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Sep 2025
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Identifying an optimal perturbation to induce a desired cell state by generative deep learning

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1. scibot 25 Sep 2025
  
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  DOI: 10.1016/j.cels.2025.101405
  
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sciencedirect.com/science/article/pii/S2405471225002388
Aug 2025
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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102317
  
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sciencedirect.com/science/article/pii/S2666379125003908
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Human cerebral organoids model tumor initiation and infiltration in an autologous astrocyte-supported setting

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113334
  
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sciencedirect.com/science/article/pii/S2589004225015950
May 2025
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Integrative characterization of MYC RNA-binding function

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xgen.2025.100878
  
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sciencedirect.com/science/article/pii/S2666979X2500134X
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer

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1. scibot 08 Feb 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0400
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11799878/
Jan 2025
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MYC Inhibition Potentiates CD8+ T Cells Against Multiple Myeloma and Overcomes Immunomodulatory Drug Resistance

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-0256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250500/
Dec 2024
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YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

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1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.007
  
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sciencedirect.com/science/article/pii/S0092867424013242
Jul 2024
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IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.05.026
  
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sciencedirect.com/science/article/pii/S1535610824002174
May 2024
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Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells

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1. scibot 30 May 2024
  
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  DOI: 10.1101/2024.05.08.593217
  
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  DOI: 10.1101/2024.05.08.593217
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11100710/
Apr 2024
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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

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1. scibot 25 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114134
  
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sciencedirect.com/science/article/pii/S2211124724004625
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BPS Publications

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1. scibot 13 Apr 2024
  
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  DOI: 10.1111/bph.16373
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16373
Nov 2023
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Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

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1. scibot 15 Nov 2023
  
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  DOI: 10.7554/eLife.80625
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10637774/
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Detection of the DNA binding of transcription factors in situ at the single-cell resolution in cultured cells by proximity ligation assay

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1. scibot 03 Nov 2023
  
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  DOI: 10.1016/j.xpro.2023.102692
  
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sciencedirect.com/science/article/pii/S2666166723006597
Oct 2023
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N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

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1. scibot 17 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.108022
  
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sciencedirect.com/science/article/pii/S2589004223020990
Jul 2023
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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112830
  
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sciencedirect.com/science/article/pii/S2211124723008410
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

K235 acetylation couples with PSPC1 to regulate the m6A demethylation activity of ALKBH5 and tumorigenesis

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1. scibot 30 Jun 2023
  
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  DOI: 10.1038/s41467-023-39414-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10300122/
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An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

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1. scibot 23 Jun 2023
  
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  RRID:AB_2631168
  
  DOI: 10.1016/j.ccell.2023.06.001
  
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sciencedirect.com/science/article/pii/S1535610823002088
May 2023
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

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1. scibot 24 May 2023
  
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  RRID:AB_2631168
  
  DOI: 10.1016/j.celrep.2023.112557
  
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sciencedirect.com/science/article/pii/S2211124723005685
Apr 2023
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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

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1. scibot 12 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101006
  
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sciencedirect.com/science/article/pii/S2666379123001167
Mar 2023
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Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

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1. scibot 29 Mar 2023
  
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  DOI: 10.1158/2767-9764.CRC-22-0255
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9949381/
Jan 2023
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Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.ccell.2022.12.008
  
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sciencedirect.com/science/article/pii/S1535610822005943
Oct 2022
www.cell.com www.cell.com

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

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1. scibot 28 Oct 2022
  
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  DOI: 10.1016/j.ccell.2022.10.004
  
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cell.com/cancer-cell/fulltext/S1535-6108(22)00495-0
Sep 2022
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Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia

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1. scibot 02 Sep 2022
  
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  DOI: 10.1158/2159-8290.CD-21-0551
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
Jul 2022
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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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1. scibot 13 Jul 2022
  
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  RRID:AB_2631168
  
  DOI: 10.1016/j.devcel.2022.06.006
  
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sciencedirect.com/science/article/pii/S1534580722004464
www.embopress.org www.embopress.org

LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

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1. scibot 09 Jul 2022
  
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  DOI: 10.15252/embr.202154195
  
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embopress.org/doi/10.15252/embr.202154195
Mar 2022
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MicroRNA-101a-3p mimic ameliorates spinal cord... : Neural Regeneration Research

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1. scibot 10 Mar 2022
  
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  DOI: 10.4103/1673-5374.335164
  
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journals.lww.com/nrronline/Fulltext/2022/17090/MicroRNA_101a_3p_mimic_ameliorates_spinal_cord.34.aspx
Dec 2021
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Yap-Myc signaling induces pancreatic stellate cell activation through regulating glutaminolysis

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1. scibot 28 Dec 2021
  
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  DOI: 10.1016/j.yexcr.2021.113000
  
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sciencedirect.com/science/article/pii/S0014482721005565
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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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1. scibot 18 Dec 2021
  
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  DOI: 10.1038/s41467-021-27502-2
  
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nature.com/articles/s41467-021-27502-2
Aug 2021
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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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  DOI: 10.1016/j.isci.2021.102845
  
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sciencedirect.com/science/article/pii/S2589004221008130
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HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

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1. scibot 15 Aug 2021
  
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  DOI: 10.7554/eLife.64148
  
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elifesciences.org/articles/64148
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Untitled document

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1. scibot 07 Aug 2021
  
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  DOI: 10.1038/s41598-018-36387-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6303337/
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Untitled document

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1. scibot 07 Aug 2021
  
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  DOI: 10.1016/j.celrep.2018.11.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6302735/
Jul 2021
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Untitled document

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.celrep.2018.11.018
  
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sciencedirect.com/science/article/pii/S2211124718317649
www.fasebj.org www.fasebj.org

Untitled document

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1. scibot 28 Jul 2021
  
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  RRID:AB_2631168
  
  DOI: 10.1096/fj.201800687
  
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fasebj.org/doi/abs/10.1096/fj.201800687
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Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

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1. scibot 03 Jul 2021
  
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  DOI: 10.1016/j.molcel.2021.06.014
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
May 2021
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Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

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  DOI: 10.1016/j.immuni.2021.04.014
  
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Apr 2021
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

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  DOI: 10.1016/j.celrep.2021.109013
  
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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

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Mar 2021
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PTEN dephosphorylates Abi1 to promote epithelial morphogenesis

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  DOI: 10.1083/jcb.201910041
  
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Feb 2021
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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

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1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.molcel.2020.12.026
  
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Jan 2021
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The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity

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1. scibot 21 Jan 2021
  
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  DOI: 10.1186/s12943-021-01308-8
  
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Sep 2020
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Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

1
1. scibot 30 Sep 2020
  
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  DOI: 10.1038/s41598-020-71550-5
  
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MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.05.001
  
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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.01.001
  
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MYC Controls the Epstein-Barr Virus Lytic Switch

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.03.025
  
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PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1

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1. scibot 04 Sep 2020
  
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  DOI: 10.1038/s41598-020-69698-1
  
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CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

1
1. scibot 03 Sep 2020
  
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  anti-MYC
  
  DOI: 10.1038/s41589-019-0424-1
  
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nature.com/articles/s41589-019-0424-1
Jan 2020
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A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.devcel.2019.07.022
  
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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ccell.2019.10.002
  
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Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2631168
  
  DOI: 10.1073/pnas.1805298115
  
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Untitled document

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  RRID:AB_2631168
  
  DOI: 10.1038/s41598-018-36387-z
  
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Untitled document

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  DOI: 10.1016/j.chembiol.2019.03.012
  
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Untitled document

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  DOI: 10.1016/j.molcel.2019.02.029
  
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sciencedirect.com/science/article/pii/S1097276519301406
Nov 2018
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

1
1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

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1. scibot 05 Nov 2018
  
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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

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1. scibot 05 Nov 2018
  
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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

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1. scibot 05 Nov 2018
  
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Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

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Nov 2017
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A conformational switch regulates the ubiquitin ligase HUWE1

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1. scibot 08 Nov 2017
  
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  AB_2631168
  
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