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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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  3. Nov 2024
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    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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  5. Sep 2024
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    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis
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    “β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease”
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    Glycogen synthase kinase‐3ß supports serotonin transporter function and trafficking in a phosphorylation‐dependent manner
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  9. Aug 2024
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    MiR-137-3p mechanisms of action and blood-brain barrier penetrating and neuron-targeting lipid nanoparticles deliver miR-137-3p for the treatment of Alzheimer's disease
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    BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
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    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
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  13. Jun 2024
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    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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  15. May 2024
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    Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking
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    Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
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    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
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  19. Apr 2024
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    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
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  21. Mar 2024
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
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  24. Feb 2024
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    Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma
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    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
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  27. Jan 2024
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    miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.
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    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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  30. Dec 2023
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    Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain
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  32. Oct 2023
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    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
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    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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  36. Aug 2023
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  38. Jul 2023
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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  40. Jun 2023
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
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  43. May 2023
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice
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    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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  47. Apr 2023
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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  49. Mar 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats
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  51. Feb 2023
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    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    sciencedirect.com/science/article/pii/S2589004223001475
  53. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    sciencedirect.com/science/article/pii/S0092867422012521
  55. Jun 2022
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    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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    Active APPL1 sequestration by Plasmodium favors liver-stage development
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  58. May 2022
  59. aacrjournals.org aacrjournals.org
    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
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      DOI: 10.1158/1541-7786.MCR-21-0699

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    aacrjournals.org/mcr/article/20/5/810/694642/Tumor-Microenvironment-Acidity-Triggers-Lipid
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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      DOI: 10.1186/s13024-022-00526-y

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  61. Apr 2022
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
    1
    1. scibot 29 Apr 2022
      RRID:AB_2636978

      DOI: 10.1038/s41467-022-29644-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC9038906/
  63. Mar 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Neddylation is essential for β-catenin degradation in Wnt signaling pathway
    1
    1. scibot 23 Mar 2022
      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2022.110538

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    sciencedirect.com/science/article/pii/S2211124722002790
  65. www.sciencedirect.com www.sciencedirect.com
    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2022.110509

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    sciencedirect.com/science/article/pii/S2211124722002455
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crry silencing alleviates Alzheimer’s disease injury by regulating neuroinflammatory cytokines and the complement system
    1
    1. scibot 04 Mar 2022
      AB_2636978

      DOI: 10.4103/1673-5374.332160

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    ncbi.nlm.nih.gov/pmc/articles/PMC8820699/
  67. Jan 2022
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
    1
    1. scibot 15 Jan 2022
      RRID:AB_2636978

      DOI: 10.7554/eLife.64498

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752093/
  69. Dec 2021
  70. www.cell.com www.cell.com
    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
    1
    1. scibot 29 Dec 2021
      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2021.110155

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    cell.com/cell-reports/fulltext/S2211-1247(21)01651-X
  71. Oct 2021
  72. www.sciencedirect.com www.sciencedirect.com
    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
    1
    1. scibot 29 Oct 2021
      RRID:AB_2636978

      DOI: 10.1016/j.isci.2021.103196

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    sciencedirect.com/science/article/pii/S2589004221011640
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation
    1
    1. scibot 21 Oct 2021
      RRID:AB_2636978

      DOI: 10.4103/1673-5374.317987

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    ncbi.nlm.nih.gov/pmc/articles/PMC8463973/
  74. Aug 2021
  75. www.sciencedirect.com www.sciencedirect.com
    An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2021.109569

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    sciencedirect.com/science/article/pii/S2211124721010032
  76. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Nonenzymatic function of DPP4 in diabetes-associated mitochondrial dysfunction and cognitive impairment
    1
    1. scibot 16 Aug 2021
      RRID:AB_2636978

      DOI: 10.1002/alz.12437

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    alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12437
  77. elifesciences.org elifesciences.org
    Untitled document
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      DOI: 10.7554/eLife.39887

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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
    1
    1. scibot 07 Aug 2021
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      DOI: 10.1016/j.isci.2021.102807

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    ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
  79. www.sciencedirect.com www.sciencedirect.com
    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
    1
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      DOI: 10.1016/j.molcel.2021.07.013

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    sciencedirect.com/science/article/pii/S1097276521005827
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.39887

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    ncbi.nlm.nih.gov/pmc/articles/PMC6214654/
  81. academic.oup.com academic.oup.com
    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
    1
    1. scibot 02 Aug 2021
      RRID:AB_2636978

      DOI: 10.1210/en.2017-00287

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    academic.oup.com/endo/article/158/9/2813/3956591
  82. Jul 2021
  83. www.sciencedirect.com www.sciencedirect.com
    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
    1
    1. scibot 30 Jul 2021
      RRID:AB_2636978

      DOI: 10.1016/j.chom.2019.11.012

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    sciencedirect.com/science/article/pii/S1931312819305943
  84. www.sciencedirect.com www.sciencedirect.com
    Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
    1
    1. scibot 30 Jul 2021
      GSK3β (D5C5Z) XP® Rabbit mAb

      DOI: 10.1016/j.ccell.2019.03.007

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    sciencedirect.com/science/article/pii/S1535610819301527
  85. academic.oup.com academic.oup.com
    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
    2
    1. scibot 28 Jul 2021
      AB_2636978

      DOI: 10.1210/en.2017-00287

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      RRID:AB_2636978

      DOI: 10.1210/en.2017-00287

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    academic.oup.com/endo/article/158/9/2813/3956591
  86. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
    1
    1. scibot 01 Jul 2021
      12456

