236 Matching Annotations
  1. Last 7 days
  2. www.nature.com www.nature.com
    Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
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  3. www.nature.com www.nature.com
    Lithocholic acid phenocopies anti-ageing effects of calorie restriction
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    Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3
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    sciencedirect.com/science/article/pii/S2211124724014086
  5. Dec 2024
  6. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle
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    DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways
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  8. Nov 2024
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-nucleus transcriptomic analysis reveals the regulatory circuitry of myofiber XBP1 during regenerative myogenesis
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    Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome
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  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GM1 Oligosaccharide Ameliorates Rett Syndrome Phenotypes In Vitro and In Vivo via Trk Receptor Activation
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  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD
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    Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model
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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms
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  15. Oct 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondria remodeling during endometrial stromal cell decidualization
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  17. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  18. Sep 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Diabesity alters the protective effects of estrogens on endothelial function through adipose tissue secretome
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    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training in Healthy Untrained Men
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  22. Aug 2024
  23. www.cell.com www.cell.com
    SLC25A48 controls mitochondrial choline import and metabolism
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    cell.com/cell-metabolism/fulltext/S1550-4131(24)00281-X
  24. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A common variant in the iron regulatory gene (Hfe) alters the metabolic and transcriptional landscape in brain regions vulnerable to neurodegeneration
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  25. Jul 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes
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    Hippocampal Warburg effect Mediates Hydrogen Sulfide-Ameliorated Diabetes-Associated Cognitive Dysfunction: Involving Promotion of Hippocampal Synaptic Plasticity
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    sciencedirect.com/science/article/pii/S0168010224000877
  28. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Metabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis: Effect of non-selective and selective β1-receptor blockers
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  29. dx.doi.org dx.doi.org
    Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation
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      DOI: 10.1093/biolre/ioae086

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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
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  31. www.sciencedirect.com www.sciencedirect.com
    Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer
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  32. Jun 2024
  33. www.cell.com www.cell.com
    Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss.
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    cell.com/iscience/abstract/S2589-0042(24)01346-4
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    Insulin and leptin oscillations license food-entrained browning and metabolic flexibility
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  35. May 2024
  36. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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  37. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle
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    SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production
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    sciencedirect.com/science/article/pii/S1934590924001760
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
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  40. www.biorxiv.org www.biorxiv.org
    Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy
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    biorxiv.org/content/10.1101/2024.01.20.576409v1
  41. Apr 2024
  42. link.springer.com link.springer.com
    Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
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    link.springer.com/article/10.1186/s13024-024-00721-z
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass and adipose metabolism for the promotion of thermogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973579/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10966194/
  46. Mar 2024
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
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    pmc.ncbi.nlm.nih.gov/articles/PMC10950823/
  48. Feb 2024
  49. www.sciencedirect.com www.sciencedirect.com
    Coordinated metabolic responses to cyclophilin D deletion in the developing heart
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    sciencedirect.com/science/article/pii/S258900422400378X
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    NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
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    sciencedirect.com/science/article/pii/S2211124724001888
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    Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice
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    SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells
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    Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB
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    Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice
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    Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats
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    Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats
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    Effects of Exercise Training on Mitochondrial Fatty Acid β-Oxidation in the Kidneys of Dahl Salt-Sensitive Rats
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    Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase
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    Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes
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    Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival.
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  100. Jan 2023
  101. www.sciencedirect.com www.sciencedirect.com
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  102. Dec 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of aging and long‐term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats
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      DOI: 10.14814/phy2.15542

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    Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis
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    VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation
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  107. Nov 2022
  108. www.cell.com www.cell.com
    Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
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  109. Oct 2022
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    Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner
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    Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities
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    Regional heterogeneity in mitochondrial function underlies region specific vulnerability in human brain ageing: Implications for neurodegeneration
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  113. Sep 2022
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    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
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  115. Aug 2022
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    TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation
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    Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes
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  118. Jul 2022
  119. 52.53.155.43 52.53.155.43
    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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  120. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  121. Jun 2022
  122. 52.53.155.43 52.53.155.43
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  123. 52.53.155.43 52.53.155.43
    Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER
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  124. May 2022
  125. www.sciencedirect.com www.sciencedirect.com
    Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
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  126. Apr 2022
  127. www.sciencedirect.com www.sciencedirect.com
    IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming
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  128. academic.oup.com academic.oup.com
    Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner
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      DOI: 10.1210/endocr/bqac018

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    Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease
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  130. Mar 2022
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    Cell-autonomous control of intracellular temperature by unsaturation of phospholipid acyl chains
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  132. 52.53.155.43 52.53.155.43
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  133. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Mitochondrial Dysfunction in Rabies Virus-Infected Human and Canine Brains
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  135. Feb 2022
  136. www.sciencedirect.com www.sciencedirect.com
    Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy
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  137. www.sciencedirect.com www.sciencedirect.com
    The early reduction of left ventricular mass after sleeve gastrectomy depends on the fall of branched-chain amino acid circulating levels
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  138. Jan 2022
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ACE2 pathway regulates thermogenesis and energy metabolism
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  140. www.sciencedirect.com www.sciencedirect.com
    Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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      DOI: 10.1126/sciadv.abl4988

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  142. Dec 2021
  143. www.science.org www.science.org
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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    NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis
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  145. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty-acid metabolism genes in the fetal sheep heart
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    Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1
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    Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation
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  148. Nov 2021
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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  150. Oct 2021
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    Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing
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    Changes in PGC-1α-Dependent Mitochondrial Biogenesis Are Associated with Inflexible Hepatic Energy Metabolism in the Offspring Born to Dexamethasone-Treated Mothers
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    MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis
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      DOI: 10.7554/eLife.70490

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  154. Sep 2021
  155. www.sciencedirect.com www.sciencedirect.com
    Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
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    Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species‐mediated mitochondrial injury
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    Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle
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    Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice
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    Importance of adipose tissue NAD+ biology in regulating metabolic flexibility
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    Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
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  207. Dec 2020
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    Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283
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  210. Nov 2020
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    CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion
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    Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure
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    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis
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  216. Sep 2020
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    Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant
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  219. elifesciences.org elifesciences.org
    Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
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    Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue
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    Astaxanthin attenuates hepatic damages and mitochondrial dysfunction in nonalcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway
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    Mitophagy, Autophagy and Cell Death: The novel cyclophilin-D-interacting protein FASTKD1 protects cells against oxidative stress-induced cell death
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      DOI: 10.1152/ajpcell.00471.2018

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    The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells
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  224. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles
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    Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism
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    Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models
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    Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium
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    Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
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    A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53
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    Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2
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    Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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      Total OXPHOS Rodent WB Antibody Cocktail

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    Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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    Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction | American Journal of Physiology-Endocrinology and Metabolism
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    Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
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  235. Jan 2020
  236. elifesciences.org elifesciences.org
    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
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    MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition
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  238. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.
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      DOI: 10.2337/db18-1112

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    Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
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    Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency
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