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Long-term confinement triggers RIPK3-independent necroptosis in amoeboid cancer cells to shape tumor evolution

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1. scibot 15 Oct 2026
  
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  DOI: 10.1016/j.devcel.2026.09.003
  
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sciencedirect.com/science/article/pii/S1534580726003515
Oct 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1

1
1. scibot 07 Oct 2026
  
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  DOI: 10.1038/s44319-026-00866-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13554060/
May 2026
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ISG15 negatively regulates RIPK3-mediated cell death and viral pathogenesis

1
1. scibot 16 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117360
  
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sciencedirect.com/science/article/pii/S2211124726004389
Apr 2026
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Tolerance to extracellular acidic pH facilitates tumor plasticity

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1. scibot 17 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117226
  
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sciencedirect.com/science/article/pii/S2211124726003049
54.241.53.176 54.241.53.176

1-s2.0-S2589004226010990-main-html.html

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54.241.53.176/3e4dd64cfd78cb2c721fb48c4f44096804ced4e8/1-s2.0-S2589004226010990-main-html.html
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IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes

1
1. scibot 02 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.005
  
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sciencedirect.com/science/article/pii/S2451945626000759
Mar 2026
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Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117130
  
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sciencedirect.com/science/article/pii/S2211124726002081
Oct 2025
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Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer

1
1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116384
  
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sciencedirect.com/science/article/pii/S2211124725011556
Sep 2025
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A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer

1
1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.stem.2025.08.006
  
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sciencedirect.com/science/article/pii/S193459092500298X
Jul 2025
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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

1
1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.005
  
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sciencedirect.com/science/article/pii/S1097276525005052
Apr 2025
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MLKL activity requires a splicing-regulated, druggable intramolecular interaction

1
1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.015
  
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sciencedirect.com/science/article/pii/S109727652500259X
Mar 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

2
1. scibot 06 Mar 2025
  
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  DOI: 10.1111/bph.17464
  
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2. scibot 06 Mar 2025
  
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  RRID:AB_2619685
  
  DOI: 10.1111/bph.17464
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An immunohistochemical atlas of necroptotic pathway expression

1
1. scibot 18 Jul 2024
  
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  RRID:AB_2619685
  
  DOI: 10.1038/s44321-024-00074-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11250867/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Fatal COVID-19 pulmonary disease involves ferroptosis

1
1. scibot 23 May 2024
  
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  RRID:AB_2619685
  
  DOI: 10.1038/s41467-024-48055-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11106344/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer’s disease by inhibiting neuroinflammation and neuronal necroptosis

1
1. scibot 30 Apr 2024
  
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  DOI: 10.1186/s13578-024-01230-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11056062/
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 11 Apr 2024
  
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  RRID:AB_2619685
  
  DOI: 10.1111/bph.16364
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16364
Mar 2024
52.53.155.43 52.53.155.43

NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38MAPK/MK2 phosphorylation in S. Typhimurium infection

1
1. scibot 08 Mar 2024
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.isci.2024.109339
  
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52.53.155.43/edc059b1f8d2daaa9b02a6bfc9253e0bab800af6/1-s2.0-S2589004224005601-main-html.html
Feb 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 16 Feb 2024
  
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  DOI: 10.1111/bph.16299
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16299
Nov 2023
www.biorxiv.org www.biorxiv.org

An immunohistochemical atlas of necroptotic pathway expression

1
1. scibot 10 Nov 2023
  
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  RRID:AB_2619685
  
  DOI: 10.1101/2023.10.31.565039
  
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biorxiv.org/content/10.1101/2023.10.31.565039v1
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Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

1
1. scibot 10 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113377
  
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sciencedirect.com/science/article/pii/S221112472301389X
Oct 2023
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Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

1
1. scibot 27 Oct 2023
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.molcel.2023.09.025
  
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sciencedirect.com/science/article/pii/S1097276523007529
May 2023
www.authorea.com www.authorea.com

Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to AAI-induced PANoptosis

1
1. scibot 13 May 2023
  
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  DOI: 10.22541/au.167662368.88903548/v1
  
