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Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RAS(ON) multi-selective inhibition drives antitumor immunity in preclinical models of NRAS-mutant melanoma

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  DOI: 10.1158/2326-6066.CIR-25-0744
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12666865/
Nov 2025
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MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors

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sciencedirect.com:5037/science/article/pii/S2666634025003630
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Hybrid apoptotic body decorated supramolecular hydrogel system for melanoma cancer immunoediting

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  DOI: 10.1016/j.cej.2025.171086
  
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Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis

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  DOI: 10.1016/j.celrep.2025.116557
  
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Oct 2025
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2025.10.24.684274v1.full-html.html

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  DOI: 10.1101/2025.10.24.684274
  
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54.241.53.176/560b23241d86210770f41b5bc2071167c8b2fca6/2025.10.24.684274v1.full-html.html
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Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

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  DOI: 10.1016/j.chembiol.2025.09.003
  
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sciencedirect.com/science/article/pii/S2451945625002685
Sep 2025
www.biorxiv.org www.biorxiv.org

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

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  DOI: 10.1101/2025.08.30.673054
  
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Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy

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  DOI: 10.1016/j.celrep.2025.116233
  
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sciencedirect.com/science/article/pii/S2211124725010046
Aug 2025
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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The absence of IL17A favours cytotoxic cell function and improves antigen-specific immunotherapies in pancreatic adenocarcinoma

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1. scibot 21 Aug 2025
  
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  DOI: 10.1002/ctm2.70442
  
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onlinelibrary.wiley.com/doi/10.1002/ctm2.70442
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Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

1
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  DOI: 10.1016/j.chembiol.2025.07.004
  
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sciencedirect.com/science/article/pii/S2451945625002272
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

1
1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

1
1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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sciencedirect.com/science/article/pii/S0092867425007287
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Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model

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1. scibot 15 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.jid.2023.12.017
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11193656/
Jun 2025
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BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102183
  
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sciencedirect.com/science/article/pii/S2666379125002563
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Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.014
  
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sciencedirect.com/science/article/pii/S1535610825002235
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Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.010
  
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sciencedirect.com/science/article/pii/S1535610825002193
Apr 2025
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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

1
1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115605
  
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sciencedirect.com/science/article/pii/S2211124725003766
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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

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  DOI: 10.1016/j.celrep.2025.115572
  
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sciencedirect.com/science/article/pii/S2211124725003432
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Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer

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  DOI: 10.1158/2326-6066.CIR-24-0775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962391/
Feb 2025
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Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease

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  DOI: 10.1016/j.celrep.2025.115294
  
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The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

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  DOI: 10.1016/j.celrep.2025.115286
  
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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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  DOI: 10.1016/j.xcrm.2024.101927
  
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Jan 2025
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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation

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  DOI: 10.1016/j.isci.2025.111756
  
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Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment

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  DOI: 10.1158/2326-6066.CIR-23-1092
  
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PDF-html.html

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  DOI: 10.1158/2326-6066.cir-24-0775
  
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52.53.155.43/009f00f9e3d39df3c2a4236499ac454ff01f615a/PDF-html.html
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Three-dimensional characteristics of T cells and vasculature in the development of mouse esophageal cancer

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  DOI: 10.1016/j.isci.2024.111380
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11629339/
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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

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  DOI: 10.1016/j.ccell.2024.11.006
  
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Nov 2024
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strobl-et-al-2024-jak-stat1-as-therapeutic-target-for-egfr-deficiency-associated-inflammation-and-scarring-alopecia-html.html

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  DOI: 10.1038/s44321-024-00166-3
  
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52.53.155.43/586ba8b525e8da6306112d5dd7635949084313ca/strobl-et-al-2024-jak-stat1-as-therapeutic-target-for-egfr-deficiency-associated-inflammation-and-scarring-alopecia-html.html
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JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

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  DOI: 10.1038/s44321-024-00166-3
  
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  DOI: 10.1038/s44321-024-00166-3
  
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embopress.org/doi/10.1038/s44321-024-00166-3
Oct 2024
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Microarray analysis of signalling interactions between inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis

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  DOI: 10.12336/biomatertransl.2024.02.007
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11438608/
Sep 2024
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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.005
  
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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

1
1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101711
  
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sciencedirect.com/science/article/pii/S2666379124004324
Jul 2024
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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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  DOI: 10.1126/science.adh4567
  
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Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment

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Jun 2024
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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May 2024
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Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival

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Apr 2024
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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

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Mar 2024
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Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

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A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

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Feb 2024
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Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

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Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

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Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer

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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Select symbionts drive high IgA levels in the mouse intestine

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Aug 2023
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Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair

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Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy

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ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

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Immune landscape of a genetically engineered murine model of glioma compared to human glioma by single-cell sequencing

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Semi-Supervised Analysis of myeloid and T cell behaviour in ex vivo ovarian tumour slices reveals changes in cell motility after treatments

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Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion

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Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

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T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers

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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Opioid-induced fragile-like regulatory T cells contribute to withdrawal

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SSRN-id4272137-html.html

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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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  DOI: 10.1158/2159-8290.CD-21-0003
  
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Across-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis

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Nov 2022
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An immunocompetent rectal cancer model to study radiation therapy

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Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

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Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

1
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PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

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Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection

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Aug 2022
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Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis

1
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Low ferroptosis score predicts chemotherapy responsiveness and immune-activation in colorectal cancer

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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity

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Topical therapy for regression and melanoma prevention of congenital giant nevi

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Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma

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Spatial CRISPR genomics identifies regulators of the tumor microenvironment

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Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection

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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

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Simultaneously Combined Cancer Cell- and CTLA4-Targeted NIR-PIT Causes a Synergistic Treatment Effect in Syngeneic Mouse Models

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

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CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

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Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease

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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

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Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

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Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

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Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics

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FEBS Press

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MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

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Vezatin is required for the maturation of the neuromuscular synapse

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Cuprizone‐induced demyelination triggers a CD8‐pronounced T cell recruitment

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Table 1 Antibodies.

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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s

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An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

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Vezatin is required for the maturation of the neuromuscular synapse

1
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Laquinimod ameliorates secondary brain inflammation

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Untitled document

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Untitled document

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