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Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.immuni.2026.09.022
  
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sciencedirect.com/science/article/pii/S1074761326003973
Oct 2026
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A non-canonical redox family protein regulates bacterial interaction machineries

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1. scibot 03 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118071
  
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sciencedirect.com/science/article/pii/S2211124726011502
Sep 2026
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Polo-like kinase phosphorylation of the orphan kinesin KIN-G negatively regulates centrin arm biogenesis in Trypanosoma brucei

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1. scibot 09 Sep 2026
  
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  DOI: 10.7554/eLife.110793
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13544905/
Aug 2026
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Deciphering protein mutation-phenotype linkages from CRISPR-based tiling mutagenesis screens

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1. scibot 14 Aug 2026
  
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  DOI: 10.1016/j.cels.2026.101651
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13463601/
Jul 2026
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Systematic discovery of pathogen effector functions across human pathogens and pathways

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  DOI: 10.1016/j.cell.2026.06.017
  
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  DOI: 10.1016/j.cell.2026.06.017
  
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sciencedirect.com/science/article/pii/S009286742600704X
Jun 2026
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Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117601
  
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sciencedirect.com/science/article/pii/S2211124726006790
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Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s41467-026-71619-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13269823/
May 2026
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2026.05.11.724407.full-html.html

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1. scibot 21 May 2026
  
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  DOI: 10.64898/2026.05.11.724407
  
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54.241.53.176/bfcffe42e71061fda5786106304e0751d5cf2645/2026.05.11.724407.full-html.html
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CRL2FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer

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1. scibot 06 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.008
  
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sciencedirect.com/science/article/pii/S109727652600242X
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OsALY4 acts as an m5C-mRNA reader facilitating mRNA export and contributing to chilling and salt tolerance in rice

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117276
  
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sciencedirect.com/science/article/pii/S2211124726003542
Apr 2026
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MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.celrep.2025.116499
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12828906/
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LRRTM4 controls cell migration via Glypican interactions

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1. scibot 21 Apr 2026
  
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  DOI: 10.64898/2026.04.14.718450
  
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biorxiv.org/content/10.64898/2026.04.14.718450v1
54.241.53.176 54.241.53.176

Yellow Fever Virus Interactomes Reveal Common and Divergent Strategies of Replication and Evolution for Mosquito-borne Flaviviruses

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1. scibot 09 Apr 2026
  
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  DOI: 10.1101/2025.06.14.659623
  
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54.241.53.176/81eae13c4928c183ed0502a4798fa83b0c53d989/2025.06.14.659623.full-html.html
Mar 2026
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UFMylation-dependent inhibition of AKT signaling by PHLDA3 in lung adenocarcinoma

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117154
  
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sciencedirect.com/science/article/pii/S2211124726002329
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Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117123
  
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sciencedirect.com/science/article/pii/S2211124726002019
Jan 2026
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Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity

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1. scibot 15 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116854
  
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sciencedirect.com/science/article/pii/S2211124725016262
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RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12952242/
Nov 2025
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VesicleVoyager: In Vivo Selection of Surface Displayed Proteins That Direct Extracellular Vesicles to Tissue‐Specific Targets

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1. scibot 24 Nov 2025
  
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  DOI: 10.1002/jev2.70184
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12603919/
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Generation of Cellular Biofactories for Scalable Production of Surface-Engineered Extracellular Vesicles via CRISPR Genome Editing

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1. scibot 23 Nov 2025
  
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  DOI: 10.1101/2025.09.30.679598
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12622020/
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Light-quality-directed plant growth strategy controlled by SnRK2s

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.004
  
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sciencedirect.com/science/article/pii/S1534580725006343
Sep 2025
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14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity and toxicity

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1. scibot 27 Sep 2025
  
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  DOI: 10.1093/hmg/ddae142
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11578116/
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Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.ccell.2025.08.008
  