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authorea.com/users/496376/articles/624950-histone-deacetylase-mediated-silencing-of-pstpip2-expression-contributes-to-aai-induced-panoptosis
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

1
1. scibot 05 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106381
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10064235/
Feb 2023
www.mdpi.com www.mdpi.com

The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis

1
1. scibot 04 Feb 2023
  
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  RRID: AB_2619685
  
  DOI: 10.3390/ijms24032749
  
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mdpi.com/1422-0067/24/3/2749
Dec 2022
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumor necrosis factor is a necroptosis-associated alarmin

1
1. scibot 30 Dec 2022
  
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  AB_2619685
  
  DOI: 10.3389/fimmu.2022.1074440
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9791252/
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

1
1. scibot 02 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105118
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9519628/
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases

1
1. scibot 27 Mar 2022
  
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  DOI: 10.1016/j.molcel.2022.03.010
  
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sciencedirect.com/science/article/pii/S1097276522002192
Jan 2022
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Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis

1
1. scibot 11 Jan 2022
  
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  DOI: 10.1016/j.devcel.2021.12.015
  
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sciencedirect.com/science/article/pii/S1534580721010352
Oct 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates

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1. scibot 28 Oct 2021
  
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  DOI: 10.1016/j.isci.2021.103207
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8524197/
www.embopress.org www.embopress.org

Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

1
1. scibot 12 Oct 2021
  
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  RRID:AB_2619685
  
  DOI: 10.15252/embr.202052254
  
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embopress.org/doi/full/10.15252/embr.202052254
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

1
1. scibot 17 Aug 2021
  
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  RRID:AB_2619685
  
  DOI: 10.1158/1078-0432.CCR-18-3683
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7887036/
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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

1
1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.026
  
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sciencedirect.com/science/article/pii/S0092867421008850
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

1
1. scibot 31 Jul 2021
  
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  Rabbit monoclonal anti-p-MLKL (Ser358)
  
  DOI: 10.1016/j.celrep.2019.11.014
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S2211124719314858
May 2021
www.sciencedirect.com www.sciencedirect.com

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

1
1. scibot 27 May 2021
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.chom.2021.04.016
  
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sciencedirect.com/science/article/pii/S193131282100192X
Apr 2021
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Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis

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1. scibot 13 Apr 2021
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.chembiol.2021.03.012
  
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The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis

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1. scibot 06 Apr 2021
  
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  anti-human phospho-MLKL
  
  DOI: 10.1016/j.bcp.2021.114542
  
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sciencedirect.com/science/article/pii/S0006295221001386
Dec 2020
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Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer’s Disease

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1. scibot 13 Dec 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.celrep.2020.108447
  
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sciencedirect.com/science/article/pii/S2211124720314364
Nov 2020
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Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3

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1. scibot 26 Nov 2020
  
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  RRID:AB_2619685
  
  DOI: 10.7554/eLife.61564
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7673785/
Sep 2020
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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

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1. scibot 25 Sep 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.cell.2020.02.050
  
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sciencedirect.com/science/article/pii/S0092867420302270
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Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death

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1. scibot 15 Sep 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.celrep.2019.12.079
  
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sciencedirect.com/science/article/pii/S2211124719317449
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Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model

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1. scibot 04 Sep 2020
  
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  DOI: 10.1038/s41419-020-2538-5
  
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nature.com/articles/s41419-020-2538-5
Jan 2020
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TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.molcel.2019.05.022
  
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sciencedirect.com/science/article/pii/S1097276519303946
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Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

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1. scibot 13 Jan 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.immuni.2019.11.005
  
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O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

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1. scibot 13 Jan 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.immuni.2019.01.007
  
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sciencedirect.com/science/article/pii/S1074761319300305
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1016/j.chembiol.2019.03.010
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2619685
  
  DOI: 10.1111/bph.14653
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14653
Nov 2018
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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

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1. scibot 05 Nov 2018
  
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Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S2451945617303240
Nov 2017
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MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

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1. scibot 08 Nov 2017
  
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  AB_2619685
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1074761317302285