98 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes
    1
    1. scibot 18 Jul 2024
      RRID:AB_259852

      DOI: 10.1016/j.celrep.2024.114346

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    ncbi.nlm.nih.gov/pmc/articles/PMC11251461/
  3. Jul 2024
  4. www.biorxiv.org www.biorxiv.org
    HumanIslets: An integrated platform for human islet data access and analysis
    1
    1. scibot 04 Jul 2024
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      DOI: 10.1101/2024.06.19.599613

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    biorxiv.org/content/10.1101/2024.06.19.599613v1
  5. Jun 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
    1
    1. scibot 13 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114047

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    ncbi.nlm.nih.gov/pmc/articles/PMC11164428/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3D Model of Mouse Embryonic Pancreas and Endocrine Compartment using Stem Cell-Derived Mesoderm and Pancreatic Progenitors
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1016/j.isci.2024.109959

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    ncbi.nlm.nih.gov/pmc/articles/PMC11144751/
  8. May 2024
  9. www.biorxiv.org www.biorxiv.org
    Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice
    1
    1. scibot 03 May 2024
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      DOI: 10.1101/2024.04.18.590140

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    biorxiv.org/content/10.1101/2024.04.18.590140v1
  10. Apr 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets
    1
    1. scibot 23 Apr 2024
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      DOI: 10.1016/j.isci.2024.109665

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    ncbi.nlm.nih.gov/pmc/articles/PMC11033163/
  12. www.sciencedirect.com www.sciencedirect.com
    Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep
    2
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.mce.2024.112234

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    sciencedirect.com/science/article/pii/S030372072400090X
  13. Dec 2023
  14. www.sciencedirect.com www.sciencedirect.com
    HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes
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    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.isci.2023.108694

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    sciencedirect.com/science/article/pii/S2589004223027712
  15. Oct 2023
  16. 52.53.155.43 52.53.155.43
    Real time quantification of apical polarity protein reveals novel dynamic processes in lumenal network establishment and remodeling in the pancreas
    1
    1. scibot 20 Oct 2023
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      DOI: 10.1101/2023.08.18.552936

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    52.53.155.43/0f0c4ae0aee27ebce60b7f3eb3f3d73940a644d7/2023.08.18.552936v1.full-html.html
  17. elifesciences.org elifesciences.org
    Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
    1
    1. scibot 14 Oct 2023
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      DOI: 10.7554/eLife.85056

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    elifesciences.org/articles/85056
  18. Sep 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation
    1
    1. scibot 08 Sep 2023
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      DOI: 10.7554/eLife.90006

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    ncbi.nlm.nih.gov/pmc/articles/PMC10482429/
  20. Aug 2023
  21. 52.53.155.43 52.53.155.43
    mmc2-html.html
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    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112970

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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic regional blood flow links the endocrine and exocrine diseases
    1
    1. scibot 02 Aug 2023
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      DOI: 10.1172/JCI166185

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    ncbi.nlm.nih.gov/pmc/articles/PMC10378168/
  23. Jul 2023
  24. 52.53.155.43 52.53.155.43
    166185.1-20230616131205-covered-e0fd13ba177f913fd3156f593ead4cfd-html.html
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    52.53.155.43/e97b662a678dd51229e49ceeba372ba9c90e51fe/166185.1-20230616131205-covered-e0fd13ba177f913fd3156f593ead4cfd-html.html
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inferring regulators of cell identity in the human adult pancreas
    1
    1. scibot 12 Jul 2023
      RRID:AB_259852

      DOI: 10.1093/nargab/lqad068

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    ncbi.nlm.nih.gov/pmc/articles/PMC10331937/
  26. May 2023
  27. 52.53.155.43 52.53.155.43
    The Loss of the E3 ubiquitin ligase TRIP12 inhibits Pancreatic Acinar Cell Plasticity and Tumor Cell Metastatic Capacity
    1
    1. scibot 27 May 2023
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      DOI: 10.1101/2023.03.08.531649

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    52.53.155.43/6e2172d18fa8c7257d2eb14576d421f7e6cd64f6/2023.03.08.531649v1.full-html.html
  28. academic.oup.com academic.oup.com
    Biosynthetic activity differs between islet cell types and in beta cells is modulated by glucose and not by secretion
    1
    1. scibot 12 May 2023
      RRID:AB_259852

      DOI: 10.1210/endocr/bqaa239

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    academic.oup.com/endo/article/162/3/bqaa239/6047597
  29. www.sciencedirect.com www.sciencedirect.com
    Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system
    1
    1. scibot 06 May 2023
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      DOI: 10.1016/j.crmeth.2023.100466

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    sciencedirect.com/science/article/pii/S2667237523000851
  30. Apr 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes
    1
    1. scibot 12 Apr 2023
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      DOI: 10.1016/j.devcel.2023.03.011