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sciencedirect.com/science/article/pii/S1535610825003654
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Teneurin-4 switches between self-recognition and canonical Latrophilin binding to direct neuronal migration

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1. scibot 16 Sep 2025
  
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  DOI: 10.1101/2025.09.09.671438
  
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biorxiv.org/content/10.1101/2025.09.09.671438v1
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Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116235
  
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sciencedirect.com/science/article/pii/S221112472501006X
Aug 2025
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Electrochemical coupling at the plasma membrane by mouse voltage-sensitive phosphatase requires association with basigin

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1. scibot 29 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116200
  
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sciencedirect.com/science/article/pii/S2211124725009714
Jul 2025
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Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis

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  DOI: 10.1016/j.devcel.2025.06.020
  
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sciencedirect.com/science/article/pii/S1534580725003752
Jun 2025
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GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake

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1. scibot 11 Jun 2025
  
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  DOI: 10.1126/science.adp3989
  
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science.org/doi/10.1126/science.adp3989
Mar 2025
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TMEM63B functions as a mammalian hyperosmolar sensor for thirst

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  DOI: 10.1016/j.neuron.2025.02.012
  
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sciencedirect.com/science/article/pii/S0896627325001308
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Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence

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  DOI: 10.1016/j.chom.2018.04.001
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5949146/
Feb 2025
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Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality

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  DOI: 10.1016/j.isci.2025.112025
  
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sciencedirect.com/science/article/pii/S2589004225002858
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PI3KC2β depletion rescues endosomal trafficking defects in Mtm1 knockout skeletal muscle cells

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  DOI: 10.1016/j.jlr.2025.100756
  
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sciencedirect.com/science/article/pii/S0022227525000161
Dec 2024
52.53.155.43 52.53.155.43

Functional specialization of MITF, TFEB and TFE3 drives radically distinct adaptive gene expression programs in melanoma

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1. scibot 27 Dec 2024
  
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  DOI: 10.1101/2024.12.23.629393
  
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52.53.155.43/e70ff79afc559a11e17818daacbae0950eb62f01/PDF-html.html
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Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine

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1. scibot 20 Dec 2024
  
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  DOI: 10.1038/s41467-024-55033-z
  
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nature.com/articles/s41467-024-55033-z
Nov 2024
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Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

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1. scibot 26 Nov 2024
  
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  DOI: 10.7554/eLife.94347
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11578589/
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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

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1. scibot 16 Nov 2024
  
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Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus

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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation

1
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RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells

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Genome-scale exon perturbation screens uncover exons critical for cell fitness

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A hominoid-specific signaling axis regulating the tempo of synaptic maturation

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DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

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Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

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Germline mutations of Holliday junction resolvase genes in multiple primary malignancies involving lung cancer lead to PARP inhibitor sensitization

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Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly

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Apr 2024
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ISGylation by HERCs facilitates STING activation

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H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction

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Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene

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Rim aperture of yeast autophagic membranes balances cargo inclusion with vesicle maturation

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Jasmonate signaling pathway confers salt tolerance through a NUCLEAR FACTOR-Y trimeric transcription factor complex in Arabidopsis

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AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ

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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

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  DOI: 10.1126/scisignal.adg5289
  
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Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion

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p53 promotes antiviral innate immunity by driving hexosamine metabolism

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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

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ADAMTS-4 enhances oligodendrocyte differentiation and remyelination by cleaving NG2 proteoglycan and attenuating PDGFRα signaling

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Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization

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PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5

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mvad090-html.html

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Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS

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  DOI: 10.1016/j.isci.2023.107841
  
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LAT1 (SLC7A5) catalyzes Copper(histidinate) transport switching from antiport to uniport mechanism.

