134 Matching Annotations
  1. May 2024
  2. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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    1. scibot 24 May 2024
      RRID:AB_2629447

      DOI: 10.1126/scisignal.adh4475

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    science.org/doi/10.1126/scisignal.adh4475
  3. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 03 May 2024
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      DOI: 10.1111/bph.16356

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16356
  4. Mar 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
    1
    1. scibot 09 Mar 2024
      AB_2629447

      DOI: 10.14814/phy2.15969

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  6. Feb 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer
    1
    1. scibot 28 Feb 2024
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      DOI: 10.1016/j.isci.2024.108794

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879682/
  8. www.sciencedirect.com www.sciencedirect.com
    TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport
    1
    1. scibot 14 Feb 2024
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      DOI: 10.1016/j.ijbiomac.2024.130055

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    sciencedirect.com/science/article/pii/S0141813024008584
  9. www.sciencedirect.com www.sciencedirect.com
    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113712

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    sciencedirect.com/science/article/pii/S2211124724000408
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
      RRID:AB_2629447

      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  11. Jan 2024
  12. link.springer.com link.springer.com
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
    1
    1. scibot 25 Jan 2024
      RRID:AB_2629447

      DOI: 10.1038/s41388-024-02947-z

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    link.springer.com/article/10.1038/s41388-024-02947-z
  13. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
      RRID:AB_2629477

      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  14. www.sciencedirect.com www.sciencedirect.com
    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
    1
    1. scibot 10 Jan 2024
      AB_2629447

      DOI: 10.1016/j.ebiom.2021.103287

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    sciencedirect.com/science/article/pii/S2352396421000803
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
    1
    1. scibot 06 Jan 2024
      RRID:AB_262944

      DOI: 10.1016/j.jbc.2023.105619

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    ncbi.nlm.nih.gov/pmc/articles/PMC10839450/
  16. Nov 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
    1
    1. scibot 17 Nov 2023
      RRID:AB_2629447

      DOI: 10.1016/j.celrep.2023.113417

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    sciencedirect.com/science/article/pii/S2211124723014298
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons
    2
    1. scibot 03 Nov 2023
      RRID:AB_2629447

      DOI: 10.1016/j.isci.2023.108152

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    2. scibot 03 Nov 2023
      RRID:AB_2629447

      DOI: 10.1016/j.isci.2023.108152

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618709/
  19. Oct 2023
  20. www.sciencedirect.com www.sciencedirect.com
    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
    1
    1. scibot 17 Oct 2023
      RRID:AB_2629447

      DOI: 10.1016/j.isci.2023.108022

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    sciencedirect.com/science/article/pii/S2589004223020990
  21. www.sciencedirect.com www.sciencedirect.com
    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
    1
    1. scibot 14 Oct 2023
      RRID:AB_2629447

      DOI: 10.1016/j.xcrm.2023.101214

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    sciencedirect.com/science/article/pii/S2666379123003816
  22. Aug 2023
  23. 52.53.155.43 52.53.155.43
    PIIS2589004223016838-html.html
    1
    1. scibot 17 Aug 2023
      RRID:AB_2629447

      DOI: 10.1016/j.isci.2023.107606

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    52.53.155.43/0595295f970fa120203481e8752220bf0b62043f/PIIS2589004223016838-html.html
  24. Jul 2023
  25. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
    1
    1. scibot 27 Jul 2023
      RRID:AB_2629447

      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
    1
    1. scibot 22 Jul 2023
      RRID:AB_2629447

      DOI: 10.1101/2023.06.27.546707

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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
  27. www.nature.com www.nature.com
    Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice
    1
    1. scibot 15 Jul 2023
      RRID:AB_2629447

      DOI: 10.1038/s41467-023-39715-8

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    nature.com/articles/s41467-023-39715-8
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell Competition Shapes Metastatic Latency and Relapse
    1
    1. scibot 12 Jul 2023
      RRID:AB_2629447

      DOI: 10.1158/2159-8290.CD-22-0236

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    ncbi.nlm.nih.gov/pmc/articles/PMC9839468/
  29. Jun 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Identification of XAF1 as an endogenous AKT inhibitor
    1
    1. scibot 29 Jun 2023
      RRID:AB_2629447

      DOI: 10.1016/j.celrep.2023.112690

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    sciencedirect.com/science/article/pii/S2211124723007015
  31. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
    2
    1. scibot 16 Jun 2023
      RRID:AB_2629447

      DOI: 10.1126/sciadv.ade1155

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    2. scibot 12 Jun 2023
      RRID:AB_2629447

      DOI: 10.1126/sciadv.ade1155

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    science.org/doi/10.1126/sciadv.ade1155
  32. 52.53.155.43 52.53.155.43
    Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis
    1
    1. scibot 16 Jun 2023
      RRID:AB_2629447

      DOI: 10.1053/j.gastro.2023.05.039

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    52.53.155.43/6547da8aa0b8d7e491fdd14880a12803f28db0ef/1-s2.0-S0016508523008120-main-html.html
  33. May 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Actuation of single downstream nodes in growth factor network steers immune cell migration
    1
    1. scibot 24 May 2023
      RRID:AB_2629447

