118 Matching Annotations
  1. May 2024
  2. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
    1
    1. scibot 25 May 2024
      AB_2687461

      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    1. scibot 24 May 2024
      RRID:AB_2687461

      DOI: 10.1016/j.isci.2024.109860

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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
  4. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
    1
    1. scibot 24 May 2024
      RRID:AB_2687461

      DOI: 10.1016/j.molcel.2024.04.026

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    sciencedirect.com/science/article/pii/S1097276524003939
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    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
    1
    1. scibot 23 May 2024
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      DOI: 10.1016/j.molcel.2024.04.025

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    sciencedirect.com/science/article/pii/S1097276524003927
  6. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
    1
    1. scibot 10 May 2024
      RRID:AB_2687461

      DOI: 10.1016/j.isci.2024.109800

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    cell.com/iscience/abstract/S2589-0042(24)01022-8
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    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
    1
    1. scibot 09 May 2024
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      DOI: 10.1016/j.molcel.2024.04.010

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    sciencedirect.com/science/article/pii/S1097276524003253
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    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
    1
    1. scibot 03 May 2024
      RRID:AB_2687461

      DOI: 10.1016/j.celrep.2024.114174

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    sciencedirect.com/science/article/pii/S2211124724005023
  9. Mar 2024
  10. www.sciencedirect.com www.sciencedirect.com
    A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53
    2
    1. scibot 21 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.018

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    2. scibot 21 Mar 2024
      RRID:AB_2687461

      DOI: 10.1016/j.molcel.2024.02.018

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    sciencedirect.com/science/article/pii/S1097276524001370
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
    1
    1. scibot 06 Mar 2024
      RRID:AB_2687461

      DOI: 10.1158/1535-7163.MCT-23-0025

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  12. Jan 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
    1
    1. scibot 26 Jan 2024
      AB_2687461

      DOI: 10.1101/2023.05.04.539399

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    ncbi.nlm.nih.gov/pmc/articles/PMC10187264/
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.003

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    sciencedirect.com/science/article/pii/S1097276523010225
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.010

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    sciencedirect.com/science/article/pii/S1097276523010298
  16. Dec 2023
  17. www.sciencedirect.com www.sciencedirect.com
    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
    1
    1. scibot 20 Dec 2023
      RRID:AB_2687461

      DOI: 10.1016/j.celrep.2023.113581

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    sciencedirect.com/science/article/pii/S2211124723015930
  18. Nov 2023
  19. link.springer.com link.springer.com
    SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
    1
    1. scibot 25 Nov 2023
      RRID:AB_2687461

      DOI: 10.1007/s00018-023-05011-3

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    link.springer.com/article/10.1007/s00018-023-05011-3
  20. www.sciencedirect.com www.sciencedirect.com
    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
    1
    1. scibot 18 Nov 2023
      RRID:AB_2687461

      DOI: 10.1016/j.isci.2023.108299

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    sciencedirect.com/science/article/pii/S2589004223023763
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101285

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    sciencedirect.com/science/article/pii/S2666379123004792
  22. Oct 2023
  23. link.springer.com link.springer.com
    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
    1
    1. scibot 31 Oct 2023
      RRID:AB_2687461

      DOI: 10.1186/s13041-023-01064-4

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    link.springer.com/article/10.1186/s13041-023-01064-4
  24. Aug 2023
  25. www.sciencedirect.com www.sciencedirect.com
    PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development
    1
    1. scibot 27 Aug 2023
      RRID:AB_2687461

      DOI: 10.1016/j.cell.2023.08.008

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    sciencedirect.com/science/article/abs/pii/S0092867423008620
  26. www.sciencedirect.com www.sciencedirect.com
    USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential
    1
    1. scibot 23 Aug 2023
      RRID:AB_2687461

      DOI: 10.1016/j.chembiol.2023.07.016

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    sciencedirect.com/science/article/abs/pii/S2451945623002465
  27. 52.53.155.43 52.53.155.43
    NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
    2
    1. scibot 17 Aug 2023
      RRID:AB_2687461

      DOI: 10.1016/j.celrep.2023.112963

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    2. scibot 10 Aug 2023
      RRID:AB_2687461

      DOI: 10.1016/j.celrep.2023.112963

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    52.53.155.43/eb7aace05cf7a189f4453bfbeb3bcf344412f769/mmc4-html.html
  28. 52.53.155.43 52.53.155.43
    mct-23-0025 (1)-html.html
    1
    1. scibot 11 Aug 2023
      AB_2687461

      DOI: 10.1158/1535-7163.mct-23-0025

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    52.53.155.43/1629e82c15a2ef751662f24158b1c1b52e5a2112/mct-23-0025 (1)-html.html
  29. Jul 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1371/journal.pgen.1010828

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    ncbi.nlm.nih.gov/pmc/articles/PMC10368295/
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    Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation
    1
    1. scibot 13 Jul 2023
      RRID:AB_2687461

      DOI: 10.1016/j.molcel.2023.06.032

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    sciencedirect.com/science/article/abs/pii/S1097276523005087
  32. www.sciencedirect.com www.sciencedirect.com
    Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors
    1
    1. scibot 05 Jul 2023
      RRID:AB_2687461

