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DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer

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1. scibot 19 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3728
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179828/
May 2026
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JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC

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1. scibot 05 May 2026
  
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  DOI: 10.1158/1078-0432.CCR-25-3720
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13133602/
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Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes

1
1. scibot 01 May 2026
  
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  DOI: 10.1016/j.xcrm.2026.102785
  
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sciencedirect.com/science/article/pii/S2666379126002028
Jan 2026
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microRNA 146a suppresses tumor progression and enhances therapeutic sensitivity by targeting the EGFR pathway in BRCA1-associated basal-like breast cancers

1
1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.adcanc.2025.100169
  
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sciencedirect.com/science/article/pii/S2667394025000383
Dec 2025
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Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer

1
1. scibot 23 Dec 2025
  
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  DOI: 10.1111/bph.70294
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
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Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition

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1. scibot 23 Dec 2025
  
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  DOI: 10.1038/s41418-025-01634-0
  
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nature.com/articles/s41418-025-01634-0
Nov 2025
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Patient-derived organoids to study glycosylation dynamics during gastric disease

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116550
  
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sciencedirect.com/science/article/pii/S221112472501321X
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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116520
  
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sciencedirect.com/science/article/pii/S2211124725012914
Jul 2025
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HIF-independent oxygen sensing via KDM6A regulates ferroptosis

1
1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.07.001
  
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sciencedirect.com/science/article/pii/S1097276525005805
May 2025
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Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

1
1. scibot 31 May 2025
  
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  DOI: 10.1080/19490976.2025.2508949
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12118437/
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Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

1
1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.003
  
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sciencedirect.com/science/article/pii/S153561082500162X
Apr 2025
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Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0386
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962398/
Jan 2025
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

1
1. scibot 25 Jan 2025
  
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  RRID:AB_2636984
  
  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
Jul 2024
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CircEZH2 Promotes Gallbladder Cancer Progression and Lipid Metabolism Reprogramming through the miR-556-5p/SCD1 Axis

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110428
  
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sciencedirect.com/science/article/pii/S2589004224016535
www.cell.com www.cell.com

Tongue orthotopic xenografts to study fusion-negative rhabdomyosarcoma invasion and metastasis in live animals

1
1. scibot 16 Jul 2024
  
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  RRID:AB_2636984
  
  DOI: 10.1016/j.crmeth.2024.100802
  
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cell.com/cell-reports-methods/abstract/S2667-2375(24)00158-9
Jun 2024
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The bidirectional role of GABAA and GABAB receptors during the differentiation process of neural precursor cells of the subventricular zone

1
1. scibot 27 Jun 2024
  
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  DOI: 10.1371/journal.pone.0305853
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11195948/
May 2024
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The bidirectional role of GABAA and GABAB receptors during the differentiation process of neural precursor cells of the subventricular zone

1
1. scibot 25 May 2024
  
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  RRID:AB_2636984
  
  DOI: 10.1101/2024.03.19.585835
  
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DOI:10.1101/2024.03.19.585835

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biorxiv.org/content/10.1101/2024.03.19.585835v1
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Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC

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1. scibot 23 May 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-2951
  
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2. scibot 23 May 2024
  
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  RRID:AB_2636984
  
  DOI: 10.1158/1078-0432.CCR-23-2951
  
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pubmed.ncbi.nlm.nih.gov/38330145/
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

1
1. scibot 17 May 2024
  
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  DOI: 10.1016/j.molcel.2024.04.009
  
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sciencedirect.com/science/article/pii/S1097276524003241
Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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1. scibot 27 Mar 2024
  
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  RRID:AB_2636984
  
  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
Feb 2024
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Stromal-derived MAOB promotes prostate cancer growth and progression

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1. scibot 14 Feb 2024
  
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  DOI: 10.1126/sciadv.adi4935
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857382/
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Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

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1. scibot 06 Feb 2024
  
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  RRID:AB_2636984
  
  DOI: 10.1158/2159-8290.CD-22-0982
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
Jan 2024
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Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer

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1. scibot 23 Jan 2024
  
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  RRID:AB_2636984
  
  DOI: 10.1016/j.xcrm.2023.101388
  
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sciencedirect.com/science/article/pii/S2666379123006171
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Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor

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1. scibot 09 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101354
  
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sciencedirect.com/science/article/pii/S2666379123005712
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Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer

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1. scibot 06 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.003
  
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sciencedirect.com/science/article/pii/S1550413123004552
Nov 2023
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Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma

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1. scibot 25 Nov 2023
  
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  RRID:AB_2636984
  
  DOI: 10.1186/s43556-023-00155-x
  
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link.springer.com/article/10.1186/s43556-023-00155-x
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Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids

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1. scibot 03 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113354
  
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sciencedirect.com/science/article/pii/S2211124723013669
Aug 2023
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Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer

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1. scibot 04 Aug 2023
  
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  DOI: 10.1158/1535-7163.MCT-23-0110
  
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aacrjournals.org/mct/article/22/8/962/727921/Vincristine-Enhances-the-Efficacy-of-MEK
Jun 2023
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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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1. scibot 02 Jun 2023
  
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  DOI: 10.1016/j.cell.2023.05.003
  
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sciencedirect.com/science/article/pii/S0092867423005226
May 2023
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A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma

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1. scibot 25 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112542
  
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sciencedirect.com/science/article/pii/S2211124723005533
Apr 2023
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112316
  
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sciencedirect.com/science/article/pii/S2211124723003273
Jan 2023
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MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

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1. scibot 07 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-21-0646
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9453853/
Dec 2022
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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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1. scibot 08 Dec 2022
  
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  DOI: 10.1016/j.molcel.2022.11.010
  
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A Novel NF2 Splicing Mutant Causes Neurofibromatosis Type 2 via Liquid-liquid Phase Separation with LATS and Hippo Pathway.

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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cd-21-0646-html.html

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Preclinical modeling of leiomyosarcoma identifies susceptibility to transcriptional CDK inhibitors through antagonism of E2F-driven oncogenic gene expression.

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Bidirectional Crosstalk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer

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Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021

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Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021

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A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

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Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

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Hsa_circ_0023990 promotes tumor growth and glycolysis in dedifferentiated TC via targeting miR-485-5p/FOXM1 axis

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Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas

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Untitled document

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Untitled document

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Untitled document

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Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

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Untitled document

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KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

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Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

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  Ki67
  
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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

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A Novel Bioengineered MicroRNA-127 Prodrug Suppresses The Growth And Metastatic Potential Of Triple Negative Breast Cancer Cells

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  Cell Signaling Technology, catalog no. 9027
  
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miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

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A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer

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CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

1
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Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma

1
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  AB_2636984
  
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IGF1R Expression in Ovarian Granulosa Cells is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice

1
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