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Mapping Dysfunctional Protein-Protein Interactions in Disease

1
1. scibot 30 Oct 2025
  
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  RRID:AB_2632593
  
  DOI: 10.3791/69197
  
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app.jove.com/t/69197/mapping-dysfunctional-protein-protein-interactions-in-disease
Jul 2025
www.biorxiv.org www.biorxiv.org

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

1
1. scibot 30 Jul 2025
  
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  RRID:AB_2632593
  
  DOI: 10.1101/2025.07.22.666069
  
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biorxiv.org/content/10.1101/2025.07.22.666069v1
Jun 2025
52.53.155.43 52.53.155.43

ENEURO.0149-16.2017.full-html.html

1
1. scibot 26 Jun 2025
  
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  RRID:AB_2632593
  
  DOI: 10.1523/eneuro.0149-16.2017
  
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52.53.155.43/15d555d90ef5c3ac2c5d7b24efa8a9a51c9e436b/ENEURO.0149-16.2017.full-html.html
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 12 Jun 2025
  
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  RRID:AB_2632593
  
  DOI: 10.1158/0008-5472.can-24-3785
  
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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
Apr 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma

1
1. scibot 01 Apr 2025
  
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  DOI: 10.1002/mc.23910
  
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onlinelibrary.wiley.com/doi/10.1002/mc.23910
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer’s Disease Spectrum

1
1. scibot 08 Mar 2025
  
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  DOI: 10.21203/rs.3.rs-5930673/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844643/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

2
1. scibot 01 May 2024
  
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  RRID: AB_2632593
  
  DOI: 10.21203/rs.3.rs-4114038/v1
  
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2. scibot 01 May 2024
  
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  RRID:AB_2632593
  
  DOI: 10.21203/rs.3.rs-4114038/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

1
1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.ccell.2024.04.004
  
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sciencedirect.com/science/article/pii/S1535610824001284
www.nature.com www.nature.com

A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells

1
1. scibot 10 Apr 2024
  
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  RRID:AB_2632593
  
  DOI: 10.1038/s41418-024-01289-3
  
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nature.com/articles/s41418-024-01289-3
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chick chorioallantoic membrane model to investigate role of migrasome in angiogenensis

1
1. scibot 23 Mar 2024
  
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  RRID:AB_2632593
  
  DOI: 10.52601/bpr.2023.230021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951478/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Interaction of PINK1 with nucleotides and kinetin

1
1. scibot 23 Jan 2024
  
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  DOI: 10.1126/sciadv.adj7408
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798554/
Oct 2023
www.sciencedirect.com www.sciencedirect.com

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

1
1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.xcrm.2023.101244
  
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sciencedirect.com/science/article/pii/S2666379123004214
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization

1
1. scibot 24 Jun 2023
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.chembiol.2023.05.011
  
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sciencedirect.com/science/article/pii/S245194562300154X
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How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view

1
1. scibot 21 Jun 2023
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.str.2023.05.017
  
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sciencedirect.com/science/article/pii/S0969212623001934
May 2023
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Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response

1
1. scibot 19 May 2023
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.celrep.2023.112522
  
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sciencedirect.com/science/article/pii/S2211124723005338
Sep 2022
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The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways

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1. scibot 21 Sep 2022
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.celrep.2022.111374
  
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sciencedirect.com/science/article/pii/S2211124722012062
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TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy

1
1. scibot 11 Sep 2022
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.crmeth.2022.100292
  
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sciencedirect.com/science/article/pii/S2667237522001746
Jul 2022
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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

1
1. scibot 08 Jul 2022
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.isci.2022.104632
  
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sciencedirect.com/science/article/pii/S258900422200904X
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

1
1. scibot 04 Jun 2022
  
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  RRID:AB_2632593
  
  DOI: 10.7554/eLife.69802
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9154743/
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

1
1. scibot 02 Mar 2022
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.celrep.2022.110436
  
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sciencedirect.com/science/article/pii/S2211124722001632
Feb 2022
link.springer.com link.springer.com

Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

1
1. scibot 02 Feb 2022
  
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  RRID:AB_2632593
  
  DOI: 10.1007/s10456-022-09831-y
  
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link.springer.com/article/10.1007/s10456-022-09831-y
Jan 2022
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Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216

1
1. scibot 22 Jan 2022
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.molcel.2021.12.005
  
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sciencedirect.com/science/article/pii/S1097276521010674
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Critical roles of a housekeeping sortase of probiotic Bifidobacterium bifidum in bacterium–host cell crosstalk

1
1. scibot 02 Dec 2021
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.isci.2021.103363
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8603203/
Jul 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Untitled document

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1. scibot 30 Jul 2021
  
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  RRID:AB_2632593
  
  DOI: 10.1111/jnc.14630
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14630
www.nature.com www.nature.com

BAX mitochondrial integration is regulated allosterically by its α1−α2 loop

1
1. scibot 22 Jul 2021
  
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  4010-05
  
  DOI: 10.1038/s41418-021-00815-x
  
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nature.com/articles/s41418-021-00815-x
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.celrep.2020.107840
  
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sciencedirect.com/science/article/pii/S2211124720308214
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

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1. scibot 13 Sep 2020
  
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  DOI: 10.1016/j.immuni.2020.07.004
  
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sciencedirect.com/science/article/pii/S1074761320302843
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

1
1. scibot 06 Sep 2020
  
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  DOI: 10.1038/s41419-020-2463-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7181796/
Jan 2020
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_2632593
  
  DOI: 10.1016/j.celrep.2019.03.040
  
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  Curator: @ethanbadger
  
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  RRID:AB_2632593 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719303560
Nov 2018
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Ensemble Properties of Bax Determine Its Function

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0969212618302521
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Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0092867417313880
Nov 2017
onlinelibrary.wiley.com onlinelibrary.wiley.com

“Prion‐like” propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum

1
1. scibot 08 Nov 2017
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14139/full
www.eneuro.org www.eneuro.org

Untitled document

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1. scibot 08 Nov 2017
  
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eneuro.org/content/4/2/ENEURO.0149-16.2017
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

1
1. scibot 08 Nov 2017
  
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  AB_2632593
  
  Curator: @chewbeccax
  
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  (SouthernBiotech Cat# 4010-05, RRID:AB_2632593)
  
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  RRID:AB_2632593 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC5367084/