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Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117188
  
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sciencedirect.com/science/article/pii/S2211124726002664
Mar 2026
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Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.03.004
  
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sciencedirect.com/science/article/pii/S153561082600156X
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Distinct Tumor Infiltrating Immune Cell Profiles in Mice by Non-Steroidal Anti-Inflammatory Drugs (Aspirin and Naproxen) During TMPRSS2-ERG (Fusion)-Driven and Non-Fusion Driven Prostate Cancer

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1. scibot 03 Mar 2026
  
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  RRID:AB_2572861E
  
  DOI: 10.1002/mc.70099
  
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  Curator: @dhovakimyan1
  
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onlinelibrary.wiley.com/doi/10.1002/mc.70099
Nov 2025
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Monocyte-derived cells promote transient insult-induced brain injury by enhancing CD8+ T cell response

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116528
  
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sciencedirect.com/science/article/pii/S2211124725012999
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

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1. scibot 25 Oct 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618275/
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Non-cell-autonomous tumor promotion in DICER1 cancer predisposition

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.devcel.2025.09.001
  
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sciencedirect.com/science/article/pii/S1534580725005398
Sep 2025
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Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116233
  
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sciencedirect.com/science/article/pii/S2211124725010046
Aug 2025
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The absence of IL17A favours cytotoxic cell function and improves antigen-specific immunotherapies in pancreatic adenocarcinoma

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1. scibot 21 Aug 2025
  
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  RRID:AB_2572861
  
  DOI: 10.1002/ctm2.70442
  
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onlinelibrary.wiley.com/doi/10.1002/ctm2.70442
Jul 2025
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Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors

1
1. scibot 22 Jul 2025
  
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  RRID:AB_2572861
  
  DOI: 10.1126/sciadv.adw5228
  
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science.org/doi/10.1126/sciadv.adw5228
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Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

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1. scibot 01 Jul 2025
  
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  AB_2572861
  
  DOI: 10.1038/s43018-024-00775-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12204312/
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S258900422500625X-main-html.html

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1. scibot 17 Apr 2025
  
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  AB_2572861
  
  DOI: 10.1016/j.isci.2025.112364
  
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52.53.155.43/910d735d2d974315eeec93884560c504f16aaecd/1-s2.0-S258900422500625X-main-html.html
Jan 2025
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Tumor Microenvironment Reprogramming Improves Nanomedicine-Based Chemo-Immunotherapy in Sarcomas

1
1. scibot 30 Jan 2025
  
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  RRID: AB_2572861
  
  DOI: 10.1158/1535-7163.MCT-23-0772
  
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  Curator: @areedewitt04
  
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aacrjournals.org/mct/article/23/11/1555/749318/Tumor-Microenvironment-Reprogramming-Improves
Sep 2024
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In vivo DNA replication dynamics unveil aging-dependent replication stress

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.cell.2024.08.034
  
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sciencedirect.com/science/article/pii/S0092867424009632
Jul 2024
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CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis

1
1. scibot 18 Jul 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1158/1078-0432.CCR-23-0433
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10872577/
Jun 2024
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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

1
1. scibot 21 Jun 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.cell.2024.05.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
May 2024
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Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

1
1. scibot 17 May 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.ccell.2024.04.011
  
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sciencedirect.com/science/article/pii/S1535610824001351
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Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer

1
1. scibot 16 May 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.immuni.2024.04.021
  
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sciencedirect.com/science/article/pii/S1074761324002267
Apr 2024
aacrjournals.org aacrjournals.org

Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

1
1. scibot 19 Apr 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1158/0008-5472.CAN-23-1542
  
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aacrjournals.org/cancerres/article/84/4/527/734130/Mesothelin-Secretion-by-Pancreatic-Cancer-Cells-Co
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CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer

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1. scibot 12 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101479
  
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sciencedirect.com/science/article/pii/S2666379124001253
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation

1
1. scibot 27 Mar 2024
  
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  RRID_2572861
  
  DOI: 10.1016/j.isci.2024.109439
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10957412/
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.013
  
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sciencedirect.com/science/article/pii/S1535610824000576
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NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

2
1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113898
  
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2. scibot 06 Mar 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.celrep.2024.113898
  
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sciencedirect.com/science/article/pii/S2211124724002262
Feb 2024
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THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1

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1. scibot 13 Feb 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.celrep.2024.113773
  
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2. scibot 13 Feb 2024
  
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  RRID:AB_2572861
  
  DOI: 10.1016/j.celrep.2024.113773
  
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sciencedirect.com/science/article/pii/S2211124724001013
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Preclinical characterization and phase 1 results of ADG106 in patients with advanced solid tumors and non-Hodgkin’s lymphoma

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.xcrm.2024.101414
  
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sciencedirect.com/science/article/pii/S2666379124000375
Dec 2023
www.cell.com www.cell.com

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice

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1. scibot 19 Dec 2023
  
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  DOI: 10.1016/j.devcel.2023.11.013
  
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cell.com/developmental-cell/fulltext/S1534-5807(23)00611-1
May 2023
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Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population

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1. scibot 13 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112501
  
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sciencedirect.com/science/article/pii/S2211124723005120
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MTHFD2 reprograms macrophage polarization by inhibiting PTEN

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1. scibot 11 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112481
  
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sciencedirect.com/science/article/pii/S2211124723004928
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Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

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1. scibot 11 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112472
  
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sciencedirect.com/science/article/pii/S2211124723004837
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Immune mechanisms shape the clonal landscape during early progression of prostate cancer

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1. scibot 06 May 2023
  
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  DOI: 10.1016/j.devcel.2023.04.010
  
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sciencedirect.com/science/article/pii/S1534580723001806
Apr 2023
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ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer

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1. scibot 13 Apr 2023
  
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  DOI: 10.1016/j.devcel.2023.03.015
  
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sciencedirect.com/science/article/pii/S1534580723001314
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A neutrophil response linked to tumor control in immunotherapy

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1. scibot 04 Apr 2023
  
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  DOI: 10.1016/j.cell.2023.02.032
  
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sciencedirect.com/science/article/pii/S0092867423002106
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy

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1. scibot 18 Mar 2023
  
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  RRID:AB_2572861
  
  DOI: 10.1136/jitc-2022-006433
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10016286/
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

1
1. scibot 10 Feb 2023
  
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  RRID:AB_2572861
  
  DOI: 10.1158/2159-8290.CD-22-0528
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9901536/
Jan 2023
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RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer

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MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

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Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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Spatial CRISPR genomics identifies regulators of the tumor microenvironment

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Tumor-derived Jagged1 promotes cancer progression through immune evasion

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A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells

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Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

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Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

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Untitled document

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Untitled document

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Extracellular Vesicle‐Based Therapeutic Targeting of β‐Catenin to Modulate Anticancer Immune Responses in Hepatocellular Cancer

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Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells

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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

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Jun 2021
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Exposure to propylparaben during pregnancy and lactation induces long-term alterations to the mammary gland in mice

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Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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Feb 2021
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

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  DOI: 10.1038/s41467-019-10676-1
  
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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

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Untitled document

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