripotent cells for differentiation

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.devcel.2024.03.008
  
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Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin

1
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Mar 2024
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The IgCAM BT-IgSF (IgSF11) Is Essential for Connexin43-Mediated Astrocyte–Astrocyte Coupling in Mice

1
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A Highlights from MBoC Selection: Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

1
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  DOI: 10.1091/mbc.E23-08-0337
  
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Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

2
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  DOI: 10.1016/j.celrep.2024.113859
  
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Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa

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  DOI: 10.1007/s00018-023-05021-1
  
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Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

1
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Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk

1
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Oct 2023
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MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis

1
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Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila

1
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Sep 2023
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3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages

1
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NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis

1
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  DOI: 10.1016/j.neuron.2023.08.010
  
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Aug 2023
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Embryo-uterine interaction coordinates mouse embryogenesis during implantation

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  DOI: 10.15252/embj.2022113280
  
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Jul 2023
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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

1
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Jun 2023
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Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells

1
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GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region

1
1. scibot 03 Jun 2023
  
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  DOI: 10.1242/jcs.261100
  
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Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing

1
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  DOI: 10.1210/endocr/bqad045
  
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RORψt+CD4+ T cells promote IL-23R-mediated neuronal cell apoptosis in the central nervous system

1
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  DOI: 10.1101/2023.04.17.537133
  
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May 2023
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Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins

1
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A junction-dependent mechanism drives murine mammary cell intercalation for ductal elongation

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Apr 2023
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Regulation of sertoli cell function by planar cell polarity (PCP) protein Fjx1

1
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Polyploidy in Xenopus lowers metabolic rate by decreasing total cell surface area

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Cynomolgus monkey embryo model captures gastrulation and early pregnancy

1
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CDK5 activity in retinal pigment epithelium contributes to gap junction dynamics during phagocytosis

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  DOI: 10.1101/2023.02.09.527850
  
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Mar 2023
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GIPC3 couples to MYO6 and PDZ domain proteins and shapes the hair cell apical region

1
1. scibot 23 Mar 2023
  
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  DOI: 10.1101/2023.02.28.530466
  
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Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization

1
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Dodecaploid Xenopus longipes provides insight into the emergence of size scaling relationships during development

1
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  DOI: 10.1016/j.cub.2023.02.021
  
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Feb 2023
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Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril

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Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes

1
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Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity

1
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  DOI: 10.1152/ajprenal.00199.2022
  
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Jan 2023
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Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

1
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  DOI: 10.1016/j.cell.2022.11.028
  
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Dec 2022
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Molecular Indicators of Blood-Brain Barrier Breakdown and Neuronal Injury in Pregnancy Complicated by Fetal Growth Restriction

1
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  DOI: 10.3390/ijms232213798
  
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Nov 2022
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Biofabrication of synthetic human liver tissue with advanced programmable functions

1
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  DOI: 10.1016/j.isci.2022.105503
  
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m6A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis

1
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  DOI: 10.1016/j.celrep.2022.111671
  
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Oct 2022
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MARK2 and MARK4 regulate Sertoli cell BTB dynamics through microtubule and actin cytoskeletons

1
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  RRID:AB_2533147
  
  DOI: 10.1210/endocr/bqac130
  
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Engineering rotating apical-out airway organoid for assessing respiratory cilia motility

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The disconnect2 mutation disrupts the tjp1b gene that is required for electrical synapse formation

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Ym1+ macrophages orchestrate fibrosis, lesion growth and progression during development of murine pancreatic cancer

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Recapitulating early human development with 8C-like cells

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Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques

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Ym1+ macrophages orchestrate fibrosis, lesion growth and progression during development of murine pancreatic cancer

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JAM-A Signals Through the Hippo Pathway to Regulate Intestinal Epithelial Proliferation

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p53 directs leader cell behavior, migration, and clearance during epithelial repair

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Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses

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Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

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Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium

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Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions

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Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

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Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces

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Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development

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Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases

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Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

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Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

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Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis

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Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7

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F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model

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Suppression of Leptin Transport Into the Brain Contributes to Leptin Resistance During Pregnancy in the Mouse

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A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

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LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images

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Neonatal susceptibility to meningitis results from the immaturity of epithelial barriers and gut microbiota

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3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration

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Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

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The Scf/Kit pathway implements self-organized epithelial patterning

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Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells

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Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

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Electrical synaptic transmission requires a postsynaptic scaffolding protein

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A cellular and spatial map of the choroid plexus across brain ventricles and ages

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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

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Cell intercalation driven by SMAD3 underlies secondary neural tube formation

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Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain

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TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

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Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage

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The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia

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High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

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16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

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Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

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Insights Into the Mechanism of MCT8 Oligomerization

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Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis

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Transplantation of iPS‐derived vascular endothelial cells improves white matter ischemic damage

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Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

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Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

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Mosaic Heterochrony in Neural Progenitors Sustains Accelerated Brain Growth and Neurogenesis in the Juvenile Killifish N. furzeri

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Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys

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Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo

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Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity

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The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine

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Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization

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Prothymosin alpha and its mimetic hexapeptide improve delayed tPA‐induced brain damage following cerebral ischemia

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Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

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Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow

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Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

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The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity

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Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis

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Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

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Novel mutations in SLC16A2 associated with a less severe phenotype of MCT8 deficiency

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Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

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Untitled document

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Chiral Cilia Orientation in the Left-Right Organizer

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Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds

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Suppression of Leptin Transport Into the Brain Contributes to Leptin Resistance During Pregnancy in the Mouse

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Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization

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High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

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Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation

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Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation

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Tension-Dependent Stretching Activates ZO-1 to Control the Junctional Localization of Its Interactors

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Effects of Chemical Chaperones on Thyroid Hormone Transport by MCT8 Mutants in Patient-Derived Fibroblasts

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Nov 2017
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Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels.

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Juxtanodin in Retinal Pigment Epithelial Cells: Expression and Biological Activities in Regulating Cell Morphology and Actin Cytoskeleton Organization

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Outward-Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights

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Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue

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Embryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain - ScienceDirect

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Perineurial Glial Plasticity and the Role of TGF-β in the Development of the Blood-Nerve-Barrier

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Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly

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Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood‐brain barrier

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Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

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Prostacyclin Prevents Pericyte Loss and Demyelination Induced by Lysophosphatidylcholine in the Central Nervous System

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