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CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

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1. scibot 01 Aug 2026
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.cell.2026.07.016
  
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sciencedirect.com/science/article/pii/S0092867426008147
Jul 2026
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LEF1 and niche factors determine T cell stemness across chronic diseases

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1. scibot 04 Jul 2026
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.cell.2026.06.022
  
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sciencedirect.com/science/article/pii/S0092867426007099
May 2026
aacrjournals.org aacrjournals.org

IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma

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1. scibot 05 May 2026
  
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  AB_2571953
  
  DOI: 10.1158/2326-6066.CIR-25-0651
  
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aacrjournals.org/cancerimmunolres/article/14/5/751/784456/IL1R2-Deficiency-Unleashes-Neutrophil-Mediated
Apr 2026
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Requirements for development of T helper 1 and T follicular helper cells from a common precursor

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1. scibot 24 Apr 2026
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.celrep.2026.117296
  
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sciencedirect.com/science/article/pii/S2211124726003748
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

1
1. scibot 09 Apr 2026
  
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  AB_2571953
  
  DOI: 10.1158/1078-0432.CCR-24-3455
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13056295/
Mar 2026
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Nasal RNA-scaffold-protein vaccine protects mice from human H5N1 clade 2.3.4.4b virus lethal infection and safeguards against vaccine-unmatched viruses

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1. scibot 24 Mar 2026
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.ebiom.2026.106228
  
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sciencedirect.com/science/article/pii/S2352396426001106
Sep 2025
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Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

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1. scibot 27 Sep 2025
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2025.09.003
  
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sciencedirect.com/science/article/pii/S1074761325004145
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Bivalent mRNA vaccine booster enhances immunity against XBB.1.5 more effectively than breakthrough infection in K18-hACE2 mice

1
1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.isci.2025.113479
  
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sciencedirect.com/science/article/pii/S2589004225017407
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T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function

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1. scibot 17 Sep 2025
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.celrep.2025.116302
  
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sciencedirect.com/science/article/pii/S2211124725010733
Jul 2025
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Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

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1. scibot 25 Jul 2025
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.ccell.2025.07.001
  
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sciencedirect.com/science/article/pii/S1535610825002727
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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.006
  
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sciencedirect.com/science/article/pii/S1074761325002754
Jun 2025
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Gene-regulatory programs that specify age-related differences during thymocyte development

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1. scibot 26 Jun 2025
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.celrep.2025.115903
  
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sciencedirect.com/science/article/pii/S2211124725006746
May 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225007692-main-html.html

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1. scibot 18 May 2025
  
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  AB_2571953
  
  DOI: 10.1016/j.isci.2025.112508
  
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52.53.155.43/bf6cba30678d0d150a13cbeb68660b4f11367a41/1-s2.0-S2589004225007692-main-html.html
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Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies

1
1. scibot 17 May 2025
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2025.03.021
  
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sciencedirect.com/science/article/pii/S1074761325001621
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

1
1. scibot 13 Feb 2025
  
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  AB_2571953
  
  DOI: 10.1126/scitranslmed.adj9366
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
Dec 2024
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Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion

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1. scibot 28 Dec 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2024.11.026
  
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sciencedirect.com/science/article/pii/S1074761324005417
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Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence

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1. scibot 21 Dec 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2024.11.007
  
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sciencedirect.com/science/article/pii/S1074761324005223
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Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes

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1. scibot 21 Dec 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.cell.2024.11.031
  
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sciencedirect.com/science/article/pii/S0092867424013473
52.53.155.43 52.53.155.43

Heightened Innate Immune State Induced by Viral Vector Leads to Enhanced Response to Challenge and Prolongs Malaria Vaccine Protection

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1. scibot 06 Dec 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.isci.2024.111468
  
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52.53.155.43/f4fd647defec02b27a99572a8bdfe7f7e8766183/1-s2.0-S2589004224026956-main-html.html
Aug 2024
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

1
1. scibot 20 Aug 2024
  
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  AB_2571953
  
  DOI: 10.1016/j.cell.2024.07.018
  
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sciencedirect.com/science/article/pii/S0092867424007785
May 2024
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.025
  
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sciencedirect.com/science/article/pii/S1074761324002309
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Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

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1. scibot 17 May 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.ccell.2024.04.011
  
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sciencedirect.com/science/article/pii/S1535610824001351
Mar 2024
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Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment

2
1. scibot 15 Mar 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.cmet.2024.02.009
  
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2. scibot 15 Mar 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.cmet.2024.02.009
  
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sciencedirect.com/science/article/pii/S155041312400055X
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SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions

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1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.011
  
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2. scibot 08 Mar 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.ccell.2024.02.011
  
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sciencedirect.com/science/article/pii/S1535610824000552
Jan 2024
aacrjournals.org aacrjournals.org

Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

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1. scibot 11 Jan 2024
  
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  RRID:AB_2571953
  
  DOI: 10.1158/2159-8290.CD-22-1301
  
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aacrjournals.org/cancerdiscovery/article/13/12/2566/731588/Formate-Supplementation-Enhances-Antitumor-CD8-T
Dec 2023
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The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

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1. scibot 20 Dec 2023
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.celrep.2023.113516
  
