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Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy

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  DOI: 10.1016/j.xcrm.2026.103127
  
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sciencedirect.com/science/article/pii/S2666379126005446
Oct 2026
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Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab

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1. scibot 24 Oct 2026
  
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  DOI: 10.1016/j.ccell.2026.09.016
  
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sciencedirect.com/science/article/pii/S1535610826004356
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Chemotherapy enhances cancer vaccine efficacy and expands stem-like TCF1+CD8+ T cells

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1. scibot 05 Oct 2026
  
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  DOI: 10.1016/j.ccell.2026.09.006
  
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sciencedirect.com/science/article/pii/S1535610826004253
Sep 2026
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Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis

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1. scibot 04 Sep 2026
  
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  DOI: 10.1016/j.cmet.2026.08.009
  
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sciencedirect.com/science/article/pii/S1550413126003347
Aug 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetically driven immune microenvironment states associate with therapeutic responses in MYD88 mutant lymphomas

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1. scibot 26 Aug 2026
  
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  DOI: 10.1186/s12943-026-02646-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13501595/
Apr 2026
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Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.immuni.2026.03.029
  
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sciencedirect.com/science/article/pii/S1074761326001408
Mar 2026
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Oncolytic virotherapy potentiates chemo-PD-1 immunotherapy by engaging chemo-resistant bystander CD8+ T cells

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1. scibot 11 Mar 2026
  
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  DOI: 10.1136/jitc-2026-014897
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12970110/
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Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer

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  DOI: 10.1016/j.ccell.2026.02.008
  
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sciencedirect.com/science/article/pii/S1535610826001066
Feb 2026
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Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.chembiol.2026.02.001
  
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sciencedirect.com/science/article/pii/S2451945626000334
Dec 2025
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Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E–restricted epitope recognition

2
1. scibot 23 Dec 2025
  
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  DOI: 10.1126/sciadv.aea8707
  
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2. scibot 23 Dec 2025
  
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  DOI: 10.1126/sciadv.aea8707
  
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science.org/doi/10.1126/sciadv.aea8707
Aug 2025
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Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116156
  
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sciencedirect.com/science/article/pii/S2211124725009271
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.012
  
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sciencedirect.com/science/article/pii/S1535610825003186
Jul 2025
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Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging

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1. scibot 02 Jul 2025
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.xcrm.2025.102209
  
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sciencedirect.com/science/article/pii/S2666379125002824
Jun 2025
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Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102204
  
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sciencedirect.com/science/article/pii/S2666379125002770
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NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1/PD-L1 pathway

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1. scibot 11 Jun 2025
  
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  RRID:AB_2561447
  
  DOI: 10.1126/sciimmunol.adl2967
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12099074/
May 2025
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1-s2.0-S2589004225007692-main-html.html

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1. scibot 18 May 2025
  
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  AB_2561447
  
  DOI: 10.1016/j.isci.2025.112508
  
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52.53.155.43/bf6cba30678d0d150a13cbeb68660b4f11367a41/1-s2.0-S2589004225007692-main-html.html
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Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115679
  
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sciencedirect.com/science/article/pii/S2211124725004504
Apr 2025
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Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.ccell.2025.03.011
  
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sciencedirect.com/science/article/pii/S1535610825001126
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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.004
  
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sciencedirect.com/science/article/pii/S1074761325001232
Mar 2025
www.cell.com www.cell.com

Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis

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1. scibot 05 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115356
  
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cell.com/cell-reports/abstract/S2211-1247(25)00127-5
Jan 2025
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Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry

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1. scibot 18 Jan 2025
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.xpro.2024.103505
  
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sciencedirect.com/science/article/pii/S2666166724006701
Dec 2024
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NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1–PD-L1

1
1. scibot 29 Dec 2024
  
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  RRID:AB_2561447
  
  DOI: 10.1126/sciimmunol.adl2967
  
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science.org/doi/10.1126/sciimmunol.adl2967
Nov 2024
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Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus

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1. scibot 14 Nov 2024
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.xcrm.2024.101822
  
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sciencedirect.com/science/article/pii/S2666379124005937
Sep 2024
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Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.019
  
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sciencedirect.com/science/article/pii/S1535610824003180
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Tumour-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signalling.