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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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  DOI: 10.15252/embr.202356948
  
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Aug 2023
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PIIS2211124723009774-html.html

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Jul 2023
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Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome

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Jun 2023
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4405.full-html.html

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May 2023
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Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

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  DOI: 10.3390/cells10102600
  
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Apr 2023
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UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

1
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γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

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Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox responses in larval fish

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Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis

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A central chaperone-like role for 14-3-3 proteins in human cells

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Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer

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COP I and II dependent trafficking controls ER-associated degradation in mammalian cells

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ARMS-NF-κB signaling regulates intracellular ROS to induce autophagy-associated cell death upon oxidative stress

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Jan 2023
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Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

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GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation

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CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart

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Z-REX uncovers a bifurcation in function of Keap1 paralogs

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GwAAP: A genome-wide amino acid coding-decoding quantitative proteomics system

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Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

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MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation

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CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

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GPC3-Unc5 receptor complex structure and role in cell migration

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Synthetic refactor of essential genes decodes functionally constrained sequences in yeast genome

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Closely related type II-C Cas9 orthologs recognize diverse PAMs

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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

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Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency

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Functional and biological heterogeneity of KRASQ61 mutations

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The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells

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Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides

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FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia

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UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth

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Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

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Mar 2022
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PTENα regulates endocytosis and modulates olfactory function

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Feb 2022
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

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TBK1-METTL3 axis facilitates antiviral immunity

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Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway

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ROPGAP-dependent interaction between brassinosteroid and ROP2-GTPase signaling controls pavement cell shape in Arabidopsis

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GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors

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Dec 2021
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Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis

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A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

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Nov 2021
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Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle

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RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage

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Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A

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Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1

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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

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Secretion of Tau via an Unconventional Non-vesicular Mechanism

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PTENα regulates endocytosis and modulates olfactory function

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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

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Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

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Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment

1
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  mouse monoclonal anti-HA
  
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FipoQ/FBXO33, a Cullin‐1‐based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein

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Dual function of VGLL4 in muscle regeneration

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  mouse anti‐HA
  
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Secretion of Tau via an Unconventional Non-vesicular Mechanism

1
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  RRID: AB_262051
  
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Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers

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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

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5'-UTR SNP of FGF13 causes translational defect and intellectual disability

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VEGF counteracts amyloid-β-induced synaptic dysfunction

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Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana

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PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis

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Apr 2021
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SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization

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Functional interrogation of DNA damage response variants with base editing screens

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Coevolution of ribosomal RNA expansion segment 7L and assembly factor Noc2p specializes the ribosome biogenesis pathway between Saccharomyces cerevisiae and Candida albicans

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SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

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Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

1
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The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6

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  HA
  
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A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

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  DOI: 10.7554/eLife.60125
  
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Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

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  DOI: 10.7554/eLife.60481
  
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Jan 2021
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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling

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Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

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Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex

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CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome

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PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain

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CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome

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Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

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Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss

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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

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ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

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A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

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Hsp90 Co-chaperones Form Plastic Genetic Networks Adapted to Client Maturation

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Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

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TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance

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Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

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A Kinesin adapter directly mediates dendritic mRNA localization during neural development in mice

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elifesciences.org elifesciences.org

MARCH8 inhibits viral infection by two different mechanisms

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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core

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Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

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The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity

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The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

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Live-Cell Single RNA Imaging Reveals Bursts of Translational Frameshifting

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The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers

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Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

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Non-coding RNA Transcription in Tetrahymena Meiotic Nuclei Requires Dedicated Mediator Complex-Associated Proteins

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Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development

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  DOI: 10.1016/j.neuron.2019.11.003
  
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Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast

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Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

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Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate

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Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

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Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication

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Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment

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Transcriptional profiling aligned with in situ expression image analysis reveals mosaically‐expressed molecular markers for GABA neuron sub‐groups in the ventral tegmental area

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Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1

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tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

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Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

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Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production

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Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

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FipoQ/FBXO33, a Cullin‐1‐based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein

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The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival

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Polarized Dock Activity Drives Shh-Mediated Axon Guidance

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Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

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