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    sciencedirect.com/science/article/pii/S1534580723001077
  32. Mar 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Protocol to generate human pluripotent stem cell-derived pancreatic β cells through methionine and zinc deprivation
    1
    1. scibot 28 Mar 2023
      RRID:AB_259852

      DOI: 10.1016/j.xpro.2023.102183

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    sciencedirect.com/science/article/pii/S2666166723001417
  34. link.springer.com link.springer.com
    Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
    1
    1. scibot 16 Mar 2023
      RRID:AB_259852

      DOI: 10.1007/s00125-023-05900-z

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    link.springer.com/article/10.1007/s00125-023-05900-z
  35. Feb 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking
    1
    1. scibot 01 Feb 2023
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      DOI: 10.1016/j.isci.2023.105938

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883185/
  37. Jan 2023
  38. diabetesjournals.org diabetesjournals.org
    GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress
    1
    1. scibot 21 Jan 2023
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      DOI: 10.2337/db22-0326

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    diabetesjournals.org/diabetes/article/72/2/275/147957/GC-Globulin-Vitamin-D-Binding-Protein-Is-Required
  39. Oct 2022
  40. academic.oup.com academic.oup.com
    Alpha cell TXNIP deletion improves diabetes-associated hyperglycemia and hyperglucagonemia
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    1. scibot 29 Oct 2022
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      DOI: 10.1210/endocr/bqac133

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    academic.oup.com/endo/article/163/11/bqac133/6661779
  41. www.sciencedirect.com www.sciencedirect.com
    BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass
    1
    1. scibot 15 Oct 2022
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      DOI: 10.1016/j.cmet.2022.09.001

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    sciencedirect.com/science/article/pii/S1550413122003916
  42. Aug 2022
  43. academic.oup.com academic.oup.com
    Circulating 1,5-anhydroglucitol as a biomarker of ß-cell mass independent of a diabetes phenotype in human subjects
    1
    1. scibot 13 Aug 2022
      RRID:AB_259852

      DOI: 10.1210/clinem/dgac444

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac444/6648530
  44. www.sciencedirect.com www.sciencedirect.com
    The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells
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    1. scibot 10 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111170

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    sciencedirect.com/science/article/pii/S2211124722009834
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optical Clearing and 3D Analysis Optimized for Mouse and Human Pancreata
    2
    1. scibot 06 Aug 2022
      AB_259852

      DOI: 10.21769/BioProtoc.4103

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    2. scibot 06 Aug 2022
      AB_259852

      DOI: 10.21769/BioProtoc.4103

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    ncbi.nlm.nih.gov/pmc/articles/PMC8376577/
  46. Jul 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization
    1
    1. scibot 27 Jul 2022
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      DOI: 10.1016/j.celrep.2022.111120

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    sciencedirect.com/science/article/pii/S2211124722009263
  48. Jun 2022
  49. www.sciencedirect.com www.sciencedirect.com
    Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice
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    1. scibot 25 Jun 2022
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      DOI: 10.1016/j.isci.2022.104567

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    sciencedirect.com/science/article/pii/S2589004222008392
  50. www.sciencedirect.com www.sciencedirect.com
    Glucagon-receptor-antagonism-mediated β-cell regeneration as an effective anti-diabetic therapy
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    1. scibot 03 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110872

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    sciencedirect.com/science/article/pii/S2211124722006477
  51. Feb 2022
  52. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells
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      DOI: 10.1016/j.celrep.2022.110377

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    pubmed.ncbi.nlm.nih.gov/35172145/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
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      DOI: 10.1038/s42255-021-00432-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC7611554/
  54. www.sciencedirect.com www.sciencedirect.com
    Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state
    3
    1. scibot 02 Feb 2022
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      DOI: 10.1016/j.cmet.2021.12.021

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      DOI: 10.1016/j.cmet.2021.12.021

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    sciencedirect.com/science/article/pii/S1550413121006859
  55. Jan 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Prenatal development of sympathetic innervation of the human pancreas
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    1. scibot 27 Jan 2022
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      DOI: 10.1016/j.aanat.2021.151880

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    sciencedirect.com/science/article/pii/S0940960221002065
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental Timing of High Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner
    1
    1. scibot 05 Jan 2022
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      DOI: 10.2337/db21-0310

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    ncbi.nlm.nih.gov/pmc/articles/PMC8660987/
  58. Dec 2021
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Two-Week Insulin Infusion in Intrauterine Growth Restricted Fetal Sheep at 75% Gestation Increases Skeletal Myoblast Replication but Did Not Restore Muscle Mass or Increase Fiber Number
    1
    1. scibot 17 Dec 2021
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      DOI: 10.3389/fendo.2021.785242

