88 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.isci.2024.110199

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    sciencedirect.com/science/article/pii/S258900422401424X
  3. May 2024
  4. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking
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    1. scibot 30 May 2024
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      DOI: 10.1111/jnc.16134

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16134
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    Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
    1
    1. scibot 14 May 2024
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      DOI: 10.1016/j.celrep.2024.114226

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    sciencedirect.com/science/article/pii/S2211124724005540
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
    1
    1. scibot 04 May 2024
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      DOI: 10.1158/0008-5472.CAN-23-2268

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063763/
  7. Apr 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.isci.2024.109540

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993184/
  9. Mar 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
    1
    1. scibot 09 Mar 2024
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      DOI: 10.14814/phy2.15969

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113927

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    ncbi.nlm.nih.gov/pmc/articles/PMC11101011/
  12. Feb 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1111/cas.16100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11007052/
  14. link.springer.com link.springer.com
    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
    1
    1. scibot 01 Feb 2024
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      DOI: 10.1007/s00213-024-06530-y

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    link.springer.com/article/10.1007/s00213-024-06530-y
  15. Jan 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1016/j.isci.2023.108650

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    ncbi.nlm.nih.gov/pmc/articles/PMC10788216/
  17. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  18. Dec 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain
    1
    1. scibot 07 Dec 2023
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      DOI: 10.1016/j.isci.2023.108409

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    ncbi.nlm.nih.gov/pmc/articles/PMC10696114/
  20. Oct 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.xcrm.2023.101238

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    sciencedirect.com/science/article/pii/S2666379123004159
  22. www.cell.com www.cell.com
    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.isci.2023.107940

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    cell.com/iscience/abstract/S2589-0042(23)02017-5
  23. www.sciencedirect.com www.sciencedirect.com
    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  24. Aug 2023
  25. 52.53.155.43 52.53.155.43
    crc-22-0293-html.html
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    1. scibot 11 Aug 2023
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      DOI: 10.1158/2767-9764.CRC-22-0293

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      DOI: 10.1158/2767-9764.crc-22-0293

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    52.53.155.43/4f107a6ec2874295e908f0e6a1a5e9653abe6492/crc-22-0293-html.html
  26. Jul 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
    1
    1. scibot 14 Jul 2023
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      DOI: 10.1016/j.ccell.2023.06.007

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    sciencedirect.com/science/article/pii/S1535610823002179
  28. Jun 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112647

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    sciencedirect.com/science/article/pii/S2211124723006587
  30. www.cell.com www.cell.com
    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
    1
    1. scibot 03 Jun 2023
      RRID:AB_2636978

      DOI: 10.1016/j.chom.2023.05.007

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    cell.com/cell-host-microbe/fulltext/S1931-3128(23)00200-7
  31. May 2023
  32. www.sciencedirect.com www.sciencedirect.com
    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
    1
    1. scibot 25 May 2023
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      DOI: 10.1016/j.celrep.2023.112536

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    sciencedirect.com/science/article/pii/S2211124723005478
  33. www.sciencedirect.com www.sciencedirect.com
    16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice
    1
    1. scibot 11 May 2023
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      DOI: 10.1016/j.celrep.2023.112485

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    sciencedirect.com/science/article/pii/S2211124723004965
  34. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
    1
    1. scibot 06 May 2023
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      DOI: 10.1038/s41467-023-38165-6

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    nature.com/articles/s41467-023-38165-6
  35. Apr 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
    1
    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.cmet.2023.03.021

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    sciencedirect.com/science/article/pii/S1550413123001262
  37. Mar 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats
    1
    1. scibot 05 Mar 2023
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      DOI: 10.1152/ajpendo.00240.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8897003/
  39. Feb 2023
  40. www.sciencedirect.com www.sciencedirect.com
    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1016/j.isci.2023.106070

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    sciencedirect.com/science/article/pii/S2589004223001475
  41. Oct 2022
  42. www.sciencedirect.com www.sciencedirect.com
    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
    1
    1. scibot 28 Oct 2022
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      DOI: 10.1016/j.cell.2022.09.033

