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Structural analysis of de novo-designed binders targeting the closed state of HSP90

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  DOI: 10.1016/j.str.2026.09.007
  
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Aug 2026
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ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway

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  DOI: 10.1016/j.isci.2026.117202
  
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Jul 2026
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Targeting KIF11 Degradation: Oxypeucedanin Inhibits Lung Adenocarcinoma Progression by Disrupting the MCM2-CDK1 Signaling Pathway

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.phymed.2026.158611
  
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PRDM16 modulates aspects of cell cycle dynamics and maturation in human iPSC-derived cardiomyocytes

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  DOI: 10.1016/j.stemcr.2026.103005
  
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Jun 2026
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Distinct ERK and PI3K dependencies mediate a heterogeneous response to RAS(ON) inhibition in KRAS-mutant colorectal cancer

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  DOI: 10.1016/j.celrep.2026.117559
  
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Increased vulnerability of colorectal cancer models with high alkylation damage to NTHL1 inactivation

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s41598-026-46639-y
  
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nature.com/articles/s41598-026-46639-y
May 2026
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Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer

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1. scibot 08 May 2026
  
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  DOI: 10.1007/s10495-026-02340-z
  
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link.springer.com/article/10.1007/s10495-026-02340-z
Feb 2026
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Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD

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1. scibot 04 Feb 2026
  
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  DOI: 10.1016/j.isci.2025.114596
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12856326/
Dec 2025
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Anti-Cancer Effects of the Ethyl Acetate Fraction From Opuntia humifusa on Human Triple-Negative Breast Cancer Cells

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1. scibot 18 Dec 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12705953/
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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

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  DOI: 10.1038/s41523-025-00851-7
  
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nature.com/articles/s41523-025-00851-7
Nov 2025
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YAP/TAZ transcriptional co-activators create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma

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  DOI: 10.1158/1078-0432.CCR-20-0018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8440125/
Oct 2025
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CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma

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1. scibot 21 Oct 2025
  
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  DOI: 10.1101/2025.10.14.681840
  
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biorxiv.org/content/10.1101/2025.10.14.681840v1
Aug 2025
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Design of multi-target peptide modulators for protein chaperone networks

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.str.2025.07.021
  
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A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.023
  
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1-s2.0-S2589004225015652-main-html.html

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1. scibot 07 Aug 2025
  
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52.53.155.43/85cee3d161a0de2e88ed1ed9d4903a9813261aae/1-s2.0-S2589004225015652-main-html.html
May 2025
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CDK4 loss-of-function mutations cause microcephaly and short stature

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1. scibot 20 May 2025
  
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  DOI: 10.1101/gad.352311.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617628/
Apr 2025
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Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors

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1. scibot 05 Apr 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2360
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11967718/
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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  DOI: 10.1016/j.ccell.2025.02.006
  
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Feb 2025
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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  DOI: 10.1016/j.xcrm.2025.101941
  
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sciencedirect.com/science/article/pii/S266637912500014X
Jan 2025
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CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-0562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250907/
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
Dec 2024
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1-s2.0-S2589004224027329-main-html.html

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Nov 2024
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00246-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
Sep 2024
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
Jul 2024
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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1. scibot 31 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0247
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
Jun 2024
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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1. scibot 28 Jun 2024
  
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  DOI: 10.1038/s41388-024-03081-6
  
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Apr 2024
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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

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  DOI: 10.1016/j.celrep.2024.114134
  
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Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

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  DOI: 10.1016/j.isci.2024.109591
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11022046/
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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  DOI: 10.21203/rs.3.rs-4095949/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996809/
Feb 2024
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YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia

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  DOI: 10.1016/j.isci.2024.109125
  
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52.53.155.43/3b983d9532a50e2ebeba730d1190ef88722ceb9a/PIIS2589004224003468-html.html
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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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  DOI: 10.1038/s41698-024-00496-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
Dec 2023
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Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

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1. scibot 29 Dec 2023
  
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  DOI: 10.1002/advs.202305620
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202305620
Nov 2023
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Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis

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  DOI: 10.1016/j.celrep.2023.113408
  
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sciencedirect.com/science/article/pii/S2211124723014201
Jul 2023
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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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1. scibot 14 Jul 2023
  
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  DOI: 10.1016/j.xcrm.2023.101120
  
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Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa

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Modeling breast cancer proliferation, drug synergies, and alternating therapies

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Feb 2023
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Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE

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A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

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Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells

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Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

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Untitled document

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RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway

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  CDK4
  
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Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

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  DOI: 10.1016/j.devcel.2021.04.030
  
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

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  DOI: 10.1016/j.molcel.2020.04.027
  
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Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

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  RRID:AB_2631166
  
  DOI: 10.1016/j.celrep.2021.108994
  
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A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy

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  DOI: 10.1007/s10637-020-01042-w
  
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p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound

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  anti-CDK4
  
  DOI: 10.1007/s10571-020-01006-x
  
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

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KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species‐mediated apoptosis

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  DOI: 10.1002/jcp.29743
  
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Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner

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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

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Untitled document

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  DOI: 10.7554/eLife.40856
  
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Untitled document

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  DOI: 10.1016/j.chembiol.2019.03.012
  
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Nov 2018
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Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate

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  AB_2631166
  
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Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

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ncbi.nlm.nih.gov/pmc/articles/PMC6427047/

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