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Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.immuni.2026.09.022
  
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sciencedirect.com/science/article/pii/S1074761326003973
Oct 2026
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A high-confidence inventory of the proteins in the mitochondrion-related organelle of Giardia

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1. scibot 03 Oct 2026
  
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  DOI: 10.1016/j.cub.2026.07.074
  
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sciencedirect.com/science/article/pii/S0960982226010055
Sep 2026
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Glutamine metabolism as a rheostat of CD4+ T cell pathogenic function in metabolic dysfunction-associated steatotic liver disease

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  DOI: 10.1016/j.cmet.2026.08.018
  
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Jul 2026
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Temporal control of macrophage pro-inflammatory phenotype by a biphasic HIF-1α regulatory program

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1. scibot 22 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.07.001
  
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54.241.53.176 54.241.53.176

chattergoon-et-al-2026-b-raf-is-required-for-normal-murine-cardiac-development-and-function-html.html

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  DOI: 10.1152/ajpregu.00063.2025
  
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54.241.53.176/a41823538ed51b2a45ce09430407b8e737619ee1/chattergoon-et-al-2026-b-raf-is-required-for-normal-murine-cardiac-development-and-function-html.html
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Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin

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  DOI: 10.1016/j.molcel.2026.06.028
  
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sciencedirect.com/science/article/pii/S109727652600417X
May 2026
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Uncovering spatially resolved functional genomics with CRISPR screen sequencing

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.049
  
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chattergoon-et-al-2026-b-raf-is-required-for-normal-murine-cardiac-development-and-function-html.html

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1. scibot 08 May 2026
  
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  DOI: 10.6084/m9.figshare.30899066
  
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54.241.53.176/7c5c26f1e44542c31f74e6bcb016b315f1dd5ff0/chattergoon-et-al-2026-b-raf-is-required-for-normal-murine-cardiac-development-and-function-html.html
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A personalized therapeutic approach for liver cancers expressing the African-centric P47S variant of TP53

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1. scibot 08 May 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-1297
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13147292/
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Long-Term Effects of vitamin D supplementation on myofibrillar protein synthesis rates in resting and exercised fed skeletal muscle of healthy adults

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  DOI: 10.1016/j.jnphys.2026.100032
  
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sciencedirect.com/science/article/pii/S3050624726000185
Apr 2026
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Natural senolytic activity of Rhodiola rosea extract alleviates age-associated phenotypes via paraptosis

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1. scibot 25 Apr 2026
  
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  DOI: 10.1016/j.isci.2026.115607
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13101718/
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Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control

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1. scibot 25 Apr 2026
  
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  DOI: 10.1016/j.immuni.2026.03.025
  
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sciencedirect.com/science/article/pii/S1074761326001366
Mar 2026
analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com

Disruption of Cytoskeleton Induces Physiologically and Morphologically Dysfunctional Mitochondria in B-ALL Cells

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1. scibot 05 Mar 2026
  
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  DOI: 10.1002/cbf.70190
  
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analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/cbf.70190
Feb 2026
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Insolubilome profiling defines molecular features that influence protein insolubility with aging

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  DOI: 10.1016/j.devcel.2026.01.015
  
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1-s2.0-S2589004226003755-main-html.html

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.115000
  
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54.241.53.176/7febf2f611c81ceceb7992509075443acaa6a3e6/1-s2.0-S2589004226003755-main-html.html
Jan 2026
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Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue

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  DOI: 10.1016/j.cmet.2025.12.008
  
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sciencedirect.com/science/article/pii/S155041312500539X
Dec 2025
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Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2159-8290.CD-25-0271
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
Oct 2025
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BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.neuron.2025.09.038
  
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sciencedirect.com/science/article/pii/S0896627325007512
Aug 2025
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IRE1α-XBP1s axis is required for BCG-induced trained immunity against viral infection by inhibiting AHR signaling

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1. scibot 30 Aug 2025
  
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  DOI: 10.1101/2025.08.21.671435
  
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biorxiv.org/content/10.1101/2025.08.21.671435v1
Jul 2025
52.53.155.43 52.53.155.43

Maturation of Lipid Metabolism in the Fetal and Newborn Sheep Heart

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1. scibot 22 Jul 2025
  
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  DOI: 10.1152/ajpregu.00122.2023
  