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    sciencedirect.com/science/article/pii/S0092867422012521
  43. Jun 2022
  44. www.sciencedirect.com www.sciencedirect.com
    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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    1. scibot 22 Jun 2022
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      DOI: 10.1016/j.molcel.2022.05.025

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    sciencedirect.com/science/article/pii/S1097276522004920
  45. www.sciencedirect.com www.sciencedirect.com
    Active APPL1 sequestration by Plasmodium favors liver-stage development
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    1. scibot 03 Jun 2022
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      DOI: 10.1016/j.celrep.2022.110886

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    sciencedirect.com/science/article/pii/S2211124722006611
  46. May 2022
  47. aacrjournals.org aacrjournals.org
    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
    1
    1. scibot 13 May 2022
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      DOI: 10.1158/1541-7786.MCR-21-0699

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    aacrjournals.org/mcr/article/20/5/810/694642/Tumor-Microenvironment-Acidity-Triggers-Lipid
  48. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
    1
    1. scibot 05 May 2022
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      DOI: 10.1186/s13024-022-00526-y

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    link.springer.com/article/10.1186/s13024-022-00526-y
  49. Apr 2022
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
    1
    1. scibot 29 Apr 2022
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      DOI: 10.1038/s41467-022-29644-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC9038906/
  51. Mar 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Neddylation is essential for β-catenin degradation in Wnt signaling pathway
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    1. scibot 23 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110538

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    sciencedirect.com/science/article/pii/S2211124722002790
  53. www.sciencedirect.com www.sciencedirect.com
    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
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      DOI: 10.1016/j.celrep.2022.110509

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    sciencedirect.com/science/article/pii/S2211124722002455
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crry silencing alleviates Alzheimer’s disease injury by regulating neuroinflammatory cytokines and the complement system
    1
    1. scibot 04 Mar 2022
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      DOI: 10.4103/1673-5374.332160

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    ncbi.nlm.nih.gov/pmc/articles/PMC8820699/
  55. Jan 2022
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
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      DOI: 10.7554/eLife.64498

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752093/
  57. Dec 2021
  58. www.cell.com www.cell.com
    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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    1. scibot 29 Dec 2021
      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2021.110155

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    cell.com/cell-reports/fulltext/S2211-1247(21)01651-X
  59. Oct 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
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    1. scibot 29 Oct 2021
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      DOI: 10.1016/j.isci.2021.103196

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    sciencedirect.com/science/article/pii/S2589004221011640
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation
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    1. scibot 21 Oct 2021
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      DOI: 10.4103/1673-5374.317987

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    ncbi.nlm.nih.gov/pmc/articles/PMC8463973/
  62. Aug 2021
  63. www.sciencedirect.com www.sciencedirect.com
    An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver
    1
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      DOI: 10.1016/j.celrep.2021.109569

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  64. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Nonenzymatic function of DPP4 in diabetes-associated mitochondrial dysfunction and cognitive impairment
    1
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      RRID:AB_2636978

      DOI: 10.1002/alz.12437

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  65. elifesciences.org elifesciences.org
    Untitled document
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      DOI: 10.7554/eLife.39887

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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
    1
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      DOI: 10.1016/j.isci.2021.102807

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    ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
  67. www.sciencedirect.com www.sciencedirect.com
    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  69. academic.oup.com academic.oup.com
    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
    1
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      RRID:AB_2636978

      DOI: 10.1210/en.2017-00287

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  70. Jul 2021
  71. www.sciencedirect.com www.sciencedirect.com
    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
    1
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      DOI: 10.1016/j.chom.2019.11.012

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  72. www.sciencedirect.com www.sciencedirect.com
    Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
    1
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      GSK3β (D5C5Z) XP® Rabbit mAb

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  73. academic.oup.com academic.oup.com
    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
    2
    1. scibot 28 Jul 2021
      AB_2636978

      DOI: 10.1210/en.2017-00287

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  74. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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      12456

