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Stochastic misfolding drives the emergence of distinct α-synuclein strains

1
1. scibot 03 Mar 2026
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.neuron.2026.01.014
  
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sciencedirect.com/science/article/pii/S0896627326000401
Jan 2026
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A monoclonal antibody targeting the C-terminal of α-synuclein fibrils mitigates pathology in a Parkinson’s disease model

1
1. scibot 23 Jan 2026
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2025.116897
  
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sciencedirect.com/science/article/pii/S2211124725016699
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Skin-derived α-synuclein strains from PD, DLB, and MSA induce distinct intracellular pathology and neurodegeneration

1
1. scibot 09 Jan 2026
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.jbc.2025.111005
  
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sciencedirect.com/science/article/pii/S0021925825028571
Dec 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225027506-main-html.html

1
1. scibot 23 Dec 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.isci.2025.114489
  
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54.241.53.176/5a2cb0471482e048a5c3a0a61565cd6584891004/1-s2.0-S2589004225027506-main-html.html
Nov 2025
link.springer.com link.springer.com

Attenuating α-synuclein pathology in mice with in situ engineered astrocytes

1
1. scibot 25 Nov 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1186/s40035-025-00518-0
  
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link.springer.com/article/10.1186/s40035-025-00518-0
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Fc-Modified IVIG with Enhanced Blood–Brain Barrier Penetration Ameliorates Cognitive Deficits and Neuropathology in A53T α-Synuclein Transgenic Mice

1
1. scibot 18 Nov 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1007/s10571-025-01626-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12618800/
Sep 2025
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α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

1
1. scibot 11 Sep 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.molcel.2025.08.022
  
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sciencedirect.com/science/article/pii/S1097276525007075
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Low-density lipoprotein receptor–related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease

1
1. scibot 07 Sep 2025
  
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  RRID:AB_2537217
  
  DOI: 10.4103/NRR.NRR-D-23-01965
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12407564/
Jul 2025
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TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy

1
1. scibot 15 Jul 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2025.116001
  
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sciencedirect.com/science/article/pii/S2211124725007727
www.eneuro.org www.eneuro.org

SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

1
1. scibot 01 Jul 2025
  
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  Abcam, 138501
  
  DOI: 10.1523/ENEURO.0166-21.2021
  
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eneuro.org/content/8/4/ENEURO.0166-21.2021
Apr 2025
www.jneurosci.org www.jneurosci.org

Coronin1A regulates the trafficking of alpha synuclein in microglia

1
1. scibot 17 Apr 2025
  
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  AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1337-24.2025
  
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jneurosci.org/content/45/11/e1337242025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

1
1. scibot 16 Apr 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1126/sciadv.adq2519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980859/
Mar 2025
link.springer.com link.springer.com

Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease

1
1. scibot 25 Mar 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1186/s40478-025-01958-5
  
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link.springer.com/article/10.1186/s40478-025-01958-5
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Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

1
1. scibot 11 Mar 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.xcrm.2025.101999
  
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sciencedirect.com/science/article/pii/S2666379125000722
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis

1
1. scibot 06 Feb 2025
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2025.115266
  
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sciencedirect.com/science/article/pii/S2211124725000373
Dec 2024
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 24 Dec 2024
  
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  AB_138501
  
  DOI: 10.1093/sleep/zsae297
  
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  Curator: @sjvitug
  
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  RRIDCUR:Unresolved RRID:AB_2537217
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52.53.155.43/a82bc61618bba92f8f86f30b899fd1de833883d0/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for generation of PD-modeling-induced neurons and detection of α-synuclein forms

1
1. scibot 21 Dec 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.xpro.2024.103447
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11609654/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

1
1. scibot 14 Dec 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1038/s41531-024-00842-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11634889/
Sep 2024
www.biorxiv.org www.biorxiv.org

Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features

1
1. scibot 28 Sep 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1101/2024.09.20.613717
  
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biorxiv.org/content/10.1101/2024.09.20.613717v1
May 2024
www.sciencedirect.com www.sciencedirect.com

Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson’s disease and dementia with Lewy bodies

1
1. scibot 21 May 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.neuron.2024.05.003
  
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sciencedirect.com/science/article/pii/S0896627324003283
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression

1
1. scibot 30 Apr 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1038/s41598-024-60613-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11055870/
www.nature.com www.nature.com

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

1
1. scibot 05 Apr 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1038/s41419-024-06534-8
  
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nature.com/articles/s41419-024-06534-8
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation

1
1. scibot 09 Mar 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1186/s13041-024-01086-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10916047/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

1
1. scibot 06 Mar 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1186/s40035-024-00403-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10910783/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Gut mucosal cells transfer α-synuclein to the vagus nerve

1
1. scibot 20 Jan 2024
  
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  RRID:AB_2537217
  
  DOI: 10.1172/jci.insight.172192
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10795834/
Aug 2023
www.biorxiv.org www.biorxiv.org