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110701
  
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sciencedirect.com/science/article/pii/S2589004224019266
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The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis

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1. scibot 04 Sep 2024
  
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  AB_256144
  
  DOI: 10.1016/j.celrep.2024.114690
  
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sciencedirect.com/science/article/pii/S2211124724010416
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance

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1. scibot 25 Aug 2024
  
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  DOI: 10.1016/j.xcrm.2024.101686
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11384939/
Jul 2024
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Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.immuni.2024.06.015
  
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sciencedirect.com/science/article/pii/S1074761324003212
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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sciencedirect.com/science/article/pii/S2666634024002484
Jun 2024
www.cell.com www.cell.com

Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss.

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1. scibot 30 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110121
  
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cell.com/iscience/abstract/S2589-0042(24)01346-4
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas

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1. scibot 15 Feb 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0399
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10863487/
Oct 2023
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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma

1
1. scibot 13 Oct 2023
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.ccell.2023.09.011
  
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sciencedirect.com/science/article/pii/S1535610823003276
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.ccell.2023.09.001
  
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sciencedirect.com/science/article/pii/S1535610823003185
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

1
1. scibot 12 Aug 2023
  
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  RRID:AB_2561447
  
  DOI: 10.1136/jitc-2022-006457
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10414095/
Jul 2023
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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

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1. scibot 07 Jul 2023
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.cell.2023.06.002
  
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sciencedirect.com/science/article/pii/S0092867423006426
Jun 2023
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Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression

1
1. scibot 08 Jun 2023
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.celrep.2023.112599
  
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sciencedirect.com/science/article/pii/S2211124723006101
May 2023
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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

1
1. scibot 12 May 2023
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.ccell.2023.04.011
  
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sciencedirect.com/science/article/pii/S153561082300137X
Nov 2022
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Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

1
1. scibot 05 Nov 2022
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.celrep.2022.111478
  
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sciencedirect.com/science/article/pii/S2211124722013286
Oct 2022
www.cell.com www.cell.com

Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment

1
1. scibot 27 Oct 2022
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.cell.2022.10.006
  
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cell.com/cell/fulltext/S0092-8674(22)01321-6
Sep 2022
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

1
1. scibot 24 Sep 2022
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.ccell.2022.08.015
  
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sciencedirect.com/science/article/pii/S1535610822003798
Jul 2022
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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

1
1. scibot 13 Jul 2022
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.devcel.2022.06.006
  
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sciencedirect.com/science/article/pii/S1534580722004464
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

1
1. scibot 08 Apr 2022
  
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  RRID:AB_2561447
  
  DOI: 10.26508/lsa.202101230
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8897596/
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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

1
1. scibot 07 Apr 2022
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.immuni.2022.03.006
  
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sciencedirect.com/science/article/pii/S1074761322001297
Jan 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models

1
1. scibot 05 Jan 2022
  
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  135218
  
  DOI: 10.1002/cti2.1364
  
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onlinelibrary.wiley.com/doi/10.1002/cti2.1364
Nov 2021
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

1
1. scibot 24 Nov 2021
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.celrep.2021.110021
  
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sciencedirect.com/science/article/pii/S2211124721015035
Jun 2021
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A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells

1
1. scibot 22 Jun 2021
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.cell.2021.05.028
  
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sciencedirect.com/science/article/pii/S0092867421006589
Apr 2021
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Follicular regulatory T cells produce neuritin to regulate B cells

1
1. scibot 27 Apr 2021
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.cell.2021.02.027
  
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sciencedirect.com/science/article/pii/S009286742100177X
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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

1
1. scibot 01 Apr 2021
  
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  AB_2561447
  
  DOI: 10.1016/j.immuni.2021.03.007
  
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sciencedirect.com/science/article/pii/S1074761321001199
Sep 2020
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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

1
1. scibot 13 Sep 2020
  
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  RRID:AB_2561447
  
  DOI: 10.1016/j.ccell.2020.02.006
  
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sciencedirect.com/science/article/pii/S1535610820300957