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  60. www.sciencedirect.com www.sciencedirect.com
    Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes
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    Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells
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  62. Nov 2021
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    Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice
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  64. Oct 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
    1
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  66. Sep 2021
  67. www.sciencedirect.com www.sciencedirect.com
    An INSULIN-GFP / GLUCAGON-mCherry reporter line for the study of human pancreatic endocrine cell development
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    Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
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  69. Aug 2021
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    Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  74. academic.oup.com academic.oup.com
    Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish
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  76. Jul 2021
  77. www.nature.com www.nature.com
    Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
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  78. www.sciencedirect.com www.sciencedirect.com
    PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq
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    Increased Chromogranin A–Positive Hormone-Negative Cells in Chronic Pancreatitis
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    Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
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  82. www.nature.com www.nature.com
    Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats
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  83. Jun 2021
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    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
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  85. May 2021
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    Prolonged Low-Dose Dioxin Exposure Impairs Metabolic Adaptability to High-Fat Diet Feeding in Female but Not Male Mice
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    A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line
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  88. Apr 2021
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    Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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  91. Feb 2021
  92. www.nature.com www.nature.com
    PDX1 LOW MAFA LOW β-cells contribute to islet function and insulin release
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      DOI: 10.1038/s41467-020-20632-z

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  93. Dec 2020
  94. www.sciencedirect.com www.sciencedirect.com
    Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8)
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      RRID:AB_259852

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  95. Oct 2020
  96. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing
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  97. Sep 2020
  98. www.sciencedirect.com www.sciencedirect.com
    ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity
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    Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis
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    Generation of a homozygous ARX nuclear CFP (ARXnCFP/nCFP) reporter human iPSC line (HMGUi001-A-4)
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      DOI: 10.1016/j.scr.2020.101874

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    Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors
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    Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion
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    Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors
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  104. Jan 2020
  105. link.springer.com link.springer.com
    Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes
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    Pancreatic endocrine cell arrangement during human ontogeny
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    Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A
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      DOI: 10.1016/j.stem.2019.07.007

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    Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes
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      DOI: 10.7554/eLife.38519

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    Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
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    PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq
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    sciencedirect.com/science/article/pii/S2211124719300920
  112. link.springer.com link.springer.com
    Pregnancy in human <Emphasis Type="Italic">IAPP</Emphasis> transgenic mice recapitulates beta cell stress in type 2 diabetes
    1
    1. scibot 12 Jan 2020
      RRID:AB_259852

      DOI: 10.1007/s00125-019-4843-z

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  113. Nov 2018
  114. www.sciencedirect.com www.sciencedirect.com
    Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point
    1
    1. scibot 05 Nov 2018
      RRID:AB_259852

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  115. academic.oup.com academic.oup.com
    Untitled document
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    academic.oup.com/endo/article/159/4/1827/4838907
  116. www.sciencedirect.com www.sciencedirect.com
    Immunohistochemical detection of vimentin in pancreatic islet β- and α-cells of macrosomic infants of diabetic and nondiabetic mothers
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    1. scibot 05 Nov 2018
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  117. academic.oup.com academic.oup.com
    Insulin deficient mouse β-cells do not fully mature but can be remedied through insulin replacement by islet transplantation
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    1. scibot 05 Nov 2018
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      Curator: @evieth

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  118. Nov 2017
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes
    2
    1. scibot 08 Nov 2017
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      Curator: @patriciaelyse_

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      Curator: @chewbeccax

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  120. academic.oup.com academic.oup.com
    Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
    1
    1. scibot 08 Nov 2017
      AB_259852 

      Curator: @kaitlinsung

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    academic.oup.com/endo/article/158/8/2503/3861370/Protective-Role-of-Complement-C3-Against-Cytokine
  121. www.sciencedirect.com www.sciencedirect.com
    Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation
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    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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  122. www.sciencedirect.com www.sciencedirect.com
    Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice
    1
    1. scibot 08 Nov 2017
      AB_259852

      Curator: @chewbeccax

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  123. academic.oup.com academic.oup.com
    RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets
    1
    1. scibot 08 Nov 2017
      AB_259852

      Curator: @bandrow

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    academic.oup.com/endo/article/158/4/743/2991881/RNA-Sequencing-Exposes-Adaptive-and-Immune
  124. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
    1
    1. scibot 08 Nov 2017
      AB_259852

      Curator: @gabimpine

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  125. www.sciencedirect.com www.sciencedirect.com
    Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development
    1
    1. scibot 08 Nov 2017
      AB_259852

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S1934590917300012
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development
    1
    1. scibot 08 Nov 2017
      AB_259852

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    ncbi.nlm.nih.gov/pmc/articles/PMC5154760/
  127. www.sciencedirect.com www.sciencedirect.com
    Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
    1
    1. scibot 08 Nov 2017
      AB_259852

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    sciencedirect.com/science/article/pii/S0092867416315239
  128. www.sciencedirect.com www.sciencedirect.com
    Structure of neuro-endocrine and neuro-epithelial interactions in human foetal pancreas
    1
    1. scibot 08 Nov 2017
      AB_259852

      Curator: @gabimpine

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      (Sigma-Aldrich Cat# G2654, RRID:AB_259852)

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    sciencedirect.com/science/article/pii/S0040816616301057