      DOI: 10.1016/j.celrep.2023.112714

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    sciencedirect.com/science/article/pii/S2211124723007258
  33. Jun 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Acetate controls endothelial-to-mesenchymal transition
    1
    1. scibot 21 Jun 2023
      RRID:AB_2687461

      DOI: 10.1016/j.cmet.2023.05.010

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    sciencedirect.com/science/article/pii/S1550413123002036
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Restored autophagy is protective against PAK3-induced cardiac dysfunction
    1
    1. scibot 17 Jun 2023
      RRID:AB_2687461

      DOI: 10.1016/j.isci.2023.106970

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    ncbi.nlm.nih.gov/pmc/articles/PMC10265534/
  36. May 2023
  37. 52.53.155.43 52.53.155.43
    Extension of the DNAJB2a isoform in a dominant neuromyopathy family
    1
    1. scibot 25 May 2023
      RRID:AB_2687461

      DOI: 10.1093/hmg/ddad058

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    52.53.155.43/396df2b483ef1c6ab6d995aa3a1866b7164b08c6/ddad058-html.html
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    A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses in Drosophila
    1
    1. scibot 12 May 2023
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      DOI: 10.1016/j.crmeth.2023.100477

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    sciencedirect.com/science/article/pii/S2667237523001005
  39. Apr 2023
  40. www.sciencedirect.com www.sciencedirect.com
    TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner
    1
    1. scibot 15 Apr 2023
      RRID:AB_2687461

      DOI: 10.1016/j.celrep.2023.112406

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    sciencedirect.com/science/article/pii/S2211124723004175
  41. Mar 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells
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      DOI: 10.1016/j.chembiol.2023.02.006

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    sciencedirect.com/science/article/pii/S2451945623000557
  43. www.sciencedirect.com www.sciencedirect.com
    COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
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      DOI: 10.1016/j.isci.2023.106232

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    sciencedirect.com/science/article/pii/S2589004223003097
  44. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.16046

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16046
  45. Feb 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
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      DOI: 10.1016/j.molcel.2023.01.023

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    sciencedirect.com/science/article/pii/S1097276523000758
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    RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex
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      DOI: 10.1016/j.celrep.2023.112097

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    sciencedirect.com/science/article/pii/S2211124723001080
  48. www.sciencedirect.com www.sciencedirect.com
    Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
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      DOI: 10.1016/j.cell.2022.12.046

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    sciencedirect.com/science/article/pii/S0092867422016294
  49. Jan 2023
  50. www.sciencedirect.com www.sciencedirect.com
    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
    1
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      DOI: 10.1016/j.cell.2022.12.025

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    sciencedirect.com/science/article/pii/S0092867422015380
  51. www.cell.com www.cell.com
    Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation
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    1. scibot 06 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.004

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    cell.com/cell/fulltext/S0092-8674(22)01517-3
  52. Dec 2022
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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      DOI: 10.1158/0008-5472.CAN-22-0446

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    ncbi.nlm.nih.gov/pmc/articles/PMC9354703/
  54. Nov 2022
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    Genome-wide survey of D/E repeats in human proteins uncovers their instability and aids in identifying their role in the chromatin regulator ATAD2
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    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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  57. Oct 2022
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    A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis
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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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  60. Sep 2022
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    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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    In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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  64. Aug 2022
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    PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis
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    Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
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    Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
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    Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels
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  70. Jun 2022
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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  73. May 2022
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    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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  75. Apr 2022
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
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  82. Feb 2022
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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  84. Jan 2022
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    YAP1 and PRDM14 converge to promote cell survival and tumorigenesis
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  86. Dec 2021
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    Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation
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  88. Nov 2021
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    Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation
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  91. Sep 2021
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    Characterization of the subunit composition and structure of adult human glycine receptors
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  93. Aug 2021
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    Molecular basis for substrate recruitment to the PRMT5 methylosome
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    TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
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  101. Jul 2021
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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      Rabbit anti-V5

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    CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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  106. Jun 2021
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    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
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  108. May 2021
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
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  112. Apr 2021
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    A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms
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    FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer
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    Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia
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  116. Mar 2021
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  118. Feb 2021
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    Leptin controls glutamatergic synaptogenesis and NMDA-receptor trafficking via Fyn kinase regulation of NR2B
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  121. Dec 2020
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    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis
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  124. Oct 2020
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  126. Sep 2020
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    LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ
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    A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay
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      Anti-V5 Rabbit monoclonal

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  133. Jan 2020
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    Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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      DOI: 10.1016/j.ccell.2018.05.002

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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells
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  139. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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      DOI: 10.1016/j.molcel.2019.07.021

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    PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
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      DOI: 10.1016/j.celrep.2019.02.111

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    Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production
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  147. Nov 2018
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    Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
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    Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
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    Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  155. Nov 2017
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    YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme
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    Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development
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      Rabbit monoclonal anti-V5 tag (D3H8Q) antibodyCell Signaling TechnologyCat#13202

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    Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
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      Rabbit anti-V5 (D3H8Q)Cell Signaling TechnologiesCat#13202

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