347 Matching Annotations
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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11649786/
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    Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
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    sciencedirect.com/science/article/pii/S0960982224016385
  4. Dec 2024
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    Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway
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    Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy
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    CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
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    sciencedirect.com/science/article/pii/S1097276524009493
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    Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders
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    sciencedirect.com/science/article/pii/S2211124724013482
  9. Nov 2024
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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    Drosophila p53 tumor suppressor directly activates conserved asymmetric stem cell division regulators
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    Axonal injury signaling is restrained by a spared synaptic branch
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    CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
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    sciencedirect.com/science/article/pii/S1934590924003692
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    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
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    Constitutive and Conditional Epitope Tagging of Endogenous G-Protein–Coupled Receptors in Drosophila
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  16. Oct 2024
  17. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  18. Sep 2024
  19. www.biorxiv.org www.biorxiv.org
    Multidirectional effect of low-intensity electrical myostimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse
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    CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
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    Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography
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    Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury
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    sciencedirect.com/science/article/pii/S2666379124004361
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    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
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  24. Aug 2024
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    Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology, cognition, and behavior in APP/PS1 mice
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    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    Generation and characterization of human-derived induced pluripotent stem cell line (IGIBi010-A) from a patient with neurodegenerative disease phenotype carrying mutation in SQSTM1/p62 gene
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  28. www.biorxiv.org www.biorxiv.org
    A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster
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  29. 52.53.155.43 52.53.155.43
    The EMBO Journal - 2023 - Pelzer - Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the-html.html
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  30. www.frontiersin.org www.frontiersin.org
    Glucocorticoids Promote Extracellular Matrix Component Remodeling by Activating YAP in Human Retinal Capillary Endothelial Cells
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  31. Jul 2024
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    Intracellular tau fragment droplets serve as seeds for tau fibrils
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Logic of Synaptic Diversity Between Drosophila Tonic and Phasic Motoneurons
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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterising replisome disassembly in human cells
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    Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium
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  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocytes facilitate gabazine-evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures
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  38. www.biorxiv.org www.biorxiv.org
    Sex-specific loss of mitochondrial membrane integrity and mass in the auditory brainstem of a mouse model of Fragile X syndrome
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preventing loss of sirt1 lowers mitochondrial oxidative stress and preserves c2c12 myotube diameter in an in vitro model of cancer cachexia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215470/
  41. www.biorxiv.org www.biorxiv.org
    Cell-specific inhibitory modulation of sound processing in the auditory thalamus
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  42. Jun 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons
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      DOI: 10.1093/nar/gkae261

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    ncbi.nlm.nih.gov/pmc/articles/PMC11194071/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Avoiding Alkaline Taste through Ionotropic Receptors
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
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  46. 52.53.155.43 52.53.155.43
    KIF22 regulates mitosis and proliferation of chondrocyte cells.
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation
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  48. May 2024
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    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
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    LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination
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  51. 52.53.155.43 52.53.155.43
    Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B Cells through Tunnelling Nanotubes
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      DOI: 10.20944/preprints202401.1738.v1

