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  1. Last 7 days
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    ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75NTR and induction of amyloid precursor protein
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    eEF2K regulates pain through translational control of BDNF
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    Temperature perception by ER UPR promotes preventive innate immunity and longevity
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  5. Dec 2024
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    IFRD1 is required for maintenance of bladder epithelial homeostasis
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    Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
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    lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing
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  9. Nov 2024
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    Regulation of synapse density by Pumilio RNA-binding proteins
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  11. Sep 2024
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    Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation
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    DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins
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    Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis
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    Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
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    eIF2B localisation and its regulation during the integrated stress response is cell-type specific
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    Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
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  18. Jul 2024
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    Identification of small molecule inhibitors of G3BP-driven stress granule formation
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    Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain
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    CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
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    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    cell.com/cell/fulltext/S0092-8674(24)00693-7
  23. Jun 2024
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    eIF4F complex dynamics are important for the activation of the integrated stress response
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    Nucleolar Localization of the RNA Helicase DDX21 Predicts Survival Outcomes in Gynecologic Cancers
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  26. May 2024
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    Centriolar satellites are sites of translation of centrosomal and ciliary proteins
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  28. Apr 2024
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α
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  31. Mar 2024
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    Xrp1 governs the stress response program to spliceosome dysfunction
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    RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma
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    PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA
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  35. Feb 2024
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    Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation
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  37. Jan 2024
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    Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle
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    FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
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  40. Dec 2023
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    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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    Master transcription factor reprograming unleashes selective translation promoting castration resistance and immune evasion in lethal prostate cancer.
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    cd-23-0306-html.html
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  44. Nov 2023
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    K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
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    CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
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      DOI: 10.1126/sciadv.adf7997

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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
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    ncbi.nlm.nih.gov/pmc/articles/PMC10637751/
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    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
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    sciencedirect.com/science/article/pii/S2211124723013931
  49. Oct 2023
  50. www.sciencedirect.com www.sciencedirect.com
    ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteostasis is differentially modulated by inhibition of translation initiation or elongation
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      DOI: 10.7554/eLife.76465

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    ncbi.nlm.nih.gov/pmc/articles/PMC10581687/
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  53. Sep 2023
  54. www.nature.com www.nature.com
    A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
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      DOI: 10.1038/s41467-023-40798-6

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    nature.com/articles/s41467-023-40798-6
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    Autophagy-mediated surveillance of Rim4-mRNA interaction safeguards programmed meiotic translation
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  56. Aug 2023
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival.
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue
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  61. Jul 2023
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice
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    NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer
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    Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape
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    Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration
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  66. Jun 2023
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    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
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    Circadian clocks are modulated by compartmentalized oscillating translation
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.
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  71. May 2023
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    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
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    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  75. Apr 2023
  76. www.sciencedirect.com www.sciencedirect.com
    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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  77. europepmc.org europepmc.org
    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    Xrp1 governs the stress response program to spliceosome dysfunction
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  79. Mar 2023
  80. www.sciencedirect.com www.sciencedirect.com
    Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity
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    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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    The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation
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    Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss
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    METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2
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  87. Feb 2023
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    Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein
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    N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis
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    Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
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    Endoplasmic reticulum associated degradation is essential for maintaining the viability or function of mature myelinating cells in adults
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  92. Jan 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma
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    METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
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    Axonal plasticity in response to active forces generated through magnetic nano-pulling
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  97. Nov 2022
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    m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation
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    Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
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  100. Oct 2022
  101. elifesciences.org elifesciences.org
    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities
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  103. Jul 2022
  104. www.sciencedirect.com www.sciencedirect.com
    Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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  123. Nov 2021
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    The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
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    A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2′3′-cGAMP
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    Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation
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    Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation
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  158. Apr 2021
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    Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  161. Feb 2021
  162. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Bicuculline regulated protein synthesis is dependent on homer1 and promotes its interaction with eEF2K through mTORC1 dependent phosphorylation
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      DOI: 10.1111/jnc.15178

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  163. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  164. Jan 2021
  165. www.jneurosci.org www.jneurosci.org
    The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation
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  166. Dec 2020
  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation in amino-acid-poor environments is limited by tRNAGln charging
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes
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  170. Nov 2020
  171. www.sciencedirect.com www.sciencedirect.com
    ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B
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  172. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4‐2 in Translational Suppression During ER Stress
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  173. Sep 2020
  174. www.sciencedirect.com www.sciencedirect.com
    Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity
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    Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes
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    The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress
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    Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
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  178. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression
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      DOI: 10.1158/0008-5472.CAN-19-3914

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    ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
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    RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
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  181. www.cell.com www.cell.com
    Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
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    Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development
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    Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
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      DOI: 10.1016/j.neuron.2020.01.020

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    UBAP2L Forms Distinct Cores that Act in Nucleating Stress Granules Upstream of G3BP1
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  186. www.pnas.org www.pnas.org
    Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway
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      DOI: 10.1073/pnas.2002427117

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    Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila
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  188. journals.physiology.org journals.physiology.org
    Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes | American Journal of Physiology-Cell Physiology
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    Redefining Single-Trial Memories in the Honeybee
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      Mouse monoclonal anti-puromycin (clone 12D10)

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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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  191. Jan 2020
  192. www.sciencedirect.com www.sciencedirect.com
    Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC
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    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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    Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response
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    CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation
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    The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma
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  197. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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      DOI: 10.1038/s41467-019-13086-5

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    On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
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    An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development
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    Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21
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    Interleukin‐8 enhances myocilin expression, Akt‐FoxO3 signaling and myogenic differentiation in rat skeletal muscle cells
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    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
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    Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome
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    Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy
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    Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function
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    Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice
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    The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity
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    Impaired Eukaryotic Translation Initiation Factor 2B Activity Specifically in Oligodendrocytes Reproduces the Pathology of Vanishing White Matter Disease in Mice
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