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Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Oxytocin treatment reduces cancer cachexia in a pre-clinical model

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Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer

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Nov 2025
54.241.53.176 54.241.53.176

2025.11.16.688689v1.full-html.html

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  DOI: 10.1101/2025.11.16.688689
  
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StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models

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  DOI: 10.1016/j.cell.2025.10.007
  
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Sep 2025
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Identifying an optimal perturbation to induce a desired cell state by generative deep learning

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  DOI: 10.1016/j.cels.2025.101405
  
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Aug 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225015780-main-html.html

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52.53.155.43/29f3ae515f83ea3f9f8bc4047bd6461c5c49ee05/1-s2.0-S2589004225015780-main-html.html
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing

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  DOI: 10.1186/s12951-025-03548-y
  
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Artificial intelligence-driven discovery of YH395A: A novel TGFβR1 inhibitor with potent anti-tumor activity against triple-negative breast cancer

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1. scibot 10 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12235933/
Feb 2025
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-22-3009
  
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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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1. scibot 11 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
Jan 2025
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The protective effects of liraglutide in reducing lipid droplets accumulation and myocardial fibrosis in diabetic cardiomyopathy

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1. scibot 15 Jan 2025
  
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  DOI: 10.1007/s00018-024-05558-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11711727/
Dec 2024
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An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.devcel.2023.08.021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7615346/
Nov 2024
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ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss

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1. scibot 17 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.020
  
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sciencedirect.com/science/article/pii/S1097276524008608
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Olanzapine enhances early brain maturation through activation of the NODAL/FOXH1 axis

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1. scibot 07 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.110917
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11519431/
Sep 2024
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Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2019.11.079
  
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sciencedirect.com/science/article/pii/S2211124719315700
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Dynamic allostery drives autocrine and paracrine TGF-β signaling

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.036
  
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sciencedirect.com/science/article/pii/S0092867424009656
Aug 2024
biosignaling.biomedcentral.com biosignaling.biomedcentral.com

FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

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1. scibot 02 Aug 2024
  
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  RRID: AB_2631089
  
  DOI: 10.1186/s12964-022-01033-9
  
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biosignaling.biomedcentral.com/articles/10.1186/s12964-022-01033-9
Jun 2024
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Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration

1
1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114342
  
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sciencedirect.com/science/article/pii/S2211124724006703
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Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti

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1. scibot 05 Jun 2024
  
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  DOI: 10.1016/j.cmet.2024.04.020
  
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Coordination between endoderm progression and mouse gastruloid elongation controls endodermal morphotype choice

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May 2024
52.53.155.43 52.53.155.43

2024.02.25.581951v1.full-html.html

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  DOI: 10.1038/nature12362
  
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52.53.155.43/3cbbb6c4022cb0d94766603ef526c2fd13dcbc89/2024.02.25.581951v1.full-html.html
Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114149
  
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Mar 2024
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Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders

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  DOI: 10.1016/j.isci.2024.109293
  
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Identification of key immune cells infiltrated in lung adenocarcinoma microenvironment and their related lncRNA

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  DOI: 10.1016/j.isci.2024.109220
  
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  DOI: 10.1016/j.isci.2024.109220
  
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Feb 2024
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Growth differentiation factor 9 regulates the expression of estrogen receptors via Smad2/3 signaling in goat cumulus cells

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  DOI: 10.1016/j.theriogenology.2024.02.021
  
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Sphingolipid metabolism controls mammalian heart regeneration

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  DOI: 10.1016/j.cmet.2024.01.017
  
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sciencedirect.com/science/article/pii/S1550413124000172
Dec 2023
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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

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  DOI: 10.1016/j.ccell.2023.12.002
  
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sciencedirect.com/science/article/pii/S1535610823004300
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An oncogenic phenoscape of colonic stem cell polarization

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  DOI: 10.1016/j.cell.2023.11.004
  
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  DOI: 10.1016/j.cell.2023.11.004
  
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Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses

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  DOI: 10.1016/j.cell.2023.11.005
  
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  DOI: 10.1016/j.cell.2023.11.005
  
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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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  DOI: 10.1016/j.celrep.2023.113564
  
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Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.devcel.2023.11.020
  
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sciencedirect.com/science/article/pii/S1534580723006184
Nov 2023
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Deep learning untangles the resistance mechanism of p53 reactivator in lung cancer cells

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1. scibot 29 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108377
  
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sciencedirect.com/science/article/pii/S2589004223024549
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TGFB1 induces fetal reprogramming and enhances intestinal regeneration

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1. scibot 10 Nov 2023
  
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  DOI: 10.1016/j.stem.2023.09.015
  
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Sep 2023
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Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice

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An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development

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British J Pharmacology - 2023 - Chen - Anthelmintics nitazoxanide protects against experimental pulmonary fibrosis-html.html

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Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells

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Protocol for analyzing transforming growth factor β signaling in dextran-sulfate-sodium-induced colitic mice using flow cytometry and western blotting

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Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis

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Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants

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Nodal signaling establishes a competency window for stochastic cell fate switching

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Combinatorial prophylactic effect of phlorotannins with photobiomodulation against tracheal stenosis

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Regulation of Nodal signaling propagation by receptor interactions and positive feedback

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Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes

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Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma

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Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

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HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs

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Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway

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Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

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CXCL4 drives fibrosis by promoting several key cellular and molecular processes

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Effect of miR-183-5p on Cholestatic Liver Fibrosis by Regulating Fork Head Box Protein O1 Expression

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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

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TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer

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Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

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Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation

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Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Untitled document

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CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota

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  Phospho-smad2 (Ser465/467)/Smad3 (Ser423/425) Rabbit mAb (D27F4)
  
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Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats

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Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration

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Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

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mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

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Deciphering the signaling network of breast cancer improves drug sensitivity prediction

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

1
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  rabbit anti-phospho-Smad2 Ser465/467/ Smad3 Ser423/425
  
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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

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Optogenetic investigation of BMP target gene expression diversity

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An integrated genomic approach identifies HOXC8 as an upstream regulator in ovarian endometrioma

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Repurposing mesalazine against cardiac fibrosis in vitro

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  Phospho-SMAD 2
  
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Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation

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BPS Publications

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  DOI: 10.1111/bph.14831
  
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TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

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Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling

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Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism

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Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish

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Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis

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KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs

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Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements

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LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation

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Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

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Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia

1
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  rabbit anti–phospho-SMAD2(S465/467)/SMAD3(S423/425)
  
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Zebrafish embryonic explants undergo genetically encoded self-assembly

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Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

1
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Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant

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A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

1
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Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

1
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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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Untitled document

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Untitled document

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Untitled document

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  DOI: 10.1016/j.immuni.2018.11.003
  
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Untitled document

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Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

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Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages

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Nov 2017
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A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis

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1. scibot 08 Nov 2017
  
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  AB_2631089
  
  Curator: @gabimpine
  
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  (Cell Signaling Technology Cat# 8828, RRID:AB_2631089)
  
  SciCrunch record: RRID:AB_2631089
  
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  RRID:AB_2631089 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1534580717303404
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Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues

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1. scibot 08 Nov 2017
  
  in Public
  
  AB_2631089
  
  Curator: @bandrow
  
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  (Cell Signaling Technology Cat# 8828, RRID:AB_2631089)
  
  SciCrunch record: RRID:AB_2631089
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2631089
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academic.oup.com/endo/article/158/5/1217/2908842/Follistatin-Targets-Distinct-Pathways-To-Promote

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