      DOI: 10.1016/j.devcel.2023.04.019

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    sciencedirect.com/science/article/pii/S1534580723001958
  35. www.nature.com www.nature.com
    Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter
    1
    1. scibot 10 May 2023
      RRID:AB_2629447

      DOI: 10.1038/s41420-023-01447-5

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    nature.com/articles/s41420-023-01447-5
  36. Apr 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP
    1
    1. scibot 28 Apr 2023
      RRID:AB_2629447

      DOI: 10.1016/j.isci.2023.106538

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    sciencedirect.com/science/article/pii/S2589004223006156
  38. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
    1
    1. scibot 27 Apr 2023
      RRID:AB_2629447

      DOI: 10.1016/j.neuron.2023.04.006

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    sciencedirect.com/science/article/pii/S0896627323002684
  39. www.nature.com www.nature.com
    Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
    1
    1. scibot 18 Apr 2023
      RRID:AB_262944

      DOI: 10.1038/s41398-023-02411-8

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    nature.com/articles/s41398-023-02411-8
  40. Feb 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
    1
    1. scibot 17 Feb 2023
      AB_2629447

      DOI: 10.1126/scisignal.abj5879

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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  42. www.sciencedirect.com www.sciencedirect.com
    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1016/j.isci.2023.106070

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    sciencedirect.com/science/article/pii/S2589004223001475
  43. Jan 2023
  44. www.jneurosci.org www.jneurosci.org
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
    1
    1. scibot 27 Jan 2023
      RRID:AB_2629447

      DOI: 10.1523/JNEUROSCI.0010-22.2022

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    jneurosci.org/content/43/4/540
  45. www.sciencedirect.com www.sciencedirect.com
    The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
    1
    1. scibot 02 Jan 2023
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      DOI: 10.1016/j.celrep.2022.111916

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    sciencedirect.com/science/article/pii/S2211124722018150
  46. Dec 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
    1
    1. scibot 16 Dec 2022
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      DOI: 10.1158/0008-5472.CAN-22-0446

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    ncbi.nlm.nih.gov/pmc/articles/PMC9354703/
  48. Nov 2022
  49. www.sciencedirect.com www.sciencedirect.com
    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
    1
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      DOI: 10.1016/j.devcel.2022.10.011

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    sciencedirect.com/science/article/pii/S1534580722007638
  50. www.sciencedirect.com www.sciencedirect.com
    Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss
    1
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      DOI: 10.1016/j.celrep.2022.111574

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    sciencedirect.com/science/article/pii/S2211124722014358
  51. Oct 2022
  52. www.sciencedirect.com www.sciencedirect.com
    KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice
    1
    1. scibot 11 Oct 2022
      RRID:AB_2629447

      DOI: 10.1016/j.devcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1534580722006372
  53. Sep 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
    1
    1. scibot 29 Sep 2022
      Rabbit polyclonal anti-pAKT (Thr308)

      DOI: 10.1016/j.celrep.2022.111422

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    sciencedirect.com/science/article/pii/S2211124722012633
  55. www.sciencedirect.com www.sciencedirect.com
    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
    1
    1. scibot 27 Sep 2022
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      DOI: 10.1016/j.jbc.2022.102532

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    sciencedirect.com/science/article/pii/S0021925822009759
  56. Aug 2022
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    Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
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    Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
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    Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer
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  63. Mar 2022
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    Coordinated changes in glycosylation regulate the germinal center through CD22
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    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
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  66. Feb 2022
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    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
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    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway
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  70. Jan 2022
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    ACE2 pathway regulates thermogenesis and energy metabolism
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  72. Dec 2021
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    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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  89. Jul 2021
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    12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
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      Phospho-Akt (Thr308)

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    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  95. Jun 2021
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    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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  99. May 2021
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    Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses
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    Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    Deciphering the signaling network of breast cancer improves drug sensitivity prediction
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    Cell Lineage-Based Stratification for Glioblastoma
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    Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
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  113. www.cell.com www.cell.com
    Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
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  114. academic.oup.com academic.oup.com
    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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  115. elifesciences.org elifesciences.org
    The kinase PDK1 is critical for promoting T follicular helper cell differentiation
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  116. Jan 2021
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
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  118. www.sciencedirect.com www.sciencedirect.com
    Impact of WIN site inhibitor on the WDR5 interactome
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  119. Dec 2020
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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
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    Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system
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    miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
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  123. Sep 2020
  124. elifesciences.org elifesciences.org
    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
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    Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers
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  129. www.sciencedirect.com www.sciencedirect.com
    Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
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  130. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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  132. academic.oup.com academic.oup.com
    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
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  133. Jan 2020
  134. elifesciences.org elifesciences.org
    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
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  135. www.cell.com www.cell.com
    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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      DOI: 10.1016/j.celrep.2019.11.085

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    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
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    OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
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    α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development
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      DOI: 10.1016/j.molcel.2019.07.007

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    Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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  144. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1038/s42003-019-0524-1

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  147. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP+
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    TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency
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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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    Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis
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  156. Nov 2018
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    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
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  158. jcb.rupress.org jcb.rupress.org
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    Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
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    Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
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    Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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  165. Nov 2017
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    A Split-Abl Kinase for Direct Activation in Cells
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    Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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  169. elifesciences.org elifesciences.org
    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
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    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
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