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  1. Last 7 days
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    Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
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    sciencedirect.com:5037/science/article/pii/S2666379125006081
  3. Jun 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181884/
  5. Feb 2025
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    BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0896627325000789
  7. 52.53.155.43 52.53.155.43
    Aβ*56 is present in brain extracts enriched for extracellular proteins
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    52.53.155.43/5022ef88225079005eaf0260a87b9aed0103ea21/2024.10.09.617424v1.full-html.html
  8. 52.53.155.43 52.53.155.43
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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    52.53.155.43/ccdd8f2b9b0076ccdaf42c273b248e5adbb5da1d/2024.09.09.611621v1.full-html.html
  9. Dec 2024
  10. molecularneurodegeneration.biomedcentral.com molecularneurodegeneration.biomedcentral.com
    Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
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    molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-024-00759-z
  11. Aug 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology, cognition, and behavior in APP/PS1 mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11317949/
  13. Jun 2024
  14. www.sciencedirect.com www.sciencedirect.com
    STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells
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    sciencedirect.com/science/article/pii/S0014488624001316
  15. Jan 2024
  16. www.jneurosci.org www.jneurosci.org
    Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
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    jneurosci.org/content/43/50/8812
  17. Oct 2023
  18. www.science.org www.science.org
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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    science.org/doi/10.1126/sciadv.abo3610
  19. Sep 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10476643/
  21. Aug 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S1550413123002735
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    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
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    sciencedirect.com/science/article/pii/S2211124723010057
  24. 52.53.155.43 52.53.155.43
    JNEUROSCI.2124-22.2023.full-html.html
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  25. May 2023
  26. journals.biologists.com journals.biologists.com
    Presenilin enhancer2 is critical for the transition of apical progenitors to neurons but not basal progenitors in the developing hippocampus
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    journals.biologists.com/dev/article/149/10/dev200272/275554/Presenilin-enhancer-2-is-crucial-for-the
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
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    ncbi.nlm.nih.gov/pmc/articles/PMC10161466/
  28. 52.53.155.43 52.53.155.43
    Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model
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  29. Mar 2023
  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15750
  31. Dec 2022
  32. link.springer.com link.springer.com
    The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities
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    link.springer.com/article/10.1007/s12035-022-03153-2
  33. Nov 2022
  34. www.researchsquare.com www.researchsquare.com
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    researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
  35. Oct 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology
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    sciencedirect.com/science/article/pii/S1044743122000914
  37. Sep 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
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    sciencedirect.com/science/article/pii/S2211124722012748
  39. Aug 2022
  40. journals.lww.com journals.lww.com
    Proteomics of serum exosomes identified fibulin-1 as a... : Neural Regeneration Research
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    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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    ncbi.nlm.nih.gov/pmc/articles/PMC9299535/
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Inhibition of PDK1 Robustly Reduces Plaque Deposition and Ameliorates Gliosis in the 5×FAD Mouse Model of Alzheimer’s Disease
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    onlinelibrary.wiley.com/doi/10.1111/nan.12839
  43. Jul 2022
  44. www.sciencedirect.com www.sciencedirect.com
    Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice
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    sciencedirect.com/science/article/pii/S2211124722008609
  45. Apr 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid
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    ncbi.nlm.nih.gov/pmc/articles/PMC8990972/
  47. Jan 2022
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC8758496/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
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    ncbi.nlm.nih.gov/pmc/articles/PMC8742943/
  50. Oct 2021
  51. www.sciencedirect.com www.sciencedirect.com
    Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice
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    sciencedirect.com/science/article/pii/S2211124721013590
  52. Aug 2021
  53. www.jneurosci.org www.jneurosci.org
    Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system
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    jneurosci.org/content/41/23/4976
  54. www.fasebj.org www.fasebj.org
    Untitled document
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    fasebj.org/doi/abs/10.1096/fj.201801319R
  55. Apr 2021
  56. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    TUFM is involved in Alzheimer’s disease‐like pathologies that are associated with ROS
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202002461R
  57. Feb 2021
  58. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15184
  59. Dec 2020
  60. www.cell.com www.cell.com
    APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival
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    cell.com/neuron/abstract/S0896-6273(20)30642-5
  61. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of truncated C‐terminal fragments of the Alzheimer’s disease amyloid protein precursor derived from sequential proteolytic pathways
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15143
  62. Sep 2020
  63. www.sciencedirect.com www.sciencedirect.com
    NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation
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    sciencedirect.com/science/article/pii/S2211124720302278
  64. www.sciencedirect.com www.sciencedirect.com
    Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity
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    sciencedirect.com/science/article/pii/S2451945620301070
  65. link.springer.com link.springer.com
    Cognitive Decline and Modulation of Alzheimer’s Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons
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    link.springer.com/article/10.1007/s12035-020-01957-8
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BPS Publications
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    pmc.ncbi.nlm.nih.gov/articles/PMC7161547/
  67. www.jneurosci.org www.jneurosci.org
    A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance
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    jneurosci.org/content/40/28/5347
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC6683996/
  69. Jan 2020
  70. www.jneurosci.org www.jneurosci.org
    Neural stem cells of the subventricular zone contribute to neuroprotection of the corpus callosum after cuprizone-induced demyelination
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    jneurosci.org/content/39/28/5481
  71. Nov 2018
  72. www.sciencedirect.com www.sciencedirect.com
    Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin
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    sciencedirect.com/science/article/pii/S1534580718304982
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The non‐peptidic δ‐opioid receptor agonist Tan‐67 mediates neuroprotection post‐ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14265/full
  74. Nov 2017
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer’s brains
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    ncbi.nlm.nih.gov/pmc/articles/PMC5522448/
  76. www.jneurosci.org www.jneurosci.org
    Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model
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    jneurosci.org/content/37/20/5099
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23880/full
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of RTN3 Deficiency on Expression of BACE1 and Amyloid Deposition
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    ncbi.nlm.nih.gov/pmc/articles/PMC4198539/