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    Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor
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    ATG9B regulates bacterial internalization via actin rearrangement
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  54. 52.53.155.43 52.53.155.43
    Tolerance thresholds underlie responses to DNA damage during germline development
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  55. Apr 2024
  56. www.embopress.org www.embopress.org
    The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor
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    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning
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    A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster
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    Human V-ATPase function is positively and negatively regulated by TLDc proteins
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    Mechanical strengthening of cell-cell adhesion during mouse embryo compaction
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  61. Mar 2024
  62. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
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    SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells
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    Generation and characterization of iPSC lines from Friedreich’s ataxia patient (FRDA) with GAA.TTC repeat expansion in the Frataxin (FXN) gene’s first intron (IGIBi016-A) and a non-FRDA healthy control individual (IGIBi017-A)
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    Characterization of novel PHEX variants in X-linked hypophosphatemic rickets and genotype-PHEX activity correlation
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    Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury
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  67. Feb 2024
  68. www.sciencedirect.com www.sciencedirect.com
    Developmental remodeling repurposes larval neurons for sexual behaviors in adult Drosophila
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  69. aacrjournals.org aacrjournals.org
    p53R245W mutation fuels cancer initiation and metastases in NASH-driven liver tumorigenesis
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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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    Generation of an induced pluripotent stem cell line (SYSUSCi004-A) from a patient with Infantile Malignant Osteopetrosis
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    Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes
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    Generation of two human induced pluripotent stem cell lines, IGIBi012-A and IGIBi013-A from Friedreich’s ataxia (FRDA) patients with homozygous GAA repeat expansion in FXN gene
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    PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends
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  77. journals.plos.org journals.plos.org
    Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene
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    A time window for rescuing dying retinal ganglion cells
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    SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex
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  80. Jan 2024
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    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
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    Protein 4.1N plays a cell-type specific role in hippocampal glutamatergic synapse regulation
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  85. Dec 2023
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    The EMBO Journal - 2023 - Pelzer - Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the-html.html
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    Generation and characterization of two human iPSC lines, IGIBi014-A and IGIBi015-A, from Friedreich's ataxia (FRDA) patients with pathogenic (GAA/TTC)n repeat expansion in first intron of the Frataxin (FXN) gene
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    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    Integrated omics landscape of hepatocellular carcinoma suggests proteomic subtypes for precision therapy
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    Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
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  91. Nov 2023
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    Pigmented skin exhibits accelerated wound healing compared to the nonpigmented skin in Guinea pig model
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  93. Oct 2023
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    Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    Peroxisomal ERK mediates Akh/glucagon action and glycemic control
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    Dental Pulp Stem Cells Accelerate Wound Healing through CCL2 induced M2 Macrophages Polarization
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    An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates
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  99. Sep 2023
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    Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate
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    Hyperglycemia-regulated tRNA-derived fragment tRF-3001a propels neurovascular dysfunction in diabetic mice
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    MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy
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    Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis
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    Image-based and machine learning-guided multiplexed serology test for SARS-CoV-2
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    Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons
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    Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
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  108. Jul 2023
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    PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics
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    A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
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    Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER
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    Alcohol Clin Exp Res - 2023 - Shanmugam - Ethanol inhibition of undifferentiated rat neural progenitor cell replication-html.html
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  115. Jun 2023
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    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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    Three induced pluripotent stem cell lines (TRNDi033-A, TRNDi034-A, TRNDi035-A) generated from lymphoblasts of three apparently healthy individuals
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    Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability
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    Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum
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  120. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C
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    Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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    APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
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    The developmental sequence of the dendritic spine and synapse maturation in transcription factor-induced human iPSC-derived neurons
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    Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis
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    The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
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  132. Mar 2023
  133. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents
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    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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    Methods to study motile ciliated cell types in the zebrafish brain
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    Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
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    Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi002-A) from a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency
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    Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation
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    Generation of induced pluripotent stem cells (iPSCs) from a microvillus inclusion disease patient with a homozygous missense mutation in UNC45A
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    Illuminating cellular and extracellular vesicle-mediated communication via a split-Nanoluc reporter in vitro and in vivo
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    ARMS-NF-κB signaling regulates intracellular ROS to induce autophagy-associated cell death upon oxidative stress
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    Prenatal low-dose methylmercury exposure causes premature neuronal differentiation and autism-like behaviors in a rodent model
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    Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits
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    The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins
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    Structural and functional integration of human forebrain organoids with the injured adult rat visual system
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    UCP2-dependent redox sensing in POMC neurons regulates feeding
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    SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
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    VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites
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    Characterization of microglia behaviour in healthy and pathological conditions with image analysis tools
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    Generation of two induced pluripotent stem cell lines from individuals without auditory disorders
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  155. Dec 2022
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    Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality
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    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
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    Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
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    Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke
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  160. Nov 2022
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    Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS
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    p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
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    Heat shock factor HSF1 regulates BDNF gene promoters upon acute stress in the hippocampus, together with pCREB
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    Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
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  165. Oct 2022
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    Zebrafish Neuromesodermal Progenitors Undergo a Critical State Transition in vivo
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    Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer
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    Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying TTN mutations
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    The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling
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    Generation of three human iPSC lines from patients with Huntington’s Disease with different CAG lengths and human control iPSC line from a healthy donor
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    Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease
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    Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila
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    Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes
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  189. Jul 2022
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    Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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    Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT-1 expression and impairment of NKA1A2 function
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    G protein-coupled estrogen receptor activates cell type-specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
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    Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection
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    hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis
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    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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    The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    sciencedirect.com/science/article/pii/S187350612100444X
  233. Oct 2021
  234. www.sciencedirect.com www.sciencedirect.com
    Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters
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    1. scibot 30 Oct 2021
      RRID:AB_2633275

      DOI: 10.1016/j.immuni.2021.10.009

      Resource: (Thermo Fisher Scientific Cat# A32723, RRID:AB_2633275)

      Curator: @scibot

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    sciencedirect.com/science/article/pii/S1074761321004465
  235. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis
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    1. scibot 23 Oct 2021
      RRID:AB_2633275

      DOI: 10.7554/eLife.66709

      Resource: (Thermo Fisher Scientific Cat# A32723, RRID:AB_2633275)

      Curator: @scibot

      SciCrunch record: RRID:AB_2633275

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      RRID:AB_2633275
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    ncbi.nlm.nih.gov/pmc/articles/PMC8516418/