135 Matching Annotations
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    IRE1α-XBP1s axis is required for BCG-induced trained immunity against viral infection by inhibiting AHR signaling
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  3. Jul 2025
  4. 52.53.155.43 52.53.155.43
    Maturation of Lipid Metabolism in the Fetal and Newborn Sheep Heart
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    OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression
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    Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart
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    pmc.ncbi.nlm.nih.gov/articles/PMC11380940/
  7. Jun 2025
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    DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
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    TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation
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    Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma
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  11. May 2025
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    Lipid exposure leads to metabolic dysfunction in fetal sheep cardiomyocytes
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    physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70386
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    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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  14. Apr 2025
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    Integrated analysis of transcriptional and metabolic responses to mitochondrial stress
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    TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation
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  17. Mar 2025
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    Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism
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    Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
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  20. Jan 2025
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    Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control
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    sciencedirect.com/science/article/pii/S1534580724007639
  22. Dec 2024
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    Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells
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  24. Oct 2024
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    Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging
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    Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma
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  27. Sep 2024
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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  29. Aug 2024
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    Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315182/
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    BDNF-dependent nano-organization of Neogenin and the WAVE Regulatory Complex promotes actin remodelling in dendritic spines
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  32. Jul 2024
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    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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    miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice
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    Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard
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  36. May 2024
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    Star1 gene mutation reveals the essentiality of 11-ketotestosterone and glucocorticoids for male fertility in Nile Tilapia (Oreochromis niloticus)
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression
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    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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  42. Apr 2024
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    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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  47. Mar 2024
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    Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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  50. Jan 2024
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    Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
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  52. Nov 2023
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    Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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  55. Oct 2023
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    Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase
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    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
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    science.org/doi/10.1126/sciadv.adi5548
  58. Sep 2023
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    Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC
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  60. Aug 2023
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    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
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    Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer
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  63. Jun 2023
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    Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion
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    An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
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  66. May 2023
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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  68. Apr 2023
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation
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  71. Feb 2023
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    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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  73. Jan 2023
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    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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    Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice
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  77. Dec 2022
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    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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  79. Nov 2022
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    R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton
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    Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
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    Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue
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  84. Oct 2022
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    Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities
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  86. Aug 2022
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    An anillin-CIN85-SEPT9 complex promotes intercellular bridge maturation required for successful cytokinesis
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    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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    LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response
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  90. Jul 2022
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    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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  93. Jun 2022
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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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  96. May 2022
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    Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue
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  98. Apr 2022
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  100. Mar 2022
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    Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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  103. Feb 2022
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    Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways
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  105. Jan 2022
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    Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation
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  107. Dec 2021
  108. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty-acid metabolism genes in the fetal sheep heart
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    PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD
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    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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  111. Nov 2021
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    ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue
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    Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy
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    SLC1A5 provides glutamine and asparagine necessary for bone development in mice
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    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
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  116. Aug 2021
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    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
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    Acetylation of Cytidine in mRNA Promotes Translation Efficiency
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    Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia
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  122. Jul 2021
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    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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    In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate
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