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52.53.155.43/247d3e3e470a27f551334518411ab3d3580b6e5e/drake-et-al-2023-maturation-of-lipid-metabolism-in-the-fetal-and-newborn-sheep-heart-html.html
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OASL enhances mRNA translation and reprograms lipid metabolism to promote cancer progression

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  DOI: 10.1016/j.celrep.2025.115901
  
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sciencedirect.com/science/article/pii/S2211124725006722
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Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart

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  DOI: 10.1152/ajpheart.00043.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11380940/
Jun 2025
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
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TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1038/s44319-025-00444-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12116916/
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Inhibition of NAD-GPx4 axis and MEK triggers ferroptosis to suppress pancreatic ductal adenocarcinoma

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  DOI: 10.1016/j.ymthe.2025.05.037
  
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52.53.155.43/971823f8b21eb8d89d5a30c0b92ea104b80dbdce/PDF-html.html
May 2025
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Lipid exposure leads to metabolic dysfunction in fetal sheep cardiomyocytes

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1. scibot 29 May 2025
  
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  DOI: 10.14814/phy2.70386
  
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physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70386
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TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

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1. scibot 16 May 2025
  
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  DOI: 10.1111/tra.70005
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
Apr 2025
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Integrated analysis of transcriptional and metabolic responses to mitochondrial stress

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  DOI: 10.1016/j.crmeth.2025.101027
  
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sciencedirect.com/science/article/pii/S2667237525000633
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TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

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  DOI: 10.1038/s44319-025-00444-2
  
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embopress.org/doi/10.1038/s44319-025-00444-2
Mar 2025
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Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

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  DOI: 10.1371/journal.pone.0320157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11940610/
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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

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  DOI: 10.1016/j.ccell.2025.02.018
  
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sciencedirect.com/science/article/pii/S1535610825000704
Jan 2025
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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

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  DOI: 10.1016/j.devcel.2024.12.024
  
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sciencedirect.com/science/article/pii/S1534580724007639
Dec 2024
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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/scisignal.adi8753
  
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science.org/doi/10.1126/scisignal.adi8753
Oct 2024
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Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.crmeth.2024.100875
  
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Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma

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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

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Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency

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BDNF-dependent nano-organization of Neogenin and the WAVE Regulatory Complex promotes actin remodelling in dendritic spines

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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice

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Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard

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Star1 gene mutation reveals the essentiality of 11-ketotestosterone and glucocorticoids for male fertility in Nile Tilapia (Oreochromis niloticus)

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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression

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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling

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CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer

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RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

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The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53

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Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss

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Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress

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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

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Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism

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Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance

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Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

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Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase

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Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import

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Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

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Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import

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Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer

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Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion

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An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

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Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

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Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation

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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells

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Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

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Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging

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Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice

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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

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R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

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Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

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Cholesterol supports bovine granulosa cell inflammatory responses to lipopolysaccharide

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Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue

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Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

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An anillin-CIN85-SEPT9 complex promotes intercellular bridge maturation required for successful cytokinesis

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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response

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Manipulating bovine granulosa cell energy metabolism limits inflammation

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

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The SETDB1–TRIM28 complex suppresses antitumor immunity

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Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

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Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

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Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

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Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

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Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty-acid metabolism genes in the fetal sheep heart

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PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

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In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling

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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

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Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy

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SLC1A5 provides glutamine and asparagine necessary for bone development in mice

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TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

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Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

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Untitled document

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Untitled document

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Acetylation of Cytidine in mRNA Promotes Translation Efficiency

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Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia

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Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF

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In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

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Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis

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Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF

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Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia

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Glutamine regulates ovarian cancer cell migration and invasion through ETS1

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Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

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Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

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Stimulation of astrocytic sigma-1 receptor is sufficient to ameliorate inflammation- induced depression

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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

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Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation

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Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells

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A High-Density Human Mitochondrial Proximity Interaction Network

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Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

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Hepatic Ago2 regulates PPARα for oxidative metabolism linked to glycemic control in obesity and post-bariatric surgery

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Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

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Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells

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Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF

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Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

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The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis

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Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity

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Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

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Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity

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Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer

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FSH-HIF-1α-VEGF pathway is critical for ovulation and oocyte health but not necessary for follicular growth in mice

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Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

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Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

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Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

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Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate

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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

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  DOI: 10.1016/j.devcel.2018.12.021
  
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Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures

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FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteinsHuman Molecular Genetics, 2018, Vol. 00, No. 0Human Molecular Genetics, 2018, Vol. 00, No. 0

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LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling

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β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling

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Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

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Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a

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