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  1. Last 7 days
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    Amphiregulin orchestrates the paracrine immune-suppressive function of amniotic-derived cells through its interplay with COX-2/PGE2/EP4 axis
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    sciencedirect.com/science/article/pii/S2589004224017334
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    Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling
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    sciencedirect.com/science/article/pii/S1934590924002509
  4. Jul 2024
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    ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells
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    sciencedirect.com/science/article/pii/S2589004224014986
  6. www.cell.com www.cell.com
    Human trophectoderm becomes multi-layered by internalization at the polar region
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    cell.com/developmental-cell/abstract/S1534-5807(24)00362-9
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    Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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    sciencedirect.com/science/article/pii/S2211124724008398
  8. Jun 2024
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    sciencedirect.com/science/article/pii/S1550413124001918
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  11. May 2024
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    sciencedirect.com/science/article/pii/S1534580724002995
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    YAP/TAZ Drive Agrin–Matrix Metalloproteinase-12 Mediated Diabetic Skin Wound Healing
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    sciencedirect.com/science/article/pii/S0022202X24003919
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YAP condensates are highly organized hubs
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    ncbi.nlm.nih.gov/pmc/articles/PMC11111833/
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    Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610824001648
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    Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
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    Molecular and pathological characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies
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    ncbi.nlm.nih.gov/pmc/articles/PMC11061608/
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    Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness
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    sciencedirect.com/science/article/pii/S155041312400130X
  19. Apr 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of human alveolar epithelial type I cells from pluripotent stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11147407/
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    α-Catenin promotes dermal fibroblasts proliferation and migration during wound healing via FAK/YAP activation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202302251R
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    NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
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    sciencedirect.com/science/article/pii/S1934590924000845
  23. Mar 2024
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    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    sciencedirect.com/science/article/pii/S2451945624000874
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    Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
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    TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves
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      DOI: 10.7554/eLife.87394

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    ncbi.nlm.nih.gov/pmc/articles/PMC10959528/
  27. Feb 2024
  28. 52.53.155.43 52.53.155.43
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    YAP mediates apoptosis through failed integrin adhesion reinforcement
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    sciencedirect.com/science/article/pii/S2211124724001396
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    Integrative modelling and analysis of signalling crosstalk reveal molecular switches coordinating YAP transcriptional activities
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    ncbi.nlm.nih.gov/pmc/articles/PMC10877689/
  31. 52.53.155.43 52.53.155.43
    YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    sciencedirect.com/science/article/pii/S2211124724000421
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis
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  34. Dec 2023
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    YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development
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    sciencedirect.com/science/article/abs/pii/S1534580723006500
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    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    sciencedirect.com/science/article/pii/S0092867423012205
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    YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration
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      DOI: 10.1016/j.celrep.2023.113497

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    sciencedirect.com/science/article/pii/S2211124723015097
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    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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      DOI: 10.1038/s41419-023-06312-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10682431/
  39. Oct 2023
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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      DOI: 10.1016/j.xcrm.2023.101244

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    sciencedirect.com/science/article/pii/S2666379123004214
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    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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      DOI: 10.1186/s12967-023-04542-4

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    link.springer.com/article/10.1186/s12967-023-04542-4
  42. Sep 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate
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      DOI: 10.1016/j.isci.2023.107964

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    sciencedirect.com/science/article/pii/S2589004223020412
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    LSR targets YAP to modulate intestinal Paneth cell differentiation
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      DOI: 10.1016/j.celrep.2023.113118

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    sciencedirect.com/science/article/pii/S2211124723011300
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    3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages
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      DOI: 10.1016/j.stem.2023.08.005

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    sciencedirect.com/science/article/pii/S1934590923002886
  46. Aug 2023
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice
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      DOI: 10.1038/s41392-023-01554-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10409725/
  48. Jul 2023
  49. www.nature.com www.nature.com
    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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      DOI: 10.1038/s41536-023-00310-6

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    nature.com/articles/s41536-023-00310-6
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    Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload
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      DOI: 10.1016/j.isci.2023.107146

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    sciencedirect.com/science/article/pii/S2589004223012233
  51. Jun 2023
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    TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2
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  53. May 2023
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    FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
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    Lysine long-chain fatty acylation regulates the TEAD transcription factor
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    Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
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  60. Mar 2023
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    Two Hippo signaling modules orchestrate liver size and tumorigenesis
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  62. Jan 2023
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined control of the fibroblast contractile program by YAP and TAZ
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  67. Dec 2022
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    YAP regulates the liver size during the fasting-refeeding transition in mice
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  70. Nov 2022
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    Multiphase coalescence mediates Hippo pathway activation
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  72. Oct 2022
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel NF2 Splicing Mutant Causes Neurofibromatosis Type 2 via Liquid-liquid Phase Separation with LATS and Hippo Pathway.
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    Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury
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    Spatial epitope barcoding reveals clonal tumor patch behaviors
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    Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
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  77. Sep 2022
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    A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
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  79. Aug 2022
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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    Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement
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    Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle
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  83. Jul 2022
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
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  85. May 2022
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    JAM-A Signals Through the Hippo Pathway to Regulate Intestinal Epithelial Proliferation
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  87. Apr 2022
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    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    FREQUENCY AND GENOMIC ASPECTS OF INTRINSIC RESISTANCE TO VISMODEGIB IN LOCALLY ADVANCED BASAL CELL CARCINOMA
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    YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia
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  91. Mar 2022
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
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    Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation
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  94. Feb 2022
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    Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction
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    RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration
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  97. Jan 2022
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    Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
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    Adaptive differentiation promotes intestinal villus recovery
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  100. Dec 2021
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    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
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    Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
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  104. Oct 2021
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Lentiviral-mediated ectopic expression of YAP and TAZ in YAPoff cancer cell lines
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  107. Sep 2021
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    Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation
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  110. Aug 2021
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    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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  116. Jul 2021
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  120. dev.biologists.org dev.biologists.org
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    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
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    MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation
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    YAP1 regulates chondrogenic differentiation of ATDC5 promoted by temporary TNF-α stimulation through AMPK signaling pathway
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    Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
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    A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer
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    The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells
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      DOI: 10.1016/j.celrep.2019.10.057

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    Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells
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      DOI: 10.1016/j.celrep.2019.11.115

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    Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1
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      DOI: 10.1016/j.celrep.2019.11.035

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  163. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sphingosine 1‐phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes
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      DOI: 10.1111/jnc.14917

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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice
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      DOI: 10.7554/eLife.45961

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  165. www.sciencedirect.com www.sciencedirect.com
    The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
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      DOI: 10.1016/j.celrep.2019.05.071

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    Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells
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      DOI: 10.1016/j.devcel.2019.05.024

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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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      DOI: 10.1016/j.celrep.2019.03.021

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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stimulation of Piezo1 by mechanical signals promotes bone anabolism
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      DOI: 10.7554/eLife.49631

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  169. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2019.03.091

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      DOI: 10.1016/j.devcel.2019.04.018

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  173. Nov 2018
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    Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
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    Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction
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    Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis
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    Paneth Cell Multipotency Induced by Notch Activation following Injury
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    Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
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  183. Nov 2017
  184. www.sciencedirect.com www.sciencedirect.com
    A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
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    YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme
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    The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
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  187. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
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      Anti-Rabbit YAP1Cell Signaling TechnologyCat# 14074

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  188. elifesciences.org elifesciences.org
    Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
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