Gut mucosal cells transfer α-synuclein to the vagus nerve

1
1. scibot 29 Aug 2023
  
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  RRID:AB_2537217
  
  DOI: 10.1101/2023.08.14.553305
  
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biorxiv.org/content/10.1101/2023.08.14.553305v1
Mar 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

The effect of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly

1
1. scibot 03 Mar 2023
  
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  RRID:AB_2537217
  
  DOI: 10.1111/jnc.15763
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15763
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

1
1. scibot 22 Nov 2022
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.isci.2022.105476
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9672966/
academic.oup.com academic.oup.com

GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines

1
1. scibot 01 Nov 2022
  
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  RRID:AB_2537217
  
  DOI: 10.1093/hmg/ddac233
  
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academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddac233/6708353
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition

1
1. scibot 26 Aug 2022
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2022.111231
  
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sciencedirect.com/science/article/pii/S2211124722010488
May 2022
www.sciencedirect.com www.sciencedirect.com

Microparticle immunocapture assay for quantitation of protein multimer amount and size

1
1. scibot 26 May 2022
  
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  RRID:AB_2537217
  
  DOI: 10.1016/j.crmeth.2022.100214
  
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sciencedirect.com/science/article/pii/S2667237522000777
www.tandfonline.com www.tandfonline.com

Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Drosophila model of Parkinson's disease

1
1. scibot 11 May 2022
  
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  RRID:AB_2537217
  
  DOI: 10.1080/01677063.2022.2064462
  
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tandfonline.com/doi/abs/10.1080/01677063.2022.2064462
Mar 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Acute inflammation down-regulates alpha-synuclein expression in enteric neurons

1
1. scibot 31 Mar 2022
  
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  RRID:AB_2537217
  
  DOI: 10.1111/jnc.14656
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14656
Jul 2021
www.jneurosci.org www.jneurosci.org

Untitled document

1
1. scibot 31 Jul 2021
  
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  RRID:AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1659-16.2016
  
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jneurosci.org/content/36/41/10510
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

4
1. scibot 27 Jul 2021
  
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  AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1659-16.2016
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Unrecognized RRID:AB_2537217
2. scibot 27 Jul 2021
  
  in Public
  
  AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1659-16.2016
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Validated RRIDCUR:Duplicate RRID:AB_2537217
3. scibot 27 Jul 2021
  
  in Public
  
  AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1659-16.2016
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Validated RRIDCUR:Duplicate RRID:AB_2537217
4. scibot 27 Jul 2021
  
  in Public
  
  AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1659-16.2016
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2537217
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RRID:AB_2537217

RRIDCUR:Unrecognized

RRIDCUR:Validated

RRIDCUR:Duplicate

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5059426/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model

1
1. scibot 23 Jul 2021
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1002/jnr.24927
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2537217
  
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  RRID:AB_2537217
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RRID:AB_2537217

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/jnr.24927
May 2021
www.sciencedirect.com www.sciencedirect.com

α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology

1
1. scibot 12 May 2021
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2021.109099
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2537217
  
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  RRID:AB_2537217
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RRID:AB_2537217

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721004332
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

1
1. scibot 09 Mar 2021
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.7554/eLife.61951
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2537217
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7929559/
onlinelibrary.wiley.com onlinelibrary.wiley.com

α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease

1
1. scibot 04 Mar 2021
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1111/jnc.15257
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2537217
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

onlinelibrary.wiley.com/doi/10.1111/jnc.15257
Feb 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia

2
1. scibot 02 Feb 2021
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1002/glia.23970
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
2. scibot 02 Feb 2021
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1002/glia.23970
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

onlinelibrary.wiley.com/doi/10.1002/glia.23970
Sep 2020
www.jneurosci.org www.jneurosci.org

Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

1
1. scibot 07 Sep 2020
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1523/JNEUROSCI.1076-19.2019
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2537217
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

jneurosci.org/content/40/2/459
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2019.09.029
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719312069
www.sciencedirect.com www.sciencedirect.com

The neuroprotective effect of fullerenols on a model of Parkinson’s disease in Drosophila melanogaster

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1016/j.bbrc.2019.12.075
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

sciencedirect.com/science/article/pii/S0006291X19324052
www.sciencedirect.com www.sciencedirect.com

Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2019.06.009
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719307673
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1016/j.celrep.2019.01.096
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

sciencedirect.com/science/article/pii/S2211124719301330
onlinelibrary.wiley.com onlinelibrary.wiley.com

Untitled document

1
1. scibot 12 Jan 2020
  
  in Public
  
  RRID:AB_2537217
  
  DOI: 10.1111/jnc.14656
  
  Resource: (Abcam Cat# ab138501, RRID:AB_2537217)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2537217
  
  What is this?
  
  RRID:AB_2537217 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_2537217

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scibot

URL

onlinelibrary.wiley.com/doi/full/10.1111/jnc.14656
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2537217
  
  Resource used:
  
  (Abcam Cat# ab138501, RRID:AB_2537217)
  
  SciCrunch record: RRID:AB_2537217
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2537217
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RRID:AB_2537217

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scibot

URL

sciencedirect.com/science/article/pii/S0197018618300251