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An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection

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  DOI: 10.1038/s41590-026-02514-6
  
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nature.com/articles/s41590-026-02514-6
May 2026
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Olfactomedin4 marks luminal progenitor cells that give rise to secretory cell lineage in the mouse cervix

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  DOI: 10.64898/2026.04.28.721179
  
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biorxiv.org/content/10.64898/2026.04.28.721179v1
Mar 2026
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VGLL4 modulates Paneth cells and sustains intestinal homeostasis

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  DOI: 10.1038/s44319-026-00699-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12979657/
Feb 2026
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The Microbial Bile Acid Metabolite 3-oxo-LCA Inhibits Colorectal Cancer Progression

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  DOI: 10.1158/0008-5472.CAN-24-3898
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12871761/
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Sleep disturbance triggers aberrant activation of vagus circuitry and induces intestinal stem cell dysfunction

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sciencedirect.com/science/article/pii/S1934590926000251
Sep 2025
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Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche

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  DOI: 10.1016/j.devcel.2025.09.004
  
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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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  DOI: 10.1158/0008-5472.CAN-18-4075
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6726494/
Jul 2025
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Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation

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1. scibot 17 Jul 2025
  
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embopress.org/doi/full/10.1038/s44319-025-00464-y
May 2025
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CapdevilaCastillo_columbia_0054D_18600-html.html

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  DOI: 10.7916/kcm5-sk40
  
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52.53.155.43/defa13d4e31bf105e951133a04f91af42d68a175/CapdevilaCastillo_columbia_0054D_18600-html.html
Mar 2025
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Vagal pathway activation links chronic stress to decline in intestinal stem cell function

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1. scibot 24 Mar 2025
  
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  DOI: 10.1016/j.stem.2025.02.016
  
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sciencedirect.com/science/article/pii/S1934590925000840
Feb 2025
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The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115286
  
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sciencedirect.com/science/article/pii/S2211124725000579
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LPA5-Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation

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  DOI: 10.1152/ajpgi.00269.2023
  
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52.53.155.43/978c5dfff0426cc212e73bbfea0ae45a47f47f85/yun-et-al-2024-lpa5-dependent-signaling-regulates-regeneration-of-the-intestinal-epithelium-following-irradiation-html.html
Dec 2024
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Maternal gut microbiota influence stem cell function in offspring

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.stem.2024.10.003
  
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sciencedirect.com/science/article/pii/S1934590924003655
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FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response

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  DOI: 10.1016/j.devcel.2024.10.022
  
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sciencedirect.com/science/article/pii/S1534580724006622
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Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility

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  DOI: 10.1016/j.devcel.2024.10.021
  
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sciencedirect.com/science/article/pii/S1534580724006610
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IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells

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  DOI: 10.1016/j.celrep.2024.114948
  
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sciencedirect.com/science/article/pii/S2211124724012993
Sep 2024
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Protocol to characterize mouse intestinal epithelial cell lineage using Opal multiplex immunofluorescence

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.xpro.2024.103303
  
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sciencedirect.com/science/article/pii/S2666166724004684
Aug 2024
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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114618
  
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sciencedirect.com/science/article/pii/S2211124724009689
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Zinc transporter 1 functions in copper uptake and cuproptosis

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  DOI: 10.1016/j.cmet.2024.07.009
  
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sciencedirect.com/science/article/pii/S1550413124002791
Jul 2024
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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

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sciencedirect.com/science/article/pii/S1534580724003794
Jun 2024
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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells

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  DOI: 10.1016/j.cell.2024.05.001
  
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sciencedirect.com/science/article/pii/S0092867424004914
May 2024
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Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation

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sciencedirect.com/science/article/pii/S1534580724002995
Mar 2024
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RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis

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ncbi.nlm.nih.gov/pmc/articles/PMC10959657/
Jan 2024
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A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

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  DOI: 10.1016/j.chom.2023.12.015
  
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sciencedirect.com/science/article/pii/S1931312823005103
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An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate

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1. scibot 18 Jan 2024
  
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  DOI: 10.1126/sciadv.adg4055
  
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science.org/doi/10.1126/sciadv.adg4055
Dec 2023
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Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting

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  DOI: 10.1038/s41551-023-01135-w
  
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link.springer.com/article/10.1038/s41551-023-01135-w
Nov 2023
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SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

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  DOI: 10.1038/s41467-023-43027-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10640587/
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p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation

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  DOI: 10.1016/j.celrep.2023.112659
  
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TGFB1 induces fetal reprogramming and enhances intestinal regeneration

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  DOI: 10.1016/j.stem.2023.09.015
  
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sciencedirect.com/science/article/pii/S1934590923003624
Sep 2023
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LSR targets YAP to modulate intestinal Paneth cell differentiation

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  DOI: 10.1016/j.celrep.2023.113118
  
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sciencedirect.com/science/article/pii/S2211124723011300
Jul 2023
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An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate

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ncbi.nlm.nih.gov/pmc/articles/PMC10337909/
May 2023
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BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia

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1. scibot 05 May 2023
  
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  DOI: 10.1126/sciimmunol.abl6543
  
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science.org/doi/10.1126/sciimmunol.abl6543
Mar 2023
pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com

CDK4/6 inhibitor modulating active and quiescent intestinal stem cells for prevention of chemotherapy-induced diarrhea

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1. scibot 30 Mar 2023
  
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  DOI: 10.1002/path.6078
  
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pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6078
Dec 2022
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Embryogenic stem cell-derived intestinal crypt fission directs de novo crypt genesis

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  DOI: 10.1016/j.celrep.2022.111796
  
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sciencedirect.com/science/article/pii/S2211124722016849
Nov 2022
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A dietary change to a high-fat diet initiates a rapid adaptation of the intestine

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  DOI: 10.1016/j.celrep.2022.111641
  
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sciencedirect.com/science/article/pii/S2211124722015121
Sep 2022
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Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation

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Bacillus subtilis programs the differentiation of intestinal secretory lineages to inhibit Salmonella infection

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Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

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Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

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Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury

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Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos

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Lymphatics act as a signaling hub to regulate intestinal stem cell activity

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G209R mutant mouse as a model for human PCSK1 polyendocrinopathy

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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

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SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal

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Adaptive differentiation promotes intestinal villus recovery

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Generation of mixed murine organoids to model cellular interactions

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Enteric glial cell heterogeneity regulates intestinal stem cell niches

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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

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Untitled document

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Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration

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High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

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Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

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Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

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Paneth Cell Multipotency Induced by Notch Activation following Injury

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Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis

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