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  1. Last 7 days
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    Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells
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    1. scibot 20 Dec 2024
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  3. Oct 2024
  4. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging
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    Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma
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  6. Sep 2024
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    m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
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  8. Aug 2024
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    Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315182/
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    BDNF-dependent nano-organization of Neogenin and the WAVE Regulatory Complex promotes actin remodelling in dendritic spines
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  11. Jul 2024
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    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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    1. scibot 20 Jul 2024
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      DOI: 10.7554/eLife.91766

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    miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice
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    Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard
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    1. scibot 12 Jul 2024
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    cell.com/developmental-cell/fulltext/S1534-5807(24)00386-1
  15. May 2024
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    Star1 gene mutation reveals the essentiality of 11-ketotestosterone and glucocorticoids for male fertility in Nile Tilapia (Oreochromis niloticus)
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    sciencedirect.com/science/article/pii/S1096495924000526
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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  18. 52.53.155.43 52.53.155.43
    ol_28_1_14449_PDF-html.html
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    Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression
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    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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      DOI: 10.1158/0008-5472.CAN-23-2268

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
  21. Apr 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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    ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
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    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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    sciencedirect.com/science/article/pii/S1550413124000536
  26. Mar 2024
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    Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress
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    sciencedirect.com/science/article/pii/S1934590923004290
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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    sciencedirect.com/science/article/pii/S0092867424002253
  29. Jan 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
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  31. Nov 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance
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      DOI: 10.1177/17590914231206657

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621302/
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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    sciencedirect.com/science/article/pii/S2589004223022460
  34. Oct 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase
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    sciencedirect.com/science/article/pii/S0014482723003713
  36. www.science.org www.science.org
    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
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      DOI: 10.1126/sciadv.adi5548

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  37. Sep 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC
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    ncbi.nlm.nih.gov/pmc/articles/PMC10494175/
  39. Aug 2023
  40. www.science.org www.science.org
    Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
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    Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer
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      DOI: 10.1016/j.isci.2023.107537

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    sciencedirect.com/science/article/pii/S2589004223016140
  42. Jun 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion
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    ncbi.nlm.nih.gov/pmc/articles/PMC10291184/
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    An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
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      DOI: 10.1016/j.molcel.2023.05.018

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    sciencedirect.com/science/article/pii/S109727652300374X
  45. May 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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    sciencedirect.com/science/article/pii/S2211124723004588
  47. Apr 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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      DOI: 10.1016/j.ccell.2023.03.002

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    sciencedirect.com/science/article/pii/S1535610823000508
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation
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      DOI: 10.1002/jcb.30381

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    onlinelibrary.wiley.com/doi/10.1002/jcb.30381
  50. Feb 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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      DOI: 10.1126/scisignal.abj5879

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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  52. Jan 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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      DOI: 10.1158/2159-8290.CD-22-0489

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827110/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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      DOI: 10.1016/j.celrep.2022.111970

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    ncbi.nlm.nih.gov/pmc/articles/PMC9933915/
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    Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice
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    sciencedirect.com/science/article/pii/S2211124722018356
  56. Dec 2022
  57. www.sciencedirect.com www.sciencedirect.com
    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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      DOI: 10.1016/j.celrep.2022.111653

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    sciencedirect.com/science/article/pii/S2211124722015248
  58. Nov 2022
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton
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  86. Dec 2021
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    Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia
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    Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways
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    Stimulation of astrocytic sigma-1 receptor is sufficient to ameliorate inflammation- induced depression
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    Hepatic Ago2 regulates PPARα for oxidative metabolism linked to glycemic control in obesity and post-bariatric surgery
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    Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways
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  126. Nov 2020
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  128. Oct 2020
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    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma
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    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
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    Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity
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    Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence
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    Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity
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    Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer
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    FSH-HIF-1α-VEGF pathway is critical for ovulation and oocyte health but not necessary for follicular growth in mice
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    Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
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  142. Jan 2020
  143. jcs.biologists.org jcs.biologists.org
    Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling
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    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
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    Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7
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    Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate
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    FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis
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  150. Nov 2018
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    Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures
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    FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteinsHuman Molecular Genetics, 2018, Vol. 00, No. 0Human Molecular Genetics, 2018, Vol. 00, No. 0
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    LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling
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  157. Nov 2017
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    β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling
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    Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2
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    Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a
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    1. scibot 08 Nov 2017
      AB_2619646

      Curator: @Zeljana_Babic

      Resource used:

      (Cell Signaling Technology Cat# 2125, RRID:AB_2619646)

      SciCrunch record: RRID:AB_2619646

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2619646 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2451945617300636