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Senescent T cells within the tumor microenvironment are a potent driver for tumor growth, stemness, and chemotherapy resistance

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1. scibot 07 Nov 2026
  
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  DOI: 10.1016/j.xcrm.2026.103141
  
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sciencedirect.com/science/article/pii/S2666379126005586
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An MMP-14/STAT3 feedback loop upregulates PD-L1 to drive immunosuppression and tumorigenesis in bladder cancer

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1. scibot 06 Nov 2026
  
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  DOI: 10.1016/j.isci.2026.118071
  
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sciencedirect.com/science/article/pii/S2589004226034541
Aug 2026
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Enrichment of CD4−CD8− cytotoxic Vδ1/3 T cells in pulmonary tuberculosis disease

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1. scibot 20 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117241
  
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sciencedirect.com/science/article/pii/S2589004226026192
Jun 2026
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DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer

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1. scibot 17 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3849
  
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aacrjournals.org/cancerres/article/86/12/2837/785625/DPY30-Is-an-Epigenetic-Decoupler-Linking
May 2026
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ANGPTL3 in the Peripheral Circulation Is Associated with Resistance to Anti-PD1 Therapy in Advanced Gastric Cancer

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1. scibot 06 May 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0793
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13138227/
Apr 2026
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Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.ccell.2026.03.016
  
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sciencedirect.com/science/article/pii/S1535610826001704
Mar 2026
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.02.013
  
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sciencedirect.com/science/article/pii/S153561082600111X
Feb 2026
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Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC class I-deficient solid tumors

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1. scibot 27 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117035
  
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sciencedirect.com/science/article/pii/S2211124726001130
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Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.stem.2026.01.013
  
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sciencedirect.com/science/article/pii/S1934590926000354
Dec 2025
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IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunity

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.ccell.2025.11.007
  
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sciencedirect.com:5037/science/article/pii/S1535610825005008
Nov 2025
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Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116557
  
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sciencedirect.com/science/article/pii/S2211124725013282
Sep 2025
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The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level

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1. scibot 12 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116249
  
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sciencedirect.com/science/article/pii/S2211124725010204
Aug 2025
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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.017
  
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sciencedirect.com/science/article/pii/S1074761325003267
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DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.014
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00320-4
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Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116102
  
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sciencedirect.com/science/article/pii/S2211124725008733
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A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma

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1. scibot 06 Aug 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1425
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12319406/
Jun 2025
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Gut microbiota dysbiosis induced by brain tumors modulates the efficacy of immunotherapy

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115825
  
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sciencedirect.com/science/article/pii/S2211124725005960
May 2025
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GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR T-cell Resistance via Macrophage Remodeling

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1. scibot 20 May 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0841
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046320/
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Regulatable C-X-C chemokine receptor type 4 in iPSC-derived NK cells improves bone marrow chemotaxis and targeting resident tumor

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.tibtech.2025.02.018
  
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sciencedirect.com/science/article/pii/S0167779925000812
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Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112396
  
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sciencedirect.com/science/article/pii/S2589004225006571
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Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.03.036
  
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sciencedirect.com/science/article/pii/S1535610825001370
Mar 2025
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1. scibot 23 Mar 2025
  
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  DOI: 10.1101/2025.03.19.643961
  
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52.53.155.43/6ffb1e8f8e61cda81dc9b10ac8db2b4f9e212959/PDF-html.html
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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33

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1. scibot 07 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.017
  
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sciencedirect.com/science/article/pii/S1535610825000698
Feb 2025
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52.53.155.43/86ea57acb426fb8853be71653237dc60cec72050/PDF-html.html
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NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection

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  DOI: 10.1016/j.isci.2025.111937
  
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sciencedirect.com/science/article/pii/S258900422500197X
Jan 2025
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Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors

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1. scibot 30 Jan 2025
  
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  DOI: 10.1038/s44319-024-00333-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11772817/
Sep 2024
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Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.029
  
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sciencedirect.com/science/article/pii/S0092867424009565
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Type I interferon signaling regulates myeloid and T cell crosstalk in the glioblastoma tumor microenvironment

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110810
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11404196/
Aug 2024
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Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition

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  DOI: 10.1016/j.celrep.2024.114632
  
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sciencedirect.com/science/article/pii/S2211124724009823
Jul 2024
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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101640
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11293343/
Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Feb 2024
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Unique immune profiles in Collaborative Cross mice linked to survival and viral clearance upon infection.

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1. scibot 18 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109103
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10867580/
Dec 2023
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Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.immuni.2023.11.018
  
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sciencedirect.com/science/article/pii/S1074761323005009
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Dietary environmental factors shape the immune defense against Cryptosporidium infection

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1. scibot 20 Dec 2023
  
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  DOI: 10.1016/j.chom.2023.11.008
  
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sciencedirect.com/science/article/pii/S1931312823004584
Jul 2023
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Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112864
  
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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment

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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8+ T cell differentiation and function

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CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

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IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

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Aug 2022
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1960-html.html

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Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma

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Jun 2022
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IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

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Apr 2022
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Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory

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Complement activation induces excessive T cell cytotoxicity in severe COVID-19

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Oct 2021
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Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation

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Sep 2021
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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Untitled document

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Jul 2021
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T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

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Jun 2021
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Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells

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May 2021
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Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

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Mar 2021
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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy

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Sep 2020
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CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

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The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

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Untitled document

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Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells

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Nov 2018
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CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

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Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

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