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sciencedirect.com/science/article/pii/S2211124723015280
52.53.155.43 52.53.155.43

cd-22-1301-html.html

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  DOI: 10.1158/2159-8290.cd-22-1301
  
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52.53.155.43/ed2c7eab61775ee4a9efbdfa91d6b4b18a13354a/cd-22-1301-html.html
Oct 2023
52.53.155.43 52.53.155.43

Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors

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1. scibot 14 Oct 2023
  
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  RRID:AB_2571953
  
  DOI: 10.1101/2023.08.11.553007
  
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52.53.155.43/7eb24570d443d458f8fd7700f91970ed0d945838/2023.08.11.553007v1.full-html.html
Aug 2023
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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade

1
1. scibot 03 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112905
  
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sciencedirect.com/science/article/pii/S2211124723009166
Jun 2023
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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells

1
1. scibot 23 Jun 2023
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2023.05.008
  
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sciencedirect.com/science/article/pii/S107476132300225X
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Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation

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1. scibot 01 Jun 2023
  
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  DOI: 10.1016/j.immuni.2023.05.004
  
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sciencedirect.com/science/article/pii/S1074761323002212
May 2023
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Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

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1. scibot 11 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112472
  
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sciencedirect.com/science/article/pii/S2211124723004837
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M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

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1. scibot 03 May 2023
  
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  DOI: 10.1016/j.immuni.2023.04.002
  
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sciencedirect.com/science/article/pii/S107476132300170X
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory

1
1. scibot 05 Apr 2023
  
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  RRID:AB_2571953
  
  DOI: 10.1126/sciimmunol.abq7432
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9835709/
Mar 2023
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Original research: Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy

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  DOI: 10.1136/jitc-2022-006433
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10016286/
Feb 2023
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OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

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  DOI: 10.1016/j.xcrm.2023.100939
  
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sciencedirect.com/science/article/pii/S2666379123000319
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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

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  DOI: 10.1016/j.cell.2022.12.038
  
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sciencedirect.com/science/article/pii/S0092867422015811
Jan 2023
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Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.immuni.2022.12.007
  
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sciencedirect.com/science/article/pii/S1074761322006434
Dec 2022
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Stress-mediated attenuation of translation undermines T-cell activity in cancer

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  DOI: 10.1158/0008-5472.CAN-22-1744
  
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aacrjournals.org/cancerres/article/82/23/4386/710692/Stress-Mediated-Attenuation-of-Translation
52.53.155.43 52.53.155.43

can-22-1744-html.html

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  DOI: 10.1158/0008-5472.can-22-1744
  
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52.53.155.43/ad84fbadafd7207ef01b11f7e83790e81459d855/can-22-1744-html.html
Oct 2022
52.53.155.43 52.53.155.43

IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation

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1. scibot 27 Oct 2022
  
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  DOI: 10.1101/2021.08.20.21261620
  
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52.53.155.43/62b31cea1ac090bac2ebe32e4dfd3474fee27f84/2021.08.20.21261620v1.full-html.html
Aug 2022
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Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

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1. scibot 26 Aug 2022
  
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  DOI: 10.1016/j.immuni.2022.07.019
  
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sciencedirect.com/science/article/pii/S1074761322003545
Nov 2021
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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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1. scibot 30 Nov 2021
  
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  DOI: 10.1016/j.immuni.2021.11.002
  
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sciencedirect.com/science/article/pii/S1074761321004933
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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

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1. scibot 17 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.110013
  
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sciencedirect.com/science/article/pii/S2211124721014959
Sep 2021
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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  DOI: 10.1016/j.cell.2021.08.020
  
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sciencedirect.com/science/article/pii/S0092867421009946
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Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

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1. scibot 17 Sep 2021
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2021.08.026
  
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sciencedirect.com/science/article/pii/S1074761321003605
May 2021
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Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

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1. scibot 12 May 2021
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.celrep.2021.109120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8195461/
Apr 2021
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Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

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1. scibot 17 Apr 2021
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.ccell.2020.05.004
  
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sciencedirect.com/science/article/pii/S1535610820302543
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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

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1. scibot 11 Apr 2021
  
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  DOI: 10.1016/j.cell.2021.02.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8054351/
Oct 2020
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In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells

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1. scibot 31 Oct 2020
  
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  DOI: 10.1016/j.celrep.2020.108320
  
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sciencedirect.com/science/article/pii/S2211124720313097
Sep 2020
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

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1. scibot 16 Sep 2020
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.celrep.2020.107827
  
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sciencedirect.com/science/article/pii/S2211124720308081
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Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

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1. scibot 08 Sep 2020
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2019.01.004
  
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cell.com/immunity/abstract/S1074-7613(19)30004-4
Jan 2020
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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

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1. scibot 13 Jan 2020
  
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  RRID:AB_2571953
  
  DOI: 10.1016/j.immuni.2019.09.013
  
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sciencedirect.com/science/article/pii/S1074761319304091
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Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.08.038
  
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sciencedirect.com/science/article/pii/S2211124719310782
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Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.02.034
  
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sciencedirect.com/science/article/pii/S2211124719302050
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Untitled document

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  DOI: 10.1016/j.immuni.2019.01.004
  
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sciencedirect.com/science/article/pii/S1074761319300044
Nov 2018
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T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761318300360