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CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

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1. scibot 01 Aug 2026
  
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  DOI: 10.1016/j.cell.2026.07.016
  
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sciencedirect.com/science/article/pii/S0092867426008147
Jul 2026
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MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion

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1. scibot 14 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.012
  
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sciencedirect.com/science/article/pii/S1074761326002633
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7

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1. scibot 03 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117204
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13222646/
May 2026
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Uncovering spatially resolved functional genomics with CRISPR screen sequencing

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.049
  
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sciencedirect.com/science/article/pii/S0092867426005167
Apr 2026
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Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117303
  
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sciencedirect.com/science/article/pii/S2211124726003815
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

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1. scibot 09 Apr 2026
  
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  DOI: 10.1158/1078-0432.CCR-24-3455
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13056295/
Jan 2026
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Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin

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1. scibot 30 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.043
  
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cell.com/cell/fulltext/S0092-8674(25)01492-8
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

1
1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
Oct 2025
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The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.immuni.2025.09.008
  
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sciencedirect.com/science/article/pii/S1074761325004194
Sep 2025
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CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116316
  
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sciencedirect.com/science/article/pii/S2211124725010873
Aug 2025
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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sciencedirect.com/science/article/pii/S2666379125003854
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.001
  
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sciencedirect.com/science/article/pii/S1074761325002481
May 2025
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Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.030
  
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sciencedirect.com/science/article/pii/S1074761325001931
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PDF-html.html

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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
Dec 2024
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Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion

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1. scibot 28 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.026
  
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sciencedirect.com/science/article/pii/S1074761324005417
Sep 2024
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Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101718
  
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sciencedirect.com/science/article/pii/S2666379124004397
Jul 2024
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Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis

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1. scibot 18 Jul 2024
  
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  DOI: 10.1126/science.adh5548
  
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science.org/doi/10.1126/science.adh5548
May 2024
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IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101567
  
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sciencedirect.com/science/article/pii/S2666379124002593
Mar 2024
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

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1. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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sciencedirect.com/science/article/pii/S1074761324000906
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NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

2
1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113898
  
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  DOI: 10.1016/j.celrep.2024.113898
  
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sciencedirect.com/science/article/pii/S2211124724002262
Feb 2024
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

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1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.011
  
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2. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.011
  
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sciencedirect.com/science/article/pii/S1074761324000360
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Nanosphere pharmacodynamics improves safety of immunostimulatory cytokine therapy

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1. scibot 03 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108836
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10831265/
Oct 2023
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Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors

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1. scibot 14 Oct 2023
  
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  DOI: 10.1101/2023.08.11.553007
  
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2. scibot 14 Oct 2023
  
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  DOI: 10.1101/2023.08.11.553007
  
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52.53.155.43/7eb24570d443d458f8fd7700f91970ed0d945838/2023.08.11.553007v1.full-html.html
Jul 2023
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A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

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1. scibot 14 Jul 2023
  
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  DOI: 10.1016/j.ccell.2023.06.008
  
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sciencedirect.com/science/article/pii/S1535610823002180
Jun 2023
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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.immuni.2023.05.011
  
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sciencedirect.com/science/article/pii/S1074761323002285
Mar 2023
europepmc.org europepmc.org

Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma

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1. scibot 25 Mar 2023
  
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  DOI: 10.1016/j.ccell.2023.03.004
  
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europepmc.org/article/med/36963400
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

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1. scibot 06 Jan 2023
  
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  DOI: 10.1158/2326-6066.CIR-21-0691
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9250641/
Dec 2022
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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.ccell.2022.11.014
  
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sciencedirect.com/science/article/pii/S153561082200561X
Jun 2022
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BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.immuni.2022.05.003
  
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sciencedirect.com/science/article/pii/S1074761322002230
Mar 2022
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Distinct hepatic immunological patterns are associated with the progression or inhibition of hepatocellular carcinoma

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1. scibot 02 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110454
  
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sciencedirect.com/science/article/pii/S2211124722001814
Nov 2021
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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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1. scibot 30 Nov 2021
  
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  DOI: 10.1016/j.immuni.2021.11.002
  
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sciencedirect.com/science/article/pii/S1074761321004933
Jan 2020
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616908
  
  DOI: 10.1016/j.immuni.2019.08.013
  
  Resource: (BioLegend Cat# 119723, RRID:AB_2616908)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2616908
  
  What is this?
  
  RRID:AB_2616908 RRIDCUR:Validated
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Tags

RRIDCUR:Validated

RRID:AB_2616908

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC6903704/
www.sciencedirect.com www.sciencedirect.com

PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2616908
  
  DOI: 10.1016/j.celrep.2019.10.092
  
  Resource: (BioLegend Cat# 119723, RRID:AB_2616908)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2616908
  
  What is this?
  
  RRID:AB_2616908 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:AB_2616908

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124719314147
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2616908
  
  DOI: 10.1016/j.immuni.2019.11.002
  
  Resource: (BioLegend Cat# 119723, RRID:AB_2616908)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2616908
  
  What is this?
  
  RRID:AB_2616908 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:AB_2616908

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC6920571/