      DOI: 10.1016/j.biocel.2021.106028

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    sciencedirect.com/science/article/pii/S1357272521001060
  87. May 2021
  88. www.sciencedirect.com www.sciencedirect.com
    A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis
    1
    1. scibot 05 May 2021
      RRID:AB_2636978

      DOI: 10.1016/j.cmet.2021.04.006

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    sciencedirect.com/science/article/pii/S1550413121001728
  89. Apr 2021
  90. www.sciencedirect.com www.sciencedirect.com
    An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
    1
    1. scibot 30 Apr 2021
      RRID:AB_26369787

      DOI: 10.1016/j.cmet.2020.12.017

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    sciencedirect.com/science/article/pii/S1550413120306720
  91. www.sciencedirect.com www.sciencedirect.com
    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
    1
    1. scibot 29 Apr 2021
      RRID:AB_2636978

      DOI: 10.1016/j.cmet.2020.08.001

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    sciencedirect.com/science/article/pii/S1550413120304149
  92. Mar 2021
  93. link.springer.com link.springer.com
    DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells
    1
    1. scibot 18 Mar 2021
      RRID:AB_2636978

      DOI: 10.1007/s11064-021-03273-6

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    link.springer.com/article/10.1007/s11064-021-03273-6
  94. Feb 2021
  95. www.sciencedirect.com www.sciencedirect.com
    Long-term kappa-carrageenan consumption leads to moderate metabolic disorder by blocking insulin binding
    1
    1. scibot 28 Feb 2021
      RRID:AB_2636978

      DOI: 10.1016/j.phrs.2020.105417

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    sciencedirect.com/science/article/pii/S1043661820317254
  96. academic.oup.com academic.oup.com
    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
    2
    1. scibot 28 Feb 2021
      RRID:AB_2636978

      DOI: 10.1210/endocr/bqaa214

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    2. scibot 24 Feb 2021
      RRID: AB_2636978

      DOI: 10.1210/endocr/bqaa214

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    academic.oup.com/endo/article/162/1/bqaa214/5992137
  97. academic.oup.com academic.oup.com
    Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes
    1
    1. scibot 24 Feb 2021
      RRID:AB_2636978

      DOI: 10.1210/endocr/bqaa003

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    academic.oup.com/endo/article/161/2/bqaa003/5698328
  98. Jan 2021
  99. link.springer.com link.springer.com
    The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
    1
    1. scibot 21 Jan 2021
      RRID:AB_2636978

      DOI: 10.1186/s12943-021-01308-8

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    link.springer.com/article/10.1186/s12943-021-01308-8
  100. link.springer.com link.springer.com
    GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats
    1
    1. scibot 06 Jan 2021
      rabbit anti-GSK3β

      DOI: 10.1007/s10571-020-01020-z

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    link.springer.com/article/10.1007/s10571-020-01020-z
  101. Oct 2020
  102. www.sciencedirect.com www.sciencedirect.com
    Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation
    1
    1. scibot 31 Oct 2020
      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.108327

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    sciencedirect.com/science/article/pii/S2211124720313164
  103. www.sciencedirect.com www.sciencedirect.com
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
    1
    1. scibot 08 Oct 2020
      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.108223

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    sciencedirect.com/science/article/pii/S2211124720312122
  104. Sep 2020
  105. onlinelibrary.wiley.com onlinelibrary.wiley.com
    microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury
    1
    1. scibot 23 Sep 2020
      RRID:AB_2636978

      DOI: 10.1111/jnc.14963

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14963
  106. www.sciencedirect.com www.sciencedirect.com
    The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.108140

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    sciencedirect.com/science/article/pii/S2211124720311293
  107. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 16 Sep 2020
      RRID:AB_2636978

      DOI: 10.1111/bph.14980

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14980
  108. www.sciencedirect.com www.sciencedirect.com
    HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
    1
    1. scibot 13 Sep 2020
      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.107625

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    sciencedirect.com/science/article/pii/S2211124720305787
  109. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 09 Sep 2020
      RRID:AB_2636978

      DOI: 10.1111/bph.14912

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14912
  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
    1
    1. scibot 04 Sep 2020
      RRID:AB_2636978

      DOI: 10.1111/jnc.14954

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14954
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
    1
    1. scibot 04 Sep 2020
      Rabbit anti-GSK-3β

      DOI: 10.3389/fncel.2020.00094

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  112. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
    1
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      GSK3β

      DOI: 10.1126/scisignal.aax2364

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  113. Jan 2020
  114. www.sciencedirect.com www.sciencedirect.com
    Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
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  115. www.sciencedirect.com www.sciencedirect.com
    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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      DOI: 10.1016/j.ebiom.2019.08.033

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    Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages
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      DOI: 10.1016/j.immuni.2019.06.014

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  117. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  118. www.sciencedirect.com www.sciencedirect.com
    The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
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      DOI: 10.1016/j.celrep.2019.08.091

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  119. www.sciencedirect.com www.sciencedirect.com
    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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      DOI: 10.1016/j.chom.2019.11.012

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  120. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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      DOI: 10.1016/j.ccell.2018.10.001

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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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  122. Nov 2018
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  124. www.frontiersin.org www.frontiersin.org
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  125. www.sciencedirect.com www.sciencedirect.com
    Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling
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  126. www.sciencedirect.com www.sciencedirect.com
    Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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  128. www.sciencedirect.com www.sciencedirect.com
    AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
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  129. www.sciencedirect.com www.sciencedirect.com
    TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
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    sciencedirect.com/science/article/pii/S0896627318300564
  130. Nov 2017
  131. www.pnas.org www.pnas.org
    Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity
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  132. www.sciencedirect.com www.sciencedirect.com
    β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling
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      Curator: @chewbeccax

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