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  75. May 2021
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    A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis
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  77. Apr 2021
  78. www.sciencedirect.com www.sciencedirect.com
    An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
    1
    1. scibot 30 Apr 2021
      RRID:AB_26369787

      DOI: 10.1016/j.cmet.2020.12.017

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  79. www.sciencedirect.com www.sciencedirect.com
    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.08.001

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    sciencedirect.com/science/article/pii/S1550413120304149
  80. Mar 2021
  81. link.springer.com link.springer.com
    DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells
    1
    1. scibot 18 Mar 2021
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      DOI: 10.1007/s11064-021-03273-6

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  82. Feb 2021
  83. www.sciencedirect.com www.sciencedirect.com
    Long-term kappa-carrageenan consumption leads to moderate metabolic disorder by blocking insulin binding
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    1. scibot 28 Feb 2021
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      DOI: 10.1016/j.phrs.2020.105417

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  84. academic.oup.com academic.oup.com
    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
    2
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      RRID:AB_2636978

      DOI: 10.1210/endocr/bqaa214

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      RRID: AB_2636978

      DOI: 10.1210/endocr/bqaa214

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  85. academic.oup.com academic.oup.com
    Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes
    1
    1. scibot 24 Feb 2021
      RRID:AB_2636978

      DOI: 10.1210/endocr/bqaa003

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  86. Jan 2021
  87. link.springer.com link.springer.com
    The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
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    1. scibot 21 Jan 2021
      RRID:AB_2636978

      DOI: 10.1186/s12943-021-01308-8

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  88. link.springer.com link.springer.com
    GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats
    1
    1. scibot 06 Jan 2021
      rabbit anti-GSK3β

      DOI: 10.1007/s10571-020-01020-z

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  89. Oct 2020
  90. www.sciencedirect.com www.sciencedirect.com
    Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.108327

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    sciencedirect.com/science/article/pii/S2211124720313164
  91. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.108223

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  92. Sep 2020
  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury
    1
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      RRID:AB_2636978

      DOI: 10.1111/jnc.14963

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14963
  94. www.sciencedirect.com www.sciencedirect.com
    The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function
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      DOI: 10.1016/j.celrep.2020.108140

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  95. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      RRID:AB_2636978

      DOI: 10.1111/bph.14980

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  96. www.sciencedirect.com www.sciencedirect.com
    HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2020.107625

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  97. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      RRID:AB_2636978

      DOI: 10.1111/bph.14912

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  98. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
    1
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      RRID:AB_2636978

      DOI: 10.1111/jnc.14954

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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
    1
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      Rabbit anti-GSK-3β

      DOI: 10.3389/fncel.2020.00094

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  100. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
    1
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      GSK3β

      DOI: 10.1126/scisignal.aax2364

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  101. Jan 2020
  102. www.sciencedirect.com www.sciencedirect.com
    Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2019.09.020

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    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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      AB_2636978

      DOI: 10.1016/j.ebiom.2019.08.033

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    Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages
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      RRID:AB_2636978

      DOI: 10.1016/j.immuni.2019.06.014

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  105. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      RRID:AB_2636978

      DOI: 10.1111/bph.14802

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  106. www.sciencedirect.com www.sciencedirect.com
    The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
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      RRID:AB_2636978

      DOI: 10.1016/j.celrep.2019.08.091

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  107. www.sciencedirect.com www.sciencedirect.com
    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.chom.2019.11.012

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  108. www.sciencedirect.com www.sciencedirect.com
    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
    1
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      RRID:AB_2636978

      DOI: 10.1016/j.ccell.2018.10.001

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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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      RRID:AB_2636978

      DOI: 10.1016/j.molcel.2019.05.009

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  110. Nov 2018
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  112. www.frontiersin.org www.frontiersin.org
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  113. www.sciencedirect.com www.sciencedirect.com
    Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling
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  114. www.sciencedirect.com www.sciencedirect.com
    Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
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    sciencedirect.com/science/article/pii/S1550413118303930
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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    AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
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    TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
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  118. Nov 2017
  119. www.pnas.org www.pnas.org
    Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity
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    β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling
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